DE69316023T2 - Stabile zusammensetzung für eine orale dosis mit verlängerter freisetzung - Google Patents

Stabile zusammensetzung für eine orale dosis mit verlängerter freisetzung

Info

Publication number
DE69316023T2
DE69316023T2 DE69316023T DE69316023T DE69316023T2 DE 69316023 T2 DE69316023 T2 DE 69316023T2 DE 69316023 T DE69316023 T DE 69316023T DE 69316023 T DE69316023 T DE 69316023T DE 69316023 T2 DE69316023 T2 DE 69316023T2
Authority
DE
Germany
Prior art keywords
oral dosage
extended release
stable composition
film
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69316023T
Other languages
English (en)
Other versions
DE69316023D1 (de
Inventor
Henry Kwan
Stephen Liebowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69316023D1 publication Critical patent/DE69316023D1/de
Publication of DE69316023T2 publication Critical patent/DE69316023T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
DE69316023T 1992-10-23 1993-10-21 Stabile zusammensetzung für eine orale dosis mit verlängerter freisetzung Expired - Lifetime DE69316023T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/965,470 US5314697A (en) 1992-10-23 1992-10-23 Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
PCT/US1993/009873 WO1994009761A1 (en) 1992-10-23 1993-10-21 Stable extended release oral dosage composition

Publications (2)

Publication Number Publication Date
DE69316023D1 DE69316023D1 (de) 1998-02-05
DE69316023T2 true DE69316023T2 (de) 1998-04-23

Family

ID=25510010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316023T Expired - Lifetime DE69316023T2 (de) 1992-10-23 1993-10-21 Stabile zusammensetzung für eine orale dosis mit verlängerter freisetzung

Country Status (28)

Country Link
US (1) US5314697A (de)
EP (1) EP0665744B1 (de)
JP (1) JP3580815B2 (de)
KR (1) KR100283709B1 (de)
CN (1) CN1038474C (de)
AT (1) ATE161420T1 (de)
AU (1) AU676229B2 (de)
CA (1) CA2147606C (de)
CZ (1) CZ287687B6 (de)
DE (1) DE69316023T2 (de)
DK (1) DK0665744T3 (de)
EE (1) EE03106B1 (de)
ES (1) ES2110633T3 (de)
FI (1) FI112916B (de)
GR (1) GR3026198T3 (de)
HK (1) HK1004327A1 (de)
HU (1) HU220629B1 (de)
IL (1) IL107354A (de)
MY (1) MY109090A (de)
NO (1) NO308771B1 (de)
NZ (1) NZ257447A (de)
PH (1) PH29940A (de)
PL (1) PL172862B1 (de)
SG (1) SG42947A1 (de)
SK (1) SK281090B6 (de)
TW (1) TW251239B (de)
WO (1) WO1994009761A1 (de)
ZA (1) ZA937830B (de)

