DE69033863T2 - Verwendung von 5-methyl-1-phenyl-2-(1H)-pyridon zur Vorbeugung fibrotischer Schädigungen - Google Patents
Verwendung von 5-methyl-1-phenyl-2-(1H)-pyridon zur Vorbeugung fibrotischer SchädigungenInfo
- Publication number
- DE69033863T2 DE69033863T2 DE69033863T DE69033863T DE69033863T2 DE 69033863 T2 DE69033863 T2 DE 69033863T2 DE 69033863 T DE69033863 T DE 69033863T DE 69033863 T DE69033863 T DE 69033863T DE 69033863 T2 DE69033863 T2 DE 69033863T2
- Authority
- DE
- Germany
- Prior art keywords
- fibrotic
- fibrosis
- pyridone
- methyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1035436A JPH02215719A (ja) | 1989-02-15 | 1989-02-15 | 線維化病変組織の修復並びに線維化病変の阻止剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69033863D1 DE69033863D1 (de) | 2002-01-03 |
| DE69033863T2 true DE69033863T2 (de) | 2002-06-13 |
Family
ID=12441800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69033863T Expired - Lifetime DE69033863T2 (de) | 1989-02-15 | 1990-02-15 | Verwendung von 5-methyl-1-phenyl-2-(1H)-pyridon zur Vorbeugung fibrotischer Schädigungen |
| DE69034143T Expired - Lifetime DE69034143T2 (de) | 1989-02-15 | 1990-02-15 | Zusammensetzung, welche 5-Methyl-1-phenyl-2-(1 H)-pyridone enthält, zur fixierung und Vermeidung von fibrotischen Schädigungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69034143T Expired - Lifetime DE69034143T2 (de) | 1989-02-15 | 1990-02-15 | Zusammensetzung, welche 5-Methyl-1-phenyl-2-(1 H)-pyridone enthält, zur fixierung und Vermeidung von fibrotischen Schädigungen |
Country Status (9)
| Country | Link |
|---|---|
| EP (3) | EP0458861B1 (enExample) |
| JP (1) | JPH02215719A (enExample) |
| AT (1) | ATE136215T1 (enExample) |
| AU (1) | AU633541B2 (enExample) |
| CA (1) | CA2010017C (enExample) |
| DE (2) | DE69033863T2 (enExample) |
| DK (1) | DK0458861T3 (enExample) |
| ES (2) | ES2220612T3 (enExample) |
| WO (1) | WO1990009176A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215719A (ja) * | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
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| JP4542743B2 (ja) | 2002-12-26 | 2010-09-15 | Ｋｄｌ株式会社 | ピリドン誘導体の溶液状医薬組成物 |
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| CN1846699A (zh) * | 2005-04-13 | 2006-10-18 | 中南大学湘雅医院 | 1－(取代苯基)－5－甲基－2－(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用 |
| NZ591443A (en) * | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| JP5213852B2 (ja) | 2006-06-15 | 2013-06-19 | シャンハイ ゲノミックス インク | 放射線肺障害の予防及び治療のためのピリドン系誘導体の使用 |
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| KR101767849B1 (ko) | 2007-06-20 | 2017-08-11 | 오스펙스 파마슈티칼스, 인코포레이티드 | 섬유증 저해제로서의 치환된 ｎ-아릴 피리디논 |
| CN101918364B (zh) * | 2008-10-21 | 2013-02-13 | 史跃年 | 用于治疗高蛋白尿的药物组合物 |
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| CN103917223B (zh) * | 2011-09-14 | 2017-08-08 | 盐野义制药株式会社 | 供吸入的药用组合物 |
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| US12226407B2 (en) | 2012-07-24 | 2025-02-18 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
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| RU2694254C1 (ru) * | 2013-12-19 | 2019-07-11 | Саншайн Лейк Фарма Ко., Лтд. | Азотсодержащие гетероциклические производные и их применение в лекарственных препаратах |
