DE69328699D1 - Hybridisierungsassay unter Verwendung von verzweigten Nukleinsäuresonden - Google Patents

Hybridisierungsassay unter Verwendung von verzweigten Nukleinsäuresonden

Info

Publication number
DE69328699D1
DE69328699D1 DE69328699T DE69328699T DE69328699D1 DE 69328699 D1 DE69328699 D1 DE 69328699D1 DE 69328699 T DE69328699 T DE 69328699T DE 69328699 T DE69328699 T DE 69328699T DE 69328699 D1 DE69328699 D1 DE 69328699D1
Authority
DE
Germany
Prior art keywords
nucleic acid
acid probes
hybridization assay
branched nucleic
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69328699T
Other languages
English (en)
Other versions
DE69328699T2 (de
Inventor
James John Hogan
Arnold, Jr
Norman Charles Nelson
Robert Bezverkov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25248124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69328699(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of DE69328699D1 publication Critical patent/DE69328699D1/de
Application granted granted Critical
Publication of DE69328699T2 publication Critical patent/DE69328699T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
DE69328699T 1992-01-22 1993-01-20 Hybridisierungsassay unter Verwendung von verzweigten Nukleinsäuresonden Expired - Lifetime DE69328699T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82702192A 1992-01-22 1992-01-22

Publications (2)

Publication Number Publication Date
DE69328699D1 true DE69328699D1 (de) 2000-06-29
DE69328699T2 DE69328699T2 (de) 2000-09-07

Family

ID=25248124

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328699T Expired - Lifetime DE69328699T2 (de) 1992-01-22 1993-01-20 Hybridisierungsassay unter Verwendung von verzweigten Nukleinsäuresonden

Country Status (6)

Country Link
US (2) US5424413A (de)
EP (1) EP0552931B1 (de)
JP (1) JP3415150B2 (de)
AU (1) AU665062B2 (de)
DE (1) DE69328699T2 (de)
WO (1) WO1993015102A1 (de)

Families Citing this family (294)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430136A (en) * 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US6197556B1 (en) * 1991-12-20 2001-03-06 The University Of Chicago Nucleic acid amplification using modular branched primers
NZ245771A (en) * 1992-02-07 1994-08-26 New England Medical Center Inc Mammalian gastrin/cholecystokinin b (cck-b) receptor and antagonists
WO1994003637A1 (en) * 1992-07-31 1994-02-17 Syntex (Usa) Inc. Method for introducing defined sequences at the 3' end of polynucleotides
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5616464A (en) * 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US6306657B1 (en) * 1994-06-28 2001-10-23 Kalyx Biosciences, Inc. Polynucleotide probe and kit for amplifying signal detection in hybridization assays
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
EP0709466B1 (de) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US5731153A (en) * 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5783387A (en) * 1995-02-06 1998-07-21 The Regents Of The University Of California Method for identifying and quantifying nucleic acid sequence aberrations
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US20020081577A1 (en) * 1995-06-06 2002-06-27 Robert L. Kilkuskie Oligonucleotides speciific for hepatitis c virus
AU707691B2 (en) * 1995-06-07 1999-07-15 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for neisseria species
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
DE19537952A1 (de) 1995-10-12 1997-04-17 Boehringer Mannheim Gmbh Verfahren zum Nachweis eines Analyten
AU7264196A (en) * 1995-10-16 1997-05-07 Chiron Corporation Method of screening for factors that modulate gene expression
WO1997023646A1 (en) * 1995-12-22 1997-07-03 Behringwerke Aktiengesellschaft Detection of differences in nucleic acids
US6180777B1 (en) * 1996-01-12 2001-01-30 Bayer Corporation Synthesis of branched nucleic acids
DE19610255B4 (de) * 1996-03-15 2004-11-04 Universität Heidelberg Verfahren zur Herstellung von Nukleinsäuresequenzen und Verfahren zum Nachweis von Translokationen zwischen Chromosomen
US5824478A (en) * 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
GB9626074D0 (en) * 1996-12-16 1997-02-05 Cytocell Ltd Nucleic acids amplification assay
CA2218439A1 (en) * 1996-12-21 1998-06-21 Henrik Orum Method of identifying a nucleic acid using triple helix formation of adjacently annealed probes
EP0983292A4 (de) * 1997-05-05 2005-05-18 Third Wave Tech Inc Zielabhängige reaktionen mittels strukturüberbrückender oligonukleotide
US6194149B1 (en) * 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US7101672B2 (en) * 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6849400B1 (en) * 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
US5935791A (en) 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6518017B1 (en) 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
WO1999029890A2 (en) * 1997-12-12 1999-06-17 Digene Corporation Assessment of human papilloma virus-related disease
EP1049806B1 (de) * 1998-01-27 2002-07-10 Cytocell Limited Verfahren zum nachweis von nukleinsäure-zielsequenzen mittels in vitro transkription von einem rna-promoter
AU752220B2 (en) * 1998-01-27 2002-09-12 British Biocell International Limited Modified nucleic acid probes and uses thereof
WO1999042616A1 (en) * 1998-02-20 1999-08-26 Dade Behring Inc. Methods for determining concentrations of nucleic acids
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
WO1999055916A1 (en) * 1998-04-29 1999-11-04 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
JP3267576B2 (ja) * 1998-11-09 2002-03-18 三光純薬株式会社 プローブ高分子の形成方法
WO2000031302A1 (en) * 1998-11-25 2000-06-02 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
US6492111B1 (en) 1998-11-25 2002-12-10 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US6900300B1 (en) * 2000-09-19 2005-05-31 Ingeneus Corporation Quadruplex DNA and duplex probe systems
US6432642B1 (en) * 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
GB9905580D0 (en) 1999-03-12 1999-05-05 Tepnel Medical Ltd Enyzymatically catalysed signal amplification
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
ES2253216T3 (es) * 1999-04-08 2006-06-01 Gen-Probe Incorporated Pares de cebadores de amplificacion y secuenciacion y uso de los mismos.
EP1173614A4 (de) * 1999-04-08 2003-10-29 Oasis Biosciences Inc Antisense oligonukleotide enthaltend universelle und/oder degenerierte basen
EP2363478B1 (de) * 1999-04-21 2019-07-24 Alnylam Pharmaceuticals, Inc. Verfahren und Zusammensetzungen zur Hemmung der Funktion der Polynukleotide Sequenzen
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
WO2001009377A1 (en) * 1999-07-29 2001-02-08 Cytocell Limited Method for detecting nucleic acid target sequences involving in vitro transcription from an rna polymerase promoter
US7005261B1 (en) 1999-07-29 2006-02-28 British Biocell International Limited Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter
US6893819B1 (en) * 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7838225B2 (en) * 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US7585632B2 (en) * 1999-10-29 2009-09-08 Hologic, Inc. Compositions and methods for the detection of a nucleic acid using a cleavage reaction
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
JP2004512813A (ja) * 1999-11-29 2004-04-30 ガミダ　センス　ダイアグノスティックス　リミテッド 試料中に標的核酸配列が存在しているか否かを検出するのに有用なオリゴヌクレオチドおよびその集合体
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7537938B2 (en) 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) * 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US6451588B1 (en) * 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
NO314206B1 (no) * 2001-04-30 2003-02-10 Erling Sundrehagen Kvantitativt kjemisk analysemetode, anordning/innretning, samt anvendelse av nevnte metode og analysesett
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US8512953B2 (en) * 2001-09-24 2013-08-20 One Lambda Diagnostic probe detection system
WO2003029441A1 (fr) * 2001-09-28 2003-04-10 Sanko Junyaku Co., Ltd. Procede d'amplification des signaux de puces adn
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
GB0130268D0 (en) * 2001-12-19 2002-02-06 Molecular Light Tech Res Ltd Methods of detecting modification of genetic material and monitoring processes thereof
SE0200531D0 (sv) * 2002-02-22 2002-02-22 Avaris Ab Novel biomolecular complexes, method for their production and use
AU2003212358A1 (en) * 2002-03-14 2003-09-22 Gnothis Holding Sa Method for identifying a nucleic acid analyte
DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
FR2842827B1 (fr) * 2002-07-26 2004-10-22 Biocortech NOUVELLE METHODE D'ANALYSE D'ACIDE NUCLEIQUE ET SON UTILISATION POUR EVALUER LE DEGRE D'EDITION DE L'ARNm DU RECEPTEUR 5-HT2c
US10730906B2 (en) * 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
EP1545762A2 (de) * 2002-09-27 2005-06-29 Carlsberg A/S Räumlich kodierte polymermatrix
ATE513055T1 (de) 2002-10-30 2011-07-15 Nuevolution As Enzymatisches codieren
WO2004044132A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Modified oligonucleotides for use in rna interference
GB2395556A (en) * 2002-11-22 2004-05-26 Dynal Biotech Ltd Nucleic acid probe
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2005010201A2 (en) * 2003-01-29 2005-02-03 Naxcor, Inc. Methods and compositions for detecting nucleic acid sequences
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
JP5117719B2 (ja) * 2003-04-18 2013-01-16 ベクトン・ディキンソン・アンド・カンパニー 免疫増幅
JP4732339B2 (ja) * 2003-06-17 2011-07-27 キージーン ナムローゼ フェンノートシャップ 改良されたオリゴヌクレオチドプローブ対を用いるライゲーションアッセイを使用して標的ヌクレオチド配列を検出するための手段および方法
CN103898207B (zh) * 2003-08-01 2016-09-14 戴诺生物技术有限公司 自杂交多重靶核酸探针及其使用方法
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
JP5117722B2 (ja) * 2003-09-02 2013-01-16 キージーン ナムローゼ フェンノートシャップ 標的核酸配列の検出のためのｏｌａベースの方法
EP1670939B1 (de) * 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
EP1531183A1 (de) * 2003-11-14 2005-05-18 bioMérieux BV Methode zur Vervielfältigung von RNA-Sequenzen
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US20050250147A1 (en) * 2004-05-10 2005-11-10 Macevicz Stephen C Digital profiling of polynucleotide populations
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
WO2006054740A1 (ja) * 2004-11-19 2006-05-26 Wakunaga Pharmaceutical Co., Ltd. 核酸検出用核酸断片および核酸検出方法
JP2006166911A (ja) * 2004-11-19 2006-06-29 Wakunaga Pharmaceut Co Ltd 核酸検出用核酸断片および核酸検出方法
WO2006076687A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Elisa assays using prion-specific peptide reagents
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
ATE526975T1 (de) 2005-10-07 2011-10-15 California Inst Of Techn Pkr-aktivierung mittels hybridisierungskettenreaktion
CA2625263C (en) 2005-10-07 2016-12-13 Johnson & Johnson Research Pty Limited Multicomponent nucleic acid enzymes and methods for their use
JP2009511086A (ja) 2005-10-17 2009-03-19 ジェン−プローブ・インコーポレーテッド レジオネラ・ニューモフィラ核酸を検出するための組成物及び方法
WO2007054682A1 (en) * 2005-11-08 2007-05-18 The University Court Of The University Of Edinburgh Switchable biosensor devices
ES2901551T3 (es) * 2005-12-01 2022-03-22 Nuevolution As Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
US8741813B2 (en) * 2005-12-15 2014-06-03 General Electric Company Composition, device and associated method
US8778845B2 (en) * 2005-12-15 2014-07-15 Genral Electric Company Composition, device and associated method
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20070196849A1 (en) * 2006-02-22 2007-08-23 Applera Corporation Double-ligation Method for Haplotype and Large-scale Polymorphism Detection
US20080058218A1 (en) * 2006-05-03 2008-03-06 Gordon David B Arrays of compound probes and methods using the same
US20070259344A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Compound probes and methods of increasing the effective probe densities of arrays
US20070259347A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Methods of increasing the effective probe densities of arrays
US20070259346A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Analysis of arrays
AU2007249286B2 (en) * 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US7745129B1 (en) * 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
ZA200901742B (en) 2006-10-06 2010-06-30 Johnson & Johnson Res Pty Ltd Moleculor switches and methods for their use
US8765643B2 (en) * 2006-12-04 2014-07-01 General Electric Company Composition, device and associated method
