DE69328231D1 - Verfahren und Vorrichtung zur Ortung und zum Zählen von Fluoreszenz-Molekülen - Google Patents

Verfahren und Vorrichtung zur Ortung und zum Zählen von Fluoreszenz-Molekülen

Info

Publication number
DE69328231D1
DE69328231D1 DE69328231T DE69328231T DE69328231D1 DE 69328231 D1 DE69328231 D1 DE 69328231D1 DE 69328231 T DE69328231 T DE 69328231T DE 69328231 T DE69328231 T DE 69328231T DE 69328231 D1 DE69328231 D1 DE 69328231D1
Authority
DE
Germany
Prior art keywords
locating
fluorescence molecules
counting fluorescence
counting
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69328231T
Other languages
English (en)
Other versions
DE69328231T2 (de
Inventor
Mitsuru Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamamatsu Photonics KK
Original Assignee
Hamamatsu Photonics KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17881152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69328231(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hamamatsu Photonics KK filed Critical Hamamatsu Photonics KK
Publication of DE69328231D1 publication Critical patent/DE69328231D1/de
Application granted granted Critical
Publication of DE69328231T2 publication Critical patent/DE69328231T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69328231T 1992-11-10 1993-11-10 Verfahren und Vorrichtung zur Ortung und zum Zählen von Fluoreszenz-Molekülen Expired - Fee Related DE69328231T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4300134A JP2575270B2 (ja) 1992-11-10 1992-11-10 核酸の塩基配列決定方法、単一分子検出方法、その装置及び試料の作成方法

Publications (2)

Publication Number Publication Date
DE69328231D1 true DE69328231D1 (de) 2000-05-04
DE69328231T2 DE69328231T2 (de) 2000-08-10

Family

ID=17881152

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328231T Expired - Fee Related DE69328231T2 (de) 1992-11-10 1993-11-10 Verfahren und Vorrichtung zur Ortung und zum Zählen von Fluoreszenz-Molekülen

Country Status (4)

