ES8304800A1 - "procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia". - Google Patents
"procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia".Info
- Publication number
- ES8304800A1 ES8304800A1 ES513485A ES513485A ES8304800A1 ES 8304800 A1 ES8304800 A1 ES 8304800A1 ES 513485 A ES513485 A ES 513485A ES 513485 A ES513485 A ES 513485A ES 8304800 A1 ES8304800 A1 ES 8304800A1
- Authority
- ES
- Spain
- Prior art keywords
- factor viia
- composition based
- hemostatic agent
- preparing same
- agent factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPOSICIONES QUE CONTIENEN EL AGENTE HEMOSTATICO ACTIVADO FACTOR VIIA; COMPOSICIONES QUE TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE PACIENTES CON DEFICIENCIAS O INHIBIDORES DE FACTOR HEMOCOAGULANTES. CONSISTE EN LA SEPARACION DEL FACTOR VII RESPECTO DEL FACTOR IX, DE UN MATERIAL QUE CONTIENE AMBOS; Y ACTIVACION DE LA FRACCION QUE CONTIENE EL FACTOR VII MEDIANTE LA SELECCION DE UNA CONDICION QUE PUEDA MODIFICARSE PARA CONTROLAR EL GRADO DE ACTIVACION DEL FACTOR VII, FIJACION DE LA MAGNITUD DE LA CONDICION NECESARIA PARA LA ACTIVACION A UN GRADO DETERMINADO, ADAPTACION DE LA CONDICION A TAL MAGNITUD, Y REALIZACION DE LA ACTIVACION DE ACUERDO CON LA CONDICION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/277,469 US4382083A (en) | 1981-06-25 | 1981-06-25 | Therapeutic method for treating blood-clotting defects with factor VIIa |
Publications (2)
Publication Number | Publication Date |
---|---|
ES513485A0 ES513485A0 (es) | 1983-04-01 |
ES8304800A1 true ES8304800A1 (es) | 1983-04-01 |
Family
ID=23061015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513485A Expired ES8304800A1 (es) | 1981-06-25 | 1982-06-25 | "procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia". |
Country Status (11)
Country | Link |
---|---|
US (1) | US4382083A (es) |
EP (1) | EP0082182B1 (es) |
JP (1) | JPS58500994A (es) |
BR (1) | BR8207762A (es) |
CA (1) | CA1186994A (es) |
DE (1) | DE3276849D1 (es) |
ES (1) | ES8304800A1 (es) |
IT (1) | IT1163004B (es) |
MX (1) | MX7191E (es) |
WO (1) | WO1983000016A1 (es) |
ZA (1) | ZA824233B (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4501731A (en) * | 1983-06-27 | 1985-02-26 | Tishkoff Garson H | Treatment of disparate bleeding disorders with factor X zymogen |
ZA862768B (en) | 1985-04-17 | 1986-12-30 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
US5180583A (en) * | 1985-11-26 | 1993-01-19 | Hedner Ulla K E | Method for the treatment of bleeding disorders |
AU593042B2 (en) * | 1985-11-26 | 1990-02-01 | Novo Nordisk Health Care Ag | Compositions and methods for the treatment of bleeding disorders |
US6013531A (en) * | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
FR2632524B1 (fr) * | 1988-06-09 | 1992-03-13 | Fondation Nale Transfusion San | Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament |
US5677160A (en) * | 1989-10-30 | 1997-10-14 | Henkel Corporation | Fat splitting process |
US5597799A (en) * | 1990-09-04 | 1997-01-28 | Cor Therapeutics, Inc. | Recombinant agents affecting thrombosis |
US5583107A (en) * | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
US20040072757A1 (en) * | 1990-09-04 | 2004-04-15 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
US5843442A (en) * | 1990-10-22 | 1998-12-01 | Corvas International, Inc. | Blood coagulation protein antagonists and uses therefor |
US5506134A (en) * | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
HUT67693A (en) * | 1991-10-11 | 1995-04-28 | Novo Nordisk As | Hemostatic composition for arresting local bleedings |
DE69306389T2 (de) * | 1992-06-12 | 1997-06-26 | Dow Chemical Co | Intelligentes prozesssteuerverbindungssystem und verfahren. |
CA2220448A1 (en) * | 1995-05-31 | 1996-12-05 | Henkel Corporation | Improved fat-splitting process |
DE19531637A1 (de) * | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
EP0796623B1 (de) * | 1996-03-20 | 2005-05-25 | Baxter Aktiengesellschaft | Pharmazeutisches Präparat zur Behandlung von Blutgerinnungsstörungen |
CA2285935C (en) | 1997-04-08 | 2011-01-18 | Baxter Aktiengesellschaft | An immunotolerant prothrombin complex preparation |
US20050032690A1 (en) * | 1997-09-10 | 2005-02-10 | Rojkjaer Lisa Payne | Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia |
DE60035260T2 (de) | 1999-02-22 | 2007-10-18 | The University Of Connecticut, Farmington | Neue albuminfreie faktor viii formulierungen |
JP4676585B2 (ja) * | 1999-12-24 | 2011-04-27 | 一般財団法人化学及血清療法研究所 | 血液凝固異常に基づく疾患の治療・予防用医薬組成物 |
US7015194B2 (en) * | 2000-05-10 | 2006-03-21 | Novo Nordisk A/S | Pharmaceutical composition comprising factor VIIa and anti-TFPI |
US20030119743A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and tissue plasminogen inhibitors |
US7125846B2 (en) | 2001-11-09 | 2006-10-24 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides |
US7291587B2 (en) | 2001-11-09 | 2007-11-06 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides |
EP1446150A1 (en) * | 2001-11-09 | 2004-08-18 | Novo Nordisk Health Care AG | Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors |
JP2005510513A (ja) | 2001-11-09 | 2005-04-21 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドおよびtafiポリペプチドを含む薬学的組成物 |
US7078479B2 (en) | 2001-11-09 | 2006-07-18 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and alpha2-antiplasmin polypeptides |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
EP1458408B1 (en) | 2001-12-21 | 2009-04-15 | Novo Nordisk Health Care AG | Liquid composition of factor vii polypeptides |
US20030186862A1 (en) * | 2002-04-02 | 2003-10-02 | Nelsestuen Gary L. | Factor VIIa compositions |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
EP1517698B2 (en) | 2002-06-21 | 2017-12-06 | Novo Nordisk Health Care AG | STABILISED SOLID COMPOSITIONS OF FACTOR VIIa POLYPEPTIDES |
JP2006524195A (ja) * | 2003-03-18 | 2006-10-26 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドの液状水性医薬組成物 |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
WO2004103398A1 (en) * | 2003-05-23 | 2004-12-02 | Novo Nordisk Health Care Ag | Protein stabilization in solution |
ATE446768T1 (de) * | 2003-07-01 | 2009-11-15 | Novo Nordisk Healthcare Ag | Flüssige wässrige pharmazeutische zusammnesetzung von factor vii polypeptiden |
EP1656158B1 (en) | 2003-08-14 | 2016-03-09 | Novo Nordisk Health Care AG | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
EP2298287B1 (en) * | 2003-12-19 | 2018-04-11 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
NZ593190A (en) | 2008-11-07 | 2013-01-25 | Baxter Int | Factor viii formulations |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3560475A (en) * | 1969-06-19 | 1971-02-02 | Baxter Laboratories Inc | Prothrombin complex prepared by precipitation with polyethylene glycol |
AT350726B (de) * | 1976-08-30 | 1979-06-11 | Immuno Ag | Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma |
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
-
1981
- 1981-06-25 US US06/277,469 patent/US4382083A/en not_active Expired - Lifetime
-
1982
- 1982-03-31 CA CA000400087A patent/CA1186994A/en not_active Expired
- 1982-05-26 JP JP57502164A patent/JPS58500994A/ja active Granted
- 1982-05-26 BR BR8207762A patent/BR8207762A/pt unknown
- 1982-05-26 EP EP82902136A patent/EP0082182B1/en not_active Expired
- 1982-05-26 DE DE8282902136T patent/DE3276849D1/de not_active Expired
- 1982-05-26 WO PCT/US1982/000724 patent/WO1983000016A1/en active IP Right Grant
- 1982-06-16 ZA ZA824233A patent/ZA824233B/xx unknown
- 1982-06-24 MX MX8210156U patent/MX7191E/es unknown
- 1982-06-24 IT IT22056/82A patent/IT1163004B/it active
- 1982-06-25 ES ES513485A patent/ES8304800A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES513485A0 (es) | 1983-04-01 |
EP0082182A4 (en) | 1983-11-09 |
WO1983000016A1 (en) | 1983-01-06 |
ZA824233B (en) | 1983-04-27 |
DE3276849D1 (en) | 1987-09-03 |
JPH0428690B2 (es) | 1992-05-15 |
JPS58500994A (ja) | 1983-06-23 |
EP0082182B1 (en) | 1987-07-29 |
IT1163004B (it) | 1987-04-08 |
BR8207762A (pt) | 1983-05-31 |
EP0082182A1 (en) | 1983-06-29 |
US4382083A (en) | 1983-05-03 |
IT8222056A0 (it) | 1982-06-24 |
CA1186994A (en) | 1985-05-14 |
MX7191E (es) | 1987-12-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20030127 |