DE69415436D1 - Phosphonsäure diester-derivate - Google Patents
Phosphonsäure diester-derivateInfo
- Publication number
- DE69415436D1 DE69415436D1 DE69415436T DE69415436T DE69415436D1 DE 69415436 D1 DE69415436 D1 DE 69415436D1 DE 69415436 T DE69415436 T DE 69415436T DE 69415436 T DE69415436 T DE 69415436T DE 69415436 D1 DE69415436 D1 DE 69415436D1
- Authority
- DE
- Germany
- Prior art keywords
- phenylated
- lower alkyl
- lower alkoxy
- treating
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 208000002177 Cataract Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- -1 cyano phenylthio, phenylsulfinyl Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2573293 | 1993-02-15 | ||
| PCT/JP1994/000209 WO1994018212A1 (en) | 1993-02-15 | 1994-02-10 | Phosphonic diester derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69415436D1 true DE69415436D1 (de) | 1999-02-04 |
| DE69415436T2 DE69415436T2 (de) | 1999-06-02 |
Family
ID=12173991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69415436T Expired - Fee Related DE69415436T2 (de) | 1993-02-15 | 1994-02-10 | Phosphonsäure diester-derivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5480874A (de) |
| EP (1) | EP0638581B1 (de) |
| JP (1) | JP2926273B2 (de) |
| KR (1) | KR100296163B1 (de) |
| CN (1) | CN1046733C (de) |
| AT (1) | ATE174923T1 (de) |
| AU (1) | AU660125B2 (de) |
| CA (1) | CA2118007C (de) |
| DE (1) | DE69415436T2 (de) |
| DK (1) | DK0638581T3 (de) |
| ES (1) | ES2126097T3 (de) |
| TW (1) | TW260664B (de) |
| WO (1) | WO1994018212A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070863C (zh) * | 1995-12-27 | 2001-09-12 | 大塚制药工场株式会社 | 膦酸二酯衍生物 |
| EP0970095B1 (de) * | 1997-03-07 | 2003-10-29 | Metabasis Therapeutics, Inc. | Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase |
| AU6452098A (en) * | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| US6340683B1 (en) | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
| PT1183245E (pt) | 1999-04-22 | 2007-07-12 | Lundbeck & Co As H | Antagonistas selectivos de npy (y5) |
| US6218408B1 (en) | 1999-06-30 | 2001-04-17 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (bicyclics) |
| US6989379B1 (en) | 1999-04-22 | 2006-01-24 | H. Lundbick A/S | Selective NPY (Y5) antagonists |
| US6222040B1 (en) | 1999-06-30 | 2001-04-24 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (tricyclics) |
| US6225330B1 (en) | 1999-06-30 | 2001-05-01 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (tricyclics) |
| US6214853B1 (en) | 1999-06-30 | 2001-04-10 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (bicyclics) |
| US7273880B2 (en) | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| CA2458533C (en) | 2001-10-09 | 2011-01-04 | Tularik Inc. | Imidazole derivates as anti-inflammatory agents |
| WO2003032916A2 (en) * | 2001-10-16 | 2003-04-24 | Structural Bioinformatics Inc. | Organosulfur inhibitors of tyrosine phosphatases |
| AU2003207589B2 (en) | 2002-01-16 | 2006-07-13 | University Of Virginia Patent Foundation | 2-Aminothiazole Allosteric Enhancers of A1 Adenosine Receptors |
| US20060135773A1 (en) * | 2004-06-17 | 2006-06-22 | Semple Joseph E | Trisubstituted nitrogen modulators of tyrosine phosphatases |
| JP2008505916A (ja) * | 2004-07-09 | 2008-02-28 | メタバシス・セラピューティクス・インコーポレイテッド | チロシンホスファターゼの酸素／窒素複素環阻害剤 |
| NZ552650A (en) | 2004-08-05 | 2010-09-30 | Hoffmann La Roche | Substituted N-acyl-2-aminothiazoles |
| WO2006028970A1 (en) | 2004-09-02 | 2006-03-16 | Cengent Therapeutics, Inc. | Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases |
| BRPI0516557A (pt) * | 2004-10-07 | 2008-09-09 | Boehringer Ingelheim Int | pi3 cinases |
| WO2006104030A1 (ja) * | 2005-03-25 | 2006-10-05 | Daiichi Sankyo Company, Limited | チアゾール化合物 |
| TW200712060A (en) * | 2005-05-19 | 2007-04-01 | Nissan Chemical Ind Ltd | Thiophene compound having phosphoric ester and process for producing the same |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035334A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| CN114681454B (zh) * | 2022-03-17 | 2024-05-07 | 江南大学 | 噻唑类化合物在制备抗sars-cov-2新型冠状病毒药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU523040B2 (en) * | 1978-05-15 | 1982-07-08 | Kanebo Limited | Calcium -antagonistic composition |
| US4434162A (en) * | 1981-02-17 | 1984-02-28 | Kanebo, Ltd. | Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same |
| JPH0651625B2 (ja) * | 1986-12-29 | 1994-07-06 | 株式会社大塚製薬工場 | 高脂質血症治療剤 |
| US4822780A (en) * | 1987-07-08 | 1989-04-18 | Otsuka Pharmaceutical Factory, Inc. | Carboxamide compounds |
| AU606808B2 (en) * | 1988-06-29 | 1991-02-14 | Otsuka Pharmaceutical Factory, Inc. | Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same |
| JPH0745508B2 (ja) * | 1988-06-29 | 1995-05-17 | 株式会社大塚製薬工場 | カルボン酸アミド誘導体 |
| JP2584336B2 (ja) * | 1989-05-30 | 1997-02-26 | 株式会社大塚製薬工場 | カルボン酸アミド誘導体 |
| WO1993023409A1 (en) * | 1992-05-21 | 1993-11-25 | Otsuka Pharmaceutical Factory, Inc. | Phosphonic diester derivative |
-
1994
- 1994-02-08 TW TW083101072A patent/TW260664B/zh active
- 1994-02-10 DK DK94906377T patent/DK0638581T3/da active
- 1994-02-10 KR KR1019940703674A patent/KR100296163B1/ko not_active IP Right Cessation
- 1994-02-10 AT AT94906377T patent/ATE174923T1/de not_active IP Right Cessation
- 1994-02-10 DE DE69415436T patent/DE69415436T2/de not_active Expired - Fee Related
- 1994-02-10 EP EP94906377A patent/EP0638581B1/de not_active Expired - Lifetime
- 1994-02-10 CA CA002118007A patent/CA2118007C/en not_active Expired - Fee Related
- 1994-02-10 JP JP6517889A patent/JP2926273B2/ja not_active Expired - Fee Related
- 1994-02-10 AU AU60107/94A patent/AU660125B2/en not_active Ceased
- 1994-02-10 CN CN94190067A patent/CN1046733C/zh not_active Expired - Fee Related
- 1994-02-10 ES ES94906377T patent/ES2126097T3/es not_active Expired - Lifetime
- 1994-02-10 WO PCT/JP1994/000209 patent/WO1994018212A1/ja active IP Right Grant
-
1995
- 1995-01-12 US US08/318,860 patent/US5480874A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0638581B1 (de) | 1998-12-23 |
| DK0638581T3 (da) | 1999-08-23 |
| EP0638581A4 (de) | 1995-04-12 |
| CN1046733C (zh) | 1999-11-24 |
| KR950700917A (ko) | 1995-02-20 |
| CA2118007A1 (en) | 1994-08-18 |
| KR100296163B1 (ko) | 2001-11-05 |
| ATE174923T1 (de) | 1999-01-15 |
| CA2118007C (en) | 2003-12-02 |
| WO1994018212A1 (en) | 1994-08-18 |
| AU660125B2 (en) | 1995-06-08 |
| US5480874A (en) | 1996-01-02 |
| DE69415436T2 (de) | 1999-06-02 |
| AU6010794A (en) | 1994-08-29 |
| ES2126097T3 (es) | 1999-03-16 |
| JP2926273B2 (ja) | 1999-07-28 |
| TW260664B (de) | 1995-10-21 |
| CN1102528A (zh) | 1995-05-10 |
| EP0638581A1 (de) | 1995-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |