DE60233049D1 - Matrix-anheftungsregionen und verfahren zu deren verwendung - Google Patents
Matrix-anheftungsregionen und verfahren zu deren verwendungInfo
- Publication number
- DE60233049D1 DE60233049D1 DE60233049T DE60233049T DE60233049D1 DE 60233049 D1 DE60233049 D1 DE 60233049D1 DE 60233049 T DE60233049 T DE 60233049T DE 60233049 T DE60233049 T DE 60233049T DE 60233049 D1 DE60233049 D1 DE 60233049D1
- Authority
- DE
- Germany
- Prior art keywords
- mounting regions
- matrix mounting
- relates
- matrix
- mar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Local Oxidation Of Silicon (AREA)
- Electric Connection Of Electric Components To Printed Circuits (AREA)
- Wire Bonding (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26435501P | 2001-01-26 | 2001-01-26 | |
US28139101P | 2001-04-04 | 2001-04-04 | |
PCT/IB2002/002137 WO2002074969A2 (en) | 2001-01-26 | 2002-01-28 | Matrix attachment regions and methods for use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60233049D1 true DE60233049D1 (de) | 2009-09-03 |
Family
ID=26950488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60233049T Expired - Lifetime DE60233049D1 (de) | 2001-01-26 | 2002-01-28 | Matrix-anheftungsregionen und verfahren zu deren verwendung |
Country Status (10)
Country | Link |
---|---|
US (1) | US7129062B2 (de) |
EP (1) | EP1395669B1 (de) |
JP (1) | JP4307079B2 (de) |
AT (1) | ATE437233T1 (de) |
CA (1) | CA2435972C (de) |
DE (1) | DE60233049D1 (de) |
DK (1) | DK1395669T3 (de) |
ES (1) | ES2330201T3 (de) |
SG (1) | SG141239A1 (de) |
WO (1) | WO2002074969A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100408844B1 (ko) * | 2000-07-29 | 2003-12-06 | 한국산업기술평가원 | 동물세포 발현벡터 |
MXPA04011624A (es) * | 2002-05-24 | 2005-03-07 | Schering Corp | Anticuerpo neutralizante humano anti-igfr. |
ES2442615T5 (es) | 2002-07-18 | 2023-03-16 | Merus Nv | Producción recombinante de mezclas de anticuerpos |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
WO2004056986A2 (en) | 2002-12-20 | 2004-07-08 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
JP2005031812A (ja) * | 2003-07-08 | 2005-02-03 | Toshiba Corp | 画像形成装置およびその制御方法 |
KR101222025B1 (ko) | 2003-10-24 | 2013-01-15 | 셀렉시스 에스. 에이. | Mar 서열의 복합 트랜스펙션 방법에 의한 포유동물세포에서의 고효율 유전자 전달 및 발현 |
CA2545755A1 (en) * | 2003-11-12 | 2005-05-26 | Schering Corporation | Plasmid system for multigene expression |
AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
GB0327919D0 (en) * | 2003-12-02 | 2004-01-07 | Plant Bioscience Ltd | Enhanced expression |
WO2005068622A2 (en) | 2004-01-20 | 2005-07-28 | Merus B.V. | Mixtures of binding proteins |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
NZ553700A (en) | 2004-11-08 | 2010-09-30 | Chromagenics Bv | Selection of host cells expressing protein at high levels using a selectable marker with a non-optimal start codon |
WO2006048459A2 (en) | 2004-11-08 | 2006-05-11 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
WO2006060419A2 (en) * | 2004-12-03 | 2006-06-08 | Schering Corporation | Biomarkers for pre-selection of patients for anti-igf1r therapy |
JP2008543283A (ja) * | 2005-06-10 | 2008-12-04 | ジェネンテック・インコーポレーテッド | インスレーターエレメントを含むベクターを使用する抗体発現の改良 |
DE602006019486D1 (de) * | 2005-08-11 | 2011-02-17 | Centocor Ortho Biotech Inc | Materialien und verfahren zur erhöhung der peptidkettenexpression |
WO2007107578A1 (en) | 2006-03-20 | 2007-09-27 | Chromagenics B.V. | Expression augmenting dna fragments, use thereof, and methods for finding thereof |
US8058027B2 (en) * | 2007-01-08 | 2011-11-15 | Millipore Corporation | Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants |
JP2010515435A (ja) * | 2007-01-08 | 2010-05-13 | ミリポア・コーポレイション | 遺伝子増幅を不要とする高発現細胞株 |
KR20140001229A (ko) | 2007-03-30 | 2014-01-06 | 아보트 러보러터리즈 | 숙주 세포에서 재조합 단백질의 발현을 증강시키기 위한 재조합 발현 벡터 요소(rEVE) |
US8563002B2 (en) | 2007-12-24 | 2013-10-22 | Glaxosmithkline Biologicals, S.A. | Recombinant RSV antigens |
PL2245145T3 (pl) | 2008-01-18 | 2017-07-31 | Biomarin Pharmaceutical Inc. | Wytwarzanie aktywnych wysoce fosforylowanych ludzkich enzymów sulfatazy lizosomalnej i ich zastosowania |
AP2011005739A0 (en) * | 2008-10-28 | 2011-06-30 | Avesthagen Ltd | An expression vector and processes thereof. |
WO2010081494A1 (en) | 2009-01-19 | 2010-07-22 | King Faisal Specialist Hospital And Research Centre | A method of increasing protein expression in eukaryotic cells |
WO2010081890A1 (en) | 2009-01-19 | 2010-07-22 | Innate Pharma | Anti-kir3d antibodies |
CA2766205A1 (en) | 2009-06-24 | 2010-12-29 | Id Biomedical Corporation Of Quebec | Vaccine comprising at least two paramyxovirus f protein antigens |
EA023054B1 (ru) | 2009-06-24 | 2016-04-29 | Глэксосмитклайн Байолоджикалз С.А. | Рекомбинантные антигены pcb |
CN102639147B (zh) | 2009-07-15 | 2015-11-25 | 诺华股份有限公司 | Rsv f 蛋白组合物和其制作方法 |
WO2011015917A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant tnk-tpa (tenecteplase) |
WO2011015918A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant cetuximab |
WO2011015916A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant infliximab |
WO2011015924A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant trastuzumab |
KR20120099376A (ko) | 2009-09-18 | 2012-09-10 | 셀렉시스 에스. 에이. | 강화된 전이 유전자 발현과 공정 방법 및 그 산물 |
AR082319A1 (es) | 2010-07-22 | 2012-11-28 | Biomarin Pharm Inc | Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos |
EA201390461A1 (ru) | 2010-10-08 | 2013-09-30 | Кадила Хелзкэр Лимитед | Вектор экспрессии для высокоэффективной экспрессии рекомбинантных белков |
WO2012095514A1 (en) | 2011-01-14 | 2012-07-19 | Vivalis | Recombinant protein production system |
EP2758437B1 (de) | 2011-09-22 | 2020-06-03 | Amgen Inc. | Cd27l-antigen-bindende proteine |
KR20230093359A (ko) | 2012-04-20 | 2023-06-27 | 메뤼스 엔.페. | Ig-유사 분자의 제조방법 및 제조수단 |
UY34813A (es) | 2012-05-18 | 2013-11-29 | Amgen Inc | Proteínas de unión a antígeno dirigidas contra el receptor st2 |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
RU2711505C9 (ru) | 2013-02-01 | 2020-08-12 | Селексис С.А. | Улучшенные экспрессия и процессинг трансгена |
US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
ES2895824T3 (es) | 2013-05-30 | 2022-02-22 | Kiniksa Pharmaceuticals Ltd | Proteínas de enlace al antígeno del receptor de oncastatina M |
EP3041863A4 (de) | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-haltige moleküle mit vorhersagbaren, konsistenten und reproduzierbaren glycoformprofilen |
WO2015060935A1 (en) * | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
BR112017021696A2 (pt) | 2015-04-10 | 2018-07-10 | Amgen Inc | muteínas de interleucina-2 para a expansão de células t regulatórias |
CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
KR102645625B1 (ko) | 2015-09-22 | 2024-03-07 | 제넨테크, 인크. | Fc-함유 단백질의 발현 |
JP6932693B2 (ja) | 2015-10-08 | 2021-09-08 | ザイムワークス,インコーポレイテッド | カッパ及びラムダ軽鎖を含む抗原結合ポリペプチド構築物及びその使用 |
CN116731147A (zh) | 2015-11-02 | 2023-09-12 | 豪夫迈·罗氏有限公司 | 制备岩藻糖基化和去岩藻糖基化形式的蛋白质的方法 |
KR20240115933A (ko) | 2016-05-04 | 2024-07-26 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
EP3293263A1 (de) * | 2016-09-07 | 2018-03-14 | Steinbeis Innovation gGmbH | Induzierbare genexpression durch lineare at-reiche dna-fragmente in säugetierzellen und zugehörige verfahren |
RU2019142330A (ru) | 2017-06-30 | 2021-07-30 | Займворкс, Инк. | Стабилизированные химерные fab |
JP2022509451A (ja) | 2018-10-24 | 2022-01-20 | セレキシス エスエー | 発現系、組み換え細胞及びその使用 |
JP2022544236A (ja) | 2019-08-13 | 2022-10-17 | アムジエン・インコーポレーテツド | 制御性t細胞の増殖のためのインターロイキン-2変異タンパク質 |
IL293471A (en) | 2019-12-17 | 2022-08-01 | Amgen Inc | Dual interleukin-2 / tnf receptor agonist for use in medicine |
TW202146430A (zh) | 2020-02-24 | 2021-12-16 | 瑞士商諾華公司 | 純化重組產生的多肽 |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8925590D0 (en) * | 1989-11-13 | 1990-01-04 | Central Blood Lab Authority | Monoclonal antibodies |
US6063630A (en) | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
AU673859B2 (en) | 1992-10-05 | 1996-11-28 | North Carolina State University | Method for increasing expression and reducing expression variability of foreign genes in plant cells |
US5610053A (en) * | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
US5888981A (en) | 1993-06-14 | 1999-03-30 | Basf Aktiengesellschaft | Methods for regulating gene expression |
US5907078A (en) * | 1994-12-09 | 1999-05-25 | Greenberg; Norman M. | Transgenic mouse model for prostate cancer |
DE19541450C2 (de) | 1995-11-07 | 1997-10-02 | Gsf Forschungszentrum Umwelt | Genkonstrukt und dessen Verwendung |
US6596514B2 (en) | 1996-01-11 | 2003-07-22 | Immunex Corporation | Expression augmenting sequence elements (EASE) for eukaryotic expression systems |
US5773695A (en) * | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
WO1997032018A2 (en) * | 1996-02-29 | 1997-09-04 | Immusol, Inc. | Hepatitis c virus ribozymes |
AU718551B2 (en) | 1996-06-06 | 2000-04-13 | Novartis Ag | Vectors comprising SAR elements |
EP1471144B1 (de) | 1996-12-02 | 2010-06-23 | Genaera Corporation | Biologische Variabilität von Asthma-assoziiertem Faktor 2 AAF2 (IL-9 Rezeptor) nützlich für die Behandlung und Diagnose von atopischen Allergien wie Asthma und Asthma-ähnlichen Erkrankungen |
US6245974B1 (en) | 1997-08-06 | 2001-06-12 | North Carolina State University | Matrix attachment regions |
US6897066B1 (en) | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
WO1999022773A2 (en) * | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
US6635806B1 (en) | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
MXPA01000830A (es) | 1998-07-21 | 2002-06-04 | Cobra Therapeutics Ltd | Un polinucleotido que comprende un elemento de abertura ubiculo de cromatina. |
AU762382B2 (en) | 1998-09-29 | 2003-06-26 | Pioneer Hi-Bred International, Inc. | MAR/SAR elements flanking RSYN7-driven construct |
DE19848017A1 (de) | 1998-10-17 | 2000-04-20 | Multigene Biotech Gmbh | Episomal replizierender Vektor zur Expression eines Transgens in Säugerzellen |
ATE279524T1 (de) | 1998-12-01 | 2004-10-15 | Dow Agrosciences Llc | Künstliche matrix-anheftungsregion zur erhöhung der expression von in pflanzen eingeführten genen |
US6225113B1 (en) | 1998-12-04 | 2001-05-01 | Genvec, Inc. | Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus |
US6194636B1 (en) | 1999-05-14 | 2001-02-27 | Dekalb Genetics Corp. | Maize RS324 promoter and methods for use thereof |
US6429357B1 (en) | 1999-05-14 | 2002-08-06 | Dekalb Genetics Corp. | Rice actin 2 promoter and intron and methods for use thereof |
US6232526B1 (en) | 1999-05-14 | 2001-05-15 | Dekalb Genetics Corp. | Maize A3 promoter and methods for use thereof |
US6207879B1 (en) | 1999-05-14 | 2001-03-27 | Dekalb Genetics Corporation | Maize RS81 promoter and methods for use thereof |
AU4940700A (en) | 1999-05-28 | 2000-12-18 | Sangamo Biosciences, Inc. | Gene switches |
US20050129669A1 (en) | 1999-06-21 | 2005-06-16 | Transkaryotic Therapies, Inc., A Massachusetts Corporation | DNA construct for effecting homologous recombination and uses thereof |
US6972349B1 (en) | 1999-11-12 | 2005-12-06 | University Of South Carolina | Control of post-transcriptional gene silencing in plants |
JP3507858B2 (ja) | 1999-11-19 | 2004-03-15 | 奈良先端科学技術大学院大学長 | 植物において外来遺伝子の発現を安定化させるdna断片、外来遺伝子を植物において安定に発現させる遺伝子導入方法、外来遺伝子を安定に発現させた形質転換植物 |
WO2001040488A1 (en) | 1999-11-30 | 2001-06-07 | Novartis Ag | Increased transgene expression in retroviral vectors having scaffold attachment region |
US6864085B2 (en) | 1999-12-14 | 2005-03-08 | Novartis Ag | Bovine immunodeficiency virus (BIV) based vectors |
US20020127199A1 (en) | 2000-02-03 | 2002-09-12 | Tang Y. Tom | Novel nucleic acids and polypeptides |
US6821775B1 (en) | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
DE10006886A1 (de) | 2000-02-16 | 2001-08-23 | Hepavec Ag Fuer Gentherapie | Nichthumaner helferabhängiger Virusvektor |
US6569681B1 (en) | 2000-03-14 | 2003-05-27 | Transkaryotic Therapies, Inc. | Methods of improving homologous recombination |
US6747189B1 (en) | 2000-03-21 | 2004-06-08 | Dekalb Genetics Corporation | Maize glycine rich protein promoter compositions and methods for use thereof |
US6730826B2 (en) | 2000-03-22 | 2004-05-04 | University Of Kentucky Research Foundation | Plant trichome gland specific promoter sequence |
CA2409408A1 (en) | 2000-06-26 | 2002-01-03 | Ulrich Laemmli | Modulation of chromosome function by chromatin remodeling agents |
US20030157715A1 (en) | 2000-06-26 | 2003-08-21 | Ulrich Laemmli | Modulation of chromosome function by chromatin remodeling agents |
AU2000265672A1 (en) | 2000-07-27 | 2002-02-13 | Apogene Gmbh And Co. Kg | Somatic cloning gene transfer for the production of recombinant proteins, cells and organs |
KR100408844B1 (ko) | 2000-07-29 | 2003-12-06 | 한국산업기술평가원 | 동물세포 발현벡터 |
EP1313868B1 (de) | 2000-08-30 | 2006-07-19 | North Carolina State University | Transgene pflanzen, die molekulare decoys enthalten, die den proteininhalt ändern |
EP1322771A2 (de) | 2000-09-09 | 2003-07-02 | BASF Plant Science GmbH | Modifiziertes tet-induzierbares system zur regulierung der genexpression in pflanzen |
GB0022995D0 (en) * | 2000-09-20 | 2000-11-01 | Cobra Therapeutics Ltd | Polynucleotide |
US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
AU4155602A (en) * | 2000-11-01 | 2002-06-18 | Elusys Therapeutics Inc | Method of producing biospecific molecules by protein trans-splicing |
DE10061150A1 (de) | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
AU2002216443A1 (en) | 2000-12-15 | 2002-06-24 | Pangen Biotech Inc. | Expression vector for animal cell containing nuclear matrix attachment region fointerferon beta |
US7151204B2 (en) | 2001-01-09 | 2006-12-19 | Monsanto Technology Llc | Maize chloroplast aldolase promoter compositions and methods for use thereof |
