DE69526784D1 - Verfahren zur herstellung von optisch aktiven mevalonolactonen - Google Patents

Verfahren zur herstellung von optisch aktiven mevalonolactonen

Info

Publication number
DE69526784D1
DE69526784D1 DE69526784T DE69526784T DE69526784D1 DE 69526784 D1 DE69526784 D1 DE 69526784D1 DE 69526784 T DE69526784 T DE 69526784T DE 69526784 T DE69526784 T DE 69526784T DE 69526784 D1 DE69526784 D1 DE 69526784D1
Authority
DE
Germany
Prior art keywords
fluid
flow
circuit
inlet port
outlet port
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69526784T
Other languages
English (en)
Other versions
DE69526784T2 (de
Inventor
Hirokazu Ikeda
Tatsushi Murakami
Hiroo Matsumoto
Yoshio Ohara
Hiroyashu Kanda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daicel Corp
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Daicel Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Daicel Chemical Industries Ltd filed Critical Nissan Chemical Corp
Publication of DE69526784D1 publication Critical patent/DE69526784D1/de
Application granted granted Critical
Publication of DE69526784T2 publication Critical patent/DE69526784T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterized by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/328—Polymers on the carrier being further modified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69526784T 1994-02-25 1995-02-22 Verfahren zur herstellung von optisch aktiven mevalonolactonen Expired - Lifetime DE69526784T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2859494 1994-02-25
PCT/JP1995/000251 WO1995023125A1 (fr) 1994-02-25 1995-02-22 Procede de production de compose de mevalonolactone optiquement actif

Publications (2)

Publication Number Publication Date
DE69526784D1 true DE69526784D1 (de) 2002-06-27
DE69526784T2 DE69526784T2 (de) 2002-09-05

Family

ID=12252925

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69526784T Expired - Lifetime DE69526784T2 (de) 1994-02-25 1995-02-22 Verfahren zur herstellung von optisch aktiven mevalonolactonen

Country Status (11)

Country Link
US (1) US5939552A (de)
EP (1) EP0747341B1 (de)
JP (1) JP3776452B2 (de)
KR (1) KR100355335B1 (de)
CN (1) CN1136183C (de)
AT (1) ATE217859T1 (de)
AU (1) AU691582B2 (de)
CA (1) CA2183071C (de)
DE (1) DE69526784T2 (de)
HU (1) HU214160B (de)
WO (1) WO1995023125A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
RU2214402C2 (ru) 1998-07-23 2003-10-20 Ниссан Кемикал Индастриз, Лтд. Способ получения 3-((2-циклопропил-4-(4-фторфенил)-3-хинолил)проп-2-еналя и промежуточное соединение
EP1334967A4 (de) * 2000-10-13 2008-05-07 Daicel Chem VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEM (3R,5S,6E)-7-ç2-CYCLOPROPYL-4-(4-FLUORPHENYL)CHINOLIN-3-YL]-3,5-DIHYDROXY-6-HEPTENSÄUREETHYLESTER
WO2002030853A1 (fr) * 2000-10-13 2002-04-18 Daicel Chemical Industries, Ltd. Matiere de remplissage pour separation d'isomeres optiques et procede permettant la separation d'isomeres optiques au moyen de cette matiere de remplissage
FR2834227A1 (fr) 2001-12-27 2003-07-04 Chiralsep Sarl Materiaux supports optiquement actifs, leur procede de preparation et leurs utilisations
KR101067314B1 (ko) 2002-09-20 2011-09-23 닛산 가가쿠 고교 가부시키 가이샤 3,5-디하이드록시-6-헵테노에이트 제조 방법
WO2004072040A1 (en) 2003-02-12 2004-08-26 Ciba Specialty Chemicals Holding Inc. Crystalline forms of pitavastatin calcium
CN100364661C (zh) * 2003-04-24 2008-01-30 大赛璐化学工业株式会社 光学异构体用分离剂
WO2004099766A1 (ja) * 2003-04-24 2004-11-18 Daicel Chemical Industries, Ltd. 光学異性体用分離剤
JP4294028B2 (ja) * 2003-04-24 2009-07-08 ダイセル化学工業株式会社 光学異性体用分離剤
CN100408562C (zh) * 2003-04-24 2008-08-06 大赛璐化学工业株式会社 (3r,5s,6e)-7-[2-环丙基-4-(4-氟苯基)喹啉-3-基]-3,5-二羟基-6-庚烯酸乙酯的制备方法
JPWO2004094377A1 (ja) * 2003-04-24 2006-07-13 ダイセル化学工業株式会社 光学活性なジヒドロキシヘプテン酸エステルの分離方法
TWI343914B (en) * 2003-10-03 2011-06-21 Nissan Chemical Ind Ltd Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative
WO2006011047A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Enantioselective method for separing substituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives
US7627159B2 (en) * 2004-10-28 2009-12-01 Siemens Medical Solutions Usa, Inc. 2D visualization for rib analysis
JP2006150214A (ja) 2004-11-29 2006-06-15 Daicel Chem Ind Ltd 光学異性体用分離剤及び光学異性体用分離カラム
CN101490544B (zh) * 2006-05-09 2013-11-20 国立大学法人名古屋大学 用于旋光异构体分离的填料
EP2037263A4 (de) 2006-06-23 2009-08-05 Daicel Chem Verfahren zur analyse optischer isomere oder verfahren zu deren trennung
CN101259397B (zh) * 2007-12-21 2010-12-15 中国科学院山西煤炭化学研究所 一种模拟移动床反应器及其应用方法
CN102143789B (zh) 2008-08-26 2013-12-25 大赛璐化学工业株式会社 使用模拟移动床色谱分离装置制造目标物质的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041507A (ja) * 1983-08-12 1985-03-05 Mitsubishi Kasei Techno Engineers Kk クロマト分離装置の制御方法
JPS60226829A (ja) * 1984-03-29 1985-11-12 Daicel Chem Ind Ltd 多糖誘導体より成る分離剤
JPH0718849B2 (ja) * 1986-03-12 1995-03-06 ダイセル化学工業株式会社 分離剤の製造方法
JPH03100459A (ja) * 1989-09-14 1991-04-25 Sumitomo Heavy Ind Ltd 擬似移動床式クロマト分離法
JP2925753B2 (ja) * 1990-02-23 1999-07-28 ダイセル化学工業株式会社 光学異性体の分離方法
JPH0695090B2 (ja) * 1990-09-21 1994-11-24 川崎重工業株式会社 擬似移動床式液体クロマト分離装置
JP3181349B2 (ja) * 1991-03-04 2001-07-03 ダイセル化学工業株式会社 多糖誘導体及びその製造法、並びに分離剤
JP3528186B2 (ja) * 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
JP3010816B2 (ja) * 1991-08-22 2000-02-21 ダイセル化学工業株式会社 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法

Also Published As

Publication number Publication date
HUT74486A (en) 1997-01-28
EP0747341B1 (de) 2002-05-22
HU214160B (hu) 1998-01-28
AU1823195A (en) 1995-09-11
JP3776452B2 (ja) 2006-05-17
EP0747341A1 (de) 1996-12-11
WO1995023125A1 (fr) 1995-08-31
DE69526784T2 (de) 2002-09-05
KR970701165A (ko) 1997-03-17
CA2183071A1 (en) 1995-08-31
CN1136183C (zh) 2004-01-28
US5939552A (en) 1999-08-17
HU9602291D0 (en) 1996-10-28
CN1141028A (zh) 1997-01-22
ATE217859T1 (de) 2002-06-15
EP0747341A4 (de) 1998-09-30
AU691582B2 (en) 1998-05-21
CA2183071C (en) 2001-12-18
KR100355335B1 (ko) 2003-04-11

Similar Documents

Publication Publication Date Title
DE69526784D1 (de) Verfahren zur herstellung von optisch aktiven mevalonolactonen
KR960010366B1 (ko) 크로마토 그래픽 분리 방법
TW351678B (en) Method for fractionating a solution to fractionate a solution
ATE503538T1 (de) Trennungsprozess durch simulierte fliessbettchromatographie
MA21562A1 (fr) Procede pour la recuperation de betaine a partir de molasses .
EP0719749A3 (de) Verfahren zur Trennung von optischen Isomeren in einem simulierten Wanderbettsystem
MY106861A (en) Process and apparatus for continuous chromatographic separation of a mixture of at least three constituents.
EP0134357A1 (de) Scheidungsmethode von Fettsäuren und ein Molekularsieb hierzu
DK2186D0 (da) Fremgangsmaade og apparat til chromatografisk separation af biologiske makromolekyler
DE69907906D1 (de) Methoden und apparat zum packen von chromatographiesäulen
ATE17890T1 (de) Fluessigkeits-chromatographensaeule, verfahren zu ihrer herstellung und ihre verwendung zur fraktionierung.
Deyl et al. Separation and partial characterization of Maillard reaction products by capillary zone electrophoresis
JP2740780B2 (ja) 擬似移動層装置
US2646171A (en) Process for separation and recovery of components of a solution
DE59910840D1 (de) Verfahren und Vorrichtung zur Durchführung biochemischer Reaktionen mit hohem Durchsatz
ATE528393T1 (de) Verfahren zur reinigung von protein und glucosedehydrogenase
ITTO920592A1 (it) Proccedimento per la produzione di ittrio-90 e generatore di ittrio-90
ATE52937T1 (de) Verfahren zur trennung von wasserstoffisotopen.
DE50301526D1 (de) Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo(4.3.0)nonan unter Verwendung von Gegenstromchromatographie
KR960000276A (ko) 의사(擬似) 이동상 크로마토분리법
Henderson et al. Enhanced UV detection of sugar phosphates by addition of a metal complex to the HPLC mobile phase
JPS5637008A (en) Separation of mixtures by adsorption
JPH0312230A (ja) 充填層の洗浄方法
JP2879961B2 (ja) クロマト分離法及び簡略式擬似移動層装置
Falcon The separation of proteins via parametric pumping and ion exchange

Legal Events

Date Code Title Description
8364 No opposition during term of opposition