ES8304800A1 - "procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia". - Google Patents

"procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia".

Info

Publication number
ES8304800A1
ES8304800A1 ES513485A ES513485A ES8304800A1 ES 8304800 A1 ES8304800 A1 ES 8304800A1 ES 513485 A ES513485 A ES 513485A ES 513485 A ES513485 A ES 513485A ES 8304800 A1 ES8304800 A1 ES 8304800A1
Authority
ES
Spain
Prior art keywords
factor viia
composition based
hemostatic agent
preparing same
agent factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513485A
Other languages
English (en)
Other versions
ES513485A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Travenol Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Travenol Laboratories Inc filed Critical Baxter Travenol Laboratories Inc
Publication of ES513485A0 publication Critical patent/ES513485A0/es
Publication of ES8304800A1 publication Critical patent/ES8304800A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPOSICIONES QUE CONTIENEN EL AGENTE HEMOSTATICO ACTIVADO FACTOR VIIA; COMPOSICIONES QUE TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE PACIENTES CON DEFICIENCIAS O INHIBIDORES DE FACTOR HEMOCOAGULANTES. CONSISTE EN LA SEPARACION DEL FACTOR VII RESPECTO DEL FACTOR IX, DE UN MATERIAL QUE CONTIENE AMBOS; Y ACTIVACION DE LA FRACCION QUE CONTIENE EL FACTOR VII MEDIANTE LA SELECCION DE UNA CONDICION QUE PUEDA MODIFICARSE PARA CONTROLAR EL GRADO DE ACTIVACION DEL FACTOR VII, FIJACION DE LA MAGNITUD DE LA CONDICION NECESARIA PARA LA ACTIVACION A UN GRADO DETERMINADO, ADAPTACION DE LA CONDICION A TAL MAGNITUD, Y REALIZACION DE LA ACTIVACION DE ACUERDO CON LA CONDICION.
ES513485A 1981-06-25 1982-06-25 "procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia". Expired ES8304800A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/277,469 US4382083A (en) 1981-06-25 1981-06-25 Therapeutic method for treating blood-clotting defects with factor VIIa

Publications (2)

Publication Number Publication Date
ES513485A0 ES513485A0 (es) 1983-04-01
ES8304800A1 true ES8304800A1 (es) 1983-04-01

Family

ID=23061015

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513485A Expired ES8304800A1 (es) 1981-06-25 1982-06-25 "procedimiento de preparacion de una composicion terapeutica en la que el unico agente hemostatico activado efectivo sea el factor viia".

Country Status (11)

Country Link
US (1) US4382083A (es)
EP (1) EP0082182B1 (es)
JP (1) JPS58500994A (es)
BR (1) BR8207762A (es)
CA (1) CA1186994A (es)
DE (1) DE3276849D1 (es)
ES (1) ES8304800A1 (es)
IT (1) IT1163004B (es)
MX (1) MX7191E (es)
WO (1) WO1983000016A1 (es)
ZA (1) ZA824233B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501731A (en) * 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
ZA862768B (en) 1985-04-17 1986-12-30 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
JPH0780783B2 (ja) * 1985-11-26 1995-08-30 ノボ ノルディスク アクティーゼルスカブ 出血障害の治療のための第▲ＶＩＩ▼ａ因子を含有する治療組成物
US5180583A (en) * 1985-11-26 1993-01-19 Hedner Ulla K E Method for the treatment of bleeding disorders
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
FR2632524B1 (fr) * 1988-06-09 1992-03-13 Fondation Nale Transfusion San Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament
US5677160A (en) * 1989-10-30 1997-10-14 Henkel Corporation Fat splitting process
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
US20040072757A1 (en) * 1990-09-04 2004-04-15 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5583107A (en) * 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5843442A (en) * 1990-10-22 1998-12-01 Corvas International, Inc. Blood coagulation protein antagonists and uses therefor
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
CZ83194A3 (en) * 1991-10-11 1994-11-16 Novo Nordisk As Haemostatic preparation for inducing blood precipitation on a bleeding wound
WO1993025965A1 (en) * 1992-06-12 1993-12-23 The Dow Chemical Company Intelligent process control communication system and method
BR9608197A (pt) * 1995-05-31 1998-07-21 Henkel Corp Processo contínuo para a produçao de ácidos carboxílicos e glicerina a partir de um glicerídeo
DE19531637A1 (de) * 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
ATE296109T1 (de) * 1996-03-20 2005-06-15 Baxter Ag Pharmazeutisches präparat zur behandlung von blutgerinnungsstörungen
CA2285935C (en) 1997-04-08 2011-01-18 Baxter Aktiengesellschaft An immunotolerant prothrombin complex preparation
US20050032690A1 (en) * 1997-09-10 2005-02-10 Rojkjaer Lisa Payne Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia
JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
JP4676585B2 (ja) * 1999-12-24 2011-04-27 一般財団法人化学及血清療法研究所 血液凝固異常に基づく疾患の治療・予防用医薬組成物
US7015194B2 (en) * 2000-05-10 2006-03-21 Novo Nordisk A/S Pharmaceutical composition comprising factor VIIa and anti-TFPI
US7291587B2 (en) 2001-11-09 2007-11-06 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides
WO2003039579A1 (en) 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and tafi polypeptides
EP1446150A1 (en) * 2001-11-09 2004-08-18 Novo Nordisk Health Care AG Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors
US20030119743A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and tissue plasminogen inhibitors
US7078479B2 (en) 2001-11-09 2006-07-18 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and alpha2-antiplasmin polypeptides
US7125846B2 (en) 2001-11-09 2006-10-24 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides
KR20040065278A (ko) * 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 변경된 인자 ⅶ 폴리펩티드의 액체 조성물
BR0215216A (pt) 2001-12-21 2004-11-16 Novo Nordisk Healthcare Ag Composição aquosa lìquida, método para preparar uma composição aquosa lìquida de um polipeptìdeo de fator vii, uso de uma composição aquosa lìquida, e, método para o tratamento de uma sìndrome de resposta ao fator vii
US20030186862A1 (en) * 2002-04-02 2003-10-02 Nelsestuen Gary L. Factor VIIa compositions
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
BRPI0311959B8 (pt) 2002-06-21 2021-05-25 Novo Nordisk Healthcare Ag composição, métodos para preparar um polipeptídeo estável do fator vii, e para tratar uma síndrome responsiva do fator vii, e, uso do polipeptídeo do fator vii
MXPA05009914A (es) * 2003-03-18 2006-01-09 Novo Nordisk Healthcare Ag Composiciones farmaceuticas acuosas, liquidas de polipeptidos del factor vii.
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
KR20060015574A (ko) * 2003-05-23 2006-02-17 노보 노르디스크 헬스 케어 악티엔게젤샤프트 용액 중 단백질 안정화
WO2005002615A1 (en) * 2003-07-01 2005-01-13 Novo Nordisk Health Care Ag Liquid, aqueous pharmaceutical composition of factor vii polypeptides
CN102872451A (zh) 2003-08-14 2013-01-16 诺和诺德医疗保健公司 因子vii多肽类的含水液体药物组合物
KR20150138427A (ko) * 2003-12-19 2015-12-09 노보 노르디스크 헬스 케어 악티엔게젤샤프트 인자 ｖｉｉ 폴리펩티드의 안정화된 조성물
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560475A (en) * 1969-06-19 1971-02-02 Baxter Laboratories Inc Prothrombin complex prepared by precipitation with polyethylene glycol
AT350726B (de) * 1976-08-30 1979-06-11 Immuno Ag Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma
US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions

Also Published As

Publication number Publication date
ES513485A0 (es) 1983-04-01
EP0082182A1 (en) 1983-06-29
MX7191E (es) 1987-12-23
EP0082182B1 (en) 1987-07-29
DE3276849D1 (en) 1987-09-03
CA1186994A (en) 1985-05-14
JPH0428690B2 (es) 1992-05-15
IT1163004B (it) 1987-04-08
ZA824233B (en) 1983-04-27
IT8222056A0 (it) 1982-06-24
US4382083A (en) 1983-05-03
BR8207762A (pt) 1983-05-31
WO1983000016A1 (en) 1983-01-06
EP0082182A4 (en) 1983-11-09
JPS58500994A (ja) 1983-06-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20030127