DE69428321D1 - 1,2-dioxetane mit verbesserter chemilumineszenz - Google Patents

1,2-dioxetane mit verbesserter chemilumineszenz

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Publication number
DE69428321D1
DE69428321D1 DE69428321T DE69428321T DE69428321D1 DE 69428321 D1 DE69428321 D1 DE 69428321D1 DE 69428321 T DE69428321 T DE 69428321T DE 69428321 T DE69428321 T DE 69428321T DE 69428321 D1 DE69428321 D1 DE 69428321D1
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Germany
Prior art keywords
dioxetane
ring
substituent
group
dioxetanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69428321T
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English (en)
Other versions
DE69428321T2 (de
Inventor
Irena Bronstein
Brooks Edwards
Alison Sparks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Tropix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/057,903 external-priority patent/US5538847A/en
Application filed by Tropix Inc filed Critical Tropix Inc
Application granted granted Critical
Publication of DE69428321D1 publication Critical patent/DE69428321D1/de
Publication of DE69428321T2 publication Critical patent/DE69428321T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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DE69428321T 1993-05-07 1994-05-06 1,2-dioxetane mit verbesserter chemilumineszenz Expired - Lifetime DE69428321T2 (de)

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US08/057,903 US5538847A (en) 1989-07-17 1993-05-07 Chemiluminescent 1,2-dioxetanes
US08/231,673 US5582980A (en) 1989-07-17 1994-04-25 Chemiluminescent 1,2-dioxetanes
PCT/US1994/004555 WO1994026726A1 (en) 1993-05-07 1994-05-06 Improved chemiluminescent 1,2-dioxetanes

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Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2506396B2 (ja) * 1986-07-24 1996-06-12 トロピックス・インコーポレーテッド ジオキセタン類の酵素的に誘導される分解を使用する物質検出法
USRE36536E (en) * 1986-07-24 2000-01-25 Tropix. Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US6022964A (en) 1989-07-17 2000-02-08 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5603868A (en) * 1992-10-30 1997-02-18 Abbott Laboratories Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes
WO1995017672A1 (en) * 1993-12-23 1995-06-29 Tropix, Inc. Chemiluminescent energy transfer assays
US5777135A (en) * 1995-07-31 1998-07-07 Lumigen, Inc. Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions
US5631167A (en) * 1995-07-31 1997-05-20 Bayer Corporation Capsule chemistry analytical methods employing dioxetane chemiluminescence
US5721370A (en) * 1995-07-31 1998-02-24 Lumigen Inc. Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability
EP1019390B1 (de) * 1995-10-17 2002-07-24 Tropix, Inc. Chemilumineszente 1,2-dioxetane mit verbesserter leistung
US5783381A (en) * 1995-10-19 1998-07-21 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6468487B1 (en) * 1997-01-14 2002-10-22 Daicel Chemical Industries, Ltd. Nitration or carboxylation catalysts
JP4519320B2 (ja) 1998-07-28 2010-08-04 アプライド バイオシステムズ， エルエルシー ベンゾチアゾールジオキセタン類
US6660529B2 (en) * 1998-07-28 2003-12-09 Pe Corporation Heteroaryl substituted benzothiazole dioxetanes
US6555698B1 (en) * 1998-11-17 2003-04-29 Tropix, Inc. Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor
ATE441725T1 (de) * 1998-12-15 2009-09-15 Applera Corp Multienzym-nachweisverfahren
CA2370520A1 (en) * 1999-04-16 2000-10-26 Komandoor Elayavalli Achyuthan Viral detection method using viral encoded enzymes and chemiluminescent substrates
US6893827B1 (en) * 2000-02-07 2005-05-17 Applera Corporation Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
ATE371747T1 (de) * 2001-01-08 2007-09-15 Applera Corp Dendritische chemilumineszierende substrate
US7368296B2 (en) 2002-01-17 2008-05-06 Applied Biosystems Solid phases optimized for chemiluminescent detection
JP2006517413A (ja) * 2003-02-12 2006-07-27 プロメガ　コーポレイション 光を発光反応から消失させる二重酵素アッセイの方法及びキット
US7390670B2 (en) * 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US20060079699A1 (en) * 2004-08-27 2006-04-13 Brooks Edwards Intermediate compounds and methods for synthesizing chemiluminescent dioxetane substrates
JP2008514737A (ja) * 2004-09-09 2008-05-08 アプレーラ コーポレイション エネルギー移動検出系のためのジオキセタンナノ粒子アセンブリ、そのアセンブリを作製する方法、およびバイオアッセイにおいてそのアセンブリを使用する方法
US7451802B2 (en) * 2006-01-25 2008-11-18 Nabco Entrances, Inc. Slidable door assemblies with automatic pivot latching
JP2007225547A (ja) * 2006-02-27 2007-09-06 Fujifilm Corp 標的物質の疎水部位の検出方法
WO2008118445A1 (en) * 2007-03-26 2008-10-02 Promega Corporation Methods to quench light from optical reactions
CN101462316A (zh) * 2007-12-19 2009-06-24 维斯塔斯风力系统有限公司 预成型件的制备方法
US9067910B2 (en) 2009-03-02 2015-06-30 Life Technologies Corporation Chemiluminescent compositions, methods, assays and kits for oxidative enzymes
CN103209970B (zh) 2010-07-08 2016-08-24 生命科技公司 原位化学发光底物和测定
EP2705031B1 (de) * 2011-05-03 2018-04-11 Life Technologies Corporation Flash- und glow-1,2-dioxetane
CN103772433A (zh) * 2012-10-18 2014-05-07 深圳市美凯特科技有限公司 一种用于免疫分析的化学发光试剂amppd的合成方法
CN103073589A (zh) * 2012-12-30 2013-05-01 杭州师范大学 一种1,2-二氧环乙烷类化合物的合成方法
CN104557890A (zh) * 2015-01-12 2015-04-29 王国平 一种碳碳氧氧四元环化合物及其在质谱检测中的应用
DE102016119810A1 (de) * 2016-10-18 2018-04-19 Hamilton Bonaduz Ag Schichten zum Nachweis von Sauerstoff

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1521089A (en) * 1975-11-12 1978-08-09 Valeas Srl Aminoethanol derivatives
JPS59501589A (ja) * 1982-08-23 1984-09-06 ジ・オ−ストラリアン・ナシヨナル・ユニバ−シテイ ３−アミノ−５−ヒドロオキシ安息香酸及びその誘導体ならびに類似体の合成方法
US5616729A (en) * 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US4983779A (en) * 1986-07-17 1991-01-08 The Board Of Governors Of Wayne State University Process for the preparation of vinyl ethers
US5112960A (en) * 1989-07-17 1992-05-12 Bronstein Irena Y Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
US4978614A (en) * 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US5220005A (en) * 1986-07-24 1993-06-15 Tropix, Inc. Substituted adamantyl dioxetanes
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
CA1340590C (en) * 1986-07-24 1999-06-08 John C. Voyta Chemiluminescence enhancement
US4956477A (en) * 1987-12-31 1990-09-11 Tropix, Inc. Synthesis of 1,2-dioxetanes
US5538847A (en) * 1989-07-17 1996-07-23 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5089630A (en) * 1987-12-31 1992-02-18 Bronstein Irena Y Dioxetanes for use in assays
US5330900A (en) * 1987-12-31 1994-07-19 Tropix, Inc. Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
US5132204A (en) * 1989-05-31 1992-07-21 Chiron Corporation Chemiluminescent double-triggered 1, 2-dioxetanes
US5326882A (en) * 1989-07-17 1994-07-05 Tropix, Inc. Chemiluminescent 3-(substituted Adamant-2'-Ylidene) 1,2-dioxetanes
DE69130668T2 (de) * 1990-08-30 1999-05-20 Tropix, Inc., Bedford, Mass. Chemolumineszente 3-(substituierte adamant-2'-ylidene)1,2-dioxetane
US5336596A (en) * 1991-12-23 1994-08-09 Tropix, Inc. Membrane for chemiluminescent blotting applications
US5603868A (en) * 1992-10-30 1997-02-18 Abbott Laboratories Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes

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AU695229B2 (en) 1998-08-06
NO950065D0 (no) 1995-01-06
AU2474997A (en) 1997-08-14
US5851771A (en) 1998-12-22
DE69428321T2 (de) 2002-07-04
DE69434814T2 (de) 2007-03-29
EP1120422A1 (de) 2001-08-01
EP1120423A1 (de) 2001-08-01
EP0649417A4 (de) 1995-02-27
EP1120422B1 (de) 2006-08-02
CA2139348C (en) 2004-03-16
DE69434940T2 (de) 2007-11-29
ATE356822T1 (de) 2007-04-15
ATE334996T1 (de) 2006-08-15
WO1994026726A1 (en) 1994-11-24
KR0154209B1 (en) 1998-11-16
FI950075A (fi) 1995-01-05
JPH07509736A (ja) 1995-10-26
ATE205839T1 (de) 2001-10-15
CA2139348A1 (en) 1994-11-24
DE69434940D1 (de) 2007-04-26
FI950075A0 (fi) 1995-01-05
US5582980A (en) 1996-12-10
EP0649417B1 (de) 2001-09-19
DE69434814D1 (de) 2006-09-14
US5840919A (en) 1998-11-24
JP2837276B2 (ja) 1998-12-14
AU6774194A (en) 1994-12-12
NO950065L (no) 1995-01-06
EP0649417A1 (de) 1995-04-26
AU676327B2 (en) 1997-03-06
NO309143B1 (no) 2000-12-18
NO20003485L (no) 1995-01-06
NO20003485D0 (no) 2000-07-06
EP1120423B1 (de) 2007-03-14
KR950702546A (ko) 1995-07-29

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