DE69318474T2 - Neue (Estradiol-Derivat)-Chlorambucil-Konjugate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate - Google Patents

Neue (Estradiol-Derivat)-Chlorambucil-Konjugate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate

Info

Publication number
DE69318474T2
DE69318474T2 DE69318474T DE69318474T DE69318474T2 DE 69318474 T2 DE69318474 T2 DE 69318474T2 DE 69318474 T DE69318474 T DE 69318474T DE 69318474 T DE69318474 T DE 69318474T DE 69318474 T2 DE69318474 T2 DE 69318474T2
Authority
DE
Germany
Prior art keywords
preparation
new
pharmaceutical preparations
estradiol derivative
chlorambucil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69318474T
Other languages
English (en)
Other versions
DE69318474D1 (de
Inventor
Fumio Tamura
Tsuyoshi Saito
Satoshi Mitsuhashi
Tadahiro Matsudaira
Kiro Asano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Publication of DE69318474D1 publication Critical patent/DE69318474D1/de
Application granted granted Critical
Publication of DE69318474T2 publication Critical patent/DE69318474T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69318474T 1992-06-11 1993-06-09 Neue (Estradiol-Derivat)-Chlorambucil-Konjugate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate Expired - Fee Related DE69318474T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4177363A JP2520074B2 (ja) 1992-06-11 1992-06-11 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤

Publications (2)

Publication Number Publication Date
DE69318474D1 DE69318474D1 (de) 1998-06-18
DE69318474T2 true DE69318474T2 (de) 1998-10-15

Family

ID=16029655

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69318474T Expired - Fee Related DE69318474T2 (de) 1992-06-11 1993-06-09 Neue (Estradiol-Derivat)-Chlorambucil-Konjugate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate

Country Status (11)

Country Link
US (3) US5354745A (de)
EP (1) EP0573977B1 (de)
JP (1) JP2520074B2 (de)
KR (1) KR970001532B1 (de)
AT (1) ATE166060T1 (de)
AU (1) AU649180B2 (de)
CA (1) CA2097137A1 (de)
DE (1) DE69318474T2 (de)
FI (1) FI932641A (de)
IL (1) IL105901A0 (de)
ZA (1) ZA933993B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07101977A (ja) * 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
US5882941A (en) * 1994-05-04 1999-03-16 Massachusette Institute Of Technology Programmable genotoxic agents and uses therefor
US6500669B1 (en) 1994-05-04 2002-12-31 Massachusetts Institute Of Technology Programmable genotoxic agents and uses therefor
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
NZ336924A (en) * 1997-02-13 2001-06-29 Bone Care Int Inc Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate
US6534037B1 (en) 1998-01-21 2003-03-18 Neorx Corporation Non-steroidal compounds for steroid receptors and uses relating thereto
US7138502B2 (en) * 2000-09-28 2006-11-21 Yale University Antibodies to the propeptide of Candida albicans and methods of use
US20120225849A1 (en) * 2011-03-01 2012-09-06 The University Of Kansas 2-Methoxyestradiol (2-ME2) Prodrug with Enhanced Bioavailability for Prophylaxis or Treatment of Cancerous or Non-Cancerous Condition
CN103772463B (zh) * 2013-12-30 2016-06-22 郑州大学 2-甲氧基雌二醇类似物及其制备方法与用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2950292A (en) * 1959-06-29 1960-08-23 Searle & Co 3-alkoxy-16-alkyl-16-hydroxy-1, 3, 5(10)-estratrien-17-ones, their ethers and esters
US3086033A (en) * 1960-03-11 1963-04-16 Merck Ag E 1-methyl-17-alkyl-11-oxygenated delta1, 3, 5 (10)-estrogenic compounds
US3031469A (en) * 1961-10-24 1962-04-24 American Cyanamid Co New 15, 17-disubstituted-1, 3, 5(10)-estratriens and method of preparing the same
NL6405462A (de) * 1963-05-17 1964-11-18
FR4339M (de) * 1965-03-29 1966-08-08
US3449383A (en) * 1967-02-16 1969-06-10 Searle & Co 17-oxygenated estra-1,3,5(10)-triene-3,11beta,16-triols,ethers and esters thereof
US3496168A (en) * 1967-09-12 1970-02-17 Smithkline Corp 4-alkoxyestradiols
DE2402482C2 (de) * 1974-01-16 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 3-Ketosteroiden durch elektrochemische Reduktion von α,β -ungesättigten 3-Ketosteroiden
US4096253A (en) * 1976-07-06 1978-06-20 Ortho Pharmaceutical Corporation 1-Oxygenated steroids
US4261910A (en) * 1978-08-14 1981-04-14 Kureha Kagaku Kogyo Kabushiki Kaisha Process for the preparation of Chlorambucil derivatives
US4260736A (en) * 1978-08-14 1981-04-07 Kureha Kagaku Kogyo Kabushiki Kaisha Steroid hormone-antitumor derivatives
JPS56110700A (en) * 1980-02-08 1981-09-01 Kureha Chem Ind Co Ltd Estradiol-17alphaderivative and ist antitumor agent
SE8305596D0 (sv) * 1983-10-12 1983-10-12 Leo Ab A selective acylation method
DE3510555A1 (de) * 1985-03-21 1986-09-25 Schering AG, 1000 Berlin und 4709 Bergkamen Estriolester
JPS61293993A (ja) * 1985-06-21 1986-12-24 Kureha Chem Ind Co Ltd 新規な螢光物質，その製造方法及び薬剤
EP0216614A3 (de) * 1985-09-19 1988-06-08 The University Of Sheffield Synthese von Steroiden und Zwischenprodukte davon
EP0240717A3 (de) * 1986-03-04 1990-05-16 Board of Regents of the University of Nebraska Prävention von Brustkrebs
JPH0621072B2 (ja) * 1986-11-12 1994-03-23 呉羽化学工業株式会社 エストラジオ−ル誘導体よりなる免疫調節剤
JPH0794377B2 (ja) * 1987-07-22 1995-10-11 呉羽化学工業株式会社 エストラジオール誘導体を含有する注射剤
JPS6445393A (en) * 1987-08-13 1989-02-17 Toa Nenryo Kogyo Kk Estradiol derivative
JPS6445392A (en) * 1987-08-13 1989-02-17 Toa Nenryo Kogyo Kk Production of estradiol derivative
SE8802402D0 (sv) * 1988-06-28 1988-06-28 Pharmacia Ab Novel esters
US5031469A (en) * 1988-11-30 1991-07-16 Blackburn Robert E Fluid sampler
CA2123472C (en) * 1994-05-12 2005-07-05 Craig W. Renwick Injection molding manifold and method with the heating element extending between the plates

Also Published As

Publication number Publication date
IL105901A0 (en) 1993-10-20
FI932641A0 (fi) 1993-06-09
CA2097137A1 (en) 1993-12-12
FI932641A (fi) 1993-12-12
DE69318474D1 (de) 1998-06-18
AU649180B2 (en) 1994-05-12
JP2520074B2 (ja) 1996-07-31
US5354745A (en) 1994-10-11
ATE166060T1 (de) 1998-05-15
KR970001532B1 (ko) 1997-02-11
ZA933993B (en) 1994-01-05
AU4011693A (en) 1993-12-16
EP0573977B1 (de) 1998-05-13
KR940005662A (ko) 1994-03-22
US5578589A (en) 1996-11-26
EP0573977A3 (en) 1996-01-31
JPH05339285A (ja) 1993-12-21
US5576309A (en) 1996-11-19
EP0573977A2 (de) 1993-12-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee