ATE136215T1 - Zusammensetzung zur reparatur und vorbeugung fibrotischer schäden - Google Patents
Zusammensetzung zur reparatur und vorbeugung fibrotischer schädenInfo
- Publication number
- ATE136215T1 ATE136215T1 AT90903464T AT90903464T ATE136215T1 AT E136215 T1 ATE136215 T1 AT E136215T1 AT 90903464 T AT90903464 T AT 90903464T AT 90903464 T AT90903464 T AT 90903464T AT E136215 T1 ATE136215 T1 AT E136215T1
- Authority
- AT
- Austria
- Prior art keywords
- prevention
- composition
- repair
- fibrotic
- fibrotic damage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1035436A JPH02215719A (ja) | 1989-02-15 | 1989-02-15 | 線維化病変組織の修復並びに線維化病変の阻止剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE136215T1 true ATE136215T1 (de) | 1996-04-15 |
Family
ID=12441800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90903464T ATE136215T1 (de) | 1989-02-15 | 1990-01-26 | Zusammensetzung zur reparatur und vorbeugung fibrotischer schäden |
Country Status (9)
Country | Link |
---|---|
EP (3) | EP0458861B1 (de) |
JP (1) | JPH02215719A (de) |
AT (1) | ATE136215T1 (de) |
AU (1) | AU633541B2 (de) |
CA (1) | CA2010017C (de) |
DE (2) | DE69033863T2 (de) |
DK (1) | DK0458861T3 (de) |
ES (2) | ES2220612T3 (de) |
WO (1) | WO1990009176A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02215719A (ja) * | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
US5716632A (en) * | 1989-11-22 | 1998-02-10 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
JPH08510251A (ja) * | 1993-05-07 | 1996-10-29 | ビー マーゴリン、ソロモン | 線維症の病変の修復と予防のための組成物および方法 |
EP0813409B1 (de) * | 1995-03-03 | 2004-05-06 | MARGOLIN, Solomon B. | Behandlung von erkrankungen, die vom cytokinwachstumsfaktor verursacht werden |
AU1226099A (en) * | 1998-09-18 | 2000-04-10 | Mepha Ag | Topical formulation of alkyl-, phenyl-pyridone |
US7867516B2 (en) | 2001-01-29 | 2011-01-11 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
JP4542743B2 (ja) | 2002-12-26 | 2010-09-15 | Kdl株式会社 | ピリドン誘導体の溶液状医薬組成物 |
TW200501952A (en) * | 2003-02-21 | 2005-01-16 | Shionogi & Co | Pirfenidone gel formulations |
WO2004073680A1 (ja) * | 2003-02-21 | 2004-09-02 | Shionogi & Co., Ltd. | 液滴分散型軟膏剤 |
US7825133B2 (en) | 2003-11-14 | 2010-11-02 | Shanghai Genomics, Inc. | Derivatives of pyridone and the use of them |
CN1846699A (zh) * | 2005-04-13 | 2006-10-18 | 中南大学湘雅医院 | 1-(取代苯基)-5-甲基-2-(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用 |
NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
ATE533486T1 (de) | 2006-06-15 | 2011-12-15 | Shanghai Genomics Inc | Verwendung von pyridonderivaten zur vorbeugung und behandlung von strahlungsbedingter lungenverletzung |
MX2007006347A (es) * | 2007-05-29 | 2009-02-18 | Cell Therapy And Technology S | Nuevo uso de 5-metil-1-fenil-2-(1h)-piridona para el tratamiento y prevencion de cicatrices hipertroficas, y composicion conteniendo la misma. |
NZ599643A (en) | 2007-06-20 | 2013-11-29 | Auspex Pharmaceuticals Inc | Substituted N-aryl pyridinones as fibrotic inhibitors |
CN101918364B (zh) * | 2008-10-21 | 2013-02-13 | 史跃年 | 用于治疗高蛋白尿的药物组合物 |
US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
US8084475B2 (en) | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
US7816383B1 (en) * | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
EP4059499A1 (de) * | 2011-01-31 | 2022-09-21 | Avalyn Pharma Inc. | Aerosolförmige pirfenidon- und pyridonanalogverbindungen und verwendungen davon |
US9018232B2 (en) | 2011-03-08 | 2015-04-28 | Auspex Pharmaceuticals, Inc. | Substituted N-aryl pyridinones |
JP5872564B2 (ja) * | 2011-09-14 | 2016-03-01 | 塩野義製薬株式会社 | 吸入用医薬組成物 |
CA2872110C (en) | 2012-07-18 | 2019-08-06 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
CA2819967C (en) | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
EP3083584B1 (de) * | 2013-12-19 | 2018-02-21 | Sunshine Lake Pharma Co., Ltd. | Heterocyclische stickstoffderivate und deren anwendung in arzneimitteln zur behandlung von der gewebefibrose |
EP3307714A1 (de) | 2015-01-26 | 2018-04-18 | Ulkar Kimya Sanayii Ve Ticaret A. S. | Verbessertes verfahren für die synthese und reinigung von pirfenidon |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
TWI745396B (zh) | 2016-07-12 | 2021-11-11 | 日商鹽野義製藥股份有限公司 | 吸入用醫藥組成物 |
CN109223723B (zh) * | 2017-07-11 | 2021-08-27 | 南京华威医药科技集团有限公司 | 吡非尼酮片剂及其制备方法和用途 |
MX368750B (es) | 2018-08-31 | 2019-10-15 | Cell Therapy And Tech S A De C V | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular. |
MX2020005775A (es) * | 2020-07-13 | 2022-01-14 | Centro De Retina Medica Y Quirurgica S C | Uso farmaceutico de pirfenidona para la reduccion de fibrosis cardiaca en pacientes con cardiomiopatia y/o esteatosis cardiaca y/o covid-19. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6816241A (de) * | 1967-12-01 | 1969-06-03 | ||
US3721676A (en) * | 1969-11-12 | 1973-03-20 | Merck & Co Inc | Certain 3-amino-2(1h)pyridones |
US3644626A (en) * | 1969-11-25 | 1972-02-22 | Merck & Co Inc | Novel pyridones in compositions and methods for treating inflammation pain and fever |
US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
US4042699A (en) * | 1972-12-18 | 1977-08-16 | Affiliated Medical Research, Inc. | Method for reducing serum glucose levels |
CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
US4052509A (en) * | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
ZA757570B (en) * | 1974-12-09 | 1977-07-27 | Affiliated Med Res | A useful n-substituted pyridone |
JPH02215719A (ja) * | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
-
1989
- 1989-02-15 JP JP1035436A patent/JPH02215719A/ja active Granted
-
1990
- 1990-01-26 EP EP90903464A patent/EP0458861B1/de not_active Expired - Lifetime
- 1990-01-26 DK DK90903464.7T patent/DK0458861T3/da active
- 1990-01-26 AT AT90903464T patent/ATE136215T1/de not_active IP Right Cessation
- 1990-01-26 WO PCT/US1990/000449 patent/WO1990009176A1/en active IP Right Grant
- 1990-02-14 CA CA002010017A patent/CA2010017C/en not_active Expired - Lifetime
- 1990-02-15 ES ES01107235T patent/ES2220612T3/es not_active Expired - Lifetime
- 1990-02-15 DE DE69033863T patent/DE69033863T2/de not_active Expired - Lifetime
- 1990-02-15 ES ES90301607T patent/ES2163389T3/es not_active Expired - Lifetime
- 1990-02-15 EP EP90301607A patent/EP0383591B1/de not_active Expired - Lifetime
- 1990-02-15 DE DE69034143T patent/DE69034143T2/de not_active Expired - Lifetime
- 1990-02-15 AU AU49812/90A patent/AU633541B2/en not_active Expired
- 1990-02-15 EP EP01107235A patent/EP1138329B8/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1990009176A1 (en) | 1990-08-23 |
DE69034143T2 (de) | 2005-06-30 |
ES2163389T3 (es) | 2002-02-01 |
EP1138329B1 (de) | 2004-06-02 |
JPH02215719A (ja) | 1990-08-28 |
EP1138329A3 (de) | 2002-04-17 |
AU4981290A (en) | 1990-08-23 |
DE69034143D1 (de) | 2004-07-08 |
CA2010017A1 (en) | 1990-08-15 |
EP1138329A2 (de) | 2001-10-04 |
DK0458861T3 (da) | 1996-08-12 |
JPH0552814B2 (de) | 1993-08-06 |
EP0383591B1 (de) | 2001-11-21 |
EP1138329B8 (de) | 2006-05-17 |
EP0458861B1 (de) | 1996-04-03 |
EP0458861A4 (en) | 1992-07-08 |
DE69033863T2 (de) | 2002-06-13 |
ES2220612T3 (es) | 2004-12-16 |
AU633541B2 (en) | 1993-02-04 |
EP0383591A2 (de) | 1990-08-22 |
DE69033863D1 (de) | 2002-01-03 |
EP0383591A3 (de) | 1992-01-15 |
EP0458861A1 (de) | 1991-12-04 |
CA2010017C (en) | 1995-09-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |