BR0317230A - Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto - Google Patents
Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um compostoInfo
- Publication number
- BR0317230A BR0317230A BR0317230-9A BR0317230A BR0317230A BR 0317230 A BR0317230 A BR 0317230A BR 0317230 A BR0317230 A BR 0317230A BR 0317230 A BR0317230 A BR 0317230A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treating
- ccr
- patient
- composition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSTO, COMPOSIçãO, MéTODOS DE ANTAGONIZAR UMA ATIVIDADE DO RECEPTOR DE QUIMIOCINA CCR-5, E DE TRATAR UMA INFECçãO VIRAL EM UM PACIENTE, E, USO DE UM COMPOSTO". A presente invenção diz respeito aos compostos da fórmula (I) ou seus derivados farmaceuticamente aceitáveis , úteis no tratamento ou profilaxia de doenças e distúrbios relacionados com CCR5, por exemplo, na inibição de replicação do HIV, a prevenção ou tratamento de uma infecção pelo HIV e no tratamento da síndrome da deficiência imuno adquirida (AIDS) resultante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43363402P | 2002-12-13 | 2002-12-13 | |
PCT/US2003/039644 WO2004054974A2 (en) | 2002-12-13 | 2003-12-12 | Piperidine derivatives as ccr5 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0317230A true BR0317230A (pt) | 2005-10-25 |
Family
ID=32595222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0317230-9A BR0317230A (pt) | 2002-12-13 | 2003-12-12 | Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto |
Country Status (15)
Country | Link |
---|---|
US (1) | US7645771B2 (pt) |
EP (1) | EP1569646A2 (pt) |
JP (1) | JP2006511554A (pt) |
KR (1) | KR20050087832A (pt) |
CN (1) | CN1744899A (pt) |
AU (1) | AU2003300902A1 (pt) |
BR (1) | BR0317230A (pt) |
CA (1) | CA2509711A1 (pt) |
CO (1) | CO5580771A2 (pt) |
MA (1) | MA27647A1 (pt) |
MX (1) | MXPA05006354A (pt) |
NO (1) | NO20052739L (pt) |
RU (1) | RU2005118407A (pt) |
WO (1) | WO2004054974A2 (pt) |
ZA (1) | ZA200505600B (pt) |
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AU5803398A (en) * | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
AU5604998A (en) * | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
KR20010013828A (ko) * | 1997-06-17 | 2001-02-26 | 둘락 노먼 씨. | 파르네실 단백질 트랜스퍼라제의 억제에 유용한벤조(5,6)사이클로헵타(1,2b)피리딘 유도체 |
AU8576098A (en) * | 1997-07-25 | 1999-02-16 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
US6518286B1 (en) * | 1999-03-26 | 2003-02-11 | Astrazeneca Ab | Compounds |
HUP0203528A3 (en) * | 1999-05-04 | 2003-11-28 | Schering Corp | Piperidine derivatives useful as ccr5 antagonists, pharmaceutical compositions containing them and their use |
GB0107907D0 (en) * | 2001-03-29 | 2001-05-23 | Smithkline Beecham Plc | Novel compounds |
JP2002348288A (ja) * | 2001-05-28 | 2002-12-04 | Ono Pharmaceut Co Ltd | スピロ複素環誘導体およびそれらを有効成分とする薬剤 |
TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
-
2003
- 2003-12-12 BR BR0317230-9A patent/BR0317230A/pt not_active IP Right Cessation
- 2003-12-12 CN CNA2003801096285A patent/CN1744899A/zh active Pending
- 2003-12-12 RU RU2005118407/04A patent/RU2005118407A/ru not_active Application Discontinuation
- 2003-12-12 CA CA002509711A patent/CA2509711A1/en not_active Abandoned
- 2003-12-12 WO PCT/US2003/039644 patent/WO2004054974A2/en active Application Filing
- 2003-12-12 EP EP03813419A patent/EP1569646A2/en not_active Withdrawn
- 2003-12-12 AU AU2003300902A patent/AU2003300902A1/en not_active Abandoned
- 2003-12-12 US US10/538,144 patent/US7645771B2/en not_active Expired - Fee Related
- 2003-12-12 MX MXPA05006354A patent/MXPA05006354A/es not_active Application Discontinuation
- 2003-12-12 KR KR1020057010809A patent/KR20050087832A/ko not_active Application Discontinuation
- 2003-12-12 JP JP2004560838A patent/JP2006511554A/ja active Pending
-
2005
- 2005-06-07 NO NO20052739A patent/NO20052739L/no not_active Application Discontinuation
- 2005-07-12 ZA ZA200505600A patent/ZA200505600B/en unknown
- 2005-07-12 CO CO05068493A patent/CO5580771A2/es not_active Application Discontinuation
- 2005-07-13 MA MA28386A patent/MA27647A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2004054974A3 (en) | 2004-09-02 |
MXPA05006354A (es) | 2005-08-26 |
EP1569646A2 (en) | 2005-09-07 |
KR20050087832A (ko) | 2005-08-31 |
MA27647A1 (fr) | 2005-12-01 |
ZA200505600B (en) | 2006-09-27 |
RU2005118407A (ru) | 2006-03-10 |
JP2006511554A (ja) | 2006-04-06 |
US7645771B2 (en) | 2010-01-12 |
US20060229336A1 (en) | 2006-10-12 |
WO2004054974A2 (en) | 2004-07-01 |
NO20052739L (no) | 2005-08-19 |
CN1744899A (zh) | 2006-03-08 |
AU2003300902A1 (en) | 2004-07-09 |
NO20052739D0 (no) | 2005-06-07 |
CO5580771A2 (es) | 2005-11-30 |
CA2509711A1 (en) | 2004-07-01 |
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