DE69625354T2 - Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen - Google Patents

Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen

Info

Publication number
DE69625354T2
DE69625354T2 DE69625354T DE69625354T DE69625354T2 DE 69625354 T2 DE69625354 T2 DE 69625354T2 DE 69625354 T DE69625354 T DE 69625354T DE 69625354 T DE69625354 T DE 69625354T DE 69625354 T2 DE69625354 T2 DE 69625354T2
Authority
DE
Germany
Prior art keywords
relaxin
factor
related methods
analogs
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69625354T
Other languages
English (en)
Other versions
DE69625354D1 (de
Inventor
Christian Schwabe
Elaine Unemori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of South Carolina
Connetics Corp
Connective Therapeutics Inc
Original Assignee
University of South Carolina
Connetics Corp
Connective Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of South Carolina, Connetics Corp, Connective Therapeutics Inc filed Critical University of South Carolina
Application granted granted Critical
Publication of DE69625354D1 publication Critical patent/DE69625354D1/de
Publication of DE69625354T2 publication Critical patent/DE69625354T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69625354T 1995-06-07 1996-05-16 Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen Expired - Lifetime DE69625354T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,219 US5911997A (en) 1995-06-07 1995-06-07 Relaxin-like factor and methods and uses thereof
PCT/US1996/007399 WO1996040186A1 (en) 1995-06-07 1996-05-16 Relaxin-like factor and methods and uses thereof

Publications (2)

Publication Number Publication Date
DE69625354D1 DE69625354D1 (de) 2003-01-23
DE69625354T2 true DE69625354T2 (de) 2003-10-30

Family

ID=23923245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69625354T Expired - Lifetime DE69625354T2 (de) 1995-06-07 1996-05-16 Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen

Country Status (9)

Country Link
US (2) US5911997A (de)
EP (1) EP0831871B1 (de)
JP (1) JP3830520B2 (de)
AT (1) ATE229340T1 (de)
AU (1) AU709115B2 (de)
CA (1) CA2224080C (de)
DE (1) DE69625354T2 (de)
ES (1) ES2188763T3 (de)
WO (1) WO1996040186A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006814A1 (en) * 1995-08-15 1997-02-27 Connective Therapeutics, Inc. Method of promoting angiogenesis
DE19641378C1 (de) * 1996-09-27 1998-04-02 Ihf Inst Fuer Hormon Und Fortp Diagnosehilfe sowie Verfahren zum Nachweis der Trächtigkeit von Wiederkäuern
GB9717652D0 (en) * 1997-08-20 1997-10-22 Nycomed Imaging As Method
AUPR814401A0 (en) 2001-10-08 2001-11-01 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin
US20050186526A1 (en) * 2002-11-01 2005-08-25 Bas Medical, Inc. Methods and systems for enabling and stabilizing tooth movement
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
US7553813B2 (en) * 2004-04-30 2009-06-30 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
EP1984016A1 (de) * 2006-02-17 2008-10-29 Associazione Foresta Per La Ricerca Nella Riproduzione Umana Verwendung von insulin-artigem faktor 3 zur behandlung von osteoporose und knochenerkrankungen
US8574851B2 (en) * 2008-11-24 2013-11-05 Corthera, Inc. Prediction and prevention of preeclampsia
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
MA34521B1 (fr) 2010-08-17 2013-09-02 Ambrx Inc Polypeptides de relaxine modifiés et leurs utilisations
CN103764674A (zh) * 2011-08-04 2014-04-30 法瑞斯生物技术有限公司 制备人松弛素-2的方法
US20160152679A1 (en) * 2012-05-24 2016-06-02 Angion Biomedica Corp. Relaxin-like compounds and uses thereof
US9393288B2 (en) 2012-05-29 2016-07-19 The University Of Vermont And State Agricultural College Methods of treating diseases associated with PPARγ
WO2014040008A1 (en) * 2012-09-10 2014-03-13 Angion Biomedica Corp. Relaxin-like peptides and uses thereof
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
EP4212180A1 (de) 2013-12-18 2023-07-19 The Scripps Research Institute Modifizierte therapeutika, geklammerte peptidlipidkonjugate und zusammensetzungen davon
MA41794A (fr) * 2015-03-18 2018-01-23 The California Institute For Biomedical Res Agents thérapeutiques modifiés et compositions associées
EP3387019B1 (de) 2015-12-09 2021-10-20 The Scripps Research Institute Relaxin-immunglobulin-fusionsproteine und verfahren zur verwendung
TW201837051A (zh) 2017-02-08 2018-10-16 美商必治妥美雅史谷比公司 包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101309B1 (de) * 1982-08-12 1991-01-16 Howard Florey Institute Of Experimental Physiology And Medicine Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia

Also Published As

Publication number Publication date
US5911997A (en) 1999-06-15
WO1996040186A1 (en) 1996-12-19
US6949506B2 (en) 2005-09-27
CA2224080A1 (en) 1996-12-19
US20030158376A1 (en) 2003-08-21
EP0831871A1 (de) 1998-04-01
ES2188763T3 (es) 2003-07-01
EP0831871A4 (de) 1999-03-03
AU5869996A (en) 1996-12-30
ATE229340T1 (de) 2002-12-15
JPH11512072A (ja) 1999-10-19
EP0831871B1 (de) 2002-12-11
AU709115B2 (en) 1999-08-19
JP3830520B2 (ja) 2006-10-04
DE69625354D1 (de) 2003-01-23
CA2224080C (en) 2010-07-27

Similar Documents

Publication Publication Date Title
DE69625354T2 (de) Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen
UA39099C2 (uk) Циклічні азотовмісні похідні, суміш їх ізомерів або окремі ізомери, або їх солі
DE69315503T2 (de) Aufblaseinrichtung für Gaskissen mit inhibierten, gaserzeugenden Zusammensetzungen
DE69716135T2 (de) In 6-position durch thio substituierte paclitaxele
DE69216532T2 (de) Azidfreie gaserzeugende Zusammensetzungen
ES2195970T3 (es) L-ribavirina y usos de la misma.
DE69004692T2 (de) Kohlenwasserstoffzusammensetzungen und Zusätze dafür.
MX9203396A (es) Monohidrato de furoato de mometasona, proceso para producirlo y composiciones farmaceuticas.
BG102259A (en) Compostions with controlled paroxetine release
DK1144472T3 (da) Vandige reaktive spartelmasser (II)
ES2181744T3 (es) Hidratos de paclitaxel cristalinos.
DE69421784T2 (de) Kraftstoffzusammensetzungen, und Zusätze dafür
MX9804588A (es) Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
IL109720A (en) N-alkylthio polyamine derivatives and radioprotective compositions containing them
DE69400872D1 (de) Kraftstoffzusammensetzungen
EA199800534A1 (ru) ПРИМЕНЕНИЕ 2-ЭТИЛГЕКСИЛ-α-ЦИАНО-β, β-ДИФЕНИЛАКРИАТА ДЛЯ УЛУЧШЕНИЯ СТАБИЛЬНОСТИ КОСМЕТИЧЕСКИХ КОМПОЗИЦИЙ, СОДЕРЖАЩИХ П-МЕТИЛБЕНЗИЛИДЕНКАМФОРУВ СОЧЕТАНИИ С ДИБЕНЗОИЛМЕТАНОВЫМ ПРОИЗВОДНЫМ
DE68920622D1 (de) Polyketonzusammensetzungen.
MX9602836A (es) MEZCLA QUE CONTIENE UNO O VARIOS ALFA-AMINOACIDOS Y SUS DERIVADOS, O AMBOS, Y UNO O VARIOS CICLOPENTANO- beta-AMINOACIDOS Y SUS DERIVADOS, O AMBOS.
MX9603199A (es) Antagonistas de receptores a endotelina.
EA200000531A1 (ru) Применение кетолидов для профилактики тромботических артериальных осложнений, связанных с атеросклерозом
DE69831737D1 (de) Neurotrypsin
DK0720597T3 (da) Triarylethylenderivater til terapeutisk anvendelse
DK0457127T3 (da) Spermicidt belægningsmiddel
ATE204286T1 (de) Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
DE68917051T2 (de) Rheologisches Zusatzmittel für Überzugsmassen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition