DE69222352D1 - N-(Aminoalkyl)piperidin-Verbindungen und ihre Enantiomere als Neurokinine-Receptoren Antagonisten, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents

N-(Aminoalkyl)piperidin-Verbindungen und ihre Enantiomere als Neurokinine-Receptoren Antagonisten, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Info

Publication number
DE69222352D1
DE69222352D1 DE69222352T DE69222352T DE69222352D1 DE 69222352 D1 DE69222352 D1 DE 69222352D1 DE 69222352 T DE69222352 T DE 69222352T DE 69222352 T DE69222352 T DE 69222352T DE 69222352 D1 DE69222352 D1 DE 69222352D1
Authority
DE
Germany
Prior art keywords
group
alkyl
unsubstituted
carbon atoms
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69222352T
Other languages
English (en)
Other versions
DE69222352T2 (de
Inventor
Xavier Emonds-Alt
Serge Martinez
Vincenzo Proietto
Broeck Didier Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69222352D1 publication Critical patent/DE69222352D1/de
Application granted granted Critical
Publication of DE69222352T2 publication Critical patent/DE69222352T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Control Of Transmission Device (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69222352T 1991-05-03 1992-04-30 N-(Aminoalkyl)piperidin-Verbindungen und ihre Enantiomere als Neurokinine-Receptoren Antagonisten, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen Expired - Fee Related DE69222352T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9105486A FR2676054B1 (fr) 1991-05-03 1991-05-03 Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
DE69222352D1 true DE69222352D1 (de) 1997-10-30
DE69222352T2 DE69222352T2 (de) 1998-04-09

Family

ID=9412519

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222352T Expired - Fee Related DE69222352T2 (de) 1991-05-03 1992-04-30 N-(Aminoalkyl)piperidin-Verbindungen und ihre Enantiomere als Neurokinine-Receptoren Antagonisten, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Country Status (26)

Country Link
US (2) US5411971A (de)
EP (1) EP0515240B1 (de)
JP (1) JP3108719B2 (de)
KR (1) KR100244063B1 (de)
AT (1) ATE158574T1 (de)
AU (1) AU657321B2 (de)
BR (1) BR9201655A (de)
CA (1) CA2067924C (de)
CZ (1) CZ282919B6 (de)
DE (1) DE69222352T2 (de)
DK (1) DK0515240T3 (de)
ES (1) ES2109987T3 (de)
FI (1) FI103041B1 (de)
FR (1) FR2676054B1 (de)
GR (1) GR3025277T3 (de)
HU (1) HU213915B (de)
IE (1) IE921365A1 (de)
IL (1) IL101762A (de)
MX (1) MX9202026A (de)
MY (1) MY113018A (de)
NO (1) NO178572C (de)
NZ (1) NZ242584A (de)
RU (1) RU2089547C1 (de)
TW (1) TW201733B (de)
UA (1) UA26894C2 (de)
ZA (1) ZA923176B (de)

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US5512680A (en) 1993-02-26 1996-04-30 Sanofi Process for the preparation of an optically pure aminoalcohol
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AU7947594A (en) * 1993-10-27 1995-05-22 Merck Sharp & Dohme Limited Substituted amides as tachykinin antagonists
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
US5589489A (en) * 1993-12-15 1996-12-31 Zeneca Limited Cyclic amide derivatives for treating asthma
FR2719311B1 (fr) * 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2717477B1 (fr) * 1994-03-18 1996-06-07 Sanofi Elf Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2717478B1 (fr) * 1994-03-18 1996-06-21 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2717802B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
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FR2725986B1 (fr) * 1994-10-21 1996-11-29 Adir Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9502644D0 (en) * 1995-02-10 1995-03-29 Zeneca Ltd Heterocyclic derivatives
GB9508786D0 (en) 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
GB9516709D0 (en) * 1995-08-15 1995-10-18 Zeneca Ltd Medicament
FR2738819B1 (fr) * 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
HU224225B1 (hu) 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
NZ325581A (en) * 1995-12-20 2000-03-27 Hoechst Marion Roussel Inc Substituted 4-(1h-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
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Also Published As

Publication number Publication date
AU657321B2 (en) 1995-03-09
EP0515240B1 (de) 1997-09-24
FI103041B (fi) 1999-04-15
NO178572C (no) 1996-04-24
CA2067924C (en) 2004-03-30
CA2067924A1 (en) 1992-11-04
ES2109987T3 (es) 1998-02-01
ZA923176B (en) 1993-04-28
HU213915B (en) 1997-11-28
NZ242584A (en) 1995-04-27
AU1591892A (en) 1992-11-05
US5606065A (en) 1997-02-25
MX9202026A (es) 1992-11-01
FI103041B1 (fi) 1999-04-15
HUT65273A (en) 1994-05-02
FI921950A0 (fi) 1992-04-30
IE921365A1 (en) 1992-11-04
ATE158574T1 (de) 1997-10-15
GR3025277T3 (en) 1998-02-27
IL101762A0 (en) 1992-12-30
CS132892A3 (en) 1992-11-18
US5411971A (en) 1995-05-02
FR2676054A1 (fr) 1992-11-06
UA26894C2 (uk) 1999-12-29
HU9201459D0 (en) 1992-07-28
CZ282919B6 (cs) 1997-11-12
NO921733D0 (no) 1992-04-30
NO921733L (no) 1992-11-04
KR100244063B1 (ko) 2000-03-02
IL101762A (en) 1996-10-16
FR2676054B1 (fr) 1993-09-03
RU2089547C1 (ru) 1997-09-10
NO178572B (no) 1996-01-15
EP0515240A1 (de) 1992-11-25
FI921950A (fi) 1992-11-04
DK0515240T3 (da) 1998-05-11
MY113018A (en) 2001-11-30
JPH05140103A (ja) 1993-06-08
JP3108719B2 (ja) 2000-11-13
BR9201655A (pt) 1992-12-15
TW201733B (de) 1993-03-11
KR920021511A (ko) 1992-12-18
DE69222352T2 (de) 1998-04-09

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8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

8339 Ceased/non-payment of the annual fee