DE69328104D1 - Antagonisten gegen den thrombinrezeptor - Google Patents

Antagonisten gegen den thrombinrezeptor

Info

Publication number
DE69328104D1
DE69328104D1 DE69328104T DE69328104T DE69328104D1 DE 69328104 D1 DE69328104 D1 DE 69328104D1 DE 69328104 T DE69328104 T DE 69328104T DE 69328104 T DE69328104 T DE 69328104T DE 69328104 D1 DE69328104 D1 DE 69328104D1
Authority
DE
Germany
Prior art keywords
hydrophobic radical
linkages
formula
image
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69328104T
Other languages
English (en)
Other versions
DE69328104T2 (de
Inventor
Robert M Scarborough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COR Therapeutics Inc
Original Assignee
COR Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COR Therapeutics Inc filed Critical COR Therapeutics Inc
Publication of DE69328104D1 publication Critical patent/DE69328104D1/de
Application granted granted Critical
Publication of DE69328104T2 publication Critical patent/DE69328104T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69328104T 1992-07-30 1993-07-08 Antagonisten gegen den thrombinrezeptor Expired - Fee Related DE69328104T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92234092A 1992-07-30 1992-07-30
US8078893A 1993-06-28 1993-06-28
PCT/US1993/006428 WO1994003479A1 (en) 1992-07-30 1993-07-08 Thrombin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69328104D1 true DE69328104D1 (de) 2000-04-20
DE69328104T2 DE69328104T2 (de) 2000-12-21

Family

ID=26763931

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328104T Expired - Fee Related DE69328104T2 (de) 1992-07-30 1993-07-08 Antagonisten gegen den thrombinrezeptor

Country Status (10)

