DE69516671D1 - Verbindungen mit analgetischem und lokalanesthetischem effekt - Google Patents

Verbindungen mit analgetischem und lokalanesthetischem effekt

Info

Publication number
DE69516671D1
DE69516671D1 DE69516671T DE69516671T DE69516671D1 DE 69516671 D1 DE69516671 D1 DE 69516671D1 DE 69516671 T DE69516671 T DE 69516671T DE 69516671 T DE69516671 T DE 69516671T DE 69516671 D1 DE69516671 D1 DE 69516671D1
Authority
DE
Germany
Prior art keywords
localanesthetic
analgetic
effect
connections
new compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69516671T
Other languages
English (en)
Other versions
DE69516671T2 (de
Inventor
Anna-Lena Ask
Lars-Inge Olsson
Rune Sandberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE69516671D1 publication Critical patent/DE69516671D1/de
Publication of DE69516671T2 publication Critical patent/DE69516671T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE69516671T 1994-02-11 1995-02-03 Verbindungen mit analgetischem und lokalanesthetischem effekt Expired - Fee Related DE69516671T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9400447A SE9400447D0 (sv) 1994-02-11 1994-02-11 New compounds
PCT/SE1995/000106 WO1995021821A1 (en) 1994-02-11 1995-02-03 New compounds with analgesic and local anaesthetic effect

Publications (2)

Publication Number Publication Date
DE69516671D1 true DE69516671D1 (de) 2000-06-08
DE69516671T2 DE69516671T2 (de) 2001-02-01

Family

ID=20392881

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69516671T Expired - Fee Related DE69516671T2 (de) 1994-02-11 1995-02-03 Verbindungen mit analgetischem und lokalanesthetischem effekt

Country Status (31)

Country Link
US (2) US5756520A (de)
EP (1) EP0743940B1 (de)
JP (1) JPH09508904A (de)
CN (1) CN1067989C (de)
AT (1) ATE192435T1 (de)
AU (1) AU686760B2 (de)
BR (1) BR9506748A (de)
CA (1) CA2181068A1 (de)
CZ (1) CZ286753B6 (de)
DE (1) DE69516671T2 (de)
DK (1) DK0743940T3 (de)
EE (1) EE03252B1 (de)
ES (1) ES2148493T3 (de)
FI (1) FI963128A (de)
GR (1) GR3033999T3 (de)
HR (1) HRP950414B1 (de)
HU (1) HU216734B (de)
IL (1) IL112374A (de)
IS (1) IS1771B (de)
MX (1) MX9603092A (de)
MY (1) MY130166A (de)
NO (1) NO306718B1 (de)
NZ (1) NZ281355A (de)
PL (1) PL180212B1 (de)
PT (1) PT743940E (de)
RU (1) RU2145599C1 (de)
SE (1) SE9400447D0 (de)
SK (1) SK281931B6 (de)
TW (1) TW348176B (de)
WO (1) WO1995021821A1 (de)
ZA (1) ZA95709B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
DE19912889A1 (de) * 1999-03-23 2000-09-28 Daimler Chrysler Ag Verfahren zur Herstellung eines Ventilsitzes
BR0317230A (pt) * 2002-12-13 2005-10-25 Smithkline Beecham Corp Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto
US20100210633A1 (en) * 2006-10-12 2010-08-19 Epix Delaware, Inc. Carboxamide compounds and their use
US8569282B2 (en) 2007-12-11 2013-10-29 Cytopathfinder, Inc. Carboxamide compounds and their use
US8473062B2 (en) * 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20100185249A1 (en) * 2009-01-22 2010-07-22 Wingeier Brett M Method and Devices for Adrenal Stimulation
WO2020152212A1 (en) 2019-01-22 2020-07-30 Icm (Institut Du Cerveau Et De La Moelle Épinière) Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951080A (en) * 1957-08-05 1960-08-30 Lilly Co Eli Novel phenyl-substituted piperidines
NL130088C (de) * 1960-03-14
US3850935A (en) * 1971-10-16 1974-11-26 Sumitomo Chemical Co Process for producing piperidine derivatives by degrading quaternary piperidinium salts
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
AU682838B2 (en) * 1992-12-14 1997-10-23 Merck Sharp & Dohme Limited 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperidines as tachykinin receptor antagonists

Also Published As

Publication number Publication date
NO963292D0 (no) 1996-08-07
MX9603092A (es) 1997-03-29
SE9400447D0 (sv) 1994-02-11
CZ286753B6 (en) 2000-06-14
EP0743940B1 (de) 2000-05-03
US5968953A (en) 1999-10-19
ZA95709B (en) 1995-08-11
GR3033999T3 (en) 2000-11-30
FI963128A0 (fi) 1996-08-09
CA2181068A1 (en) 1995-08-17
JPH09508904A (ja) 1997-09-09
CN1140448A (zh) 1997-01-15
AU1826995A (en) 1995-08-29
IL112374A0 (en) 1995-03-30
EP0743940A1 (de) 1996-11-27
NO306718B1 (no) 1999-12-13
WO1995021821A1 (en) 1995-08-17
SK281931B6 (sk) 2001-09-11
DE69516671T2 (de) 2001-02-01
AU686760B2 (en) 1998-02-12
HU216734B (hu) 1999-08-30
DK0743940T3 (da) 2000-08-14
IS1771B (is) 2001-05-28
MY130166A (en) 2007-06-29
PL180212B1 (pl) 2001-01-31
PT743940E (pt) 2000-08-31
US5756520A (en) 1998-05-26
HRP950414A2 (en) 1997-10-31
ATE192435T1 (de) 2000-05-15
HUT75641A (en) 1997-05-28
CN1067989C (zh) 2001-07-04
TW348176B (en) 1998-12-21
FI963128A (fi) 1996-08-09
HU9602206D0 (en) 1996-10-28
IS4251A (is) 1995-08-12
CZ203296A3 (en) 1996-12-11
NO963292L (no) 1996-08-07
RU2145599C1 (ru) 2000-02-20
SK92896A3 (en) 1997-07-09
HRP950414B1 (en) 2001-02-28
PL315777A1 (en) 1996-12-09
BR9506748A (pt) 1997-09-16
EE03252B1 (et) 2000-02-15
NZ281355A (en) 1998-02-26
ES2148493T3 (es) 2000-10-16
IL112374A (en) 1999-12-31

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA AB, SOEDERTAELJE, SE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee