DE69131355T2 - Die knochenresorption hemmende verbindungen und zusammensetzungen - Google Patents

Die knochenresorption hemmende verbindungen und zusammensetzungen

Info

Publication number
DE69131355T2
DE69131355T2 DE69131355T DE69131355T DE69131355T2 DE 69131355 T2 DE69131355 T2 DE 69131355T2 DE 69131355 T DE69131355 T DE 69131355T DE 69131355 T DE69131355 T DE 69131355T DE 69131355 T2 DE69131355 T2 DE 69131355T2
Authority
DE
Germany
Prior art keywords
pthrp
amino acid
bone resorption
derivative
inhibitory activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131355T
Other languages
German (de)
English (en)
Other versions
DE69131355D1 (de
Inventor
Anna Jane Fenton
R. Hammonds
Bruce Kemp
Thomas Martin
Geoffrey Charles Nicholson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Genentech Inc
Original Assignee
University of Melbourne
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Melbourne, Genentech Inc filed Critical University of Melbourne
Application granted granted Critical
Publication of DE69131355D1 publication Critical patent/DE69131355D1/de
Publication of DE69131355T2 publication Critical patent/DE69131355T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Transceivers (AREA)
DE69131355T 1990-12-13 1991-12-13 Die knochenresorption hemmende verbindungen und zusammensetzungen Expired - Lifetime DE69131355T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPK387990 1990-12-13
AUPK956791 1991-11-19
PCT/AU1991/000580 WO1992010511A1 (en) 1990-12-13 1991-12-13 Compounds and compositions which inhibit bone resorption

Publications (2)

Publication Number Publication Date
DE69131355D1 DE69131355D1 (de) 1999-07-22
DE69131355T2 true DE69131355T2 (de) 1999-12-30

Family

ID=25643990

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131355T Expired - Lifetime DE69131355T2 (de) 1990-12-13 1991-12-13 Die knochenresorption hemmende verbindungen und zusammensetzungen

Country Status (12)

Country Link
US (1) US5688760A (enExample)
EP (1) EP0561877B1 (enExample)
JP (1) JP3280021B2 (enExample)
AT (1) ATE181336T1 (enExample)
AU (1) AU666838B2 (enExample)
CA (1) CA2096933C (enExample)
DE (1) DE69131355T2 (enExample)
DK (1) DK0561877T3 (enExample)
ES (1) ES2135398T3 (enExample)
GR (1) GR3030947T3 (enExample)
HU (1) HUT64565A (enExample)
WO (1) WO1992010511A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2158762A1 (en) * 1993-04-08 1994-10-27 Hans Rink Cyclic compounds and compositions which inhibit bone resorption
GB9425582D0 (en) * 1994-12-19 1995-02-15 Iaf Biochem Int Peptides having immunomodulatory activity
DE69637104T2 (de) * 1995-02-20 2008-01-31 Yukio Kato Heilmittel für arthrosis deformans und entzündliche gelenkerkrankungen
DE69604936T2 (de) * 1995-03-20 2000-05-18 Shell Internationale Research Maatschappij B.V., Den Haag/S'gravenhage Verfahren zur regeneration von katalysatoren
EP0902036A1 (en) * 1997-09-05 1999-03-17 Roche Diagnostics GmbH Peptide containing an arginine mimetic for the treatment of osteoporosis, their production, and drugs containing these compounds
JP4394279B2 (ja) * 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体
JP2005525312A (ja) * 2002-01-10 2005-08-25 オステオトロフィン エルエルシー 骨同化物質を用いた骨疾患の治療方法
JP2006508646A (ja) * 2002-08-15 2006-03-16 バスキュロスタティン エルエルシー ＰＴＨｒＰ由来の平滑筋増殖モジュレータ
KR20100058555A (ko) * 2007-09-11 2010-06-03 몬도바이오테크 래보래토리즈 아게 치료제로서의 ｂｐｐ－ｂ의 용도
ES2605813B1 (es) * 2015-09-16 2018-01-17 Fundación Instituto De Investigación Sanitaria Fundación Jiménez Díaz Uso de osteostatina en la preparación de un medicamento para el tratamiento de artrosis
US11858974B2 (en) * 2017-05-22 2024-01-02 Resq Biotech Macrocyclic modulators of disease associated protein misfolding and aggregation
EP4713000A2 (en) * 2023-05-15 2026-03-25 Purdue Research Foundation A cytokine-like propeptide gene therapy platform

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78342A (en) * 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
JPS63259972A (ja) * 1987-04-17 1988-10-27 Fuji Electric Co Ltd 燃料電池設備
US5312810A (en) * 1987-05-20 1994-05-17 The University Of Melbourne Method and compositions for making ACSF and ACSF antagonists
JP2795657B2 (ja) * 1987-05-20 1998-09-10 ジェネンテク，インコーポレイテッド Ａｃｓｆおよびａｃｓｆアンタゴニストの製造方法および組成物
US4819504A (en) * 1987-05-27 1989-04-11 Sampson Sports, Inc. Self contained braking system for bicycle pedals
EP0341962B1 (en) * 1988-05-09 1995-03-15 Merck & Co. Inc. Humoral hypercalcemic factor antagonists
JP2752987B2 (ja) * 1988-06-01 1998-05-18 株式会社東芝 リン酸型燃料電池発電プラント

Also Published As

Publication number Publication date
ATE181336T1 (de) 1999-07-15
HU9301726D0 (en) 1993-10-28
WO1992010511A1 (en) 1992-06-25
CA2096933A1 (en) 1992-06-14
DK0561877T3 (da) 1999-12-27
JP3280021B2 (ja) 2002-04-30
HUT64565A (en) 1994-01-28
DE69131355D1 (de) 1999-07-22
AU666838B2 (en) 1996-02-29
GR3030947T3 (en) 1999-11-30
EP0561877A1 (en) 1993-09-29
CA2096933C (en) 2003-05-13
JPH06503330A (ja) 1994-04-14
EP0561877B1 (en) 1999-06-16
US5688760A (en) 1997-11-18
ES2135398T3 (es) 1999-11-01
AU9063291A (en) 1992-07-08
EP0561877A4 (enExample) 1994-03-23

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