DE60229881D1 - Chimere tnf-liganden - Google Patents

Chimere tnf-liganden

Info

Publication number
DE60229881D1
DE60229881D1 DE60229881T DE60229881T DE60229881D1 DE 60229881 D1 DE60229881 D1 DE 60229881D1 DE 60229881 T DE60229881 T DE 60229881T DE 60229881 T DE60229881 T DE 60229881T DE 60229881 D1 DE60229881 D1 DE 60229881D1
Authority
DE
Germany
Prior art keywords
tnfα
cell
sequence encoding
chimeric
subdomain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60229881T
Other languages
German (de)
English (en)
Inventor
Charles E Prussak
Thomas J Kipps
Mark J Cantwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE60229881D1 publication Critical patent/DE60229881D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE60229881T 2001-12-06 2002-12-05 Chimere tnf-liganden Expired - Lifetime DE60229881D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,305 US7786282B2 (en) 2001-12-06 2001-12-06 Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
PCT/US2002/039245 WO2003050254A2 (en) 2001-12-06 2002-12-05 Novel chimeric tnf ligands

Publications (1)

Publication Number Publication Date
DE60229881D1 true DE60229881D1 (de) 2008-12-24

Family

ID=21720251

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60229881T Expired - Lifetime DE60229881D1 (de) 2001-12-06 2002-12-05 Chimere tnf-liganden

Country Status (17)

Country Link
US (3) US7786282B2 (ja)
EP (1) EP1465912B9 (ja)
JP (1) JP4610194B2 (ja)
CN (1) CN1316022C (ja)
AT (1) ATE414103T1 (ja)
AU (2) AU2002362205B2 (ja)
CA (1) CA2469494A1 (ja)
CY (1) CY1110473T1 (ja)
DE (1) DE60229881D1 (ja)
DK (1) DK1465912T3 (ja)
ES (1) ES2316638T3 (ja)
HK (1) HK1070077A1 (ja)
IL (2) IL162357A0 (ja)
PT (1) PT1465912E (ja)
SI (1) SI1465912T1 (ja)
TW (1) TWI275644B (ja)
WO (1) WO2003050254A2 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
EP2114432B1 (en) * 2006-12-05 2014-07-30 Memgen LLC Methods of increasing cancer sensitivity to chemotherapeutic agents using chimeric isf35
PL391627A1 (pl) * 2010-06-25 2012-01-02 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
PL219845B1 (pl) * 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
GB201406705D0 (en) 2014-04-15 2014-05-28 Univ Liverpool Fusion proteins,polynucleotides,expression vectors, and their uses
CN112051399B (zh) 2015-03-23 2024-09-10 赛多利斯生物分析仪器股份有限公司 用于评估生物材料中的非缔合的病毒尺寸颗粒的流式细胞术方法
WO2017079297A1 (en) 2015-11-02 2017-05-11 Memgen Llc Methods for treatment of cancer
HUP1600456A2 (en) 2016-07-19 2018-01-29 Richter Gedeon Nyrt Novel cell-based tnf-alpha binding assay
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
EP4058559A1 (en) * 2019-11-13 2022-09-21 CRISPR Therapeutics AG Methods of manufacturing car-t cells
EP4319782A1 (en) * 2021-04-05 2024-02-14 Implicyte, Inc. Armed chimeric oncolytic viruses
WO2024064637A2 (en) * 2022-09-19 2024-03-28 Emendobio Inc. Biallelic knockout of faslg

