DK239685A - Substituerede pyrrolidinoner, fremgangsmaade til deres fremstilling og laegemidler indeholdende forbindelserne - Google Patents

Substituerede pyrrolidinoner, fremgangsmaade til deres fremstilling og laegemidler indeholdende forbindelserne Download PDF

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Publication number
DK239685A
DK239685A DK239685A DK239685A DK239685A DK 239685 A DK239685 A DK 239685A DK 239685 A DK239685 A DK 239685A DK 239685 A DK239685 A DK 239685A DK 239685 A DK239685 A DK 239685A
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Prior art keywords
group
carbon atoms
substituted
alkyl group
chained
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Application number
DK239685A
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English (en)
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DK239685D0 (da
Inventor
Karl-Heinz Weber
Claus Schneider
Gerard Walter
Dieter Hinzen
Franz Josef Kuhn
Erich Lehr
Helmut Ensinger
Wolfgang Troeger
Original Assignee
Boehringer Ingelheim Kg
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Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DK239685D0 publication Critical patent/DK239685D0/da
Publication of DK239685A publication Critical patent/DK239685A/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK239685A 1984-05-30 1985-05-29 Substituerede pyrrolidinoner, fremgangsmaade til deres fremstilling og laegemidler indeholdende forbindelserne DK239685A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420193 DE3420193A1 (de) 1984-05-30 1984-05-30 Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel

Publications (2)

Publication Number Publication Date
DK239685D0 DK239685D0 (da) 1985-05-29
DK239685A true DK239685A (da) 1985-12-01

Family

ID=6237240

Family Applications (1)

Application Number Title Priority Date Filing Date
DK239685A DK239685A (da) 1984-05-30 1985-05-29 Substituerede pyrrolidinoner, fremgangsmaade til deres fremstilling og laegemidler indeholdende forbindelserne

Country Status (22)

Country Link
US (4) US4670456A (da)
EP (1) EP0163260B1 (da)
JP (1) JPS6168A (da)
KR (1) KR850008343A (da)
AT (1) ATE36151T1 (da)
AU (1) AU581438B2 (da)
CA (1) CA1255664A (da)
CS (1) CS261883B2 (da)
DD (1) DD235256A5 (da)
DE (2) DE3420193A1 (da)
DK (1) DK239685A (da)
ES (4) ES8607926A1 (da)
FI (1) FI78462C (da)
GR (1) GR851306B (da)
HU (1) HU193393B (da)
IL (1) IL75339A (da)
NO (1) NO852133L (da)
NZ (1) NZ212241A (da)
PL (1) PL144921B1 (da)
PT (1) PT80545B (da)
SU (1) SU1360583A3 (da)
ZA (1) ZA854072B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
FR2597100A1 (fr) * 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd Derives du pyroglutamide
US4960776A (en) * 1987-01-28 1990-10-02 A. H. Robins Company, Inc. 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides
CA1305148C (en) * 1987-08-19 1992-07-14 Hiromu Matsumura Carbamoylpyrrolidone derivatives and drugs for senile dementia
US4833139A (en) * 1988-01-25 1989-05-23 Hoechst-Roussel Pharmaceuticals, Inc. Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrolidinyl)-2-butynyl]-2-pyrrolidinones and related compounds
IE61631B1 (en) * 1988-05-20 1994-11-16 Zambon Spa Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them
JPH02137427A (ja) * 1988-11-18 1990-05-25 Du Pont Opt Electron Kk 光電気的接続装置及び光コンセント
US4981974A (en) * 1989-05-08 1991-01-01 Gaf Chemicals Corporation Polymerizable pyrrolidonyl oxazoline monomers
AU2007225088B2 (en) * 2006-03-13 2012-09-13 Kyorin Pharmaceutical Co., Ltd Aminoquinolones as GSK-3 inhibitors
CN101855228B (zh) * 2007-09-11 2012-10-24 杏林制药株式会社 作为gsk-3抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
EP2229362A1 (en) * 2007-12-05 2010-09-22 AstraZeneca AB Piperazines as anti-obesity agents
AU2008333183A1 (en) 2007-12-05 2009-06-11 Astrazeneca Ab (Publ) Piperazine derivatives and their use as leptin receptor modulators
MX2010013353A (es) * 2008-06-04 2010-12-21 Astrazeneca Ab Nuevos compuestos vii.
EP2406266B1 (en) * 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as gsk-3 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838914A (en) * 1957-07-03 1958-06-17 Olin Mathieson Isonicotinic acid hydrazide derivatives
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
JPS4924916B1 (da) * 1970-08-14 1974-06-26
FR2387218A1 (fr) * 1977-04-15 1978-11-10 Ile De France Nouveaux n-(1'-ethyl 2'-oxo 5'-pyrrolidinyl methyl) benzamides, leurs procedes de preparation et leur application comme modificateurs du comportement
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
US4670436A (en) * 1986-08-29 1987-06-02 Mcneilab, Inc. Hypoglycemic 5-substituted pyrrolidinylidene compounds, compositions and use

Also Published As

Publication number Publication date
AU581438B2 (en) 1989-02-23
JPH0517904B2 (da) 1993-03-10
ES8607926A1 (es) 1986-06-01
FI78462B (fi) 1989-04-28
DD235256A5 (de) 1986-04-30
CS385485A2 (en) 1988-06-15
AU4317085A (en) 1985-12-05
HU193393B (en) 1987-09-28
FI852130L (fi) 1985-12-01
US4670456A (en) 1987-06-02
ES552410A0 (es) 1987-09-01
SU1360583A3 (ru) 1987-12-15
ES543592A0 (es) 1986-06-01
EP0163260A1 (de) 1985-12-04
FI852130A0 (fi) 1985-05-29
EP0163260B1 (de) 1988-08-03
KR850008343A (ko) 1985-12-16
CA1255664A (en) 1989-06-13
GR851306B (da) 1985-11-25
ES8707928A1 (es) 1987-09-01
ES552411A0 (es) 1987-09-01
US4762832A (en) 1988-08-09
PT80545B (de) 1987-04-06
PT80545A (de) 1985-06-01
DK239685D0 (da) 1985-05-29
ATE36151T1 (de) 1988-08-15
HUT37751A (en) 1986-02-28
US4891378A (en) 1990-01-02
PL144921B1 (en) 1988-07-30
FI78462C (fi) 1989-08-10
IL75339A0 (en) 1985-09-29
NO852133L (no) 1985-12-02
PL253668A1 (en) 1986-05-20
DE3564105D1 (en) 1988-09-08
ES552409A0 (es) 1987-12-16
IL75339A (en) 1988-07-31
ZA854072B (en) 1987-02-25
CS261883B2 (en) 1989-02-10
DE3420193A1 (de) 1985-12-05
ES8707927A1 (es) 1987-09-01
US4857528A (en) 1989-08-15
NZ212241A (en) 1989-07-27
ES8801200A1 (es) 1987-12-16
JPS6168A (ja) 1986-01-06

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