BR0317230A - Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto - Google Patents

Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto

Info

Publication number
BR0317230A
BR0317230A BR0317230-9A BR0317230A BR0317230A BR 0317230 A BR0317230 A BR 0317230A BR 0317230 A BR0317230 A BR 0317230A BR 0317230 A BR0317230 A BR 0317230A
Authority
BR
Brazil
Prior art keywords
compound
treating
ccr
patient
composition
Prior art date
Application number
BR0317230-9A
Other languages
English (en)
Inventor
Wieslaw Mieczyslaw Kazmierski
Christopher Joseph Aquino
Neil Bifulco
Eric Eugene Boros
Brian Andrew Chauder
Pek Yoke Chong
Maosheng Duan
Felix Deanda Jr
Cecilia Suarez Koble
Ed Williams Mclean
Jennifer Poole Peckham
Angilique C Perkins
James Benjamin Thompson
Dana Vanderwall
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0317230A publication Critical patent/BR0317230A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO, COMPOSIçãO, MéTODOS DE ANTAGONIZAR UMA ATIVIDADE DO RECEPTOR DE QUIMIOCINA CCR-5, E DE TRATAR UMA INFECçãO VIRAL EM UM PACIENTE, E, USO DE UM COMPOSTO". A presente invenção diz respeito aos compostos da fórmula (I) ou seus derivados farmaceuticamente aceitáveis , úteis no tratamento ou profilaxia de doenças e distúrbios relacionados com CCR5, por exemplo, na inibição de replicação do HIV, a prevenção ou tratamento de uma infecção pelo HIV e no tratamento da síndrome da deficiência imuno adquirida (AIDS) resultante.
BR0317230-9A 2002-12-13 2003-12-12 Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto BR0317230A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43363402P 2002-12-13 2002-12-13
PCT/US2003/039644 WO2004054974A2 (en) 2002-12-13 2003-12-12 Piperidine derivatives as ccr5 antagonists

Publications (1)

Publication Number Publication Date
BR0317230A true BR0317230A (pt) 2005-10-25

Family

ID=32595222

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317230-9A BR0317230A (pt) 2002-12-13 2003-12-12 Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto

Country Status (15)

Country Link
US (1) US7645771B2 (pt)
EP (1) EP1569646A2 (pt)
JP (1) JP2006511554A (pt)
KR (1) KR20050087832A (pt)
CN (1) CN1744899A (pt)
AU (1) AU2003300902A1 (pt)
BR (1) BR0317230A (pt)
CA (1) CA2509711A1 (pt)
CO (1) CO5580771A2 (pt)
MA (1) MA27647A1 (pt)
MX (1) MXPA05006354A (pt)
NO (1) NO20052739L (pt)
RU (1) RU2005118407A (pt)
WO (1) WO2004054974A2 (pt)
ZA (1) ZA200505600B (pt)

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WO2004054974A3 (en) 2004-09-02
MXPA05006354A (es) 2005-08-26
EP1569646A2 (en) 2005-09-07
KR20050087832A (ko) 2005-08-31
MA27647A1 (fr) 2005-12-01
ZA200505600B (en) 2006-09-27
RU2005118407A (ru) 2006-03-10
JP2006511554A (ja) 2006-04-06
US7645771B2 (en) 2010-01-12
US20060229336A1 (en) 2006-10-12
WO2004054974A2 (en) 2004-07-01
NO20052739L (no) 2005-08-19
CN1744899A (zh) 2006-03-08
AU2003300902A1 (en) 2004-07-09
NO20052739D0 (no) 2005-06-07
CO5580771A2 (es) 2005-11-30
CA2509711A1 (en) 2004-07-01

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