DE69432751D1 - Präparation und stabilisation von zellen - Google Patents
Präparation und stabilisation von zellenInfo
- Publication number
- DE69432751D1 DE69432751D1 DE69432751T DE69432751T DE69432751D1 DE 69432751 D1 DE69432751 D1 DE 69432751D1 DE 69432751 T DE69432751 T DE 69432751T DE 69432751 T DE69432751 T DE 69432751T DE 69432751 D1 DE69432751 D1 DE 69432751D1
- Authority
- DE
- Germany
- Prior art keywords
- blood
- leucocytes
- composition
- stabilizing
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/05—Reference solutions for assays of biological material containing blood cells or plasma
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939313962A GB9313962D0 (en) | 1993-07-05 | 1993-07-05 | Preparation and stabilisation of leucocytes |
GB9313962 | 1993-07-05 | ||
GB939315871A GB9315871D0 (en) | 1993-07-05 | 1993-07-20 | Preparation and stabilisation of leucocytes |
GB9315871 | 1993-07-20 | ||
GB9406698A GB9406698D0 (en) | 1994-04-05 | 1994-04-05 | Preparation and stabilisation of cell suspensions |
GB9406698 | 1994-04-05 | ||
PCT/EP1994/002189 WO1995001796A1 (en) | 1993-07-05 | 1994-07-05 | Preparation and stabilisation of cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432751D1 true DE69432751D1 (de) | 2003-07-03 |
DE69432751T2 DE69432751T2 (de) | 2004-04-29 |
Family
ID=27266764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0708649T Pending DE708649T1 (de) | 1993-07-05 | 1994-07-05 | Präparation und stabilisation von zellen |
DE69432751T Expired - Fee Related DE69432751T2 (de) | 1993-07-05 | 1994-07-05 | Präparation und stabilisation von zellen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0708649T Pending DE708649T1 (de) | 1993-07-05 | 1994-07-05 | Präparation und stabilisation von zellen |
Country Status (14)
Country | Link |
---|---|
US (2) | US6197540B1 (de) |
EP (1) | EP0708649B1 (de) |
JP (1) | JPH09503051A (de) |
AT (1) | ATE241368T1 (de) |
AU (2) | AU700699B2 (de) |
BR (1) | BR9407003A (de) |
CA (1) | CA2166729A1 (de) |
DE (2) | DE708649T1 (de) |
ES (1) | ES2197168T3 (de) |
FI (1) | FI960045A0 (de) |
GB (1) | GB2279653B (de) |
NO (1) | NO960049L (de) |
NZ (1) | NZ271318A (de) |
WO (1) | WO1995001796A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2166729A1 (en) | 1993-07-05 | 1995-01-19 | Vivian Granger | Preparation and stabilisation of cells |
DE69504646T2 (de) * | 1994-04-05 | 1999-04-29 | North Gen Hospital Nhs Trust | Herstellung und stabilisierung von zellsuspensionen |
GB2313288B (en) | 1996-05-24 | 2000-07-12 | North Gen Hospital Nhs Trust | Specimen collection fluid |
EP1182457A1 (de) * | 2000-08-17 | 2002-02-27 | Mallinckrodt Baker B.V. | Verfahren und Reagens zur Analyse von Blutproben, im besonderen für tierärztliche Anwendungen |
US6913932B2 (en) * | 2002-08-23 | 2005-07-05 | Beckman Coulter, Inc. | Formaldehyde-ammonium salt complexes for the stabilization of blood cells |
CA2445204C (en) * | 2002-10-16 | 2014-08-12 | Streck Laboratories, Inc. | Method and device for collecting and preserving cells for analysis |
US7267980B1 (en) | 2003-04-04 | 2007-09-11 | Research & Diagnostic Systems, Inc. | Stabilizing solution for cells and tissues |
US20050085028A1 (en) * | 2003-10-21 | 2005-04-21 | International Business Machines Corporation | Method and structure to suppress external latch-up |
CN100376669C (zh) * | 2005-02-25 | 2008-03-26 | 深圳迈瑞生物医疗电子股份有限公司 | 生物红细胞体积长期稳定的处理方法 |
US20070015134A1 (en) * | 2005-07-15 | 2007-01-18 | Beckman Coulter, Inc. | Quantitative stabilized cell reference control products and methods |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
EP2316036B1 (de) * | 2008-07-11 | 2013-12-25 | The Secretary of State for Health | Stimulierte zellstandards |
WO2010078194A1 (en) | 2008-12-30 | 2010-07-08 | Streck, Inc. | Method for screening blood using a preservative that may be in a substantially solid state form |
US11634747B2 (en) * | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
NO2398912T3 (de) | 2009-02-18 | 2018-02-10 | ||
WO2011057184A1 (en) * | 2009-11-09 | 2011-05-12 | Streck, Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
AU2011255641A1 (en) | 2010-05-18 | 2012-12-06 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
WO2012151391A2 (en) | 2011-05-04 | 2012-11-08 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
CA2917912C (en) | 2013-07-24 | 2019-09-17 | Streck, Inc. | Compositions and methods for stabilizing circulating tumor cells |
RU2717641C2 (ru) | 2014-04-21 | 2020-03-24 | Натера, Инк. | Обнаружение мутаций и плоидности в хромосомных сегментах |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
WO2018022991A1 (en) | 2016-07-29 | 2018-02-01 | Streck, Inc. | Suspension composition for hematology analysis control |
US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
CA3050906A1 (en) | 2017-01-22 | 2018-07-26 | Chryos, Llc | Composition and method of use of the same for preserving cells for analysis |
WO2019210306A1 (en) * | 2018-04-27 | 2019-10-31 | Momenta Pharmaceuticals , Inc. | Blood preparation |
US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
CN113325171B (zh) * | 2021-08-02 | 2021-12-21 | 天津康博尔生物基因技术有限公司 | 检测人体红细胞叶酸含量的试剂盒、检测方法及用途 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1068862B (de) | 1957-05-03 | 1959-11-12 | Penicillin-Gesellschaft Dauelsberg a Co., Göttingen | Verfahren zur Verlängerung der Haltbarkeit von Blutkonserven |
DE1147004B (de) * | 1959-10-16 | 1963-04-11 | Dr Med Herbert Fischer | Verfahren zur Konservierung von lebenden menschlichen oder tierischen Zellpraeparaten, insbesondere von Blut und Blutbestandteilen |
CA933092A (en) * | 1969-04-10 | 1973-09-04 | V. Collins Zeola | Method of prolonging the viability of lymphocytes |
FR2202688B1 (de) | 1972-10-17 | 1977-04-15 | Cepbepe | |
US4045488A (en) | 1974-11-06 | 1977-08-30 | Pfizer Inc. | Aminophenyltetralin compounds |
IT1065125B (it) | 1975-08-20 | 1985-02-25 | Boehringer Mannheim Gmbh | Processo per mantenere costante l attivita di fosfatasi alcalina e siero di controllo contenente tale fosfatasi |
DE2551208C3 (de) * | 1975-11-14 | 1981-05-27 | Behringwerke Ag, 3550 Marburg | Verfahren zur Herstellung einer stabilen Erythrozyten-Präparation |
US4040785A (en) | 1976-10-18 | 1977-08-09 | Technicon Instruments Corporation | Lysable blood preservative composition |
US4152208A (en) * | 1977-03-29 | 1979-05-01 | Hoffmann-La Roche Inc. | Stabilized leucocytes |
US4302355A (en) * | 1977-08-01 | 1981-11-24 | Warner-Lambert Company | Platelet reference control |
DE2828820A1 (de) * | 1977-08-01 | 1979-02-08 | Warner Lambert Co | Verfahren zur herstellung einer stabilen blutplaettchensuspension und nach dem verfahren erhaltene stabile blutplaettchensuspension |
US4324687A (en) | 1979-02-15 | 1982-04-13 | Louderback Allan Lee | Blood biochemistry control standard |
DE2949824A1 (de) * | 1979-12-12 | 1981-07-02 | Marianne Dr. 5000 Köln Sehrbundt | Verfahren zur stabilisierung von lymphozyten/thrombozytennmischsuspensionen |
US4346018A (en) | 1980-06-16 | 1982-08-24 | Coulter Electronics, Inc. | Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes |
US4405719A (en) * | 1981-05-29 | 1983-09-20 | Coulter Electronics, Inc. | Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; diluents therefor; and combination stabilization procedures |
US4704352A (en) | 1985-06-25 | 1987-11-03 | Baxter Travenol Laboratories, Inc. | L-ascorbate-2-phosphate salts in blood cell storage |
JPH06100606B2 (ja) | 1985-08-08 | 1994-12-12 | リス、エ−ベルハルト | 採取血中のグルコース含量の低減防止法 |
US4675185A (en) * | 1985-12-06 | 1987-06-23 | Baxter Travenol Laboratories, Inc. | Solution for stabilizing red blood cells during storage |
US4729959A (en) | 1986-02-24 | 1988-03-08 | Streck Laboratories, Inc. | Glucose reference control for glucose test strips |
US4806343A (en) | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
IT1188132B (it) * | 1986-05-07 | 1987-12-30 | Fameccanica Spa | Procedimento e dispositivo per la produzione di film perforati particolarmente film perforati di materiale plastico per articoli igienico sanitari |
US5250438A (en) | 1990-05-09 | 1993-10-05 | Streck Laboratories, Inc. | Method for differential determination of white blood cells using diazolidinyl urea to stabilize white blood cells |
SU1767436A1 (ru) | 1990-05-22 | 1992-10-07 | Черновицкий Государственный Университет | Способ определени глюкозы в крови |
US5260048A (en) | 1991-05-08 | 1993-11-09 | Streck Laboratories, Inc. | Tissue fixative solution and method |
US5270208A (en) * | 1991-05-09 | 1993-12-14 | Streck Laboratories, Inc. | White blood cell hematology control |
JPH0820452B2 (ja) | 1991-12-16 | 1996-03-04 | 株式会社いかがく | 血液中糖類の微生物による消費阻止方法 |
US5422277A (en) * | 1992-03-27 | 1995-06-06 | Ortho Diagnostic Systems Inc. | Cell fixative composition and method of staining cells without destroying the cell surface |
WO1993021928A1 (en) | 1992-04-24 | 1993-11-11 | Streck Laboratories, Inc. | Liquid glucose control solution and process of making the same |
US5407794A (en) * | 1992-09-08 | 1995-04-18 | Cytocolor Inc. | Oxazine stained lymphocytes and method |
CA2123227C (en) | 1992-09-10 | 2009-04-28 | Wayne L. Ryan | Method and composition for preserving antigens and process for utilizing cytological material produced by same |
FR2705359B1 (fr) * | 1993-05-19 | 1995-08-18 | Immunotech Sa | Méthode de protection des cellules leucocytaires, composition protectrice, composition de sang protégée, et méthode d'analyse sanguine. |
CA2166729A1 (en) | 1993-07-05 | 1995-01-19 | Vivian Granger | Preparation and stabilisation of cells |
DE69504646T2 (de) * | 1994-04-05 | 1999-04-29 | North Gen Hospital Nhs Trust | Herstellung und stabilisierung von zellsuspensionen |
-
1994
- 1994-07-05 CA CA002166729A patent/CA2166729A1/en not_active Abandoned
- 1994-07-05 US US08/578,591 patent/US6197540B1/en not_active Expired - Fee Related
- 1994-07-05 DE DE0708649T patent/DE708649T1/de active Pending
- 1994-07-05 GB GB9413558A patent/GB2279653B/en not_active Revoked
- 1994-07-05 AU AU74909/94A patent/AU700699B2/en not_active Ceased
- 1994-07-05 AT AT94924715T patent/ATE241368T1/de not_active IP Right Cessation
- 1994-07-05 ES ES94924715T patent/ES2197168T3/es not_active Expired - Lifetime
- 1994-07-05 WO PCT/EP1994/002189 patent/WO1995001796A1/en active IP Right Grant
- 1994-07-05 DE DE69432751T patent/DE69432751T2/de not_active Expired - Fee Related
- 1994-07-05 BR BR9407003A patent/BR9407003A/pt not_active Application Discontinuation
- 1994-07-05 JP JP7503819A patent/JPH09503051A/ja active Pending
- 1994-07-05 EP EP94924715A patent/EP0708649B1/de not_active Expired - Lifetime
- 1994-07-05 NZ NZ271318A patent/NZ271318A/en unknown
-
1996
- 1996-01-05 FI FI960045A patent/FI960045A0/fi unknown
- 1996-01-05 NO NO960049A patent/NO960049L/no not_active Application Discontinuation
- 1996-02-05 AU AU44410/96A patent/AU4441096A/en not_active Abandoned
- 1996-06-24 US US08/677,603 patent/US6197539B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2166729A1 (en) | 1995-01-19 |
WO1995001796A1 (en) | 1995-01-19 |
DE708649T1 (de) | 2001-09-20 |
BR9407003A (pt) | 1996-03-26 |
FI960045A (fi) | 1996-01-05 |
EP0708649B1 (de) | 2003-05-28 |
JPH09503051A (ja) | 1997-03-25 |
GB9413558D0 (en) | 1994-08-24 |
DE69432751T2 (de) | 2004-04-29 |
ES2197168T3 (es) | 2004-01-01 |
FI960045A0 (fi) | 1996-01-05 |
GB2279653B (en) | 1998-02-11 |
NZ271318A (en) | 1998-08-26 |
AU4441096A (en) | 1996-06-06 |
EP0708649A1 (de) | 1996-05-01 |
NO960049L (no) | 1996-03-05 |
US6197539B1 (en) | 2001-03-06 |
US6197540B1 (en) | 2001-03-06 |
AU7490994A (en) | 1995-02-06 |
AU700699B2 (en) | 1999-01-14 |
ATE241368T1 (de) | 2003-06-15 |
NO960049D0 (no) | 1996-01-05 |
GB2279653A (en) | 1995-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |