DE69132563D1 - Ausgabeverfahren für fibrindichtungsmittel - Google Patents

Ausgabeverfahren für fibrindichtungsmittel

Info

Publication number
DE69132563D1
DE69132563D1 DE69132563T DE69132563T DE69132563D1 DE 69132563 D1 DE69132563 D1 DE 69132563D1 DE 69132563 T DE69132563 T DE 69132563T DE 69132563 T DE69132563 T DE 69132563T DE 69132563 D1 DE69132563 D1 DE 69132563D1
Authority
DE
Germany
Prior art keywords
thrombin
fibrin sealant
fibrine
sealants
dispensing procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132563T
Other languages
English (en)
Other versions
DE69132563T2 (de
Inventor
Smith Brenda Morse
Denise Turner
T Mcnally
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artivion Inc
Original Assignee
Cryolife Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryolife Inc filed Critical Cryolife Inc
Publication of DE69132563D1 publication Critical patent/DE69132563D1/de
Application granted granted Critical
Publication of DE69132563T2 publication Critical patent/DE69132563T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
DE69132563T 1990-01-03 1991-01-02 Ausgabeverfahren für fibrindichtungsmittel Expired - Fee Related DE69132563T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/460,379 US5219328A (en) 1990-01-03 1990-01-03 Fibrin sealant delivery method
PCT/US1991/000003 WO1991009641A1 (en) 1990-01-03 1991-01-02 Fibrin sealant delivery method

Publications (2)

Publication Number Publication Date
DE69132563D1 true DE69132563D1 (de) 2001-04-26
DE69132563T2 DE69132563T2 (de) 2001-10-31

Family

ID=23828479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132563T Expired - Fee Related DE69132563T2 (de) 1990-01-03 1991-01-02 Ausgabeverfahren für fibrindichtungsmittel

Country Status (11)

