ATE165972T1 - 2(5h)- in position 3-substituierte furanone als ca 2+ antagonisten und entzündungshemmende mittel - Google Patents
2(5h)- in position 3-substituierte furanone als ca 2+ antagonisten und entzündungshemmende mittelInfo
- Publication number
- ATE165972T1 ATE165972T1 AT91907515T AT91907515T ATE165972T1 AT E165972 T1 ATE165972 T1 AT E165972T1 AT 91907515 T AT91907515 T AT 91907515T AT 91907515 T AT91907515 T AT 91907515T AT E165972 T1 ATE165972 T1 AT E165972T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- arylalkyl
- alkyl
- inflammatory agents
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/510,367 US5043457A (en) | 1990-04-17 | 1990-04-17 | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE165972T1 true ATE165972T1 (de) | 1998-05-15 |
Family
ID=24030459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91907515T ATE165972T1 (de) | 1990-04-17 | 1991-03-25 | 2(5h)- in position 3-substituierte furanone als ca 2+ antagonisten und entzündungshemmende mittel |
Country Status (9)
Country | Link |
---|---|
US (1) | US5043457A (de) |
EP (1) | EP0525002B1 (de) |
JP (1) | JPH05506024A (de) |
AT (1) | ATE165972T1 (de) |
CA (1) | CA2078770A1 (de) |
DE (1) | DE69129408T2 (de) |
ES (1) | ES2116290T3 (de) |
IE (1) | IE911266A1 (de) |
WO (1) | WO1991016048A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5089485A (en) * | 1988-11-18 | 1992-02-18 | Allergan, Inc. | Anti-inflammatory furanones |
US5171863A (en) * | 1987-06-08 | 1992-12-15 | Allergan, Inc. | Intermediates for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents |
US5134128A (en) * | 1987-06-08 | 1992-07-28 | Allergan, Inc. | Anti-inflammatory furanones |
US5045564A (en) * | 1988-12-07 | 1991-09-03 | Allergan, Inc. | Anti-inflammatory 2-furanones |
US5112853A (en) * | 1989-11-20 | 1992-05-12 | Allergan, Inc. | Anti-inflammatory furanone compounds |
US5258400A (en) * | 1989-11-20 | 1993-11-02 | Allergan, Inc. | Anti-inflammatory furanone compounds |
US5183906A (en) * | 1991-04-30 | 1993-02-02 | Allergan, Inc. | 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5h)-furanones as anti-inflammatory agents |
US5225571A (en) * | 1991-04-30 | 1993-07-06 | Allergan, Inc. | Substituted dihydroxy-bis-[5-hydroxy-2(5H)-furanone-4-yl]-alkanes as anti-inflammatory agents |
US5171864A (en) * | 1991-08-30 | 1992-12-15 | Allergan, Inc. | Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and N,N-bis-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5169963A (en) * | 1991-08-30 | 1992-12-08 | Allergan, Inc. | Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5268387A (en) * | 1992-04-24 | 1993-12-07 | Allergan, Inc. | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss |
US5451686A (en) * | 1994-04-15 | 1995-09-19 | Allergan, Inc. | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents |
EP1554572B1 (de) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
ATE424448T1 (de) * | 2002-10-10 | 2009-03-15 | Merck & Co Inc | Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
EP2398500B1 (de) | 2009-02-20 | 2019-03-13 | 2-BBB Medicines B.V. | Arzneiabgabesystem auf glutathion-basis |
CA2760945A1 (en) | 2009-05-06 | 2010-11-11 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2359096A (en) * | 1941-03-21 | 1944-09-26 | Lilly Co Eli | beta-substituted-delta alpha, beta-gamma-butyrolactones and beta-substituted - beta - hydroxy-gamma-butyrolactones and methods of preparing them |
US2359208A (en) * | 1941-03-21 | 1944-09-26 | Lilly Co Eli | beta-substituted-delta alpha,beta-gamma-butyrolactones and beta-substituted-beta-hydroxy-gamma-butyrolactones and the methods of preparing them |
US4447455A (en) * | 1980-12-01 | 1984-05-08 | Madaus And Company | Oral urolithiasis remedy |
US4616089A (en) * | 1983-08-03 | 1986-10-07 | University Of California | Synthetic anti-inflammatory derivatives of manoalide |
EP0133376B1 (de) * | 1983-08-03 | 1988-07-27 | The Regents Of The University Of California | Synthetische analgetische und/oder antiinflammatorische Derivate des Manoalides |
JPS6058973A (ja) * | 1983-09-13 | 1985-04-05 | Mitsubishi Yuka Yakuhin Kk | γ−プチロラクトン誘導体及びそれを有効成分とする免疫調節剤 |
US4789749A (en) * | 1984-06-18 | 1988-12-06 | The Regents Of The University Of California | Manoalide analogs |
ZA864674B (en) * | 1985-07-01 | 1988-02-24 | Lilly Co Eli | Furanone derivatives |
US4786651A (en) * | 1986-02-03 | 1988-11-22 | Allergan, Inc. | Treatment of cutaneous hyperproliferative dermatoses with manoalide |
DE3615157A1 (de) * | 1986-05-05 | 1987-11-12 | Schwabe Willmar Gmbh & Co | 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe |
CA1329390C (en) * | 1987-06-08 | 1994-05-10 | John N. Bonfiglio | Anti-inflammatory furanones |
US4916241A (en) * | 1988-06-06 | 1990-04-10 | American Home Products Corporation | Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones |
US4935530A (en) * | 1988-10-18 | 1990-06-19 | Allergan, Inc. | Process for preparing 5-substituted-3-furaldehydes |
US4957917A (en) * | 1989-10-25 | 1990-09-18 | Allergan, Inc. | Anti-inflammatory furanones |
US5013850A (en) * | 1990-03-30 | 1991-05-07 | Allergan, Inc. | 4-ethyl and 4-ethenyl-5-hydroxy-2(5H)-furanones substituted on alpha carbon of the ethyl or ethenyl side chain with a long chain alkyl group and on the beta carbon with a polar group, as anti-inflammatory agents |
-
1990
- 1990-04-17 US US07/510,367 patent/US5043457A/en not_active Expired - Fee Related
-
1991
- 1991-03-25 JP JP91507355A patent/JPH05506024A/ja active Pending
- 1991-03-25 EP EP91907515A patent/EP0525002B1/de not_active Expired - Lifetime
- 1991-03-25 WO PCT/US1991/002006 patent/WO1991016048A1/en active IP Right Grant
- 1991-03-25 ES ES91907515T patent/ES2116290T3/es not_active Expired - Lifetime
- 1991-03-25 CA CA002078770A patent/CA2078770A1/en not_active Abandoned
- 1991-03-25 DE DE69129408T patent/DE69129408T2/de not_active Expired - Fee Related
- 1991-03-25 AT AT91907515T patent/ATE165972T1/de active
- 1991-04-16 IE IE126691A patent/IE911266A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2116290T3 (es) | 1998-07-16 |
EP0525002A4 (en) | 1993-03-10 |
DE69129408D1 (de) | 1998-06-18 |
IE911266A1 (en) | 1991-10-23 |
CA2078770A1 (en) | 1991-10-18 |
US5043457A (en) | 1991-08-27 |
EP0525002B1 (de) | 1998-05-13 |
WO1991016048A1 (en) | 1991-10-31 |
EP0525002A1 (de) | 1993-02-03 |
JPH05506024A (ja) | 1993-09-02 |
DE69129408T2 (de) | 1998-09-03 |
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