FR2717478B1 - Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. - Google Patents
Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.Info
- Publication number
- FR2717478B1 FR2717478B1 FR9409478A FR9409478A FR2717478B1 FR 2717478 B1 FR2717478 B1 FR 2717478B1 FR 9409478 A FR9409478 A FR 9409478A FR 9409478 A FR9409478 A FR 9409478A FR 2717478 B1 FR2717478 B1 FR 2717478B1
- Authority
- FR
- France
- Prior art keywords
- receptor
- drugs
- compounds
- human
- diagnostic tools
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9409478A FR2717478B1 (fr) | 1994-03-18 | 1994-07-29 | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
FR9500571A FR2719311B1 (fr) | 1994-03-18 | 1995-01-19 | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
NZ270727A NZ270727A (en) | 1994-03-18 | 1995-03-16 | Piperidine derivatives and pharmaceutical compositions |
PL95307723A PL185075B1 (pl) | 1994-03-18 | 1995-03-16 | Nowe pochodne N-(3,4-dichlorofenylopropylo)piperydyny będące selektywnymi antagonistami ludzkiego receptora NK3, sposób ich wytwarzania oraz kompozycje farmaceutyczne zawierające te związki |
DE69522355T DE69522355T2 (de) | 1994-03-18 | 1995-03-17 | Neue N-(3,4-Dichlorphenyl-propyl)-piperidin-Derivate als selektive humane NK3-Rezeptorantagonisten |
IL11302695A IL113026A (en) | 1994-03-18 | 1995-03-17 | Selective antagonists of the human nk3 receptor their preparation pharmaceutical compositions containing them and their use for the preparation of phamraceutical compositions |
RU95103737/04A RU2143425C1 (ru) | 1994-03-18 | 1995-03-17 | Производные пиперидина, их соли, способы их получения, фармацевтическая композиция на их основе и промежуточные вещества |
AU14909/95A AU693845B2 (en) | 1994-03-18 | 1995-03-17 | Compounds which are selective antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
FI951265A FI116621B (fi) | 1994-03-18 | 1995-03-17 | Ihmisen NK3-reseptoreille selektiivisiä antagonistiyhdisteitä, valmistusmenetelmiä, niitä sisältäviä farmaseuttisia koostumuksia ja niiden käyttö lääkeaineina ja diagnostisina aineina |
HU9500806A HUT72065A (en) | 1994-03-18 | 1995-03-17 | Selective antagonistic compounds of human nk3 receptor and their use in pharmaceutical and diagnostical compositions |
AT95400590T ATE204863T1 (de) | 1994-03-18 | 1995-03-17 | Neue n-(3,4-dichlorphenyl-propyl)-piperidin- derivate als selektive humane nk3- rezeptorantagonisten |
EP95400590A EP0673928B1 (fr) | 1994-03-18 | 1995-03-17 | Nouveaux dérivés de la N-(3,4-dichlorophényl-propyl)-pipéridine comme antagonistes sélectifs du récepteur NK3 humain |
PT95400590T PT673928E (pt) | 1994-03-18 | 1995-03-17 | Novos derivaos da n-(3,4-diclorofenil-propil)-piperidina como antagonistas selectivos do receptor nk3 humano |
NO951044A NO302944B1 (no) | 1994-03-18 | 1995-03-17 | Selektive antagonist-forbindelser for menneske-NK3-reseptor, farmasöytiske preparater inneholdende dem, og deres anvendelse til fremstilling av medikamenter |
DK95400590T DK0673928T3 (da) | 1994-03-18 | 1995-03-17 | Nye N-(3,4-dichlorphenyl-propyl)-piperidin-derivater som selektive humane NK3-receptorantagonister |
ES95400590T ES2164746T3 (es) | 1994-03-18 | 1995-03-17 | Nuevos derivados de la n-(3,4-diclorofenil-propil)-piperidina como antagonistas selectivos del receptor nk3 humano. |
CN95103542A CN1056605C (zh) | 1994-03-18 | 1995-03-17 | 作为人速激肽ⅲ受体的选择性拮抗剂的化合物及其用途 |
SI9530543T SI0673928T1 (en) | 1994-03-18 | 1995-03-17 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists |
TW084102614A TW380138B (en) | 1994-03-18 | 1995-03-18 | Piperidine derivatives which are selective antagonists of the human NK3 receptor and their use as medicinal products |
KR1019950005722A KR100238343B1 (ko) | 1994-03-18 | 1995-03-18 | 인간 nk3 수용기의 선택적 길항제인 화합물, 및 의약품 및 진단기구로서의 그의 용도 |
JP7061419A JP2922816B2 (ja) | 1994-03-18 | 1995-03-20 | ヒトnk3受容体の選択的拮抗剤である化合物並びに医薬品及び診断ツールとしてのこれらの使用 |
CA002145000A CA2145000C (fr) | 1994-03-18 | 1995-03-20 | Antagonistes selectifs du recepteur humain nk3 et leur utilisation comme produits medicinaux et diagnostiques |
US08/608,718 US5942523A (en) | 1994-03-18 | 1996-02-29 | Compounds which are selective antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
US08/607,976 US5741910A (en) | 1994-03-18 | 1996-02-29 | Compounds which are selective antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
NO975089A NO303823B1 (no) | 1994-03-18 | 1997-11-04 | Piperidinderivater |
HK98104342A HK1005137A1 (en) | 1994-03-18 | 1998-05-19 | Novel n-(3,4-dichlorophenylpropyl) piperidine derivatives as selective human nk3-receptor antagonists |
US09/306,825 US6124316A (en) | 1994-03-18 | 1999-05-07 | Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
CY0200032A CY2278B1 (en) | 1994-03-18 | 2002-05-15 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selectibe human nk3-receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9403193A FR2717477B1 (fr) | 1994-03-18 | 1994-03-18 | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
FR9409478A FR2717478B1 (fr) | 1994-03-18 | 1994-07-29 | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2717478A1 FR2717478A1 (fr) | 1995-09-22 |
FR2717478B1 true FR2717478B1 (fr) | 1996-06-21 |
Family
ID=26231016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9409478A Expired - Fee Related FR2717478B1 (fr) | 1994-03-18 | 1994-07-29 | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2717478B1 (fr) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2688219B1 (fr) * | 1992-03-03 | 1994-07-08 | Sanofi Elf | Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant. |
-
1994
- 1994-07-29 FR FR9409478A patent/FR2717478B1/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2717478A1 (fr) | 1995-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CA | Change of address | ||
TP | Transmission of property | ||
CD | Change of name or company name | ||
ST | Notification of lapse |
Effective date: 20100331 |