ES2070277T3 - Citosina desaminasa termicamente estable. - Google Patents
Citosina desaminasa termicamente estable.Info
- Publication number
- ES2070277T3 ES2070277T3 ES90306131T ES90306131T ES2070277T3 ES 2070277 T3 ES2070277 T3 ES 2070277T3 ES 90306131 T ES90306131 T ES 90306131T ES 90306131 T ES90306131 T ES 90306131T ES 2070277 T3 ES2070277 T3 ES 2070277T3
- Authority
- ES
- Spain
- Prior art keywords
- thermally stable
- cdase
- cytosine deaminase
- kda
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REVALA LA DEAMINASA DE CITOSINA TERMICAMENTE ESTABLE (CDASA), Y POR LO TANTO LA CODIFICACION DE GENES, ASI COMO LOS METODOS DE AISLAMIENTO, PURIFICACION Y PRODUCCION RECOMBINANTE DEL MISMO. LA CDASA TERMICAMENTE ESTABLE PUEDE AISLARSE DEL "SACCHAROMYCES CEREVISIAE". LA ENZIMA AISLADA DEL FERMENTO TIENE UN PESO MOLECULAR APROXIMADO DE 32 KDA, SEGUN LO DETERMINA LA CROMATOGRAFIA POR FILTRACION DE GELES, Y ESTA COMPUESTA DE DOS SUBUNIDADES, CADA UNA CON UN PESO MOLECULAR APROXIMADO DE 17 KDA. LA CDASA DE FERMENTO TERMICAMENTE ESTABLE ASI PURIFICADA NO PRESENTA NINGUNA HOMOLOGIA SIGNIFICATIVA DE SECUENCIAS CON OTRAS PROTEINAS SECUENCIADAS CONOCIDAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36502089A | 1989-06-09 | 1989-06-09 | |
US07/531,646 US5338678A (en) | 1989-06-09 | 1990-06-01 | Expression of DNA sequences encoding a thermally stable cytosine deaminase from saccharomyces |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2070277T3 true ES2070277T3 (es) | 1995-06-01 |
Family
ID=27002759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90306131T Expired - Lifetime ES2070277T3 (es) | 1989-06-09 | 1990-06-06 | Citosina desaminasa termicamente estable. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5545548A (es) |
EP (1) | EP0402108B1 (es) |
JP (1) | JP3001933B2 (es) |
CN (1) | CN1052263C (es) |
AT (1) | ATE118040T1 (es) |
CA (1) | CA2018273C (es) |
CZ (1) | CZ283492B6 (es) |
DE (1) | DE69016502T2 (es) |
DK (1) | DK0402108T3 (es) |
ES (1) | ES2070277T3 (es) |
FI (1) | FI95046C (es) |
GR (1) | GR3015207T3 (es) |
IE (1) | IE66054B1 (es) |
IL (1) | IL94649A (es) |
MY (1) | MY105816A (es) |
NO (1) | NO301487B1 (es) |
NZ (1) | NZ233949A (es) |
OA (1) | OA09214A (es) |
PL (1) | PL165149B1 (es) |
PT (1) | PT94331B (es) |
YU (1) | YU112090A (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6555370B1 (en) | 1990-11-13 | 2003-04-29 | Immunex Corporation | Bifunctional selectable fusion genes |
US5358866A (en) * | 1991-07-03 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Cytosine deaminase negative selection system for gene transfer techniques and therapies |
EP0804590A1 (en) * | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
US6451571B1 (en) | 1994-05-02 | 2002-09-17 | University Of Washington | Thymidine kinase mutants |
US5856153A (en) * | 1994-11-17 | 1999-01-05 | Cayla | Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases |
CA2243985C (en) | 1997-09-11 | 2004-08-10 | F. Hoffmann-La Roche Ag | Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes |
GB9810752D0 (en) * | 1998-05-19 | 1998-07-15 | Glaxo Group Ltd | Cystosine deaminase gene |
US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US8716558B2 (en) | 1999-06-30 | 2014-05-06 | Marker Gene Technologies, Inc. | Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase |
US6656917B1 (en) * | 1999-06-30 | 2003-12-02 | Marker Gene Technologies, Inc. | Compositions and methods for targeted enzymatic release of cell regulatory compounds |
EP2283869A3 (en) | 2002-07-15 | 2012-06-27 | Board of Regents, The University of Texas System | Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in the treatment of viral infections and cancer |
CA2531773A1 (en) | 2003-07-21 | 2005-02-17 | Transgene S.A. | Novel multifunctional cytokines |
PT1649023E (pt) * | 2003-07-21 | 2008-11-20 | Transgene Sa | Polipéptido com actividade de citosina desaminase melhorada |
JP4733635B2 (ja) | 2003-07-31 | 2011-07-27 | イミューノメディクス、インコーポレイテッド | 抗cd19抗体 |
WO2005086922A2 (en) * | 2004-03-10 | 2005-09-22 | Board Of Regents, University Of Texas System | Oncolytic adenovirus armed with therapeutic genes |
CN1950501B (zh) * | 2004-04-28 | 2012-06-13 | 天野酶株式会社 | 放线菌来源的amp脱氨酶及其应用 |
MX2010005104A (es) | 2007-11-09 | 2010-08-04 | Peregrine Pharmaceuticals Inc | Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos. |
US20090263884A1 (en) * | 2008-04-22 | 2009-10-22 | Organica Biotech, Inc. | Multi-action drain cleaning composition and method |
AU2009303690B2 (en) | 2008-09-26 | 2014-06-19 | Tocagen Inc. | Gene therapy vectors and cytosine deaminases |
CN103031296B (zh) * | 2012-12-10 | 2014-12-17 | 浙江工业大学 | 冬虫夏草dCMP脱氨酶、编码基因及其应用 |
CN103045573B (zh) * | 2012-12-10 | 2015-03-18 | 浙江工业大学 | 冬虫夏草胞嘧啶脱氨酶、编码基因及其应用 |
CN109207535B (zh) * | 2018-09-20 | 2021-06-25 | 新乡拓新药业股份有限公司 | 利用铜绿假单胞菌合成尿嘧啶的方法 |
CN116143947B (zh) * | 2023-01-16 | 2024-05-24 | 中国科学院青岛生物能源与过程研究所 | 一种酵母胞嘧啶脱氨酶融合蛋白及其突变体和应用 |
-
1990
- 1990-06-05 CA CA002018273A patent/CA2018273C/en not_active Expired - Lifetime
- 1990-06-06 IL IL9464990A patent/IL94649A/en active IP Right Grant
- 1990-06-06 AT AT90306131T patent/ATE118040T1/de not_active IP Right Cessation
- 1990-06-06 ES ES90306131T patent/ES2070277T3/es not_active Expired - Lifetime
- 1990-06-06 EP EP90306131A patent/EP0402108B1/en not_active Expired - Lifetime
- 1990-06-06 DE DE69016502T patent/DE69016502T2/de not_active Expired - Lifetime
- 1990-06-06 DK DK90306131.5T patent/DK0402108T3/da active
- 1990-06-06 NZ NZ233949A patent/NZ233949A/en unknown
- 1990-06-07 FI FI902855A patent/FI95046C/fi active IP Right Grant
- 1990-06-08 PT PT94331A patent/PT94331B/pt not_active IP Right Cessation
- 1990-06-08 OA OA59803A patent/OA09214A/xx unknown
- 1990-06-08 CZ CS902865A patent/CZ283492B6/cs not_active IP Right Cessation
- 1990-06-08 MY MYPI90000950A patent/MY105816A/en unknown
- 1990-06-08 IE IE207990A patent/IE66054B1/en not_active IP Right Cessation
- 1990-06-08 PL PL90285552A patent/PL165149B1/pl unknown
- 1990-06-08 NO NO902551A patent/NO301487B1/no not_active IP Right Cessation
- 1990-06-08 YU YU01120/90A patent/YU112090A/xx unknown
- 1990-06-09 CN CN90104922A patent/CN1052263C/zh not_active Expired - Lifetime
- 1990-06-11 JP JP2153799A patent/JP3001933B2/ja not_active Expired - Lifetime
-
1994
- 1994-06-20 US US08/262,238 patent/US5545548A/en not_active Expired - Lifetime
-
1995
- 1995-02-28 GR GR940403976T patent/GR3015207T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI95046C (fi) | 1995-12-11 |
JP3001933B2 (ja) | 2000-01-24 |
IL94649A0 (en) | 1991-04-15 |
NO902551D0 (no) | 1990-06-08 |
YU112090A (en) | 1992-05-28 |
DE69016502T2 (de) | 1995-06-01 |
US5545548A (en) | 1996-08-13 |
ATE118040T1 (de) | 1995-02-15 |
IE902079L (en) | 1990-12-09 |
FI95046B (fi) | 1995-08-31 |
DE69016502D1 (de) | 1995-03-16 |
EP0402108A1 (en) | 1990-12-12 |
EP0402108B1 (en) | 1995-02-01 |
NO301487B1 (no) | 1997-11-03 |
DK0402108T3 (da) | 1995-04-10 |
CS286590A3 (en) | 1992-02-19 |
PT94331B (pt) | 1997-04-30 |
OA09214A (en) | 1992-06-30 |
NO902551L (no) | 1990-12-10 |
CN1052263C (zh) | 2000-05-10 |
CZ283492B6 (cs) | 1998-04-15 |
IE66054B1 (en) | 1995-12-13 |
PT94331A (pt) | 1991-03-20 |
PL165149B1 (pl) | 1994-11-30 |
JPH04131084A (ja) | 1992-05-01 |
CN1050221A (zh) | 1991-03-27 |
FI902855A0 (fi) | 1990-06-07 |
CA2018273A1 (en) | 1990-12-09 |
MY105816A (en) | 1995-01-30 |
IL94649A (en) | 1995-11-27 |
NZ233949A (en) | 1992-06-25 |
CA2018273C (en) | 1999-04-06 |
GR3015207T3 (en) | 1995-05-31 |
PL285552A1 (en) | 1991-02-25 |
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Legal Events
Date | Code | Title | Description |
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FG2A | Definitive protection |
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