DE69229733T2 - Oralaktive antivirale verbindungen - Google Patents

Oralaktive antivirale verbindungen

Info

Publication number
DE69229733T2
DE69229733T2 DE69229733T DE69229733T DE69229733T2 DE 69229733 T2 DE69229733 T2 DE 69229733T2 DE 69229733 T DE69229733 T DE 69229733T DE 69229733 T DE69229733 T DE 69229733T DE 69229733 T2 DE69229733 T2 DE 69229733T2
Authority
DE
Germany
Prior art keywords
compound
alkyl
substituted
formula
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69229733T
Other languages
German (de)
English (en)
Other versions
DE69229733D1 (de
Inventor
Ashit Ganguly
Viyyoor Girijavallabhan
Patrick Pinto
Anil Saksena
Richard Versace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69229733D1 publication Critical patent/DE69229733D1/de
Application granted granted Critical
Publication of DE69229733T2 publication Critical patent/DE69229733T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Dental Preparations (AREA)
DE69229733T 1991-06-19 1992-06-17 Oralaktive antivirale verbindungen Expired - Lifetime DE69229733T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71745191A 1991-06-19 1991-06-19
PCT/US1992/004961 WO1992022520A1 (en) 1991-06-19 1992-06-17 Orally active antiviral compounds

Publications (2)

Publication Number Publication Date
DE69229733D1 DE69229733D1 (de) 1999-09-09
DE69229733T2 true DE69229733T2 (de) 1999-12-02

Family

ID=24882086

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229733T Expired - Lifetime DE69229733T2 (de) 1991-06-19 1992-06-17 Oralaktive antivirale verbindungen

Country Status (23)

Country Link
US (4) US5559133A (zh)
EP (2) EP0519702A1 (zh)
JP (1) JP2625258B2 (zh)
KR (1) KR960004887B1 (zh)
AT (1) ATE182874T1 (zh)
AU (1) AU674657B2 (zh)
CA (1) CA2111854C (zh)
CZ (1) CZ279793A3 (zh)
DE (1) DE69229733T2 (zh)
ES (1) ES2134808T3 (zh)
FI (1) FI935690A (zh)
IE (1) IE921971A1 (zh)
IL (1) IL102241A0 (zh)
MX (1) MX9203068A (zh)
MY (1) MY107993A (zh)
NZ (1) NZ243180A (zh)
OA (1) OA09828A (zh)
PL (1) PL169699B1 (zh)
SK (1) SK144293A3 (zh)
TW (1) TW260658B (zh)
WO (1) WO1992022520A1 (zh)
YU (1) YU63392A (zh)
ZA (1) ZA924445B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2625258B2 (ja) * 1991-06-19 1997-07-02 シェリング・コーポレーション 経口活性抗ウィルス化合物
CA2156916A1 (en) * 1993-02-26 1994-09-01 Edward J. Rozhon Use of 2-chloro-1¬¬4-(2,6-dichlorophenoxy)methyl|-phenyl|methoxy|- 4-methoxy-benzene for the selective treatment of enteroviral infections in humans
DE69830751T2 (de) * 1997-04-10 2006-05-18 Pharmacia & Upjohn Co. Llc, Kalamazoo Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen
AU6462500A (en) * 1999-07-29 2001-02-19 Patrick T. Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418571A1 (de) * 1973-04-18 1974-11-14 Ciba Geigy Ag Phenyl-aralkyl-aether, diphenyle und benzophenone, verfahren zu ihrer herstellung und ihre verwendung
JPS509785A (zh) * 1973-05-31 1975-01-31
JPS5922697B2 (ja) * 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
DE3066406D1 (en) 1979-09-13 1984-03-08 Wellcome Found Diaryl compounds and pharmaceutical formulations containing them
US4531009A (en) * 1982-01-29 1985-07-23 Toray Industries, Inc. Process for preparing α,ω-bis(2-chlorophenoxy)alkane-4,4'-dicarboxylic acid or its lower alkyl ester
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
JPH0621083B2 (ja) * 1986-12-22 1994-03-23 株式会社三光開発科学研究所 ジ（アリ−ルオキシ）アルカンの製造方法
US4891449A (en) * 1988-06-30 1990-01-02 Great Lakes Chemical Corporation Halogenated unsymmetrical higher alkyl phenoxy alkanes
KR920701167A (ko) * 1989-07-07 1992-08-11 에릭 에스. 딕커 약제학적 활성 화합물
JP2625258B2 (ja) * 1991-06-19 1997-07-02 シェリング・コーポレーション 経口活性抗ウィルス化合物

Also Published As

Publication number Publication date
AU2221392A (en) 1993-01-12
WO1992022520A1 (en) 1992-12-23
JP2625258B2 (ja) 1997-07-02
US5449782A (en) 1995-09-12
FI935690A0 (fi) 1993-12-17
ES2134808T3 (es) 1999-10-16
YU63392A (sh) 1994-11-15
US5618849A (en) 1997-04-08
US5559133A (en) 1996-09-24
JPH06503839A (ja) 1994-04-28
EP0590026A1 (en) 1994-04-06
DE69229733D1 (de) 1999-09-09
EP0590026B1 (en) 1999-08-04
NZ243180A (en) 1995-08-28
OA09828A (en) 1994-04-15
PL169699B1 (en) 1996-08-30
IE921971A1 (en) 1992-12-30
AU674657B2 (en) 1997-01-09
US5350772A (en) 1994-09-27
SK144293A3 (en) 1994-06-08
ZA924445B (en) 1993-02-24
FI935690A (fi) 1993-12-17
EP0519702A1 (en) 1992-12-23
CA2111854C (en) 2001-01-09
CZ279793A3 (en) 1994-05-18
KR960004887B1 (ko) 1996-04-16
TW260658B (zh) 1995-10-21
IL102241A0 (en) 1993-01-14
CA2111854A1 (en) 1992-12-23
ATE182874T1 (de) 1999-08-15
MX9203068A (es) 1993-07-01
MY107993A (en) 1996-07-15

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