DE60314427T2 - Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen - Google Patents

Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen Download PDF

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Publication number
DE60314427T2
DE60314427T2 DE60314427T DE60314427T DE60314427T2 DE 60314427 T2 DE60314427 T2 DE 60314427T2 DE 60314427 T DE60314427 T DE 60314427T DE 60314427 T DE60314427 T DE 60314427T DE 60314427 T2 DE60314427 T2 DE 60314427T2
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DE
Germany
Prior art keywords
solvate
group
alkyl
acceptable salt
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60314427T
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German (de)
English (en)
Other versions
DE60314427D1 (de
Inventor
Timothy J. Chatham GUZI
Kamil Garwood PARUCH
Michael P. Scotch Plains DWYER
Ronald J. Convent Station DOLL
Viyyoor Moopil Parsippany GIRIJAVALLABHAN
Lawrence W. Yardley DILLARD
Vinh D. Fountain Valley TRAN
Zhen Min Princeton HE
Ray Anthony Bensalem JAMES
Haengsoon Plainsboro PARK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Pharmacopeia LLC
Original Assignee
Pharmacopeia Inc
Schering Corp
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Application filed by Pharmacopeia Inc, Schering Corp filed Critical Pharmacopeia Inc
Application granted granted Critical
Publication of DE60314427D1 publication Critical patent/DE60314427D1/de
Publication of DE60314427T2 publication Critical patent/DE60314427T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60314427T 2002-09-04 2003-09-03 Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen Expired - Lifetime DE60314427T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40803002P 2002-09-04 2002-09-04
US408030P 2002-09-04
PCT/US2003/027405 WO2004022559A1 (en) 2002-09-04 2003-09-03 Pyrazolopyrimidines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60314427D1 DE60314427D1 (de) 2007-07-26
DE60314427T2 true DE60314427T2 (de) 2008-06-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60314427T Expired - Lifetime DE60314427T2 (de) 2002-09-04 2003-09-03 Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen

Country Status (17)

Country Link
US (2) US7078525B2 (https=)
EP (1) EP1534709B1 (https=)
JP (2) JP2006501260A (https=)
KR (1) KR20050058507A (https=)
CN (1) CN1310918C (https=)
AR (1) AR041134A1 (https=)
AT (1) ATE364608T1 (https=)
CA (1) CA2497444C (https=)
DE (1) DE60314427T2 (https=)
ES (1) ES2285164T3 (https=)
MX (1) MXPA05002573A (https=)
MY (1) MY139336A (https=)
NZ (1) NZ539162A (https=)
PE (1) PE20041076A1 (https=)
TW (1) TW200413377A (https=)
WO (1) WO2004022559A1 (https=)
ZA (1) ZA200501851B (https=)

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Also Published As

Publication number Publication date
US7078525B2 (en) 2006-07-18
CN1738821A (zh) 2006-02-22
ZA200501851B (en) 2005-09-08
CA2497444A1 (en) 2004-03-18
HK1071570A1 (en) 2005-07-22
ES2285164T3 (es) 2007-11-16
MY139336A (en) 2009-09-30
NZ539162A (en) 2006-07-28
AU2003268357A1 (en) 2004-03-29
MXPA05002573A (es) 2005-09-08
EP1534709A1 (en) 2005-06-01
ATE364608T1 (de) 2007-07-15
CN1310918C (zh) 2007-04-18
JP2010132704A (ja) 2010-06-17
KR20050058507A (ko) 2005-06-16
EP1534709B1 (en) 2007-06-13
JP2006501260A (ja) 2006-01-12
US7470695B2 (en) 2008-12-30
DE60314427D1 (de) 2007-07-26
AR041134A1 (es) 2005-05-04
CA2497444C (en) 2010-11-30
TW200413377A (en) 2004-08-01
PE20041076A1 (es) 2005-01-22
WO2004022559A1 (en) 2004-03-18
US20040102451A1 (en) 2004-05-27
US20060235025A1 (en) 2006-10-19

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