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US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US7214683B1 (en) 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
US7211582B1 (en) 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
EP0812195B1 (de) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Arzneizubereitungen für piperidinalkanolderivate
US5807579A (en) * 1995-11-16 1998-09-15 F.H. Faulding & Co. Limited Pseudoephedrine combination pharmaceutical compositions
EP0811374A1 (de) 1996-05-29 1997-12-10 Pfizer Inc. Formulierung für ein Kombinationspräparat mit Cetirizin und Pseudoephedrin
PL333056A1 (en) * 1996-10-31 1999-11-08 Schering Corp Composition intended to treat asthma, containing loratadin and a hyperaemia reducing drug
TW522014B (en) * 1997-02-07 2003-03-01 Sepracor Inc Lactose-free, non-hygroscopic and anhydrous pharmaceutical unit dosage form containing descarboethoxyloratadine
BE1011045A3 (fr) * 1997-03-14 1999-04-06 Ucb Sa Compositions pharmaceutiques pour la liberation controlee de substances actives.
PT998272E (pt) * 1997-08-26 2003-09-30 Aventis Pharma Inc Composicao farmaceutica para combinacao do descongestionante piperidinoalcanol
CO5271713A1 (es) * 1998-09-10 2003-04-30 Schering Corp Metodos y composiciones para tratar sinusitis, otitis media y otros desordenes relacionados usando antihistaminas
US6051585A (en) * 1998-12-07 2000-04-18 Weinstein; Robert E. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6521254B2 (en) 1998-12-07 2003-02-18 J-Med Pharmaceuticals, Inc. Single-dose antihistamine/decongestant formulations for treating rhinitis
KR100505899B1 (ko) * 1999-02-23 2005-08-01 주식회사유한양행 로라타딘과 슈도에페드린을 함유한 캅셀제 조성물
ATE253354T1 (de) * 1999-02-23 2003-11-15 Yuhan Corp Kapseln mit loratadin und pseudoephedrin enthaltenden zusammensetzungen
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6267986B1 (en) * 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US6114346A (en) 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
AU2277101A (en) * 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
US6613357B2 (en) * 2000-01-13 2003-09-02 Osmotica Corp. Osmotic device containing pseudoephedrine and an H1 antagonist
US7147870B2 (en) * 2000-01-13 2006-12-12 Osmotica Corp. Osmotic device containing pseudoephedrine and an H1 antagonist
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
CA2405238C (en) * 2000-04-14 2014-03-18 J-Med Pharmaceuticals, Inc. Single-dose antihistamine/decongestant formulations for treating rhinitis
US20020094345A1 (en) * 2000-10-06 2002-07-18 Sara Abelaira Pharmaceutical compositions containing epinastine and pseudoephedrine
WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
MXPA03011705A (es) * 2001-06-20 2004-03-19 Schering Corp Antihistaminas para el tratamiento de congestion nasal y obstruccion nasal.
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
US6863901B2 (en) 2001-11-30 2005-03-08 Collegium Pharmaceutical, Inc. Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
US6827946B2 (en) * 2001-12-05 2004-12-07 Collegium Pharmaceutical, Inc. Compositions containing both sedative and non-sedative antihistamines
AU2002351655A1 (en) * 2002-08-29 2004-03-19 Osmotica Corp. Device for release of a drug containing oseltamivir and a h1 antagonist
US20040051686A1 (en) * 2002-09-17 2004-03-18 Yuan-Sung Weng Carry-on device having functions of both digital photographing and timing
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
NZ546148A (en) 2003-09-26 2009-05-31 Alza Corp Drug coating providing high drug loading and methods for providing the same
US20050095288A1 (en) * 2003-11-03 2005-05-05 Andrx Labs, Llc Decongestant and expectorant tablets
EP1700591A4 (de) * 2003-12-01 2011-08-03 Takeda Pharmaceutical Verfahren zur behandlung einer festen pharmazeutischen zubereitung vor dem bedrucken und vor dem bedrucken behandelte feste pharmazeutische zubereitung
US20050266032A1 (en) * 2003-12-17 2005-12-01 Sovereign Pharmaceuticals, Ltd. Dosage form containing multiple drugs
SE0401031D0 (sv) 2004-04-22 2004-04-22 Duocort Ab A new glucocorticoid replacement therapy
US20060024368A1 (en) * 2004-07-30 2006-02-02 Reza Fassihi Compressed composite delivery system for release-rate modulation of bioactives
NZ556630A (en) * 2005-01-27 2010-12-24 Alembic Ltd Extended release formulation of levetiracetam including a hydrophilic rate controlling polymer
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
TWI405567B (zh) * 2006-06-01 2013-08-21 Merck Sharp & Dohme 持續釋放脫羥腎上腺素之醫藥組合物
CN101015519B (zh) * 2007-02-27 2012-03-21 重庆医药工业研究院有限责任公司 一种氯雷他定口服复方药物组合物
EP2120945A1 (de) * 2007-02-28 2009-11-25 Collegium Pharmaceutical, Inc. Antihistamin-kombination
EP2299983A4 (de) * 2008-07-24 2012-10-10 Handa Pharmaceuticals Llc Stabilisierte atypische antipsychotische formulierung
WO2010099508A1 (en) 2009-02-26 2010-09-02 Theraquest Biosciences, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
CN102160859B (zh) * 2011-02-23 2012-11-07 海南斯达制药有限公司 一种氯雷伪麻复方缓释药物
JP5752578B2 (ja) * 2011-12-09 2015-07-22 ジェイ−メド ファーマシューティカルズ，インコーポレーティッド 鼻炎治療のための単一投与抗ヒスタミン薬／鬱血除去薬製剤
CN104983708A (zh) * 2015-06-24 2015-10-21 万特制药(海南)有限公司 一种地氯雷他定硫酸伪麻黄碱缓释片及其制备方法
CN108576895B (zh) * 2018-03-06 2021-04-30 特素生物科技（天津）有限公司 缓释营养主食及其制备方法
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina

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US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US4601894A (en) * 1985-03-29 1986-07-22 Schering Corporation Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate
IE60311B1 (en) * 1987-09-24 1994-06-29 American Home Prod Sustained release etodolac
CN1053570C (zh) * 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine

Also Published As

Publication number Publication date
FI951901A (fi) 1995-04-21
SG42947A1 (en) 1997-10-17
EE03106B1 (et) 1998-08-17
SK52295A3 (en) 1997-05-07
US5314697A (en) 1994-05-24
ATE161420T1 (de) 1998-01-15
CA2147606C (en) 2000-10-10
GR3026198T3 (en) 1998-05-29
PH29940A (en) 1996-09-16
WO1994009761A1 (en) 1994-05-11
NO308771B1 (no) 2000-10-30
HK1004327A1 (en) 1998-11-20
NO951527L (no) 1995-06-20
TW251239B (de) 1995-07-11
EP0665744A1 (de) 1995-08-09
HUT71682A (en) 1996-01-29
HU220629B1 (hu) 2002-03-28
CZ287687B6 (en) 2001-01-17
NZ257447A (en) 1996-09-25
PL172862B1 (pl) 1997-12-31
PL308491A1 (en) 1995-08-07
CN1089471A (zh) 1994-07-20
JPH08502516A (ja) 1996-03-19
EP0665744B1 (de) 1997-12-29
AU676229B2 (en) 1997-03-06
HU9501143D0 (en) 1995-06-28
AU5405094A (en) 1994-05-24
IL107354A0 (en) 1994-01-25
KR950703937A (ko) 1995-11-17
ZA937830B (en) 1994-04-21
FI951901A0 (fi) 1995-04-21
FI112916B (fi) 2004-02-13
MY109090A (en) 1996-11-30
DK0665744T3 (da) 1998-09-07
NO951527D0 (no) 1995-04-21
KR100283709B1 (ko) 2001-03-02
DE69316023D1 (de) 1998-02-05
IL107354A (en) 1998-02-08
ES2110633T3 (es) 1998-02-16
SK281090B6 (sk) 2000-11-07
CA2147606A1 (en) 1994-05-11
CZ101495A3 (en) 1996-02-14
CN1038474C (zh) 1998-05-27
JP3580815B2 (ja) 2004-10-27

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Legal Events

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8364 No opposition during term of opposition