ATE251134T1 - Beta-lactam, verfahren zur herstellung taxane- derivate und taxane mit seitenketten - Google Patents

Beta-lactam, verfahren zur herstellung taxane- derivate und taxane mit seitenketten

Info

Publication number
ATE251134T1
ATE251134T1 AT94301809T AT94301809T ATE251134T1 AT E251134 T1 ATE251134 T1 AT E251134T1 AT 94301809 T AT94301809 T AT 94301809T AT 94301809 T AT94301809 T AT 94301809T AT E251134 T1 ATE251134 T1 AT E251134T1
Authority
AT
Austria
Prior art keywords
taxanes
beta
lactam
side chains
taxane derivatives
Prior art date
Application number
AT94301809T
Other languages
English (en)
Inventor
John K Thottathil
Ivan D Trifunovich
David J Kucera
Wen-Sen Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE251134T1 publication Critical patent/ATE251134T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
AT94301809T 1993-03-19 1994-03-14 Beta-lactam, verfahren zur herstellung taxane- derivate und taxane mit seitenketten ATE251134T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3359893A 1993-03-19 1993-03-19

Publications (1)

Publication Number Publication Date
ATE251134T1 true ATE251134T1 (de) 2003-10-15

Family

ID=21871323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94301809T ATE251134T1 (de) 1993-03-19 1994-03-14 Beta-lactam, verfahren zur herstellung taxane- derivate und taxane mit seitenketten

Country Status (18)

Country Link
US (5) US6350887B1 (de)
EP (2) EP1361222A1 (de)
JP (1) JPH06321896A (de)
KR (1) KR100309973B1 (de)
CN (2) CN1080256C (de)
AT (1) ATE251134T1 (de)
CA (1) CA2116093A1 (de)
CY (1) CY2405B1 (de)
DE (1) DE69433188T2 (de)
DK (1) DK0617018T3 (de)
ES (1) ES2208649T3 (de)
FI (1) FI941286A (de)
HK (1) HK1002005A1 (de)
HU (1) HUT69733A (de)
IL (3) IL123063A (de)
PT (1) PT617018E (de)
SG (1) SG50463A1 (de)
TW (1) TW467896B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163837C (en) † 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
DE19703549C1 (de) * 1997-01-31 1999-03-04 Clariant Gmbh Verfahren zur Herstellung von Diacylimiden
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
PT1178979E (pt) 1999-05-17 2004-04-30 Bristol Myers Squibb Co Novas condicoes de reaccao para a clivagem de eteres de sililo na preparacao de paclitaxel (taxol(r)) e analogos de paclitaxel
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
BRPI0511109A (pt) * 2004-05-14 2007-11-27 Immunogen Inc método fácil para sintetizar compostos de baccatin iii
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
EP2285792A2 (de) * 2008-05-07 2011-02-23 Ivax Research, Llc Verfahren zur herstellung von taxanen und zwischenprodukte dafür
EP2331140B1 (de) 2008-08-11 2018-07-04 Nektar Therapeutics Mehrarmige polymer-alkanoat-konjugate
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
US8785669B2 (en) 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0176064A1 (de) 1980-11-06 1986-04-02 Hoechst Uk Limited Zwischenprodukte zur Herstellung von 7-Oxo-4-thia-1-aza[3,2,0]heptan- und 7-oxo-4-thia-1-aza[3,2,0]hept-2-en-Derivaten
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
CA2023645C (fr) 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2671799B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
SG52496A1 (en) * 1991-09-23 1998-09-28 Univ Florida State Preparation of substituted isoserine esters using metal alkoxides and beta-lactams
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
IL108763A0 (en) 1994-06-24
ES2208649T3 (es) 2004-06-16
EP0617018B1 (de) 2003-10-01
US6310201B1 (en) 2001-10-30
PT617018E (pt) 2004-02-27
IL123063A (en) 2000-02-17
CN1271729A (zh) 2000-11-01
TW467896B (en) 2001-12-11
HK1002005A1 (en) 1998-07-24
CN1097416A (zh) 1995-01-18
HUT69733A (en) 1995-09-28
CN1080256C (zh) 2002-03-06
EP1361222A1 (de) 2003-11-12
IL108763A (en) 1998-07-15
CA2116093A1 (en) 1994-09-20
US20020137927A1 (en) 2002-09-26
DE69433188D1 (de) 2003-11-06
US20050107605A1 (en) 2005-05-19
KR940021522A (ko) 1994-10-19
KR100309973B1 (ko) 2002-02-28
CY2405B1 (en) 2004-09-10
AU5791994A (en) 1994-09-22
JPH06321896A (ja) 1994-11-22
US7176326B2 (en) 2007-02-13
SG50463A1 (en) 1998-07-20
IL123063A0 (en) 1998-09-24
EP0617018A1 (de) 1994-09-28
AU676879B2 (en) 1997-03-27
US6350887B1 (en) 2002-02-26
FI941286A0 (fi) 1994-03-18
US6350886B1 (en) 2002-02-26
DE69433188T2 (de) 2004-07-29
DK0617018T3 (da) 2004-01-26
FI941286A (fi) 1994-09-20
HU9400803D0 (en) 1994-06-28

Similar Documents

Publication Publication Date Title
ATE251134T1 (de) Beta-lactam, verfahren zur herstellung taxane- derivate und taxane mit seitenketten
ATE195973T1 (de) Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
NO932870D0 (no) Ny fremgangsmaate for fremstilling av 9-amino-6-demetyl-6-deoksyetracykliner
DE69528762T2 (de) Herstellung von camptothecinderivaten durch intramolekulare cyclisierung
DE69214369D1 (de) Verfahren zur Herstellung von Pyranonen und Pyrandionen
DE69231815T2 (de) Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
DE3683883D1 (de) Verfahren zur herstellung von organopolysilanen und verwendung der so hergestellten organopolysilane.
TW359671B (en) Novel methods for the preparation of taxanes using oxazolidine intermediates
ATE519747T1 (de) Verfahren zur herstellung von cyclopentaägüchinazolin-derivaten
ATE355296T1 (de) Verfahren zur herstellung von (e,z) 3-(2- aminoethoxyimino)-androstane-6,17-dione und analoge
DE60106057D1 (de) Verfahren zur herstellung von baccatin iii-derivativen
DE69404991D1 (de) Verfahren zur herstellung einer oxazolidincarbon säure nützlich für die herstellung von therapeutischen taxoiden
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
ATE202071T1 (de) Verfahren zur herstellung von alph-beta- ungesättigten trifluormethylcarboxylverbindungen
DE69915951D1 (de) Verfahren zur Herstellung von Pyrrolidinderivaten
ATE260267T1 (de) Verfahren zur herstellung von c-4-deacetyltaxanen
ATE466847T1 (de) Verfahren zur herstellung von 14-beta- hydroxybaccatin-iii-1,14-carbonat
ATE537160T1 (de) Verfahren zur herstellung von 14beta- hydroxybaccatin-iii-1,14-carbonat
ATE104959T1 (de) Verfahren zur herstellung von vitamin a aldehyd.
ATE499353T1 (de) Verfahren zur herstellung von taxanderivaten
ATE111093T1 (de) Verfahren zur herstellung von enantiomeren von 3- aminchromanderivaten.
ATE283863T1 (de) Verfahren zur herstellung von indolopyrrolocarbazol-derivaten
ATE319785T1 (de) Verfahren zur herstellung von farbmitteln

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0617018

Country of ref document: EP

REN Ceased due to non-payment of the annual fee