DE69131233T2 - Verfahren und reagens zum nachweis von spezifischen nukleotid-variationen - Google Patents

Verfahren und reagens zum nachweis von spezifischen nukleotid-variationen

Info

Publication number
DE69131233T2
DE69131233T2 DE69131233T DE69131233T DE69131233T2 DE 69131233 T2 DE69131233 T2 DE 69131233T2 DE 69131233 T DE69131233 T DE 69131233T DE 69131233 T DE69131233 T DE 69131233T DE 69131233 T2 DE69131233 T2 DE 69131233T2
Authority
DE
Germany
Prior art keywords
detection step
incorporation
variable nucleotide
reagent
primer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131233T
Other languages
English (en)
Other versions
DE69131233D1 (de
Inventor
Hans Soederlund
Ann-Christine Syvaenen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANGTEC MEDICAL BROMMA AB
Original Assignee
SANGTEC MEDICAL BROMMA AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANGTEC MEDICAL BROMMA AB filed Critical SANGTEC MEDICAL BROMMA AB
Publication of DE69131233D1 publication Critical patent/DE69131233D1/de
Application granted granted Critical
Publication of DE69131233T2 publication Critical patent/DE69131233T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69131233T 1990-02-16 1991-02-15 Verfahren und reagens zum nachweis von spezifischen nukleotid-variationen Expired - Fee Related DE69131233T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48200590A 1990-02-16 1990-02-16
PCT/FI1991/000046 WO1991013075A2 (en) 1990-02-16 1991-02-15 Method and reagent for determining specific nucleotide variations

Publications (2)

Publication Number Publication Date
DE69131233D1 DE69131233D1 (de) 1999-06-17
DE69131233T2 true DE69131233T2 (de) 1999-11-04

Family

ID=23914258

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0648280T Pending DE648280T1 (de) 1990-02-16 1991-02-15 Verfahren und reagens zum nachweis von spezifischen nukleotid-variationen.
DE69131233T Expired - Fee Related DE69131233T2 (de) 1990-02-16 1991-02-15 Verfahren und reagens zum nachweis von spezifischen nukleotid-variationen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0648280T Pending DE648280T1 (de) 1990-02-16 1991-02-15 Verfahren und reagens zum nachweis von spezifischen nukleotid-variationen.

Country Status (18)

Country Link
EP (1) EP0648280B1 (de)
JP (1) JP2786011B2 (de)
AT (1) ATE180019T1 (de)
AU (1) AU642709B2 (de)
CA (1) CA2071537C (de)
DE (2) DE648280T1 (de)
DK (1) DK0648280T3 (de)
ES (1) ES2072235T3 (de)
FI (1) FI102297B (de)
GR (2) GR950300047T1 (de)
HU (1) HU211058B (de)
IE (1) IE910525A1 (de)
IL (1) IL97222A (de)
NO (1) NO311529B1 (de)
NZ (1) NZ237134A (de)
PT (1) PT96776B (de)
WO (1) WO1991013075A2 (de)
ZA (1) ZA911152B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
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DE10245145A1 (de) * 2002-09-27 2004-04-08 IPK-Institut für Pflanzengenetik und Kulturpflanzenforschung Verfahren zum Nachweis von SNPs auf polydimensionalen Microarrays

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US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US6004744A (en) * 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
AU1741692A (en) * 1991-03-13 1992-10-21 Regents Of The University Of California, The Detection of 3'-azido-3'-deoxythymidine resistance
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
US7026115B1 (en) 1991-09-24 2006-04-11 Keygene N.V. Selective restriction fragment amplification: fingerprinting
GB9208000D0 (en) * 1992-04-10 1992-05-27 Univ London Quantitative viral assay
WO1993022457A1 (en) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Screening for genetic variation
JP2001507921A (ja) * 1992-04-27 2001-06-19 トラスティーズ オブ ダートマス カレッジ 生物学的液体中の遺伝子配列の検出
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US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
DE69232846T2 (de) * 1992-06-17 2003-08-21 City Of Hope Duarte Verfahren zum nachweis und unterscheiden von nukleinsäuresequenzen
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US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
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Publication number Priority date Publication date Assignee Title
DE10245145A1 (de) * 2002-09-27 2004-04-08 IPK-Institut für Pflanzengenetik und Kulturpflanzenforschung Verfahren zum Nachweis von SNPs auf polydimensionalen Microarrays
DE10245145B4 (de) * 2002-09-27 2004-12-02 IPK-Institut für Pflanzengenetik und Kulturpflanzenforschung Verfahren zum Nachweis von SNPs auf polydimensionalen Microarrays

Also Published As

Publication number Publication date
NO311529B1 (no) 2001-12-03
AU642709B2 (en) 1993-10-28
FI923653A (fi) 1992-08-14
GR950300047T1 (en) 1995-07-31
WO1991013075A3 (en) 1991-10-17
FI102297B1 (fi) 1998-11-13
FI923653A0 (fi) 1992-08-14
FI102297B (fi) 1998-11-13
HU910516D0 (en) 1991-09-30
IL97222A0 (en) 1992-05-25
DE648280T1 (de) 1995-11-30
GR3030790T3 (en) 1999-11-30
DE69131233D1 (de) 1999-06-17
PT96776B (pt) 1998-05-29
IE910525A1 (en) 1991-08-28
JP2786011B2 (ja) 1998-08-13
EP0648280A1 (de) 1995-04-19
WO1991013075A2 (en) 1991-09-05
AU7235191A (en) 1991-09-18
JPH05504477A (ja) 1993-07-15
ES2072235T3 (es) 1999-07-16
DK0648280T3 (da) 1999-11-01
ES2072235T1 (es) 1995-07-16
IL97222A (en) 1995-08-31
CA2071537A1 (en) 1991-08-17
PT96776A (pt) 1991-10-31
CA2071537C (en) 2003-02-11
NO923116L (no) 1992-08-10
HU211058B (en) 1995-10-30
ATE180019T1 (de) 1999-05-15
ZA911152B (en) 1991-11-27
EP0648280B1 (de) 1999-05-12
HUT61330A (en) 1992-12-28
NO923116D0 (no) 1992-08-10
NZ237134A (en) 1992-06-25

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