DE69016502D1 - Thermostabile Cytosin deaminase. - Google Patents

Thermostabile Cytosin deaminase.

Info

Publication number
DE69016502D1
DE69016502D1 DE69016502T DE69016502T DE69016502D1 DE 69016502 D1 DE69016502 D1 DE 69016502D1 DE 69016502 T DE69016502 T DE 69016502T DE 69016502 T DE69016502 T DE 69016502T DE 69016502 D1 DE69016502 D1 DE 69016502D1
Authority
DE
Germany
Prior art keywords
cdase
thermally stable
cytosine deaminase
kda
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69016502T
Other languages
English (en)
Other versions
DE69016502T2 (de
Inventor
Peter Dana Senter
Peter Chong-Dug Su
Hans Marquardt
Martha S Hayden
Peter Linsley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/531,646 external-priority patent/US5338678A/en
Application filed by Oncogen LP filed Critical Oncogen LP
Application granted granted Critical
Publication of DE69016502D1 publication Critical patent/DE69016502D1/de
Publication of DE69016502T2 publication Critical patent/DE69016502T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69016502T 1989-06-09 1990-06-06 Thermostabile Cytosin deaminase. Expired - Lifetime DE69016502T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36502089A 1989-06-09 1989-06-09
US07/531,646 US5338678A (en) 1989-06-09 1990-06-01 Expression of DNA sequences encoding a thermally stable cytosine deaminase from saccharomyces

Publications (2)

Publication Number Publication Date
DE69016502D1 true DE69016502D1 (de) 1995-03-16
DE69016502T2 DE69016502T2 (de) 1995-06-01

Family

ID=27002759

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69016502T Expired - Lifetime DE69016502T2 (de) 1989-06-09 1990-06-06 Thermostabile Cytosin deaminase.

Country Status (21)

Country Link
US (1) US5545548A (de)
EP (1) EP0402108B1 (de)
JP (1) JP3001933B2 (de)
CN (1) CN1052263C (de)
AT (1) ATE118040T1 (de)
CA (1) CA2018273C (de)
CZ (1) CZ283492B6 (de)
DE (1) DE69016502T2 (de)
DK (1) DK0402108T3 (de)
ES (1) ES2070277T3 (de)
FI (1) FI95046C (de)
GR (1) GR3015207T3 (de)
IE (1) IE66054B1 (de)
IL (1) IL94649A (de)
MY (1) MY105816A (de)
NO (1) NO301487B1 (de)
NZ (1) NZ233949A (de)
OA (1) OA09214A (de)
PL (1) PL165149B1 (de)
PT (1) PT94331B (de)
YU (1) YU112090A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555370B1 (en) 1990-11-13 2003-04-29 Immunex Corporation Bifunctional selectable fusion genes
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
EP0804590A1 (de) * 1993-05-21 1997-11-05 Targeted Genetics Corporation Bifunktionelle selektierbare fusionsgene auf dem cytosin-deaminase (cd) gen beruhend
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
US5856153A (en) * 1994-11-17 1999-01-05 Cayla Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases
CA2243985C (en) 1997-09-11 2004-08-10 F. Hoffmann-La Roche Ag Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
GB9810752D0 (en) * 1998-05-19 1998-07-15 Glaxo Group Ltd Cystosine deaminase gene
US6962702B2 (en) 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
US6656917B1 (en) * 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
EP2283869A3 (de) 2002-07-15 2012-06-27 Board of Regents, The University of Texas System Ausgewählte Antikörper und Duramycin-Peptide mit Bindung an anionische Phospholiden und Aminophospholiden und ihre Verwendung bei der Behandlung von Virusinfektionen und Krebs
CA2531773A1 (en) 2003-07-21 2005-02-17 Transgene S.A. Novel multifunctional cytokines
PT1649023E (pt) * 2003-07-21 2008-11-20 Transgene Sa Polipéptido com actividade de citosina desaminase melhorada
JP4733635B2 (ja) 2003-07-31 2011-07-27 イミューノメディクス、インコーポレイテッド 抗ｃｄ１９抗体
WO2005086922A2 (en) * 2004-03-10 2005-09-22 Board Of Regents, University Of Texas System Oncolytic adenovirus armed with therapeutic genes
CN1950501B (zh) * 2004-04-28 2012-06-13 天野酶株式会社 放线菌来源的amp脱氨酶及其应用
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
US20090263884A1 (en) * 2008-04-22 2009-10-22 Organica Biotech, Inc. Multi-action drain cleaning composition and method
AU2009303690B2 (en) 2008-09-26 2014-06-19 Tocagen Inc. Gene therapy vectors and cytosine deaminases
CN103031296B (zh) * 2012-12-10 2014-12-17 浙江工业大学 冬虫夏草dCMP脱氨酶、编码基因及其应用
CN103045573B (zh) * 2012-12-10 2015-03-18 浙江工业大学 冬虫夏草胞嘧啶脱氨酶、编码基因及其应用
CN109207535B (zh) * 2018-09-20 2021-06-25 新乡拓新药业股份有限公司 利用铜绿假单胞菌合成尿嘧啶的方法
CN116143947B (zh) * 2023-01-16 2024-05-24 中国科学院青岛生物能源与过程研究所 一种酵母胞嘧啶脱氨酶融合蛋白及其突变体和应用

Also Published As

Publication number Publication date
FI95046C (fi) 1995-12-11
JP3001933B2 (ja) 2000-01-24
IL94649A0 (en) 1991-04-15
NO902551D0 (no) 1990-06-08
YU112090A (en) 1992-05-28
DE69016502T2 (de) 1995-06-01
US5545548A (en) 1996-08-13
ATE118040T1 (de) 1995-02-15
IE902079L (en) 1990-12-09
FI95046B (fi) 1995-08-31
EP0402108A1 (de) 1990-12-12
EP0402108B1 (de) 1995-02-01
NO301487B1 (no) 1997-11-03
DK0402108T3 (da) 1995-04-10
CS286590A3 (en) 1992-02-19
PT94331B (pt) 1997-04-30
OA09214A (en) 1992-06-30
NO902551L (no) 1990-12-10
CN1052263C (zh) 2000-05-10
CZ283492B6 (cs) 1998-04-15
IE66054B1 (en) 1995-12-13
PT94331A (pt) 1991-03-20
PL165149B1 (pl) 1994-11-30
JPH04131084A (ja) 1992-05-01
CN1050221A (zh) 1991-03-27
FI902855A0 (fi) 1990-06-07
CA2018273A1 (en) 1990-12-09
MY105816A (en) 1995-01-30
IL94649A (en) 1995-11-27
NZ233949A (en) 1992-06-25
ES2070277T3 (es) 1995-06-01
CA2018273C (en) 1999-04-06
GR3015207T3 (en) 1995-05-31
PL285552A1 (en) 1991-02-25

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