DE69430701T2 - Vorrichtung zur simulation des einflusses des lebenden organismus auf die formveraenderung; das zufalls- und aufloeseverhalten bzw. die wirkstoffabgabe einer pharmazeutischen darreichungsform - Google Patents

Vorrichtung zur simulation des einflusses des lebenden organismus auf die formveraenderung; das zufalls- und aufloeseverhalten bzw. die wirkstoffabgabe einer pharmazeutischen darreichungsform

Info

Publication number
DE69430701T2
DE69430701T2 DE69430701T DE69430701T DE69430701T2 DE 69430701 T2 DE69430701 T2 DE 69430701T2 DE 69430701 T DE69430701 T DE 69430701T DE 69430701 T DE69430701 T DE 69430701T DE 69430701 T2 DE69430701 T2 DE 69430701T2
Authority
DE
Germany
Prior art keywords
container
pct
head portion
piston
piston rod
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430701T
Other languages
English (en)
Other versions
DE69430701D1 (de
Inventor
Joel Sinnreich
Christian Bosshard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sinnreich Technologien Basel Ch GmbH
Original Assignee
Novartis Erfindungen Verwaltungs GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfindungen Verwaltungs GmbH, Novartis AG filed Critical Novartis Erfindungen Verwaltungs GmbH
Publication of DE69430701D1 publication Critical patent/DE69430701D1/de
Application granted granted Critical
Publication of DE69430701T2 publication Critical patent/DE69430701T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B01F21/10—Dissolving using driven stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/445—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing an oscillatory movement about an axis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
DE69430701T 1993-08-06 1994-07-28 Vorrichtung zur simulation des einflusses des lebenden organismus auf die formveraenderung; das zufalls- und aufloeseverhalten bzw. die wirkstoffabgabe einer pharmazeutischen darreichungsform Expired - Fee Related DE69430701T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH234993 1993-08-06
PCT/EP1994/002485 WO1995004923A1 (en) 1993-08-06 1994-07-28 Apparatus for simulating the effect of the living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form

Publications (2)

Publication Number Publication Date
DE69430701D1 DE69430701D1 (de) 2002-07-04
DE69430701T2 true DE69430701T2 (de) 2002-11-07

Family

ID=4231718

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430701T Expired - Fee Related DE69430701T2 (de) 1993-08-06 1994-07-28 Vorrichtung zur simulation des einflusses des lebenden organismus auf die formveraenderung; das zufalls- und aufloeseverhalten bzw. die wirkstoffabgabe einer pharmazeutischen darreichungsform

Country Status (8)

Country Link
US (1) US5827984A (de)
EP (1) EP0712490B1 (de)
JP (1) JP3421770B2 (de)
AT (1) ATE218205T1 (de)
AU (1) AU7533494A (de)
CA (1) CA2167196A1 (de)
DE (1) DE69430701T2 (de)
WO (1) WO1995004923A1 (de)