Country Link
US (1) US5219328A (de)
EP (1) EP0509041B1 (de)
JP (1) JP3136157B2 (de)
KR (1) KR100197930B1 (de)
AT (1) ATE199833T1 (de)
AU (1) AU641472B2 (de)
CA (1) CA2072355C (de)
DE (1) DE69132563T2 (de)
ES (1) ES2155055T3 (de)
RU (1) RU2104701C1 (de)
WO (1) WO1991009641A1 (de)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US5403278A (en) * 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
FR2696095B1 (fr) * 1992-09-30 1994-11-25 Inoteb Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application.
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5552452A (en) * 1993-03-15 1996-09-03 Arch Development Corp. Organic tissue glue for closure of wounds
AU6705894A (en) * 1993-04-20 1994-11-08 Medchem Products, Inc. Apparatus and method for applying a particulate hemostatic agent to living tissue
US6017359A (en) 1993-05-25 2000-01-25 Vascular Solutions, Inc. Vascular sealing apparatus
US5383896A (en) * 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5759194A (en) * 1993-09-28 1998-06-02 Hemodynamics, Inc. Vascular patch applicator
US5843124A (en) * 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5653730A (en) * 1993-09-28 1997-08-05 Hemodynamics, Inc. Surface opening adhesive sealer
US6033401A (en) * 1997-03-12 2000-03-07 Advanced Closure Systems, Inc. Vascular sealing device with microwave antenna
US6302898B1 (en) 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels
US5660873A (en) * 1994-09-09 1997-08-26 Bioseal, Limited Liability Corporaton Coating intraluminal stents
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US6965014B1 (en) * 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5674394A (en) 1995-03-24 1997-10-07 Johnson & Johnson Medical, Inc. Single use system for preparation of autologous plasma
US6217603B1 (en) 1997-08-29 2001-04-17 Closure Medical Corporation Methods of applying monomeric compositions effective as wound closure devices
US20020018689A1 (en) * 1995-06-07 2002-02-14 Badejo Ibraheem T. Adhesive applicators with improved polymerization initiators
US6676322B1 (en) 1995-06-07 2004-01-13 Closure Medical Corporation Impregnated applicator tip
US5928611A (en) * 1995-06-07 1999-07-27 Closure Medical Corporation Impregnated applicator tip
AU7398196A (en) * 1995-10-11 1997-04-30 Fusion Medical Technologies, Inc. Device and method for sealing tissue
JP2000509307A (ja) * 1996-04-30 2000-07-25 メドトロニック，インコーポレイテッド 自己由来フィブリン密封材の製造方法
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
WO1998005259A1 (en) 1996-08-06 1998-02-12 Quinton Instrument Company Insertion assembly and method of inserting a hemostatic closure device into an incision
US8603511B2 (en) * 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20090324721A1 (en) 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US5844087A (en) * 1996-11-05 1998-12-01 Bayer Corporation Method and device for delivering fibrin glue
US6733515B1 (en) 1997-03-12 2004-05-11 Neomend, Inc. Universal introducer
JP2002514960A (ja) 1997-06-18 2002-05-21 コヘージョン テクノロジーズ，インコーポレイテッド トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法
US6168788B1 (en) 1997-09-26 2001-01-02 Leon Wortham Fibrin glue without fibrinogen and biosealant compositions and methods
US6033427A (en) * 1998-01-07 2000-03-07 Lee; Benjamin I. Method and device for percutaneous sealing of internal puncture sites
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US20050196431A1 (en) * 1998-04-30 2005-09-08 Upvan Narang Adhesive applicator tip with a polymerization initiator, polymerization rate modifier, and/or bioactive material
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
WO2000033764A1 (en) 1998-12-04 2000-06-15 Pathak Chandrashekhar P Biocompatible crosslinked polymers
US6310036B1 (en) 1999-01-09 2001-10-30 Last Chance Tissue Adhesives Corporation High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US20050049178A1 (en) * 1999-07-06 2005-03-03 Oberschwabenklinik Gmbh Agent for the occlusion of blood vessels
DE29911689U1 (de) * 1999-07-06 2000-04-06 Sterk, Peter, Dr., 88212 Ravensburg Mittel für den Gefässverschluß von organischem Gewebe
US6425704B2 (en) 2000-01-07 2002-07-30 Closure Medical Corporation Adhesive applicators with improved applicator tips
US6428234B1 (en) 2000-01-07 2002-08-06 Closure Medical Corporation Adhesive applicator tips with improved flow properties
US6428233B1 (en) 2000-01-07 2002-08-06 Closure Medical Corporation Adhesive applicator tips with improved flow properties
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
AU2001280595A1 (en) * 2000-07-17 2002-01-30 Haemacure Corporation Spray head for applying a multi-component mixture
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US20020155096A1 (en) 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
CN1254273C (zh) * 2001-07-10 2006-05-03 财团法人化学及血清疗法研究所 药学上稳定的止血组合物
US6616019B2 (en) 2001-07-18 2003-09-09 Closure Medical Corporation Adhesive applicator with improved applicator tip
EP1465521A4 (de) 2001-11-01 2008-10-08 Spine Wave Inc System und verfahren zur vorbehandlung der endplatten einer bandscheibe
JP3993855B2 (ja) * 2001-11-01 2007-10-17 スパイン・ウェイブ・インコーポレーテッド 脊椎椎間板の回復のための装置
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US20060155234A1 (en) * 2002-09-10 2006-07-13 American National Red Cross Hemostatic dressing
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
WO2005070071A2 (en) 2004-01-08 2005-08-04 Spine Wave Inc. Apparatus and method for injecting fluent material at a distracted tissue site
WO2006004887A2 (en) * 2004-06-29 2006-01-12 Spine Wave, Inc. Methods for treating defects and injuries of an intervertebral disc
US8206448B2 (en) * 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US7597687B2 (en) * 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
EP1799192A2 (de) * 2004-07-22 2007-06-27 Allan D. Pronovost Zusammensetzungen und verfahren zur behandlung von sehr starken blutungen
US20110213464A1 (en) * 2004-10-29 2011-09-01 Whitlock Steven I Injection of fibrin sealant in the absence of corticosteroids in spinal applications
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
JP4961354B2 (ja) 2005-02-07 2012-06-27 ハヌマン リミテッド ライアビリティ カンパニー 多血小板血漿濃縮装置および方法
US7708152B2 (en) 2005-02-07 2010-05-04 Hanuman Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
JP2008530305A (ja) 2005-02-09 2008-08-07 タイコ ヘルスケア グループ エルピー 合成封止剤
US7766900B2 (en) * 2005-02-21 2010-08-03 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
WO2007127198A2 (en) 2006-04-24 2007-11-08 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
BRPI0712088B8 (pt) * 2006-05-31 2021-06-22 Baxter Healthcare Sa uso de uma biomatriz de lâmina de colágeno de múltiplas camadas microscópicas não porosa e hermética a fluido
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
ES2389813T3 (es) * 2006-08-04 2012-11-02 Stb Lifesaving Technologies, Inc. Procedimientos para la producción de apósito sólido para tratar tejido lesionado
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
WO2009020612A1 (en) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
MX2010004838A (es) 2007-10-30 2010-05-21 Baxter Int Uso de una biomatriz de colageno biofuncional regenerativa para tratar defectos viscerales o parietales.
WO2009059121A1 (en) * 2007-11-02 2009-05-07 Genzyme Corporation Methods of augmenting or repairing soft tissue
PL2259774T3 (pl) 2008-02-27 2013-04-30 Biomet Biologics Llc Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US8518272B2 (en) 2008-04-04 2013-08-27 Biomet Biologics, Llc Sterile blood separating system
JP2011519679A (ja) 2008-05-06 2011-07-14 ウィルソン−クック・メディカル・インコーポレーテッド 治療薬を送達するための器具及び方法
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
JP5631332B2 (ja) 2008-12-23 2014-11-26 クック メディカル テクノロジーズ エルエルシーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ 治療薬を収容及び送達するための器械及び方法
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
EP2442834A2 (de) * 2009-06-15 2012-04-25 Technion Research and Development Foundation, Ltd. Verstärkte chirurgische haft- und versiegelungsmittel sowie ihre in-situ-anwendung
BRPI1015979A8 (pt) * 2009-06-16 2018-06-19 Baxter Healthcare Sa esponja porosa hemostática, e, método para fabricar uma esponja porosa hemostática
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
WO2011031476A2 (en) * 2009-08-25 2011-03-17 Emory University Compositions and methods for treatment or prevention of post-operative organ or tissue inflammation
KR101811070B1 (ko) * 2009-12-16 2017-12-20 백스터 인터내셔널 인코포레이티드 지혈 스폰지
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
WO2011151384A1 (en) 2010-06-01 2011-12-08 Baxter International Inc. Process for making dry and stable hemostatic compositions
BR112012030457B1 (pt) 2010-06-01 2021-03-09 Baxter International Inc. processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, método para prover uma composição hemostática pronta para uso, e, kit para administrar uma composição hemostática
EP2575770B1 (de) 2010-06-01 2017-03-22 Baxter International Inc Verfahren zur herstellung von trockenen und stabilen hämostatischen zusammensetzungen
US8440309B2 (en) 2011-01-31 2013-05-14 Confluent Surgical, Inc. Crosslinked polymers with the crosslinker as therapeutic for sustained release
AU2012232814A1 (en) 2011-03-24 2013-10-03 Sofradim Production Enzymatically degradable compositions
ES2938566T3 (es) 2011-10-11 2023-04-12 Baxter Int Composiciones hemostaticas
JP6195569B2 (ja) 2011-10-11 2017-09-13 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 止血組成物
MX347623B (es) 2011-10-27 2017-05-04 Baxter Int Composiciones hemostaticas.
US20130202656A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and kits for the fabrication of tissue patches
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
CN104349797B (zh) 2012-06-12 2017-10-27 弗罗桑医疗设备公司 干止血组合物
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US10016527B2 (en) 2012-10-23 2018-07-10 Orthovita, Inc. Materials and methods for repair of cartilage defects
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
CA2912357C (en) 2013-06-21 2019-12-31 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス 押し出し増強因子を含んでいる乾燥組成物
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
IL230151A0 (en) * 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
EA026104B1 (ru) * 2015-04-02 2017-03-31 Общество С Ограниченной Ответственностью "Тектум" Кровоостанавливающее и ранозаживляющее средство
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
EP3316930B1 (de) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Spritze zum mischen zweier komponenten und zum aufrechterhalten eines vakuums im lagerzustand
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
US10588998B2 (en) 2015-08-07 2020-03-17 Xcede Technologies, Inc. Adhesive compositions and related methods
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática
EP3934542A1 (de) 2019-03-06 2022-01-12 Gambro Lundia AB Vorrichtung und verfahren zur abgabe eines thrombinaktivierten fibrinversiegelers

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2533004A (en) * 1943-10-27 1950-12-05 John D Ferry Fibrin clots and methods for preparing the same
US2492458A (en) * 1944-12-08 1949-12-27 Jr Edgar A Bering Fibrin foam
US3723244A (en) * 1971-01-18 1973-03-27 Atomic Energy Commission Fibrous fibrin sheet and method for producing same
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT366916B (de) * 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4359463A (en) * 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
DE3105624A1 (de) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
DE3171072D1 (en) * 1981-06-25 1985-07-25 Stroetmann M Serapharm Enriched plasma derivative for promoting wound sealing and wound covering
US4442655A (en) * 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
AT379311B (de) * 1984-03-29 1985-12-27 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
JPS6144825A (ja) * 1984-08-09 1986-03-04 Unitika Ltd 止血剤
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
AT382783B (de) * 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
DE3622642A1 (de) * 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
US4902281A (en) * 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit

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EP0509041A1 (de) 1992-10-21
WO1991009641A1 (en) 1991-07-11
JP3136157B2 (ja) 2001-02-19
AU641472B2 (en) 1993-09-23
ES2155055T3 (es) 2001-05-01
DE69132563T2 (de) 2001-10-31
JPH05504950A (ja) 1993-07-29
ATE199833T1 (de) 2001-04-15
RU2104701C1 (ru) 1998-02-20
CA2072355A1 (en) 1991-07-04
KR100197930B1 (ko) 1999-06-15
US5219328A (en) 1993-06-15
EP0509041B1 (de) 2001-03-21
KR927003146A (ko) 1992-12-17
EP0509041A4 (en) 1993-10-13
AU7173391A (en) 1991-07-24
CA2072355C (en) 2001-05-15

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