| EP3307714A1 (en) | 2015-01-26 | 2018-04-18 | Ulkar Kimya Sanayii Ve Ticaret A. S. | An improved method for the synthesis and purification of pirfenidone |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| TWI745396B (zh) | 2016-07-12 | 2021-11-11 | 日商鹽野義製藥股份有限公司 | 吸入用醫藥組成物 |
| CN109223723B (zh) * | 2017-07-11 | 2021-08-27 | 南京华威医药科技集团有限公司 | 吡非尼酮片剂及其制备方法和用途 |
| MX368750B (es) | 2018-08-31 | 2019-10-15 | Cell Therapy And Tech S A De C V | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6816241A (enExample) * | 1967-12-01 | 1969-06-03 | ||
| US3721676A (en) * | 1969-11-12 | 1973-03-20 | Merck & Co Inc | Certain 3-amino-2(1h)pyridones |
| US3644626A (en) * | 1969-11-25 | 1972-02-22 | Merck & Co Inc | Novel pyridones in compositions and methods for treating inflammation pain and fever |
| US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
| CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| US4042699A (en) * | 1972-12-18 | 1977-08-16 | Affiliated Medical Research, Inc. | Method for reducing serum glucose levels |
| US4052509A (en) * | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
| ZA757570B (en) * | 1974-12-09 | 1977-07-27 | Affiliated Med Res | A useful n-substituted pyridone |
| JPH02215719A (ja) * | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
-
1989
- 1989-02-15 JP JP1035436A patent/JPH02215719A/ja active Granted
-
1990
- 1990-01-26 DK DK90903464.7T patent/DK0458861T3/da active
- 1990-01-26 WO PCT/US1990/000449 patent/WO1990009176A1/en not_active Ceased
- 1990-01-26 AT AT90903464T patent/ATE136215T1/de not_active IP Right Cessation
- 1990-01-26 EP EP90903464A patent/EP0458861B1/en not_active Expired - Lifetime
- 1990-02-14 CA CA002010017A patent/CA2010017C/en not_active Expired - Lifetime
- 1990-02-15 ES ES01107235T patent/ES2220612T3/es not_active Expired - Lifetime
- 1990-02-15 DE DE69033863T patent/DE69033863T2/de not_active Expired - Lifetime
- 1990-02-15 ES ES90301607T patent/ES2163389T3/es not_active Expired - Lifetime
- 1990-02-15 EP EP01107235A patent/EP1138329B8/en not_active Expired - Lifetime
- 1990-02-15 EP EP90301607A patent/EP0383591B1/en not_active Expired - Lifetime
- 1990-02-15 AU AU49812/90A patent/AU633541B2/en not_active Expired
- 1990-02-15 DE DE69034143T patent/DE69034143T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1138329B1 (en) | 2004-06-02 |
| EP0383591B1 (en) | 2001-11-21 |
| EP0458861B1 (en) | 1996-04-03 |
| WO1990009176A1 (en) | 1990-08-23 |
| DE69034143D1 (de) | 2004-07-08 |
| JPH0552814B2 (enExample) | 1993-08-06 |
| ES2163389T3 (es) | 2002-02-01 |
| DE69034143T2 (de) | 2005-06-30 |
| DK0458861T3 (da) | 1996-08-12 |
| EP0383591A2 (en) | 1990-08-22 |
| AU4981290A (en) | 1990-08-23 |
| ATE136215T1 (de) | 1996-04-15 |
| EP0383591A3 (en) | 1992-01-15 |
| JPH02215719A (ja) | 1990-08-28 |
| CA2010017A1 (en) | 1990-08-15 |
| EP1138329A2 (en) | 2001-10-04 |
| ES2220612T3 (es) | 2004-12-16 |
| EP1138329B8 (en) | 2006-05-17 |
| AU633541B2 (en) | 1993-02-04 |
| CA2010017C (en) | 1995-09-05 |
| DE69033863D1 (de) | 2002-01-03 |
| EP0458861A4 (en) | 1992-07-08 |
| EP1138329A3 (en) | 2002-04-17 |
| EP0458861A1 (en) | 1991-12-04 |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: KDL GMBH, ZUG, CH Owner name: MARGOLIN, SOLOMON B., DALLAS, TEX., US |
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| 8327 | Change in the person/name/address of the patent owner |
Owner name: INTERMUNE, INC., BRISBANE, CALIF., US |