IL123063A - Sidechain-bearing taxanes - Google Patents

Sidechain-bearing taxanes

Info

Publication number
IL123063A
IL123063A IL12306394A IL12306394A IL123063A IL 123063 A IL123063 A IL 123063A IL 12306394 A IL12306394 A IL 12306394A IL 12306394 A IL12306394 A IL 12306394A IL 123063 A IL123063 A IL 123063A
Authority
IL
Israel
Prior art keywords
sidechain
bearing taxanes
taxol
taxanes
novel
Prior art date
Application number
IL12306394A
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL123063A publication Critical patent/IL123063A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Novel beta -lactams find utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention relates to novel sidechain-bearing taxanes of formula (VII). <CHEM>
IL12306394A 1993-03-19 1994-02-24 Sidechain-bearing taxanes IL123063A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3359893A 1993-03-19 1993-03-19
IL10876394A IL108763A (en) 1993-03-19 1994-02-24 Beta-lactam derivatives and processes for the preparation of taxanes utilizing the same

Publications (1)

Publication Number Publication Date
IL123063A true IL123063A (en) 2000-02-17

Family

ID=21871323

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12306394A IL123063A (en) 1993-03-19 1994-02-24 Sidechain-bearing taxanes
IL10876394A IL108763A (en) 1993-03-19 1994-02-24 Beta-lactam derivatives and processes for the preparation of taxanes utilizing the same
IL12306398A IL123063A0 (en) 1993-03-19 1998-01-26 Sidechain-bearing taxanes and methods for their preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL10876394A IL108763A (en) 1993-03-19 1994-02-24 Beta-lactam derivatives and processes for the preparation of taxanes utilizing the same
IL12306398A IL123063A0 (en) 1993-03-19 1998-01-26 Sidechain-bearing taxanes and methods for their preparation

Country Status (18)

Country Link
US (5) US6350887B1 (en)
EP (2) EP0617018B1 (en)
JP (1) JPH06321896A (en)
KR (1) KR100309973B1 (en)
CN (2) CN1080256C (en)
AT (1) ATE251134T1 (en)
CA (1) CA2116093A1 (en)
CY (1) CY2405B1 (en)
DE (1) DE69433188T2 (en)
DK (1) DK0617018T3 (en)
ES (1) ES2208649T3 (en)
FI (1) FI941286A (en)
HK (1) HK1002005A1 (en)
HU (1) HUT69733A (en)
IL (3) IL123063A (en)
PT (1) PT617018E (en)
SG (1) SG50463A1 (en)
TW (1) TW467896B (en)

Families Citing this family (23)

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CA2163837C (en) † 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
MA23823A1 (en) 1995-03-27 1996-10-01 Aventis Pharma Sa NEW TAXOIDS, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
DE19703549C1 (en) * 1997-01-31 1999-03-04 Clariant Gmbh Process for the preparation of diacylimides
FR2771092B1 (en) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF DERIVATIVES OF THE TAXOID CLASS
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
JP2002544269A (en) 1999-05-17 2002-12-24 ブリストル−マイヤーズ スクイブ カンパニー New reaction conditions for the cleavage of silyl ethers in the production of paclitaxel and paclitaxel analogs
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
MXPA06012606A (en) * 2004-05-14 2007-01-31 Immunogen Inc A facile method for synthesizing baccatin iii compounds.
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
CA2723654A1 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
KR101671537B1 (en) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 Multi-arm polymeric alkanoate Conjugates
PL388144A1 (en) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate 4-acetoxy-2?-benzoiloxy-5� ,20-epoxy-1, 7�, 10�-trihydroxy-9-oxo-taks-11 -en-13?-yl solvates, a method for their production and application thereof
US8785669B2 (en) 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
WO2012088433A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE21105T1 (en) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-OXO-4-THIA-1-AZA(3.2.0)HEPTANE AND 7-OXO-4-THIA-1-AZA-(3.2.0)HEPT-2-EN DERIVATIVES.
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2601675B1 (en) 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2601676B1 (en) 1986-07-17 1988-09-23 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF TAXOL AND DESACETYL-10 TAXOL
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629819B1 (en) 1988-04-06 1990-11-16 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF BACCATIN III AND DESACETYL-10 BACCATIN III DERIVATIVES
FR2629818B1 (en) 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
CA2023645C (en) 1989-08-23 2002-03-26 Jean-Noel Denis Process for the enantioselective preparation of phenylisoserin derivatives
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2671799B1 (en) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa B-PHENYLISOSERINE- (2R, 3S), ITS SALTS, ITS PREPARATION AND ITS USE.
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
CA2418125C (en) * 1991-09-23 2007-12-04 Florida State University Beta-lactams useful in the preparation of substituted isoserine esters
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (en) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co Benzoate derivative of taxole
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
CN1271729A (en) 2000-11-01
DE69433188T2 (en) 2004-07-29
CN1080256C (en) 2002-03-06
US6310201B1 (en) 2001-10-30
IL108763A0 (en) 1994-06-24
IL108763A (en) 1998-07-15
HK1002005A1 (en) 1998-07-24
KR940021522A (en) 1994-10-19
ATE251134T1 (en) 2003-10-15
IL123063A0 (en) 1998-09-24
US6350887B1 (en) 2002-02-26
ES2208649T3 (en) 2004-06-16
JPH06321896A (en) 1994-11-22
EP0617018A1 (en) 1994-09-28
DK0617018T3 (en) 2004-01-26
US6350886B1 (en) 2002-02-26
HUT69733A (en) 1995-09-28
CN1097416A (en) 1995-01-18
TW467896B (en) 2001-12-11
DE69433188D1 (en) 2003-11-06
EP0617018B1 (en) 2003-10-01
CA2116093A1 (en) 1994-09-20
SG50463A1 (en) 1998-07-20
KR100309973B1 (en) 2002-02-28
US20020137927A1 (en) 2002-09-26
US20050107605A1 (en) 2005-05-19
AU676879B2 (en) 1997-03-27
FI941286A0 (en) 1994-03-18
EP1361222A1 (en) 2003-11-12
HU9400803D0 (en) 1994-06-28
FI941286A (en) 1994-09-20
CY2405B1 (en) 2004-09-10
PT617018E (en) 2004-02-27
US7176326B2 (en) 2007-02-13
AU5791994A (en) 1994-09-22

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
MM9K Patent not in force due to non-payment of renewal fees