Country Link
US (1) US5866681A (de)
EP (1) EP0656008B1 (de)
JP (1) JP2675438B2 (de)
AT (1) ATE190625T1 (de)
AU (1) AU669922B2 (de)
CA (1) CA2140543C (de)
DE (1) DE69328104T2 (de)
IL (1) IL106197A (de)
SG (1) SG49772A1 (de)
WO (1) WO1994003479A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
ATE266025T1 (de) * 1997-11-25 2004-05-15 Schering Corp Thrombin-rezeptor antagonisten
DE69902887T2 (de) * 1998-02-19 2003-08-07 Ortho-Mcneil Pharmaceutical, Inc. Azole peptidomimetische verbindungen als thrombin rezeptor antagoniste
US6017890A (en) * 1998-02-19 2000-01-25 Ortho-Mcneil Pharmaceutical, Inc. Azole peptidomimetics as thrombin receptor antagonists
US6544982B1 (en) 1999-10-29 2003-04-08 Merck & Co., Inc. Thrombin receptor antagonists
US6403612B2 (en) 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
US6515023B2 (en) 2000-01-31 2003-02-04 Merck & Co., Inc. Thrombin receptor antagonists
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US6645987B2 (en) 2000-06-15 2003-11-11 Schering Corporation Nor-seco himbacine derivatives useful as thrombin receptor antagonists
EP1343751A2 (de) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Cyclische derivate als modulatoren der chemokinrezeptoraktivität
HUP0303540A2 (hu) 2000-12-20 2004-01-28 Bristol-Myers Squibb Pharma Co. Diaminok mint kemokin receptor aktivitás modulátorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US20040096443A1 (en) * 2002-03-08 2004-05-20 Traynelis Stephen Francis Treatment of neurodegenerative diseases and conditions using par1 antagonists
PL371948A1 (en) 2001-10-18 2005-07-11 Schering Corporation Himbacine analogues as thrombin receptor antagonists
IL164376A0 (en) * 2002-04-03 2005-12-18 Applied Research Systems Ox4or binding agents, their preparation and pharmaceutical compositions containing them
EP2062890B1 (de) 2002-04-16 2011-01-05 Schering Corporation Tricyclischer Thrombinrezeptorantagonist
US7074765B2 (en) 2003-05-01 2006-07-11 The Regents Of The University Of Michigan Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
CN1984905B (zh) * 2004-05-28 2011-06-22 先灵公司 作为凝血酶受体拮抗剂的约束喜巴辛类似物
MX2007004197A (es) 2004-10-08 2007-06-15 Schering Corp Antagonistas del receptor de trombina.
EP1863778B1 (de) 2005-03-31 2015-12-30 Merck Sharp & Dohme Corp. Spirocyclische thrombinrezeptorantagonisten
CN101460463A (zh) 2006-03-29 2009-06-17 先灵公司 可作为凝血酶受体拮抗剂的单环和双环喜巴辛衍生物
WO2007120730A2 (en) 2006-04-13 2007-10-25 Schering Corporation Fused ring thrombin receptor antagonists
KR20090031544A (ko) 2006-06-29 2009-03-26 쉐링 코포레이션 치환된 비사이클릭 및 트리사이클릭 트롬빈 수용체 길항제
JP2010505842A (ja) 2006-10-04 2010-02-25 シェーリング コーポレイション トロンビン受容体拮抗薬としての二環式誘導体および三環式誘導体
WO2008118320A1 (en) * 2007-03-23 2008-10-02 Schering Corporation Reduction of adverse events.after percutaneous intervention by use of a thrombin receptor antagonist
US20090022729A1 (en) * 2007-04-13 2009-01-22 Nigel Mackman Methods and compositions for treating cardiac dysfunctions
CN102099340A (zh) 2008-05-19 2011-06-15 先灵公司 作为因子ixa抑制剂的杂环化合物
AR077695A1 (es) 2009-08-04 2011-09-14 Schering Corp Derivados de pirimidina como inhibidores del factor ixa
EP2335717A1 (de) 2009-11-16 2011-06-22 Institut National De La Recherche Agronomique PAR-1-Antagonisten zur Verwendung bei der Behandlung oder Prävention von Influenzavirus-Typ-A-Infektionen
EP2822557B1 (de) 2012-03-06 2017-08-23 Merck Sharp & Dohme Corp. Herstellung und verwendung bicyclischer himbacinderivate als par-rezeptor-antagonisten
US9701669B2 (en) 2013-08-22 2017-07-11 Merck Sharp & Dohme Corp. Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
WO2015026685A1 (en) 2013-08-22 2015-02-26 Merck Sharp & Dohme Corp. 7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
US9808473B2 (en) 2013-08-22 2017-11-07 Merck Sharp & Dohme Corp. Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
EP4185587A1 (de) 2020-07-22 2023-05-31 JANSSEN Pharmaceutica NV Verbindungen als faktor-xia-hemmer
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11897880B2 (en) 2021-04-30 2024-02-13 Janssen Pharmaceutica Nv 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
US11958856B2 (en) 2021-07-22 2024-04-16 Janssen Pharmaceutica Nv Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2589720A1 (fr) * 1985-11-14 1987-05-15 Aubaniac Jean Ensemble prothetique pour l'articulation du genou
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5688768A (en) * 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US5256766A (en) * 1991-02-19 1993-10-26 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
JPH07507995A (ja) * 1992-03-02 1995-09-07 バイオジェン，インコーポレイテッド トロンビンレセプターアンタゴニスト

Also Published As

Publication number Publication date
IL106197A0 (en) 1994-05-30
CA2140543C (en) 2001-04-10
IL106197A (en) 1999-11-30
SG49772A1 (en) 1998-06-15
AU669922B2 (en) 1996-06-27
AU4668593A (en) 1994-03-03
JP2675438B2 (ja) 1997-11-12
JPH07506115A (ja) 1995-07-06
CA2140543A1 (en) 1994-02-17
EP0656008A1 (de) 1995-06-07
DE69328104T2 (de) 2000-12-21
US5866681A (en) 1999-02-02
EP0656008B1 (de) 2000-03-15
WO1994003479A1 (en) 1994-02-17
ATE190625T1 (de) 2000-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee