DE69028935D1 - Methode zur Produktion von Glukagon - Google Patents

Methode zur Produktion von Glukagon

Info

Publication number
DE69028935D1
DE69028935D1 DE69028935T DE69028935T DE69028935D1 DE 69028935 D1 DE69028935 D1 DE 69028935D1 DE 69028935 T DE69028935 T DE 69028935T DE 69028935 T DE69028935 T DE 69028935T DE 69028935 D1 DE69028935 D1 DE 69028935D1
Authority
DE
Germany
Prior art keywords
glucagon
fusion protein
glu
glutamic acid
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69028935T
Other languages
English (en)
Other versions
DE69028935T2 (de
Inventor
Jun Ishizaki
Mikio Tamaki
Masaru Shin
Hiroshi Teraoka
Nobuo Yoshida
Hiroshige Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69028935D1 publication Critical patent/DE69028935D1/de
Application granted granted Critical
Publication of DE69028935T2 publication Critical patent/DE69028935T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Control Of El Displays (AREA)
  • Earth Drilling (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diaphragms And Bellows (AREA)
  • Separation By Low-Temperature Treatments (AREA)
DE69028935T 1989-02-01 1990-01-30 Methode zur Produktion von Glukagon Expired - Fee Related DE69028935T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2415889 1989-02-01

Publications (2)

Publication Number Publication Date
DE69028935D1 true DE69028935D1 (de) 1996-11-28
DE69028935T2 DE69028935T2 (de) 1997-03-06

Family

ID=12130531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028935T Expired - Fee Related DE69028935T2 (de) 1989-02-01 1990-01-30 Methode zur Produktion von Glukagon

Country Status (18)

Country Link
EP (1) EP0381433B1 (de)
JP (1) JPH0748999B2 (de)
KR (1) KR0161656B1 (de)
CN (1) CN1063795C (de)
AT (1) ATE144551T1 (de)
BR (1) BR9000445A (de)
CA (1) CA2008824C (de)
DE (1) DE69028935T2 (de)
DK (1) DK0381433T3 (de)
ES (1) ES2095236T3 (de)
FI (1) FI900497A0 (de)
GR (1) GR3021965T3 (de)
HU (1) HUT54410A (de)
IL (1) IL93173A0 (de)
NO (1) NO900410L (de)
NZ (1) NZ232255A (de)
PT (1) PT93031A (de)
ZA (1) ZA90533B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506595B2 (en) * 1998-03-31 2003-01-14 Itoham Foods Inc. DNAs encoding new fusion proteins and processes for preparing useful polypeptides through expression of the DNAs
CN100480374C (zh) * 2001-09-28 2009-04-22 中国科学院上海生命科学研究院 制备重组人类胰高血糖素肽－1氨基酸7－37肽段的方法
US20130143798A1 (en) * 2010-03-26 2013-06-06 Novo Nordisk A/S Novel glucagon analogues
JP6352806B2 (ja) 2011-09-23 2018-07-04 ノヴォ ノルディスク アー／エス 新規のグルカゴン類似体
WO2014170496A1 (en) 2013-04-18 2014-10-23 Novo Nordisk A/S Stable, protracted glp-1/glucagon receptor co-agonists for medical use
US10570184B2 (en) 2014-06-04 2020-02-25 Novo Nordisk A/S GLP-1/glucagon receptor co-agonists for medical use
CN104593399A (zh) * 2014-12-22 2015-05-06 广西大学 一种转基因胰岛素的合成工艺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK27885A (da) * 1985-01-22 1986-07-23 Novo Industri As Fremstilling af peptider
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof

Also Published As

Publication number Publication date
CN1046559A (zh) 1990-10-31
PT93031A (pt) 1990-08-31
HUT54410A (en) 1991-02-28
GR3021965T3 (en) 1997-03-31
KR0161656B1 (ko) 1998-11-16
DK0381433T3 (da) 1996-11-18
EP0381433A1 (de) 1990-08-08
AU634999B2 (en) 1993-03-11
EP0381433B1 (de) 1996-10-23
NO900410L (no) 1990-08-02
CA2008824C (en) 1997-08-05
IL93173A0 (en) 1990-11-05
ZA90533B (en) 1990-10-31
FI900497A0 (fi) 1990-01-31
ATE144551T1 (de) 1996-11-15
NZ232255A (en) 1992-03-26
JPH03254692A (ja) 1991-11-13
BR9000445A (pt) 1991-01-15
NO900410D0 (no) 1990-01-29
AU4898990A (en) 1990-08-09
CN1063795C (zh) 2001-03-28
HU900614D0 (en) 1990-04-28
KR900013077A (ko) 1990-09-03
JPH0748999B2 (ja) 1995-05-31
DE69028935T2 (de) 1997-03-06
ES2095236T3 (es) 1997-02-16
CA2008824A1 (en) 1990-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee