KR920006007A - 이식 물질 - Google Patents

이식 물질 Download PDF

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Publication number
KR920006007A
KR920006007A KR1019910015694A KR910015694A KR920006007A KR 920006007 A KR920006007 A KR 920006007A KR 1019910015694 A KR1019910015694 A KR 1019910015694A KR 910015694 A KR910015694 A KR 910015694A KR 920006007 A KR920006007 A KR 920006007A
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KR
South Korea
Prior art keywords
acid
bone
carried out
process according
temperature
Prior art date
Application number
KR1019910015694A
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English (en)
Inventor
외르그 바우어 한스
카쩬마이어 비안카
쿤츠 마티아스
Original Assignee
위르겐 호이만·라인하르트 슈틀러
메르크 파텐트 게젤샤프트 미트 베쉬랭크터 하프퉁
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 위르겐 호이만·라인하르트 슈틀러, 메르크 파텐트 게젤샤프트 미트 베쉬랭크터 하프퉁 filed Critical 위르겐 호이만·라인하르트 슈틀러
Publication of KR920006007A publication Critical patent/KR920006007A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Materials For Medical Uses (AREA)
  • Inorganic Insulating Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Dental Prosthetics (AREA)
  • Saccharide Compounds (AREA)
  • Prostheses (AREA)
  • Preparation Of Clay, And Manufacture Of Mixtures Containing Clay Or Cement (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)

Abstract

내용 없음

Description

이식 물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 뼈의 다공성 미세 구조가 필수적으로 변하지 않는 형태로 존재하고, X-선에 의하면 99% 이상의 수산화인회석으로 이루어진 소결된 세라믹 물질임을 특징으로 하는, 천연 뼈를 기재로 하는 이식 물질.
  2. 모든 유기 성분이 제거된 뼈 물질을 지방족 C1-5-모노카복실산, 말론산, 타르트론산, 숙신산, 말산, 타르타르산 및 시트르산을 포함하는 그룹중에서 선택된 유기산 수용액으로 처리한 후 900 내지 1400℃의 온도에서 소결시킴을 특징으로 하는, 제1항에 따른 이식 물질의 제조방법.
  3. 제2항에 있어서, 1 내지 30중량%의 유기산을 함유하는 수용액을 사용하여 산 처리함을 특징으로 하는 방법.
  4. 제2항 또는 제3항에 있어서, 상기 산 처리를 20℃ 내지 비등 온도에서 2분 내지 24시간 동안 수행함을 특징으로 하는 방법.
  5. 제2항 내지 제4항중 어느 한 항에 있어서, 시트르산 수용액을 사용하여 산 처리함을 특징으로 하는 방법.
  6. 제2항 내지 제5항중 어느 한 항에 있어서, 뼈 물질을 산 처리하기 전에 600 내지 1000℃의 온도에서 예비소결시킴을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910015694A 1990-09-10 1991-09-09 이식 물질 KR920006007A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4028683A DE4028683A1 (de) 1990-09-10 1990-09-10 Implantatmaterial
DEP4028683.5 1990-09-10

Publications (1)

Publication Number Publication Date
KR920006007A true KR920006007A (ko) 1992-04-27

Family

ID=6413960

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910015694A KR920006007A (ko) 1990-09-10 1991-09-09 이식 물질

Country Status (18)

Country Link
US (1) US5306302A (ko)
EP (1) EP0475189B1 (ko)
JP (1) JP3224833B2 (ko)
KR (1) KR920006007A (ko)
AT (1) ATE139450T1 (ko)
AU (1) AU634416B2 (ko)
CA (1) CA2050848A1 (ko)
CZ (1) CZ280714B6 (ko)
DE (2) DE4028683A1 (ko)
DK (1) DK0475189T3 (ko)
ES (1) ES2089070T3 (ko)
GR (1) GR3021047T3 (ko)
HU (1) HU207956B (ko)
IE (1) IE76140B1 (ko)
PT (1) PT98889B (ko)
SK (1) SK278671B6 (ko)
TW (1) TW211518B (ko)
ZA (1) ZA917184B (ko)

Families Citing this family (37)

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US6033437A (en) 1991-09-30 2000-03-07 Orbital Implant Technology Pegs for orbital implants
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
US7060287B1 (en) * 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
SE501288C2 (sv) * 1993-11-30 1995-01-09 Corimed Gmbh Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial
DE4440149A1 (de) * 1994-11-10 1996-05-15 Merck Patent Gmbh Verfahren zur Herstellung von calciumoxidarmer Spongiosa-Knochenkeramik
DE19504955A1 (de) * 1995-02-15 1996-08-22 Merck Patent Gmbh Verfahren zur Herstellung von Spongiosa-Knochenkeramikformkörpern
US20050186673A1 (en) * 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US5702449A (en) * 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
US6039762A (en) * 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
DE19543110C2 (de) * 1995-11-18 1998-05-28 Guy Florian Draenert Steriles Knochenmaterial nativen Ursprungs für die Transplantation und Verfahren zur Hitzesterilisierung des Knochenmaterials
US6033438A (en) 1997-06-03 2000-03-07 Sdgi Holdings, Inc. Open intervertebral spacer
US6482584B1 (en) * 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
US20050186283A1 (en) * 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US20030180263A1 (en) * 2002-02-21 2003-09-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of bone
US8858981B2 (en) * 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6063117A (en) * 1998-01-22 2000-05-16 Perry; Arthur C. Porous orbital implant structure
US6986788B2 (en) * 1998-01-30 2006-01-17 Synthes (U.S.A.) Intervertebral allograft spacer
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
DE19825419C2 (de) * 1998-06-06 2002-09-19 Gerber Thomas Verfahren zur Herstellung eines hochporösen Knochenersatzmaterials sowie dessen Verwendung
ES2217796T3 (es) 1998-08-03 2004-11-01 Synthes Ag Chur Separador de injerto intervertebral.
US6174311B1 (en) * 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
GB9922562D0 (en) * 1999-09-24 1999-11-24 Biocomposites Ltd Implant material
KR100331608B1 (ko) * 1999-11-25 2002-04-09 김정근 동물 뼈를 이용한 골이식 대체재 및 그 제조 방법
US7018416B2 (en) * 2000-07-06 2006-03-28 Zimmer Spine, Inc. Bone implants and methods
AU2002244116A1 (en) * 2001-02-16 2002-09-04 Sulzer Spine-Tech Inc. Bone implants and methods
US8740987B2 (en) * 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
JP2005503866A (ja) * 2001-09-27 2005-02-10 サルツァー スパイン−テック インク モジュラー式脊椎固定デバイス
EP1893174A2 (en) * 2005-05-10 2008-03-05 Cytophil, Inc. Injectable hydrogels and methods of making and using same
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
CA2649970C (en) * 2006-05-12 2011-10-18 Seoul National University Industry Foundation Method for preparing a prion-free bone grafting substitute
US8043377B2 (en) * 2006-09-02 2011-10-25 Osprey Biomedical, Inc. Implantable intervertebral fusion device
CN101528195B (zh) * 2006-09-07 2012-03-28 埃德盖斯特利希索恩化学工业股份公司 羟甲基转移剂在制备治疗骨癌的药物中的用途
AU2007328548A1 (en) * 2006-12-08 2008-06-12 Graftoss Limited A medical preparation
US20090012620A1 (en) * 2007-07-06 2009-01-08 Jim Youssef Implantable Cervical Fusion Device
JP2018002579A (ja) * 2016-12-27 2018-01-11 株式会社ソフセラ リン酸カルシウム焼結体粒子の製造方法

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JPS5645814A (en) * 1979-09-25 1981-04-25 Kureha Chem Ind Co Ltd Hydroxyapatite, its ceramic material and its manufacture
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
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US4778471A (en) * 1986-11-19 1988-10-18 University Of Dayton Zcap ceramics
US4861733A (en) * 1987-02-13 1989-08-29 Interpore International Calcium phosphate bone substitute materials
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JPH021285A (ja) * 1988-01-11 1990-01-05 Asahi Optical Co Ltd 固着可能な歯科用及び医科用顆粒状骨補填材、その固着方法及び骨補填物
DE3903695A1 (de) * 1989-02-08 1990-08-09 Merck Patent Gmbh Resorbierbare knochenkeramik auf basis von tricalciumphosphat

Also Published As

Publication number Publication date
HU912920D0 (en) 1992-01-28
ATE139450T1 (de) 1996-07-15
ES2089070T3 (es) 1996-10-01
CS274291A3 (en) 1992-03-18
DK0475189T3 (da) 1996-09-09
PT98889B (pt) 1999-01-29
EP0475189A2 (de) 1992-03-18
AU8247891A (en) 1992-03-12
IE76140B1 (en) 1997-10-08
GR3021047T3 (en) 1996-12-31
JP3224833B2 (ja) 2001-11-05
DE4028683A1 (de) 1992-03-12
AU634416B2 (en) 1993-02-18
HU207956B (en) 1993-07-28
CZ280714B6 (cs) 1996-04-17
EP0475189B1 (de) 1996-06-19
SK278671B6 (en) 1997-12-10
ZA917184B (en) 1992-05-27
HUT59614A (en) 1992-06-29
CA2050848A1 (en) 1992-03-11
DE59107945D1 (de) 1996-07-25
US5306302A (en) 1994-04-26
EP0475189A3 (en) 1993-01-27
JPH04226669A (ja) 1992-08-17
PT98889A (pt) 1992-07-31
TW211518B (ko) 1993-08-21
IE913160A1 (en) 1992-03-11

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