Country Link
US (2) US5528046A (de)
EP (1) EP0601714B1 (de)
JP (1) JP2575270B2 (de)
DE (1) DE69328231T2 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU673245B2 (en) * 1993-02-01 1996-10-31 Seq, Ltd. Methods and apparatus for DNA sequencing
JP3438927B2 (ja) * 1993-12-06 2003-08-18 日清紡績株式会社 ビオチン化標識化合物及びそれを利用した蛍光標識化方法
JP3393701B2 (ja) * 1994-03-18 2003-04-07 株式会社東北テクノアーチ イオン性検体のスポットテスト法
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6078681A (en) * 1996-03-18 2000-06-20 Marine Biological Laboratory Analytical imaging system and process
EP1736554B1 (de) 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Bestimmung von Unterschieden in der Nukleinsäuresequenz mittels einer Kombination von Ligasebestimmung und Polymerasekettenreaktion
DE19634873A1 (de) * 1996-08-29 1998-03-12 Boehringer Mannheim Gmbh System zur Unterscheidung fluoreszierender Molekülgruppen durch zeitaufgelöste Fluoreszenzmessung
EP0836090A1 (de) * 1996-10-12 1998-04-15 Evotec BioSystems GmbH Probenanalyseverfahren durch Bestimmung der spezifischen Helligkeitsverteilung von Teilchen
US5965446A (en) * 1996-10-24 1999-10-12 Hamamatsu Photonics K.K. Method for placing fluorescent single molecules on surface of substrate and method for visualizing structural defect of surface of substrate
US6135965A (en) * 1996-12-02 2000-10-24 Board Of Regents, The University Of Texas System Spectroscopic detection of cervical pre-cancer using radial basis function networks
WO1998035012A2 (en) * 1997-02-12 1998-08-13 Chan Eugene Y Methods and products for analyzing polymers
US6097025A (en) * 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6992761B2 (en) * 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
WO2000006991A2 (en) 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
DE19742227A1 (de) * 1997-09-25 1999-04-01 Juergen Prof Dipl Phys Wolfrum Verfahren zum Sequenzieren eines einzelnen DNA-Moleküls
DE19822452C2 (de) * 1998-04-22 2003-02-13 Stefan Seeger Verfahren zur Bestimmung der Dichte lumineszierender Moleküle an einer Oberfläche, Verwendung des Verfahrens zur Bestimmung von Adsorptions- und Bindungskinetiken und Gleichgewichts- und Bindungskonstanten von Molekülen an einer Oberfläche durch Lumineszenz-Messungen und Vorrichtung zur Durchführung des Verfahrens
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
JP2000121559A (ja) * 1998-10-14 2000-04-28 Hitachi Denshi Ltd 微小点光量読取装置
AT410718B (de) * 1998-10-28 2003-07-25 Schindler Hansgeorg Dr Vorrichtung zur visualisierung von molekülen
AU3005400A (en) 1999-02-23 2000-09-14 Ljl Biosystems, Inc. Frequency-domain light detection device
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6506594B1 (en) 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6376843B1 (en) * 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
US6355921B1 (en) 1999-05-17 2002-03-12 Agilent Technologies, Inc. Large dynamic range light detection
US6515120B1 (en) 1999-05-25 2003-02-04 Praelux Incorporated Method for sequencing and characterizing polymeric biomolecules using aptamers and a method for producing aptamers
JP3729043B2 (ja) * 2000-08-09 2005-12-21 株式会社日立製作所 蛍光画像検出方法並びにｄｎａ検査方法及びその装置
JP5508654B2 (ja) 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
EP1162450A1 (de) 2000-06-07 2001-12-12 F. Hoffmann-La Roche Ag Eichvorrichtung zur Auswertung der Leistungsfähigkeit eines konfokalen Laser-Rastermikroskops sowie Verfahren und System zum Ausführen der Auswertung
JP4494606B2 (ja) * 2000-08-11 2010-06-30 浜松ホトニクス株式会社 液体含有物質分析装置及び液体含有物質分析方法
EP1180679B1 (de) * 2000-08-14 2012-10-10 Evotec AG Verfahren zur Detektion fluoreszierender Proben mittels einer Momentenanalyse
JP2002062261A (ja) * 2000-08-21 2002-02-28 Olympus Optical Co Ltd 光学装置および顕微鏡
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AU2002217660A1 (en) * 2001-01-12 2002-07-24 Karolinska Innovations Ab Substrate for fluorescence analysis
US20020146052A1 (en) * 2001-02-07 2002-10-10 Moerner William E. Room-temperature source of single photons based on a single molecule
US7068698B2 (en) * 2001-02-07 2006-06-27 The Board Of Trustees Of The Leland Stanford Junior University Room-temperature source of single photons based on a single molecule in a condensed matter host
WO2002066986A2 (en) * 2001-02-15 2002-08-29 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
US6844563B2 (en) 2001-05-22 2005-01-18 Matsushita Electric Industrial Co., Ltd. Fluorescence detecting device with integrated circuit and photodiode, and detection method
US6653083B2 (en) 2001-05-22 2003-11-25 Matsushita Electric Industrial Co., Ltd. Fluorescence detecting device, method for producing the same, and fluorescence detecting method employing the same
SE0104077D0 (sv) * 2001-10-21 2001-12-05 Gyros Ab A method and instrumentation for micro dispensation of droplets
US7588641B2 (en) 2001-08-30 2009-09-15 Hamamatsu Photonics K.K. Method of forming liquid-drops of mixed liquid, and device for forming liquid-drops of mixed liquid
DE10144435B4 (de) * 2001-09-06 2005-03-24 EuroPhoton GmbH Gesellschaft für optische Sensorik Verfahren zur Charakterisierung der Eigenschaften von fluoreszierenden Proben, insbesondere lebenden Zellen und Geweben, in multi-well, in in-vitro Fluoreszenz-Assays, in DNA-Chips, Vorrichtungen zur Durchführung des Verfahrens und deren Verwendung
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US20030054563A1 (en) * 2001-09-17 2003-03-20 Gyros Ab Detector arrangement for microfluidic devices
US7221783B2 (en) 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
US20030136921A1 (en) * 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
JP4112935B2 (ja) 2002-09-30 2008-07-02 浜松ホトニクス株式会社 混合液の液滴形成方法及び液滴形成装置、並びにインクジェット印刷方法及び装置
JPWO2004090517A1 (ja) * 2003-04-04 2006-07-06 独立行政法人産業技術総合研究所 蛍光寿命を利用した物質の定量用試薬、方法及び装置
JP4184228B2 (ja) * 2003-10-20 2008-11-19 オリンパス株式会社 蛍光寿命測定装置
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
JP4302591B2 (ja) 2004-08-20 2009-07-29 浜松ホトニクス株式会社 液滴形成条件決定方法、液滴の体積計測方法、粒子数計測方法、及び液滴形成装置
KR20070095306A (ko) * 2004-12-17 2007-09-28 루미넥스 코포레이션 시스템, 조명 서브 시스템 및 형광원에 의해 방출된 형광을증가하는 방법
JP4557723B2 (ja) * 2005-01-14 2010-10-06 独立行政法人理化学研究所 非走査型時間分解蛍光顕微鏡
JP2006247489A (ja) * 2005-03-09 2006-09-21 Seiko Epson Corp パターン形成方法、識別コード形成方法、液滴吐出装置
GB0601183D0 (en) * 2006-01-20 2006-03-01 Perkinelmer Ltd Improvements in and relating to imaging
EP2244086B1 (de) * 2006-04-08 2021-06-09 Roche Diabetes Care GmbH Analyse optischer Daten mit Hilfe von Histogrammen
US8038947B2 (en) 2007-04-09 2011-10-18 University Of Maryland, Baltimore Analyte sensor devices and holders, and methods and systems utilizing the same
DE102009006364A1 (de) * 2008-02-08 2009-09-10 Yokogawa Electric Corporation, Musashino Instrument zur Molekularitätsmessung und Verfahren zur Molekularitätsmessung
JP4835730B2 (ja) * 2009-08-06 2011-12-14 横河電機株式会社 蛍光量または吸光量の測定方法および測定装置
JP5504797B2 (ja) * 2009-09-30 2014-05-28 東洋紡株式会社 核酸増幅器
JP5841315B2 (ja) 2010-04-28 2016-01-13 ソニー株式会社 微小粒子分析装置
JP2013029326A (ja) * 2011-07-26 2013-02-07 V Technology Co Ltd 有機ｅｌパネルの欠陥検査方法及び欠陥検査装置
WO2013031141A1 (ja) * 2011-08-29 2013-03-07 パナソニック株式会社 分子検出装置、分子検出方法及び分子検出用カートリッジ
GB201217772D0 (en) 2012-10-04 2012-11-14 Base4 Innovation Ltd Sequencing method
GB201306445D0 (en) 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
GB201306444D0 (en) 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
GB201310584D0 (en) 2013-06-13 2013-07-31 Base4 Innovation Ltd Droplet storage method
WO2015054434A1 (en) * 2013-10-08 2015-04-16 Rutgers, The State University Of New Jersey Process for providing luminescence in or from a food product
GB201412977D0 (en) 2014-07-22 2014-09-03 Base4 Innovation Ltd Single nucleotide detection method
JP5975074B2 (ja) * 2014-08-07 2016-08-23 ソニー株式会社 データ表示方法、プログラム、データ解析装置及び微小粒子分析システム
WO2016187564A1 (en) * 2015-05-20 2016-11-24 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
JP6559187B2 (ja) * 2016-07-01 2019-08-14 ツィンファ ユニバーシティ 単一分子検出用のキャリア及び単一分子検出装置
CN107561053B (zh) * 2016-07-01 2020-04-28 清华大学 一种单分子检测方法
JP6172356B2 (ja) * 2016-07-21 2017-08-02 ソニー株式会社 表示方法及び微小粒子分析装置
EP3555972A1 (de) 2016-12-16 2019-10-23 Quantum-si Incorporated Kompaktes modengekoppeltes lasermodul
MX2019007069A (es) 2016-12-16 2019-08-01 Quantum Si Inc Ensamblaje de conformacion y direccion de haz compacto.
JP6796858B2 (ja) * 2017-03-06 2020-12-09 国立研究開発法人物質・材料研究機構 ３次元ラマン分光方法
MX2020013680A (es) 2018-06-15 2021-03-02 Quantum Si Inc Control y adquisicion de datos para instrumentos analiticos avanzados que tienen fuentes opticas pulsadas.
AU2020294144A1 (en) 2019-06-14 2022-01-27 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
CN111122595A (zh) * 2020-01-07 2020-05-08 歌尔股份有限公司 一种滤光片污点检测方法及检测装置
JP7028287B2 (ja) * 2020-07-22 2022-03-02 ソニーグループ株式会社 微小粒子分析システム及び微小粒子分析方法
CN113693724B (zh) * 2021-08-19 2022-10-14 南京诺源医疗器械有限公司 适用于荧光影像导航手术的照射方法、装置及存储介质
CN114216402B (zh) * 2021-12-14 2023-09-22 西南科技大学 一种测量表面张力引起的软基体微变形的方法和装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61153568A (ja) * 1975-06-30 1986-07-12 ア−ウイン、ウイ−ダ− 免疫螢光分析のための螢光抗体
US4962037A (en) * 1987-10-07 1990-10-09 United States Of America Method for rapid base sequencing in DNA and RNA
JPH02168161A (ja) * 1988-12-22 1990-06-28 Nikon Corp 細胞の良・悪性判定装置
US5062942A (en) * 1989-04-12 1991-11-05 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
US4979824A (en) * 1989-05-26 1990-12-25 Board Of Trustees Of The Leland Stanford Junior University High sensitivity fluorescent single particle and single molecule detection apparatus and method
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
DE4024545A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
GB9108066D0 (en) * 1991-04-16 1991-06-05 Amersham Int Plc Method and apparatus for forming an array of biological particles
JPH05118988A (ja) * 1991-10-29 1993-05-14 Hamamatsu Photonics Kk 塩基の光学的識別装置
JP2821050B2 (ja) * 1991-10-31 1998-11-05 浜松ホトニクス株式会社 核酸塩基識別法

Also Published As

Publication number Publication date
EP0601714B1 (de) 2000-03-29
JPH06148076A (ja) 1994-05-27
US5528046A (en) 1996-06-18
DE69328231T2 (de) 2000-08-10
JP2575270B2 (ja) 1997-01-22
EP0601714A1 (de) 1994-06-15
US5739040A (en) 1998-04-14

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