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US6336739B1 (en) * 2001-03-02 2002-01-08 Luke Lee Air bath dissolution tester
DE60212421T2 (de) * 2001-10-11 2006-12-28 Elan Pharma International Ltd. Vorrichtung und verfahren zur gleichzeitigen beobachtung der auflösung und des äusseren erscheinungsbildes von arzneimitteln in fester darreichungsform
US20030091630A1 (en) * 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
DE60316344T2 (de) * 2002-12-16 2008-06-12 N.V. Organon Behälter ,vorrichtung und verfahren zur prüfung des auflösens von pharmazeutischen zusammensetzungen
US7357046B2 (en) * 2002-12-16 2008-04-15 N. V. Organon Method for dissolution testing of a pharmaceutical delivery device
US7051606B2 (en) * 2004-01-30 2006-05-30 Andrx Labs Llc Dosage form holder device and methods for immersion testing
US8043270B2 (en) * 2004-11-05 2011-10-25 Glaxosmith Kline Llc Pharmaceutical analysis apparatus and method
FI20050385A0 (fi) * 2005-04-14 2005-04-14 Jukka Rantanen Menetelmä ja laitteisto kiinteän aineen liuottamiseksi nesteeseen
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
JPWO2007086470A1 (ja) * 2006-01-30 2009-06-18 富山産業株式会社 口腔内崩壊錠試験器
EP2150810A4 (de) * 2007-05-04 2013-11-13 Glaxosmithkline Llc Pharmazeutische analysevorrichtung und verfahren
EP2205967B1 (de) * 2007-10-17 2013-05-01 Syneron Medical Ltd. Überprüfung der auflösungsrate
DE102008024840B3 (de) * 2008-05-23 2009-11-12 Merck Patent Gmbh Vorrichtung zur Aufnahme eines Feststoffes in einer Messzelle
US7938032B2 (en) * 2008-10-30 2011-05-10 Agilent Technologies, Inc. Dissolution testing with in-situ gravimetric volume measurement
EP2284821A1 (de) * 2009-08-07 2011-02-16 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Verfahren, Vorrichtung und Computerprogrammprodukt zur Beurteilung der Desintegration einer Dosierform im Verdauungstrakt
JP5576337B2 (ja) * 2010-06-30 2014-08-20 ローム アンド ハース カンパニー 医薬剤形を溶出試験装置に分配するための送達装置
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
KR101094962B1 (ko) * 2011-10-21 2011-12-15 한국지질자원연구원 광물 용해실험 장치
ITTO20120730A1 (it) * 2012-08-14 2014-02-15 Fond Istituto Italiano Di Tecnologia Dispositivo e metodo per determinare la cinetica di dissoluzione di nanoparticelle colloidali
ITRM20130163A1 (it) * 2013-03-18 2014-09-19 Univ Roma Dispositivi e metodo per testare film sottili e strisce
GB2515197B (en) * 2014-07-10 2015-06-24 Cambtek Ltd Improved extraction apparatus
US10228358B2 (en) 2015-04-17 2019-03-12 Pion Inc. Apparatus and method for the assessment of concentration profiling and permeability rates
JP6213933B2 (ja) * 2015-05-29 2017-10-18 有限会社サキダス 攪拌装置、メタン発酵装置及びバイオマス処理システム
CN105784952A (zh) * 2016-05-25 2016-07-20 延边大学 简易型流通池溶出度试验装置
DK3279618T3 (da) * 2016-08-01 2021-05-10 Hoefliger Harro Verpackung Kalibreringsindretning og fremgangsmåde til dosering af administrationsenheder
JPWO2020209249A1 (de) * 2019-04-08 2020-10-15
JP7261655B2 (ja) * 2019-05-15 2023-04-20 日立造船株式会社 消化器官における薬剤の溶解試験装置
US10732080B1 (en) * 2019-10-14 2020-08-04 Sotax Corporation Integrated dissolution processing and sample transfer system
CN113058448A (zh) * 2021-03-26 2021-07-02 南昌大学第二附属医院 一种体外诊断试剂的预溶解装置
CN113433277B (zh) * 2021-08-08 2022-04-01 湖南慧泽生物医药科技有限公司 药物体外溶出的循环溶出仪系统及检测药物溶出的方法

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US2530065A (en) * 1946-12-18 1950-11-14 Sterling Drug Inc Serine synthesis
US3618395A (en) * 1970-04-09 1971-11-09 Welsh Tablet disintegration apparatus
US3791221A (en) * 1972-04-07 1974-02-12 Warner Lambert Co Dissolution testing device
US3802272A (en) * 1973-01-24 1974-04-09 Dow Chemical Co Automatic dissolution rate determinator
DE2409222C2 (de) * 1974-02-27 1975-11-13 Sandoz Ag, 8500 Nuernberg Tablettenzerfallstester
DE2530065C3 (de) * 1975-07-05 1980-10-30 Dr. Madaus & Co, 5000 Koeln Vorrichtung zur Bestimmung der Zerfallszeit von Tabletten
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DE3715961A1 (de) * 1987-05-13 1988-11-24 Pharma Test Apparatebau Gmbh Vorrichtung zur messung der aufloesegeschwindigkeit von tabletten
DE3804688A1 (de) * 1988-02-15 1989-08-24 Erweka Apparatebau Gmbh Zerfallstestgeraet
US4855821A (en) * 1988-02-16 1989-08-08 Swon James E Video timing device for pharmaceutical tablet testing
US5412979A (en) * 1993-05-03 1995-05-09 Temple University - Of The Commonwealth System Of Higher Education Method and apparatus for dissolution testing of a dosage form

Also Published As

Publication number Publication date
JP3421770B2 (ja) 2003-06-30
EP0712490A1 (de) 1996-05-22
ATE218205T1 (de) 2002-06-15
WO1995004923A1 (en) 1995-02-16
EP0712490B1 (de) 2002-05-29
DE69430701D1 (de) 2002-07-04
CA2167196A1 (en) 1995-02-16
JPH09501238A (ja) 1997-02-04
AU7533494A (en) 1995-02-28
US5827984A (en) 1998-10-27

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SINNREICH TECHNOLOGIEN GMBH, BASEL, CH

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee