IL123063A - Sidechain-bearing taxanes - Google Patents

Sidechain-bearing taxanes

Info

Publication number
IL123063A
IL123063A IL12306394A IL12306394A IL123063A IL 123063 A IL123063 A IL 123063A IL 12306394 A IL12306394 A IL 12306394A IL 12306394 A IL12306394 A IL 12306394A IL 123063 A IL123063 A IL 123063A
Authority
IL
Israel
Prior art keywords
sidechain
bearing taxanes
taxol
taxanes
novel
Prior art date
Application number
IL12306394A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL123063A publication Critical patent/IL123063A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
IL12306394A 1993-03-19 1994-02-24 Sidechain-bearing taxanes IL123063A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3359893A 1993-03-19 1993-03-19
IL10876394A IL108763A (en) 1993-03-19 1994-02-24 History of lactam and processes for making taxanes that use them

Publications (1)

Publication Number Publication Date
IL123063A true IL123063A (en) 2000-02-17

Family

ID=21871323

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12306394A IL123063A (en) 1993-03-19 1994-02-24 Sidechain-bearing taxanes
IL10876394A IL108763A (en) 1993-03-19 1994-02-24 History of lactam and processes for making taxanes that use them
IL12306398A IL123063A0 (en) 1993-03-19 1998-01-26 Sidechain-bearing taxanes and methods for their preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL10876394A IL108763A (en) 1993-03-19 1994-02-24 History of lactam and processes for making taxanes that use them
IL12306398A IL123063A0 (en) 1993-03-19 1998-01-26 Sidechain-bearing taxanes and methods for their preparation

Country Status (18)

Country Link
US (5) US6350887B1 (xx)
EP (2) EP0617018B1 (xx)
JP (1) JPH06321896A (xx)
KR (1) KR100309973B1 (xx)
CN (2) CN1080256C (xx)
AT (1) ATE251134T1 (xx)
CA (1) CA2116093A1 (xx)
CY (1) CY2405B1 (xx)
DE (1) DE69433188T2 (xx)
DK (1) DK0617018T3 (xx)
ES (1) ES2208649T3 (xx)
FI (1) FI941286A (xx)
HK (1) HK1002005A1 (xx)
HU (1) HUT69733A (xx)
IL (3) IL123063A (xx)
PT (1) PT617018E (xx)
SG (1) SG50463A1 (xx)
TW (1) TW467896B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163837C (en) † 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
DE19703549C1 (de) * 1997-01-31 1999-03-04 Clariant Gmbh Verfahren zur Herstellung von Diacylimiden
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
MXPA01011046A (es) 1999-05-17 2002-07-22 Squibb Bristol Myers Co Novedosas condiciones de reaccion para la escicion de teres de sililo en la preparacion de paclitaxel (taxol, marca registrada) y analogos de paclitaxel.
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7989490B2 (en) * 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
CA2563905A1 (en) * 2004-05-14 2005-12-01 Immunogen, Inc. A facile method for synthesizing baccatin iii compounds
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
WO2009137084A2 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8785669B2 (en) 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE21105T1 (de) 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
CA2023645C (fr) 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2671799B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
DE69233292T2 (de) * 1991-09-23 2004-06-09 Florida State University, Tallahassee Metallalkoxide
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
HK1002005A1 (en) 1998-07-24
TW467896B (en) 2001-12-11
US20050107605A1 (en) 2005-05-19
JPH06321896A (ja) 1994-11-22
CN1080256C (zh) 2002-03-06
EP1361222A1 (en) 2003-11-12
AU5791994A (en) 1994-09-22
CA2116093A1 (en) 1994-09-20
EP0617018A1 (en) 1994-09-28
FI941286A (fi) 1994-09-20
ATE251134T1 (de) 2003-10-15
IL108763A (en) 1998-07-15
IL108763A0 (en) 1994-06-24
CN1271729A (zh) 2000-11-01
EP0617018B1 (en) 2003-10-01
SG50463A1 (en) 1998-07-20
DK0617018T3 (da) 2004-01-26
IL123063A0 (en) 1998-09-24
US6350887B1 (en) 2002-02-26
US20020137927A1 (en) 2002-09-26
US6350886B1 (en) 2002-02-26
HUT69733A (en) 1995-09-28
US7176326B2 (en) 2007-02-13
KR940021522A (ko) 1994-10-19
HU9400803D0 (en) 1994-06-28
AU676879B2 (en) 1997-03-27
DE69433188T2 (de) 2004-07-29
FI941286A0 (fi) 1994-03-18
US6310201B1 (en) 2001-10-30
ES2208649T3 (es) 2004-06-16
PT617018E (pt) 2004-02-27
KR100309973B1 (ko) 2002-02-28
CN1097416A (zh) 1995-01-18
CY2405B1 (en) 2004-09-10
DE69433188D1 (de) 2003-11-06

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
MM9K Patent not in force due to non-payment of renewal fees