DE10109780A1 (de) | 2001-02-28 | 2002-09-05 | Cardion Ag | Episomale Vektoren enthaltend Matrix-Anheftungsregionen zur zellspezifischen Genexpression |
CA2441006A1 (en) | 2001-03-08 | 2002-09-19 | Hyseq, Inc. | Methods and materials relating to fibulin-like polypeptides and polynucleotides |
JP4817514B2 (ja) | 2001-03-09 | 2011-11-16 | 協和発酵キリン株式会社 | 新規動物細胞用ベクターおよびその使用 |
AU2002252370A1 (en) | 2001-03-12 | 2002-09-24 | Irm, Llc. | Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters |
NZ527937A (en) | 2001-03-13 | 2005-03-24 | Novartis Ag | Stable cell lines to express high levels of lentiviral Gag/Pol proteins for generation of HIV- or BIV- based lentiviral vectors |
EP1478751A4 (de) | 2001-03-30 | 2005-10-19 | Avigenics Inc | Lysozym-promotor in vögeln |
DE10129010A1 (de) | 2001-06-13 | 2002-12-19 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
US20040126189A1 (en) * | 2001-06-27 | 2004-07-01 | Chowdhury Ajit K. | Method for stabilizing chromium-contaminated materials |
US20030032597A1 (en) | 2001-07-31 | 2003-02-13 | Sebestyen Magdolna G. | Targeting nucleic acids to a cellular nucleus |
US7122715B2 (en) | 2001-09-20 | 2006-10-17 | Monsanto Technology Llc | In vitro method to create circular molecules for use in transformation |
AU2002341795A1 (en) | 2001-09-21 | 2003-04-01 | Avigenics, Inc. | Production of transgenic avians using sperm-mediated transfection |
US7138278B2 (en) | 2001-11-20 | 2006-11-21 | Monsanto Technology, L.L.C. | Maize cytoplasmic glutamine synthetase promoter compositions and methods for use thereof |
FR2832423B1 (fr) | 2001-11-22 | 2004-10-08 | Vivalis | Systeme d'expression de proteines exogenes dans un systeme aviaire |
US6875588B2 (en) | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
CA2427190A1 (en) | 2002-04-30 | 2003-10-30 | Alberta Research Council Inc. | Production of recombinant epidermal growth factor in plants |
US20030224477A1 (en) | 2002-05-31 | 2003-12-04 | Heartlein Michael W. | Optimized promoter constructs |
AU2003267967B2 (en) | 2002-06-18 | 2008-11-20 | Zymogenetics, Inc. | Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter |
US20040016015A1 (en) | 2002-07-17 | 2004-01-22 | Nguyen Thanh-Tuyen T. | High efficiency germline transformation system |
US6933136B2 (en) | 2002-09-20 | 2005-08-23 | Novo Nordisk A/S | Method for making recombinant proteins |
CN1263860C (zh) | 2002-09-30 | 2006-07-12 | 华南农业大学 | 多基因载体的构建方法与应用 |
WO2004053106A2 (en) | 2002-12-05 | 2004-06-24 | Regulome Corporation | Profiled regulatory sites useful for gene control |
WO2004053137A2 (en) | 2002-12-11 | 2004-06-24 | Cytos Biotechnology Ag | Method for protein production |
AU2002953381A0 (en) | 2002-12-18 | 2003-01-09 | Diatech Pty Ltd | In vivo affinity maturation scheme |
EP1445320A1 (de) | 2003-02-05 | 2004-08-11 | ARTEMIS Pharmaceuticals GmbH | Automatisches Gen-Targeting mittels nicht toxisischer nachweissbarer Marker |
WO2004094640A1 (en) | 2003-04-15 | 2004-11-04 | University Of Georgia Research Foundation, Inc. | Avian transgenesis using a chicken ovalbumin gene region |
WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
EP1644508A1 (de) | 2003-07-11 | 2006-04-12 | Cytos Biotechnology AG | Genexpressionssystem |
US20070143872A1 (en) | 2003-08-27 | 2007-06-21 | Orf Liftaekni Hf. | Enhancing accumulation of heterologous polypeptides in plant seeds through targeted suppression of endogenous storage proteins |
SI1675956T1 (sl) | 2003-10-21 | 2010-12-31 | Merck Serono Sa | Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov |
-
2002
- 2002-01-28 EP EP02726395A patent/EP1395669B1/de not_active Expired - Lifetime
- 2002-01-28 AT AT02726395T patent/ATE437233T1/de active
- 2002-01-28 CA CA2435972A patent/CA2435972C/en not_active Expired - Lifetime
- 2002-01-28 SG SG200504635-4A patent/SG141239A1/en unknown
- 2002-01-28 WO PCT/IB2002/002137 patent/WO2002074969A2/en active IP Right Grant
- 2002-01-28 JP JP2002574359A patent/JP4307079B2/ja not_active Expired - Lifetime
- 2002-01-28 DK DK02726395T patent/DK1395669T3/da active
- 2002-01-28 ES ES02726395T patent/ES2330201T3/es not_active Expired - Lifetime
- 2002-01-28 US US10/059,561 patent/US7129062B2/en not_active Expired - Lifetime
- 2002-01-28 DE DE60233049T patent/DE60233049D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1395669A2 (de) | 2004-03-10 |
WO2002074969A3 (en) | 2003-12-24 |
EP1395669B1 (de) | 2009-07-22 |
SG141239A1 (en) | 2008-04-28 |
JP2004519246A (ja) | 2004-07-02 |
CA2435972C (en) | 2011-09-13 |
JP4307079B2 (ja) | 2009-08-05 |
DK1395669T3 (da) | 2009-11-16 |
CA2435972A1 (en) | 2002-09-26 |
ES2330201T3 (es) | 2009-12-07 |
WO2002074969A2 (en) | 2002-09-26 |
ATE437233T1 (de) | 2009-08-15 |
US20030087342A1 (en) | 2003-05-08 |
US7129062B2 (en) | 2006-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60233049D1 (de) | Matrix-anheftungsregionen und verfahren zu deren verwendung | |
BR0209989A (pt) | Plataformas baseadas em cromossomas | |
ATE402254T1 (de) | Aav5 vektoren und deren verwendung | |
DK1546174T3 (da) | Fremgangsmåder og sammensætninger til RNA-interferens | |
ATE549395T1 (de) | Medium und kultur von embryonalen stammzellen | |
DE69942459D1 (de) | Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung | |
ATE430195T1 (de) | Verfahren und zusammensetzungen zur reinigung von nukleinsäure aus einer wirtszelle | |
AR025683A1 (es) | Composiciones de d-endotoxina de bacillus thuringiensis activas contra lepidopteros y metodos de uso | |
ATE311363T1 (de) | Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren | |
DK1137798T3 (da) | Fremgangsmåde til isolering af stamceller | |
DE60332157D1 (de) | Expansion erneuerbarer stammzellpopulationen | |
BR9813740A (pt) | Teriparatìdeo cristalino | |
DK1379671T3 (da) | Fremgangsmåder til dyrkning af circovirus | |
DE69839215D1 (de) | Dendritische zellhybride | |
DK1474507T3 (da) | Fremgangsmåder og materialer til produktion af organiske produkter i celler af Candida arter | |
WO2005003315A3 (en) | Compositions and methods for peptide-assisted transfection | |
DK1321477T3 (da) | Fremgangsmåde til frembringelsen af genetisk modificerede vertebrate precursor-lymfocytter og anvendelse deraf til fremstillingen af heterologe bindende proteiner | |
BR0313145A (pt) | Sistema de célula eletroquìmica, célula metal-ar e método de operar um sistema de célula eletroquìmica | |
ATE505549T1 (de) | Männliche fertilitätvermittelnde nukleotidsequenzen und deren verwendung | |
ATE171212T1 (de) | Corticotropin freisetzende rezeptoren des faktor 2 | |
WO1999047558A3 (en) | T cell costimulatory proteins, sequences and uses thereof | |
DE60323267D1 (en) | Rna-bioassay | |
WO2003106625A3 (en) | HAMMER HEAD RIBOZYMES | |
SG146623A1 (en) | Rodent expression systems utilising polyoma virus and epstein barr virus sequences | |
DK0643719T3 (da) | Nukleinsyresekvenser, som koder for eller er komplementære til nukleinsyresekvenser, som koder for interleukin 9-receptor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |