DE68905585T2 - 2-imino-benzothiazolin-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten. - Google Patents

2-imino-benzothiazolin-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.

Info

Publication number
DE68905585T2
DE68905585T2 DE8989403458T DE68905585T DE68905585T2 DE 68905585 T2 DE68905585 T2 DE 68905585T2 DE 8989403458 T DE8989403458 T DE 8989403458T DE 68905585 T DE68905585 T DE 68905585T DE 68905585 T2 DE68905585 T2 DE 68905585T2
Authority
DE
Germany
Prior art keywords
imino
production
products containing
medicinal products
benzothiazoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989403458T
Other languages
English (en)
Other versions
DE68905585D1 (de
Inventor
Claude Gueremy
Patrick Jimonet
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8816546A external-priority patent/FR2640622B1/fr
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Application granted granted Critical
Publication of DE68905585D1 publication Critical patent/DE68905585D1/de
Publication of DE68905585T2 publication Critical patent/DE68905585T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DE8989403458T 1988-12-15 1989-12-13 2-imino-benzothiazolin-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten. Expired - Fee Related DE68905585T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8816546A FR2640622B1 (fr) 1988-12-15 1988-12-15 Derives de l'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant
FR898909480A FR2649701B2 (fr) 1988-12-15 1989-07-13 Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant

Publications (2)

Publication Number Publication Date
DE68905585D1 DE68905585D1 (de) 1993-04-29
DE68905585T2 true DE68905585T2 (de) 1993-09-16

Family

ID=26227049

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989403458T Expired - Fee Related DE68905585T2 (de) 1988-12-15 1989-12-13 2-imino-benzothiazolin-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.

Country Status (22)

Country Link
US (1) US5008280A (de)
EP (1) EP0374040B1 (de)
JP (1) JPH0733376B2 (de)
AU (1) AU618432B2 (de)
CA (1) CA2005590A1 (de)
CZ (1) CZ280107B6 (de)
DE (1) DE68905585T2 (de)
DK (1) DK169967B1 (de)
ES (1) ES2054068T3 (de)
FI (1) FI93106C (de)
FR (1) FR2649701B2 (de)
GR (1) GR3007788T3 (de)
HU (1) HU203088B (de)
IE (1) IE62714B1 (de)
IL (1) IL92710A (de)
NO (1) NO173060C (de)
NZ (1) NZ231793A (de)
PL (2) PL161336B1 (de)
PT (1) PT92604B (de)
RU (1) RU2037489C1 (de)
SK (1) SK708189A3 (de)
YU (1) YU47337B (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985855A (en) 1996-09-27 1999-11-16 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using NAALADase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6413948B1 (en) 1996-09-27 2002-07-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2649702B1 (fr) * 1989-07-13 1991-11-22 Rhone Poulenc Sante Derives d'alkylimino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant
DE69007196T2 (de) * 1989-07-13 1994-06-30 Rhone Poulenc Sante 2-Imino-3 heterocyclylamino-benzothiazoline, ihre Herstellung und sie enthaltende Arzneimittel.
US5260297A (en) * 1989-07-13 1993-11-09 Rhone Poulenc Rorer, S.A. 2-imino-3-alkylbenzothiazoline derivatives bearing a heterocyclic substituent on the alkyl group, their preparation and medicinal products containing them.
FR2671081B1 (fr) * 1991-01-02 1994-09-30 Rhone Poulenc Rorer Sa Derives d'imino-2 polyfluoroalkyl-6 heterocyclylalkyl-3 benzothiazoline, leur preparation et les medicaments les contenant.
US5240948A (en) * 1989-12-13 1993-08-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. 3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and the medicament containing them
FR2663029B1 (fr) * 1990-06-07 1992-07-31 Rhone Poulenc Sante Derives de benzothiazole, leur preparation et les medicaments les contenant.
FR2678619B1 (fr) * 1991-07-04 1993-09-17 Rhone Poulenc Rorer Sa Derives de 1,2,4-thiadiazolo[3,4-b]benzothiazole, leur preparation et les medicaments les contenant.
FR2726271B1 (fr) * 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa Derives de 6-polyfluoroalcoxy-2-aminobenzothiazole
FR2741804B1 (fr) * 1995-12-01 1998-01-02 Rhone Poulenc Rorer Sa Application de 2-iminobenzothiazolines dans le traitement de la maladie de parkinson et des syndromes parkinsoniens
FR2766487B1 (fr) * 1997-07-28 1999-08-27 Rhone Poulenc Rorer Sa Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
DE60020556T2 (de) * 1999-05-12 2005-10-27 Neurosearch A/S Ionenkanal modulierende mittel
GB0307067D0 (en) 2002-12-17 2003-04-30 Aventis Pharma Inc Use of thiazolobenzoheterocycles for treating multiple sclerosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631163B2 (de) * 1976-07-10 1978-06-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 2-Iminobenzothiazolen
FR2492258A1 (fr) * 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4826860A (en) * 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
US4918090A (en) * 1988-01-25 1990-04-17 Warner-Lambert Company Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985855A (en) 1996-09-27 1999-11-16 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using NAALADase inhibitors
US6004946A (en) 1996-09-27 1999-12-21 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6413948B1 (en) 1996-09-27 2002-07-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors

Also Published As

Publication number Publication date
EP0374040A1 (de) 1990-06-20
JPH0733376B2 (ja) 1995-04-12
PL161369B1 (en) 1993-06-30
IE894006L (en) 1990-06-15
FR2649701A2 (fr) 1991-01-18
SK278349B6 (en) 1997-01-08
IL92710A0 (en) 1990-09-17
NO895030D0 (no) 1989-12-14
FR2649701B2 (fr) 1991-11-22
YU236989A (en) 1991-02-28
NO173060C (no) 1993-10-20
PT92604A (pt) 1990-06-29
CZ280107B6 (cs) 1995-10-18
DK633689D0 (da) 1989-12-14
AU4618989A (en) 1990-06-21
JPH02223569A (ja) 1990-09-05
HU896612D0 (en) 1990-02-28
NO895030L (no) 1990-06-18
DE68905585D1 (de) 1993-04-29
HU203088B (en) 1991-05-28
PL161336B1 (pl) 1993-06-30
RU2037489C1 (ru) 1995-06-19
PT92604B (pt) 1995-09-12
NZ231793A (en) 1991-03-26
FI93106C (fi) 1995-02-27
YU47337B (sh) 1995-01-31
ES2054068T3 (es) 1994-08-01
EP0374040B1 (de) 1993-03-24
HUT53625A (en) 1990-11-28
DK169967B1 (da) 1995-04-18
GR3007788T3 (de) 1993-08-31
US5008280A (en) 1991-04-16
FI93106B (fi) 1994-11-15
CA2005590A1 (fr) 1990-06-15
CZ708189A3 (en) 1995-06-14
NO173060B (no) 1993-07-12
AU618432B2 (en) 1991-12-19
IL92710A (en) 1993-06-10
FI895981A0 (fi) 1989-12-14
IE62714B1 (en) 1995-02-22
DK633689A (da) 1990-06-16
SK708189A3 (en) 1997-01-08

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8339 Ceased/non-payment of the annual fee