DE69433188D1 - Beta-Lactam, Verfahren zur Herstellung Taxane-Derivate und Taxane mit Seitenketten - Google Patents

Beta-Lactam, Verfahren zur Herstellung Taxane-Derivate und Taxane mit Seitenketten

Info

Publication number
DE69433188D1
DE69433188D1 DE69433188T DE69433188T DE69433188D1 DE 69433188 D1 DE69433188 D1 DE 69433188D1 DE 69433188 T DE69433188 T DE 69433188T DE 69433188 T DE69433188 T DE 69433188T DE 69433188 D1 DE69433188 D1 DE 69433188D1
Authority
DE
Germany
Prior art keywords
preparation
taxanes
beta
lactam
side chains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69433188T
Other languages
English (en)
Other versions
DE69433188T2 (de
Inventor
John K Thottathil
Ivan D Trifunovich
David J Kucera
Wen-Sen Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69433188D1 publication Critical patent/DE69433188D1/de
Publication of DE69433188T2 publication Critical patent/DE69433188T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
DE69433188T 1993-03-19 1994-03-14 Beta-Lactam, Verfahren zur Herstellung Taxane-Derivate und Taxane mit Seitenketten Expired - Fee Related DE69433188T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3359893A 1993-03-19 1993-03-19
US33598 1993-03-19

Publications (2)

Publication Number Publication Date
DE69433188D1 true DE69433188D1 (de) 2003-11-06
DE69433188T2 DE69433188T2 (de) 2004-07-29

Family

ID=21871323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433188T Expired - Fee Related DE69433188T2 (de) 1993-03-19 1994-03-14 Beta-Lactam, Verfahren zur Herstellung Taxane-Derivate und Taxane mit Seitenketten

Country Status (18)

Country Link
US (5) US6350887B1 (de)
EP (2) EP0617018B1 (de)
JP (1) JPH06321896A (de)
KR (1) KR100309973B1 (de)
CN (2) CN1080256C (de)
AT (1) ATE251134T1 (de)
CA (1) CA2116093A1 (de)
CY (1) CY2405B1 (de)
DE (1) DE69433188T2 (de)
DK (1) DK0617018T3 (de)
ES (1) ES2208649T3 (de)
FI (1) FI941286A (de)
HK (1) HK1002005A1 (de)
HU (1) HUT69733A (de)
IL (3) IL123063A (de)
PT (1) PT617018E (de)
SG (1) SG50463A1 (de)
TW (1) TW467896B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163837C (en) † 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
DE19703549C1 (de) * 1997-01-31 1999-03-04 Clariant Gmbh Verfahren zur Herstellung von Diacylimiden
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
ES2211550T3 (es) 1999-05-17 2004-07-16 Bristol-Myers Squibb Company Nuevas condiciones de reaccion para la escision de eteres de sililo en la preparacion de paclitaxel (taxol(r)) y analogos de paclitaxel.
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7989490B2 (en) * 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
BRPI0511109A (pt) * 2004-05-14 2007-11-27 Immunogen Inc método fácil para sintetizar compostos de baccatin iii
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
CA2723654A1 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
CA2732508C (en) 2008-08-11 2016-03-15 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
US8785669B2 (en) 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE21105T1 (de) 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
IL95436A (en) 1989-08-23 1996-07-23 Centre Nat Rech Scient Process for preparing the history of phenylisosarine
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2671799B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
SG52496A1 (en) * 1991-09-23 1998-09-28 Univ Florida State Preparation of substituted isoserine esters using metal alkoxides and beta-lactams
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
US6310201B1 (en) 2001-10-30
HK1002005A1 (en) 1998-07-24
IL108763A0 (en) 1994-06-24
CA2116093A1 (en) 1994-09-20
EP0617018A1 (de) 1994-09-28
US6350886B1 (en) 2002-02-26
HU9400803D0 (en) 1994-06-28
EP1361222A1 (de) 2003-11-12
FI941286A0 (fi) 1994-03-18
TW467896B (en) 2001-12-11
CN1097416A (zh) 1995-01-18
DK0617018T3 (da) 2004-01-26
US20020137927A1 (en) 2002-09-26
PT617018E (pt) 2004-02-27
JPH06321896A (ja) 1994-11-22
EP0617018B1 (de) 2003-10-01
KR940021522A (ko) 1994-10-19
IL108763A (en) 1998-07-15
AU5791994A (en) 1994-09-22
DE69433188T2 (de) 2004-07-29
AU676879B2 (en) 1997-03-27
CN1271729A (zh) 2000-11-01
CY2405B1 (en) 2004-09-10
HUT69733A (en) 1995-09-28
US20050107605A1 (en) 2005-05-19
IL123063A (en) 2000-02-17
ATE251134T1 (de) 2003-10-15
SG50463A1 (en) 1998-07-20
IL123063A0 (en) 1998-09-24
KR100309973B1 (ko) 2002-02-28
US7176326B2 (en) 2007-02-13
US6350887B1 (en) 2002-02-26
ES2208649T3 (es) 2004-06-16
FI941286A (fi) 1994-09-20
CN1080256C (zh) 2002-03-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee