DE69415436T2 - Phosphonsäure diester-derivate - Google Patents

Phosphonsäure diester-derivate

Info

Publication number
DE69415436T2
DE69415436T2 DE69415436T DE69415436T DE69415436T2 DE 69415436 T2 DE69415436 T2 DE 69415436T2 DE 69415436 T DE69415436 T DE 69415436T DE 69415436 T DE69415436 T DE 69415436T DE 69415436 T2 DE69415436 T2 DE 69415436T2
Authority
DE
Germany
Prior art keywords
group
formula
alkyl group
diethyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69415436T
Other languages
German (de)
English (en)
Other versions
DE69415436D1 (de
Inventor
Yasuhide Tokushima 772 Inoue
Yasuo Shinseibiru 302 Muya-Cho Naruto-Shi Tokushima 772 Shoji
Yoshihiko Tokushima 772 Tsuda
Kazuhiko Tokushima 770 Tsutsumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69415436D1 publication Critical patent/DE69415436D1/de
Publication of DE69415436T2 publication Critical patent/DE69415436T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69415436T 1993-02-15 1994-02-10 Phosphonsäure diester-derivate Expired - Fee Related DE69415436T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2573293 1993-02-15
PCT/JP1994/000209 WO1994018212A1 (en) 1993-02-15 1994-02-10 Phosphonic diester derivative

Publications (2)

Publication Number Publication Date
DE69415436D1 DE69415436D1 (de) 1999-02-04
DE69415436T2 true DE69415436T2 (de) 1999-06-02

Family

ID=12173991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415436T Expired - Fee Related DE69415436T2 (de) 1993-02-15 1994-02-10 Phosphonsäure diester-derivate

Country Status (13)

Country Link
US (1) US5480874A (OSRAM)
EP (1) EP0638581B1 (OSRAM)
JP (1) JP2926273B2 (OSRAM)
KR (1) KR100296163B1 (OSRAM)
CN (1) CN1046733C (OSRAM)
AT (1) ATE174923T1 (OSRAM)
AU (1) AU660125B2 (OSRAM)
CA (1) CA2118007C (OSRAM)
DE (1) DE69415436T2 (OSRAM)
DK (1) DK0638581T3 (OSRAM)
ES (1) ES2126097T3 (OSRAM)
TW (1) TW260664B (OSRAM)
WO (1) WO1994018212A1 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985858A (en) * 1995-12-27 1999-11-16 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivatives
WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
ATE253073T1 (de) 1997-03-07 2003-11-15 Metabasis Therapeutics Inc Neue benzimidazol inhibitoren der fructose-1,6- bisphosphatase
WO2000064880A1 (en) 1999-04-22 2000-11-02 Synaptic Pharmaceutical Corporation Selective npy (y5) antagonists
US6989379B1 (en) 1999-04-22 2006-01-24 H. Lundbick A/S Selective NPY (Y5) antagonists
US6340683B1 (en) 1999-04-22 2002-01-22 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
US6218408B1 (en) 1999-06-30 2001-04-17 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6225330B1 (en) 1999-06-30 2001-05-01 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US6214853B1 (en) 1999-06-30 2001-04-10 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6222040B1 (en) 1999-06-30 2001-04-24 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
ATE511840T1 (de) 2001-10-09 2011-06-15 Amgen Inc Imidazolderivate als entzündungshemmende mittel
WO2003032916A2 (en) * 2001-10-16 2003-04-24 Structural Bioinformatics Inc. Organosulfur inhibitors of tyrosine phosphatases
JP2005529846A (ja) 2002-01-16 2005-10-06 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ
US20060135773A1 (en) * 2004-06-17 2006-06-22 Semple Joseph E Trisubstituted nitrogen modulators of tyrosine phosphatases
EP1786421A2 (en) * 2004-07-09 2007-05-23 Cengent Therapeutics, Inc. Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases
WO2006013054A1 (en) * 2004-08-05 2006-02-09 F. Hoffmann-La Roche Ag Substituted n-acyl-2-aminothiazoles
WO2006028970A1 (en) 2004-09-02 2006-03-16 Cengent Therapeutics, Inc. Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
AU2005293607A1 (en) * 2004-10-07 2006-04-20 Boehringer Ingelheim International Gmbh PI3 kinases
WO2006104030A1 (ja) * 2005-03-25 2006-10-05 Daiichi Sankyo Company, Limited チアゾール化合物
TW200712060A (en) * 2005-05-19 2007-04-01 Nissan Chemical Ind Ltd Thiophene compound having phosphoric ester and process for producing the same
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
DE102007012284A1 (de) 2007-03-16 2008-09-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035334A1 (de) * 2007-07-27 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035333A1 (de) 2007-07-27 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007042154A1 (de) 2007-09-05 2009-03-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
CN114681454B (zh) * 2022-03-17 2024-05-07 江南大学 噻唑类化合物在制备抗sars-cov-2新型冠状病毒药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
US4434162A (en) * 1981-02-17 1984-02-28 Kanebo, Ltd. Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
JPH0745508B2 (ja) * 1988-06-29 1995-05-17 株式会社大塚製薬工場 カルボン酸アミド誘導体
AU606808B2 (en) * 1988-06-29 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
JP2584336B2 (ja) * 1989-05-30 1997-02-26 株式会社大塚製薬工場 カルボン酸アミド誘導体
DE69327572T2 (de) * 1992-05-21 2000-06-21 Otsuka Pharmaceutical Factory, Inc. Phosphonsäurediester-derivat

Also Published As

Publication number Publication date
EP0638581A4 (en) 1995-04-12
KR100296163B1 (ko) 2001-11-05
EP0638581A1 (en) 1995-02-15
DE69415436D1 (de) 1999-02-04
ATE174923T1 (de) 1999-01-15
AU660125B2 (en) 1995-06-08
CA2118007C (en) 2003-12-02
KR950700917A (ko) 1995-02-20
CN1102528A (zh) 1995-05-10
DK0638581T3 (da) 1999-08-23
ES2126097T3 (es) 1999-03-16
WO1994018212A1 (en) 1994-08-18
CN1046733C (zh) 1999-11-24
US5480874A (en) 1996-01-02
TW260664B (OSRAM) 1995-10-21
EP0638581B1 (en) 1998-12-23
CA2118007A1 (en) 1994-08-18
JP2926273B2 (ja) 1999-07-28
AU6010794A (en) 1994-08-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee