ES2184761T3 - Derivados de taxanos c10 y composiciones farmaceuticas. - Google Patents

Derivados de taxanos c10 y composiciones farmaceuticas.

Info

Publication number
ES2184761T3
ES2184761T3 ES94909453T ES94909453T ES2184761T3 ES 2184761 T3 ES2184761 T3 ES 2184761T3 ES 94909453 T ES94909453 T ES 94909453T ES 94909453 T ES94909453 T ES 94909453T ES 2184761 T3 ES2184761 T3 ES 2184761T3
Authority
ES
Spain
Prior art keywords
taxanos
derivatives
pharmaceutical compositions
novel
antileukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909453T
Other languages
English (en)
Inventor
Robert A Holton
Ki-Byung Chai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/005,229 external-priority patent/US5338872A/en
Application filed by Florida State University filed Critical Florida State University
Application granted granted Critical
Publication of ES2184761T3 publication Critical patent/ES2184761T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE TAXANO SUSTITUIDOS EN LA POSICION C10 CON NUEVOS SUSTITUYENTES. LOS NUEVOS COMPUESTOS TIENEN UTILIDAD COMO AGENTES ANTILEUCEMICOS Y ANTITUMORALES.
ES94909453T 1993-01-15 1994-01-14 Derivados de taxanos c10 y composiciones farmaceuticas. Expired - Lifetime ES2184761T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/005,229 US5338872A (en) 1993-01-15 1993-01-15 Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
US3485293A 1993-03-22 1993-03-22
US9454593A 1993-07-20 1993-07-20

Publications (1)

Publication Number Publication Date
ES2184761T3 true ES2184761T3 (es) 2003-04-16

Family

ID=27357839

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94909453T Expired - Lifetime ES2184761T3 (es) 1993-01-15 1994-01-14 Derivados de taxanos c10 y composiciones farmaceuticas.
ES02005075T Expired - Lifetime ES2225671T3 (es) 1993-01-15 1994-01-14 Derivados de taxano en c10 y composiciones farmaceuticas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02005075T Expired - Lifetime ES2225671T3 (es) 1993-01-15 1994-01-14 Derivados de taxano en c10 y composiciones farmaceuticas.

Country Status (12)

Country Link
EP (2) EP1211250B1 (es)
JP (1) JP3917173B2 (es)
CN (2) CN1125060C (es)
AT (2) ATE225656T1 (es)
AU (1) AU682852B2 (es)
CA (1) CA2153805C (es)
DE (2) DE69433856T2 (es)
DK (2) DK1211250T3 (es)
ES (2) ES2184761T3 (es)
IL (1) IL108316A (es)
PT (2) PT1211250E (es)
WO (1) WO1994015599A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5440056A (en) * 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
AU682173B2 (en) * 1993-01-15 1997-09-25 Florida State University Process for the preparation of 10-desacetoxybaccatin III
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
DK0902783T3 (da) * 1995-09-12 2002-07-22 Liposome Co Inc Hydrolysefremmende, hydrofobe taxanderivater
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
DE60131537T2 (de) 2000-06-22 2008-10-23 Nitromed, Inc., Lexington Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
US8785669B2 (en) * 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
FR2707293A1 (fr) * 1993-07-08 1995-01-13 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
DK0679082T3 (da) 2003-02-17
JP3917173B2 (ja) 2007-05-23
DE69433856T2 (de) 2004-11-04
EP1211250B1 (en) 2004-06-16
DE69431514D1 (de) 2002-11-14
EP0679082B1 (en) 2002-10-09
EP0679082A1 (en) 1995-11-02
DE69431514T2 (de) 2003-02-13
CN1495177A (zh) 2004-05-12
EP0679082A4 (en) 1995-12-20
AU6229594A (en) 1994-08-15
CN1097746A (zh) 1995-01-25
CA2153805C (en) 2006-03-28
PT679082E (pt) 2003-02-28
WO1994015599A1 (en) 1994-07-21
ATE225656T1 (de) 2002-10-15
PT1211250E (pt) 2004-10-29
CA2153805A1 (en) 1994-07-21
CN1244569C (zh) 2006-03-08
AU682852B2 (en) 1997-10-23
DE69433856D1 (de) 2004-07-22
ES2225671T3 (es) 2005-03-16
EP1211250A1 (en) 2002-06-05
IL108316A (en) 2006-10-31
IL108316A0 (en) 1994-04-12
ATE269315T1 (de) 2004-07-15
CN1125060C (zh) 2003-10-22
DK1211250T3 (da) 2004-10-25
JPH08505627A (ja) 1996-06-18

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