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
JP5340167B2 (ja) 2006-12-21 2013-11-13 ジェン−プロウブ インコーポレイテッド 核酸増幅のための方法および組成物
EP2142673B1 (de) 2007-04-05 2013-05-22 Johnson & Johnson Research Pty Limited Nukleinsäureenzyme und komplexe sowie verfahren zur verwendung davon
WO2008144562A1 (en) * 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
JP5282088B2 (ja) 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド 処理実行に使用する機器および容器
WO2009022682A1 (ja) * 2007-08-14 2009-02-19 Eisai R & D Management Co., Ltd. 標的物質の検出方法
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
EP2071035A1 (de) * 2007-12-13 2009-06-17 Epigenomics AG Vermittler und Verstärkungsverfahren
EP2235214B1 (de) * 2007-12-26 2014-07-09 Gen Probe Inc Zusammensetzungen und verfahren für den nachweis von candida albicans-nukleinsäure
AU2009243060A1 (en) * 2008-04-30 2009-11-05 Novartis Ag. Assay for pathogenic conformers
US20100021904A1 (en) * 2008-05-21 2010-01-28 Pierce Niles A Shielded cross-linking probes
US20100021901A1 (en) * 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
US20110207132A1 (en) * 2008-08-04 2011-08-25 University Of Maryland Probes and methods for detecting analytes
WO2010062546A1 (en) * 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
WO2010088292A1 (en) * 2009-01-28 2010-08-05 Qiagen Gaithersburg, Inc. Sequence-specific large volume sample preparation method and assay
EP2391452B1 (de) 2009-01-30 2015-06-17 Gen-Probe Incorporated Systeme und verfahren zur erfassung eines signals und beaufschlagung des signalübertragungselements mit wärmeenergie
WO2010086622A1 (en) 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Adaptors for nucleic acid constructs in transmembrane sequencing
US9797000B2 (en) * 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
US20100316998A1 (en) * 2009-06-15 2010-12-16 Massachusetts Institute Of Technology Methods and compositions for empirical selection of drugs or other molecules
IN2012DN00715A (de) 2009-06-24 2015-06-19 Health Corp Rambam
US9169512B2 (en) 2009-07-01 2015-10-27 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
EP2478087B1 (de) 2009-09-14 2017-01-18 QIAGEN Gaithersburg, Inc. Zusammensetzungen und verfahren zur rückgewinnung von nukleinsäuren oder proteinen aus in zytologischen medien fixierten gewebeproben
US8975019B2 (en) * 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
JP6147502B2 (ja) 2009-10-27 2017-06-14 スウィフト バイオサイエンシーズ， インコーポレイテッド ポリヌクレオチドプライマー及びプローブ
CN102725639A (zh) 2009-11-04 2012-10-10 诺华有限公司 蛋白质聚集物与单体分离中作为结合试剂的带正电物质
US8916349B2 (en) 2009-11-23 2014-12-23 Becton, Dickinson And Company Assay method for target nucleic acid by signal amplification using probe hybridization and restriction
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9605303B2 (en) 2010-01-29 2017-03-28 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an HPV in a sample
US9689047B2 (en) 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9181593B2 (en) 2010-02-17 2015-11-10 Gen-Probe Incorporated Compositions and methods to detect Atopobium vaginae nucleic acid
JP5481250B2 (ja) * 2010-03-26 2014-04-23 富士フイルム株式会社 複屈折パターンを有する物品
WO2011133811A2 (en) 2010-04-21 2011-10-27 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
AU2011255638B2 (en) 2010-05-19 2016-08-25 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
US8962241B2 (en) * 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US8877438B2 (en) * 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
CN110878345A (zh) 2010-09-21 2020-03-13 安捷伦科技有限公司 通过分子计数提高等位基因调用的置信度
GB2497495B (en) 2010-10-04 2018-06-06 Gen Probe Prodesse Inc Compositions, methods and kits to detect adenovirus nucleic acids
US9765341B2 (en) * 2010-11-04 2017-09-19 President And Fellows Of Harvard College DNA origami devices
KR101968352B1 (ko) * 2010-11-19 2019-04-11 스피디엑스 피티와이 리미티드 신호 증폭
WO2012116220A2 (en) 2011-02-24 2012-08-30 Qiagen Gaithersburg, Inc. Materials and methods for detection of hpv nucleic acid
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
US9657352B2 (en) 2011-04-25 2017-05-23 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US10597701B2 (en) * 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
WO2013014451A1 (en) 2011-07-25 2013-01-31 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US9663829B2 (en) 2011-09-08 2017-05-30 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
EP2769213A4 (de) * 2011-10-18 2015-03-18 Twistnostics Llc Detektoren und verfahren zum nachweis eines zielanalyten
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
GB2504240B (en) 2012-02-27 2015-05-27 Cellular Res Inc Compositions and kits for molecular counting of nucleic acids
EP2820174B1 (de) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Verfahren und verwendung für molekulare tags
EP3287531B1 (de) 2012-02-28 2019-06-19 Agilent Technologies, Inc. Verfahren zur befestigung einer zählersequenz an einer nukleinsäureprobe
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013202354A1 (en) * 2012-06-18 2014-01-16 Speedx Pty Ltd Target detection and signal amplification
US11155860B2 (en) 2012-07-19 2021-10-26 Oxford Nanopore Technologies Ltd. SSB method
CA2883219C (en) 2012-08-30 2020-12-29 Gen-Probe Incorporated Multiphase nucleic acid amplification
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP3591073B1 (de) 2012-09-04 2021-12-01 Guardant Health, Inc. Verfahren zur detektion von seltenen mutationen und kopienzahlvariationen
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
SG11201504691TA (en) * 2012-12-21 2015-07-30 Univ Nanyang Tech Site-specific induction of bimolecular quadruplex-duplex hybrids and methods of using the same
ES2900102T3 (es) * 2013-02-20 2022-03-15 Univ Emory Composiciones para la secuenciación de ácidos nucleicos en mezclas
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
EP2964779B1 (de) 2013-03-08 2018-08-29 Oxford Nanopore Technologies Limited Verwendung von spacer-elementen in einer nukleinsäure zur kontrolle der bewegung einer helicase
WO2014145620A2 (en) * 2013-03-15 2014-09-18 The Broad Institute, Inc. Novel hybridization probes and uses thereof
US10510435B2 (en) 2013-04-30 2019-12-17 California Institute Of Technology Error correction of multiplex imaging analysis by sequential hybridization
WO2014182528A2 (en) * 2013-04-30 2014-11-13 California Institute Of Technology Multiplex labeling of molecules by sequential hybridization barcoding
GB201310823D0 (en) * 2013-06-18 2013-07-31 Lgc Ltd Fluorophore-based oligonucleotide probes with a universal element
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
JP6475718B2 (ja) 2013-07-30 2019-02-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 定量的なｄｎａベースのイメージング及び超解像イメージング
KR102129506B1 (ko) * 2013-08-09 2020-07-06 루미넥스 코포레이션 핵산 에세이에서의 향상된 용융 식별 및 복합화를 위한 프로브
WO2015023892A1 (en) 2013-08-14 2015-02-19 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
KR102536833B1 (ko) 2013-08-28 2023-05-26 벡톤 디킨슨 앤드 컴퍼니 대량의 동시 단일 세포 분석
CN105745528A (zh) 2013-10-07 2016-07-06 赛卢拉研究公司 用于以数字方式对阵列上的特征进行计数的方法和系统
EP3524694B1 (de) 2013-12-28 2020-07-15 Guardant Health, Inc. Verfahren und systeme für den nachweis genetischer varianten
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
DE102015203606C5 (de) 2014-02-28 2023-12-21 Gen-Probe Incorporated Verfahren zur Isolierung von Nukleinsäure von zytologischen Proben in flüssigen Konservierungsmitteln, die Formaldehyd enthalten
EP3670663A1 (de) 2014-02-28 2020-06-24 Gen-Probe Incorporated Verfahren zur isolierung von nukleinsäure aus proben in flüssigkeitsbasierten zytologischen konservierungsmitteln mit formaldehyd
US11091810B2 (en) * 2015-01-27 2021-08-17 BioSpyder Technologies, Inc. Focal gene expression profiling of stained FFPE tissues with spatial correlation to morphology
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
CA2965661C (en) * 2014-10-23 2023-09-26 Ricardo Mancebo Reagents and methods for isothermal chain reaction
JP6944873B2 (ja) 2015-01-09 2021-10-06 ジェン−プローブ・インコーポレーテッド 細菌性膣症を診断するための方法および組成物
WO2016116935A1 (en) 2015-01-21 2016-07-28 Yeda Research And Development Co. Ltd. Use of rasa2 as a prognostic and therapeutic marker for melanoma
EP3259371B1 (de) 2015-02-19 2020-09-02 Becton, Dickinson and Company Hochdurchsatzeinzelzellenanalyse mit kombination von proteomischen und genomischen informationen
EP3262192B1 (de) 2015-02-27 2020-09-16 Becton, Dickinson and Company Räumlich adressierbare molekulare barcodierung
JP6796593B2 (ja) 2015-03-16 2020-12-09 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
EP4180535A1 (de) 2015-03-30 2023-05-17 Becton, Dickinson and Company Verfahren und zusammensetzungen für kombinatorische barcodierung
EP3286326A1 (de) 2015-04-23 2018-02-28 Cellular Research, Inc. Verfahren und zusammensetzungen zur gesamttranskriptomamplifikation
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
US11092606B2 (en) * 2015-08-07 2021-08-17 President And Fellows Of Harvard College Super resolution imaging of protein-protein interactions
US10619186B2 (en) 2015-09-11 2020-04-14 Cellular Research, Inc. Methods and compositions for library normalization
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
WO2017120216A2 (en) 2016-01-04 2017-07-13 Gen-Probe Incorporated Methods and compositions for detecting candida species
WO2017173279A1 (en) * 2016-03-31 2017-10-05 Arizona Board Of Regents On Behalf Of Arizona State University Probes and methods for measuring tandem repeats
WO2017189525A1 (en) 2016-04-25 2017-11-02 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
US10563247B2 (en) * 2016-04-27 2020-02-18 Kent State University Single-molecule mechanoanalytical DNA device for ultrasensitive sensing of analytes
CA3021914A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
WO2017192387A1 (en) 2016-05-02 2017-11-09 Cellular Research, Inc. Accurate molecular barcoding
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US11397882B2 (en) 2016-05-26 2022-07-26 Becton, Dickinson And Company Molecular label counting adjustment methods
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
JP6803930B2 (ja) 2016-06-10 2021-01-06 ジェン−プローブ・インコーポレーテッド Ｚｉｋａウイルス核酸を検出するための組成物および方法
EP3472342A1 (de) 2016-06-19 2019-04-24 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Screening auf chemotherapieresistenz in menschlichen haploidzellen
EP3481843B1 (de) 2016-07-05 2022-01-26 California Institute of Technology Hybridisierungskettenreaktion mit fraktioniertem initiator
CA3034617A1 (en) 2016-08-30 2018-03-08 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
CN110352252A (zh) * 2016-09-22 2019-10-18 威廉马歇莱思大学 用于复杂序列捕获和分析的分子杂交探针
SG11201901733PA (en) 2016-09-26 2019-04-29 Cellular Res Inc Measurement of protein expression using reagents with barcoded oligonucleotide sequences
US11447835B2 (en) 2016-10-19 2022-09-20 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
KR20190077061A (ko) 2016-11-08 2019-07-02 셀룰러 리서치, 인크. 세포 표지 분류 방법
CN117594126A (zh) 2016-11-08 2024-02-23 贝克顿迪金森公司 用于表达谱分类的方法
JP7125395B2 (ja) 2016-11-21 2022-08-24 ジェン－プローブ・インコーポレーテッド Ｂ型肝炎ウイルスを検出または定量化するための組成物および方法
KR20180072480A (ko) * 2016-12-21 2018-06-29 한국생명공학연구원 자가 형광 신호 증폭이 가능한 마이크로 rna 검출용 바이오 프로브 세트 및 이의 용도
ES2961580T3 (es) 2017-01-13 2024-03-12 Cellular Res Inc Revestimiento hidrófilo de canales de fluidos
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
EP4056716A1 (de) 2017-03-24 2022-09-14 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus
EP4219769A3 (de) 2017-03-25 2023-10-11 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zum nachweis von rhinovirus-nukleinsäure
EP3630790B1 (de) * 2017-05-23 2023-05-10 Rutgers, The State University of New Jersey In-situ-vermitteltes ziel
AU2018281745B2 (en) 2017-06-05 2022-05-19 Becton, Dickinson And Company Sample indexing for single cells
EP4276201A3 (de) 2017-06-07 2024-01-17 Gen-Probe Incorporated Nachweis von nukleinsäure der babesia-spezies in einer probe
US11542542B2 (en) * 2017-07-18 2023-01-03 Ohio State Innovation Foundation Antisense fingerloop DNAs and uses thereof
AU2018316218A1 (en) 2017-08-11 2020-03-05 Gen-Probe Incorporated Compositions and methods for detecting Staphylococcus aureus
EP3696275A4 (de) * 2017-10-11 2021-05-26 MGI Tech Co., Ltd. Verfahren zur verbesserung der belastung und stabilität von nukleinsäuren auf einem festen träger
WO2019099629A1 (en) 2017-11-17 2019-05-23 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID
WO2019118735A1 (en) 2017-12-15 2019-06-20 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
JP7407128B2 (ja) 2018-05-03 2023-12-28 ベクトン・ディキンソン・アンド・カンパニー ハイスループットマルチオミクスサンプル解析
WO2019213237A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
CA3106975A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
US11441182B2 (en) * 2018-08-08 2022-09-13 Virginia Commonwealth University Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers
US20220074002A1 (en) 2018-08-21 2022-03-10 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
JP7389111B2 (ja) 2018-08-24 2023-11-29 ジェン－プローブ・インコーポレーテッド 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
EP3856934A2 (de) 2018-09-27 2021-08-04 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von bordetella-pertussis- und bordetella-parapertussis-nukleinsäure
CN112805389A (zh) 2018-10-01 2021-05-14 贝克顿迪金森公司 确定5’转录物序列
AU2019365821A1 (en) 2018-10-22 2021-06-10 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus BK virus
IL262658A (en) 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
JP2022506546A (ja) 2018-11-08 2022-01-17 ベクトン・ディキンソン・アンド・カンパニー ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析
IL263184A (en) 2018-11-21 2020-05-31 Yarden Yosef Method of treating cancer and compositions for same
EP3894552A1 (de) 2018-12-13 2021-10-20 Becton, Dickinson and Company Selektive verlängerung in der vollständigen transkriptomanalyse von einzelzellen
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
ES2945227T3 (es) 2019-01-23 2023-06-29 Becton Dickinson Co Oligonucleótidos asociados con anticuerpos
AU2020210753A1 (en) 2019-01-25 2021-09-02 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
WO2021003331A1 (en) 2019-07-03 2021-01-07 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
US11939622B2 (en) 2019-07-22 2024-03-26 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
GB201910635D0 (en) * 2019-07-25 2019-09-11 Ttp Plc Detection of target oligonucleotides
US11773436B2 (en) 2019-11-08 2023-10-03 Becton, Dickinson And Company Using random priming to obtain full-length V(D)J information for immune repertoire sequencing
CN115244184A (zh) 2020-01-13 2022-10-25 贝克顿迪金森公司 用于定量蛋白和rna的方法和组合物
WO2021224873A1 (en) 2020-05-07 2021-11-11 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
AU2021308095A1 (en) 2020-07-17 2023-03-09 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
WO2022079719A1 (en) 2020-10-15 2022-04-21 Yeda Research And Development Co. Ltd. Method of treating myeloid malignancies
EP4247967A1 (de) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profilierung von stark exprimierten und schwach exprimierten proteinen
US11873485B2 (en) 2021-01-26 2024-01-16 California Institute Of Technology Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas
WO2023010008A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
EP0151631A1 (de) * 1983-08-03 1985-08-21 The Research Foundation Of State University Of New York Verzweigte verbindungen von nukleinsäure mit einer präzise bestimmten migration
US4647529A (en) * 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
WO1987004165A1 (en) * 1985-12-27 1987-07-16 Toray Industries, Inc. Dna probe and method of preparing the same
DE3639109A1 (de) * 1986-11-15 1988-05-19 Merck Patent Gmbh Verfahren zur bestimmung von nucleinsaeuren
ES2074051T3 (es) * 1987-09-21 1995-09-01 Gen Probe Inc Ensayo de proteccion homogeneo.
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
JP2856804B2 (ja) * 1988-03-24 1999-02-10 ユニバーシティ オブ アイオワ リサーチ ファウンデイション 標識された相補的核酸プローブを開裂する触媒反応の補因子としての活性に基づく核酸配列検出のための触媒ハイブリッド形成系
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
WO1990015884A1 (en) * 1989-06-19 1990-12-27 The Johns Hopkins University Formation of triple helix complexes of double stranded dna using nucleoside oligomers
NO904633L (no) * 1989-11-09 1991-05-10 Molecular Diagnostics Inc Amplifikasjon av nukleinsyrer ved transkriberbar haarnaalsprobe.
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
EP0453301A3 (en) * 1990-04-20 1993-07-21 Syntex (U.S.A.) Inc. Double receptor polynucleotide assay method

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