AU3539089A - Ligase-based amplification method - Google Patents

Ligase-based amplification method

Info

Publication number
AU3539089A
AU3539089A AU35390/89A AU3539089A AU3539089A AU 3539089 A AU3539089 A AU 3539089A AU 35390/89 A AU35390/89 A AU 35390/89A AU 3539089 A AU3539089 A AU 3539089A AU 3539089 A AU3539089 A AU 3539089A
Authority
AU
Australia
Prior art keywords
ligase
amplification method
based amplification
amplification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35390/89A
Inventor
Leslie E. Orgel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of AU3539089A publication Critical patent/AU3539089A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • AIDS & HIV (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU35390/89A 1988-04-08 1989-04-07 Ligase-based amplification method Abandoned AU3539089A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17947888A 1988-04-08 1988-04-08
US179478 1988-04-08

Publications (1)

Publication Number Publication Date
AU3539089A true AU3539089A (en) 1989-11-03

Family

ID=22656760

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35390/89A Abandoned AU3539089A (en) 1988-04-08 1989-04-07 Ligase-based amplification method

Country Status (2)

Country Link
AU (1) AU3539089A (en)
WO (1) WO1989009835A1 (en)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
ATE144556T1 (en) * 1988-06-24 1996-11-15 Amgen Inc METHOD AND MEANS FOR DETECTING NUCLEIC ACID SEQUENCES
US6004826A (en) * 1988-07-20 1999-12-21 David Segev Repair-mediated process for amplifying and detecting nucleic acid sequences
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5683896A (en) * 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and reagent for determining specific nucleotide variations
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
DK0528882T3 (en) * 1990-05-03 2008-01-14 Cornell Res Foundation Inc DNA amplification system for detection of genetic diseases by thermostable ligase
US5439793A (en) * 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
CA2049879A1 (en) * 1990-08-30 1992-03-01 Keith C. Backman Controlled initial target-dependent production of templates for ligase chain reaction
GB9112251D0 (en) * 1991-06-07 1991-07-24 Amersham Int Plc Quantitative detection of nucleic acid amplification products
EP0519338B1 (en) 1991-06-20 1996-08-28 F. Hoffmann-La Roche Ag Improved methods for nucleic acid amplification
DE4129653A1 (en) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh PROCESS FOR DETECTION OF SIMILAR NUCLEIC ACIDS
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US6100099A (en) * 1994-09-06 2000-08-08 Abbott Laboratories Test strip having a diagonal array of capture spots
US5869252A (en) * 1992-03-31 1999-02-09 Abbott Laboratories Method of multiplex ligase chain reaction
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
DE69424541T2 (en) * 1993-03-22 2000-12-14 The Perkin-Elmer Corp., Norwalk ENZYMATIC LIGATION OF 3'-AMINO SUBSTITUTED OLIGONUCLEOTIDES
US5593826A (en) * 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
US6406841B1 (en) 1993-07-01 2002-06-18 Abbott Laboratories Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides
DE69506393T2 (en) * 1994-04-04 1999-07-01 Ciba Corning Diagnostics Corp., Medfield, Mass. HYBRIDISATION-LIGITATION METHOD FOR DETECTING SPECIFIC DNA SEQUENCES
WO1995029251A1 (en) * 1994-04-25 1995-11-02 Applied Technology Genetics Corporation Detection of mutation by resolvase cleavage
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
DE69535882D1 (en) * 1994-12-30 2008-12-18 Univ Georgetown FLUORESCENT TEST FOR DETECTING THE CLEAVAGE OF NUCLEIC ACID
US20030165908A1 (en) 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6113905A (en) * 1995-01-06 2000-09-05 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6077510A (en) * 1995-01-06 2000-06-20 Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6015660A (en) * 1995-01-06 2000-01-18 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
DE69605803T2 (en) * 1995-05-11 2000-07-20 Arild Lagerkvist DETECTION OF MALFUNCTIONS BY CUTTING WITH A RESOLVASE ON A SOLID CARRIER
US5770368A (en) * 1996-05-09 1998-06-23 Metropolitan Water District Of Southern California Cryptosporidium detection method
US6436638B1 (en) 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
EP1053352B1 (en) * 1998-02-04 2002-09-18 Variagenics, Inc. Mismatch detection techniques
CN1361829A (en) 1999-03-18 2002-07-31 埃克西库恩公司 Detection of mutations in genes by specific LNA primers
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
ATE413467T1 (en) 1999-04-20 2008-11-15 Illumina Inc DETECTION OF NUCLEIC ACID REACTIONS ON BEAD ARRAYS
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
AU3838901A (en) 2000-02-16 2001-08-27 Illumina Inc Parallel genotyping of multiple patient samples
ATE380883T1 (en) 2000-10-24 2007-12-15 Univ Leland Stanford Junior DIRECT MULTIPLEX CHARACTERIZATION OF GENOMIC DNA
AU2003303395A1 (en) 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
EP1481076A4 (en) 2001-07-12 2005-05-11 Illumina Inc Multiplex nucleic acid reactions
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CA2528577C (en) 2003-06-20 2012-08-07 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CA2530810A1 (en) 2003-07-03 2005-01-27 The Regents Of The University Of California Genome mapping of functional dna elements and cellular proteins
WO2005114166A1 (en) 2004-05-21 2005-12-01 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
CN102680440A (en) 2004-06-07 2012-09-19 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
WO2007059179A1 (en) 2005-11-14 2007-05-24 Gen-Probe Incorporated Parametric calibration method
US7981606B2 (en) 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
JP6017458B2 (en) 2011-02-02 2016-11-02 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション Mass parallel continuity mapping
WO2014018885A2 (en) 2012-07-27 2014-01-30 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US20160110498A1 (en) 2013-03-13 2016-04-21 Illumina, Inc. Methods and systems for aligning repetitive dna elements
CA2898456C (en) 2013-03-13 2020-11-10 Illumina, Inc. Methods and compositions for nucleic acid sequencing
JP6463332B2 (en) 2013-03-15 2019-01-30 ジェン−プローブ・インコーポレーテッド Calibration method, apparatus and computer program product
EP3080268A1 (en) 2013-12-09 2016-10-19 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
CN106414765A (en) 2013-12-20 2017-02-15 Illumina公司 Preserving genomic connectivity information in fragmented genomic DNA samples
WO2015108663A1 (en) 2014-01-16 2015-07-23 Illumina, Inc. Amplicon preparation and sequencing on solid supports
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
EP3110960B1 (en) 2014-02-28 2020-02-19 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
GB2528344B (en) 2014-02-28 2018-10-31 Gen Probe Inc Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
EP3155125A1 (en) 2014-06-13 2017-04-19 Illumina Cambridge Limited Methods and compositions for preparing sequencing libraries
SG11201610910QA (en) 2014-06-30 2017-01-27 Illumina Inc Methods and compositions using one-sided transposition
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
EP3194627B1 (en) 2014-09-18 2023-08-16 Illumina, Inc. Methods and systems for analyzing nucleic acid sequencing data
CA2964799A1 (en) 2014-10-17 2016-04-21 Illumina Cambridge Limited Contiguity preserving transposition
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
CN107532205B (en) 2015-03-31 2021-06-08 伊卢米纳剑桥有限公司 Surface concatemerization of templates
WO2016164407A2 (en) 2015-04-07 2016-10-13 Polyskope Labs Detection of one or more pathogens
CN115261468A (en) 2015-07-06 2022-11-01 伊卢米纳剑桥有限公司 Sample preparation for nucleic acid amplification
DK3377226T3 (en) 2016-03-28 2021-04-26 Illumina Inc Micro rows in several levels
EP3904514A1 (en) 2016-07-22 2021-11-03 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
DK3615691T3 (en) 2017-04-23 2021-07-26 Illumina Inc Compositions and methods for improving sample identification in indexed nucleic acid libraries
US11459610B2 (en) 2017-04-23 2022-10-04 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
AU2018260627B2 (en) 2017-04-23 2024-08-22 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
EP3635136B1 (en) 2017-06-07 2021-10-20 Oregon Health & Science University Single cell whole genome libraries for methylation sequencing
CN110785813A (en) 2017-07-31 2020-02-11 伊鲁米那股份有限公司 Sequencing system with multi-path biological sample aggregation
CA3067048C (en) 2017-08-01 2024-03-05 Illumina, Inc. Hydrogel beads for nucleotide sequencing
KR20220123327A (en) 2018-02-13 2022-09-06 일루미나, 인코포레이티드 DNA sequencing using hydrogel beads
AU2019248635B2 (en) 2018-04-02 2022-01-27 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
KR20240052875A (en) 2018-04-20 2024-04-23 일루미나, 인코포레이티드 Methods of encapsulating single cells, the encapsulated cells and uses thereof
CA3206377A1 (en) 2018-05-17 2019-11-21 Illumina, Inc. High-throughput single-cell sequencing with reduced amplification bias
KR102507415B1 (en) 2018-06-04 2023-03-07 일루미나, 인코포레이티드 High-throughput single-cell transcriptome libraries and methods of making and of using
EP3870721A1 (en) 2018-10-26 2021-09-01 Illumina Inc Modulating polymer beads for dna processing
US12104281B2 (en) 2018-11-30 2024-10-01 Illumina, Inc. Analysis of multiple analytes using a single assay
CN113302300A (en) 2019-03-01 2021-08-24 伊路敏纳公司 High throughput single cell nuclei and single cell libraries and methods of making and using the same
AU2020312787A1 (en) 2019-07-12 2021-06-17 Illumina Cambridge Limited Nucleic acid library preparation using electrophoresis
US20220154173A1 (en) 2019-07-12 2022-05-19 Iiiumina Cambridge Limited Compositions and Methods for Preparing Nucleic Acid Sequencing Libraries Using CRISPR/CAS9 Immobilized on a Solid Support
EP4073268B1 (en) 2019-12-09 2024-04-10 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
MX2021011847A (en) 2019-12-19 2021-11-17 Illumina Inc High-throughput single-cell libraries and methods of making and of using.
EP4127220B1 (en) 2020-03-30 2024-06-05 Illumina, Inc. Methods and compositions for preparing nucleic acid libraries
WO2021231477A2 (en) 2020-05-12 2021-11-18 Illumina, Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
KR20230037503A (en) 2020-06-30 2023-03-16 일루미나, 인코포레이티드 Sequencing by catalytically controlled synthesis to generate traceless DNA
EP4192951A1 (en) 2020-08-06 2023-06-14 Illumina, Inc. Preparation of rna and dna sequencing libraries using bead-linked transposomes
KR20230051508A (en) 2020-08-18 2023-04-18 일루미나, 인코포레이티드 Sequence-specific targeted translocation and selection and sorting of nucleic acids
JP2023540177A (en) 2020-09-11 2023-09-22 イルミナ ケンブリッジ リミテッド How to enrich target sequences from sequencing libraries using hairpin adapters
CA3208854A1 (en) 2021-02-04 2022-08-11 Illumina, Inc. Long indexed-linked read generation on transposome bound beads
MX2023011219A (en) 2021-03-29 2023-10-02 Illumina Inc Compositions and methods for assessing dna damage in a library and normalizing amplicon size bias.
MX2023010814A (en) 2021-03-29 2023-09-27 Illumina Inc Improved methods of library preparation.
MX2023010495A (en) 2021-03-30 2023-09-18 Illumina Inc Improved methods of isothermal complementary dna and library preparation.
CA3211172A1 (en) 2021-03-31 2022-10-06 Illumina, Inc. Methods of preparing directional tagmentation sequencing libraries using transposon-based technology with unique molecular identifiers for error correction
CA3223722A1 (en) 2022-04-07 2023-10-12 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073659A1 (en) 2022-09-30 2024-04-04 Biotheranostics, Inc. Biomarker assay to select breast cancer therapy
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663283A (en) * 1980-03-24 1987-05-05 Genentech, Inc. Method of altering double-stranded DNA
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences

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