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US22017A (en) * 1858-11-09 Pen-fountain
US209295A (en) * 1878-10-22 Improvement in water-closets
US158831A (en) * 1875-01-19 Improvement in washing-machines
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
EP0317641B1 (en) 1987-05-29 1993-03-17 Sagami Chemical Research Center Fused protein containing lymphotoxin
JP2930713B2 (ja) 1989-08-16 1999-08-03 カイロン コーポレイション タンパク質ホルモン形成の抑制用の組成物およびその使用法
US5519119A (en) * 1990-09-21 1996-05-21 Ishihara Sangyo Kaisha Ltd. Muteins of TNF pharmaceutical compositions and a method of making
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
DK0667901T4 (da) 1991-10-25 2008-11-10 Immunex Corp Hidtil ukendt cytokin
US5962406A (en) * 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
EP0670730B1 (en) 1992-03-30 2003-06-04 Immunex Corporation Fusion protein comprising two tumor necrosis factor receptors
SK376492A3 (en) * 1992-04-02 1995-06-07 Hoffmann La Roche Tnf - muteins and method of their production
DK0615451T3 (da) * 1992-05-26 2006-04-24 Immunex Corp Hidtil ukendt cytokin der binder til CD30
AU5098493A (en) 1992-08-21 1994-03-15 Schering Corporation Cd40 ligand, anti cd40 antibodies, and soluble cd40
JPH07508179A (ja) 1992-08-21 1995-09-14 シェリング・コーポレーション ヒトインターロイキン−１３
US5540926A (en) 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
US5573924A (en) * 1992-09-08 1996-11-12 Immunex Corporation CD27 ligand
ES2211876T3 (es) 1993-01-22 2004-07-16 Immunex Corporation Deteccion y tratamiento de mutaciones en un gel del ligando de cd40.
US5565321A (en) * 1993-01-22 1996-10-15 Immunex Corporation Detection of mutations in a CD40 ligand gene
US5830463A (en) 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
US5861310A (en) 1993-11-03 1999-01-19 Dana-Farber Cancer Institute Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
JPH08127594A (ja) 1993-11-10 1996-05-21 Mochida Pharmaceut Co Ltd Ｆａｓ抗原に結合する新規蛋白質およびそれをコードするＤＮＡ
AU1059095A (en) 1993-11-24 1995-06-13 Australian National University, The Treatment of viral disease with cd40l peptide
PT751781E (pt) 1993-12-23 2004-09-30 Nat Inst Of Health As Repr By Utilizacao de anticorpos monoclonais ou ligandos oligomericos soluveis no fabrico de um medicamento para a prevencao ou tratamento de desordens neoplasicas
EP0739350B1 (en) 1994-01-07 2008-02-27 Mochida Pharmaceutical Co., Ltd. Ligand that binds fas antigen
DK0763057T3 (da) * 1994-04-28 2006-03-27 Boehringer Ingelheim Pharma Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf
US5606023A (en) * 1994-05-24 1997-02-25 Thomas Jefferson University Mutant tumor necrosis factor proteins
US5759536A (en) 1994-05-27 1998-06-02 University Technology Corporation Use of fas ligand to supress T-lymphocyte-mediated immune responses
BR9508419A (pt) 1994-07-22 1997-11-18 Hoffmann La Roche Composições farmacêuticas compreendendo uma proteina de ligação de tnf quinerica
GB9425060D0 (en) 1994-12-13 1995-02-08 Univ Birmingham Carcinoma treatment
US5888764A (en) 1995-01-20 1999-03-30 Uab Research Foundation Human fas gene promoter region
US6017527A (en) * 1996-07-10 2000-01-25 Immunex Corporation Activated dendritic cells and methods for their activation
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US6016832A (en) * 1997-04-16 2000-01-25 Woodward Governor Company Valve for controlling gas mass flow
JP4162849B2 (ja) 1997-09-17 2008-10-08 持田製薬株式会社 新規Ｆａｓリガンド誘導体
US6451759B1 (en) 1998-01-14 2002-09-17 The Regents Of The University Of California Noncleavable Fas ligand
US7300774B1 (en) * 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
WO2001078769A2 (en) 2000-04-12 2001-10-25 University Of South Florida Regulation of systemic immune responses utilizing soluble cd40
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
GB2392158B (en) 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof

Also Published As

Publication number Publication date
EP1465912A4 (en) 2005-04-13
US20050048476A1 (en) 2005-03-03
EP1465912B9 (en) 2009-08-12
PT1465912E (pt) 2009-02-19
IL162357A (en) 2010-12-30
US7964712B2 (en) 2011-06-21
CA2469494A1 (en) 2003-06-19
IL162357A0 (en) 2005-11-20
SI1465912T1 (sl) 2009-04-30
US20110008842A1 (en) 2011-01-13
JP4610194B2 (ja) 2011-01-12
TWI275644B (en) 2007-03-11
EP1465912A2 (en) 2004-10-13
US7786282B2 (en) 2010-08-31
WO2003050254A2 (en) 2003-06-19
HK1070077A1 (en) 2005-06-10
EP1465912B1 (en) 2008-11-12
AU2002362205B2 (en) 2009-12-10
CY1110473T1 (el) 2015-04-29
ES2316638T3 (es) 2009-04-16
ATE414103T1 (de) 2008-11-15
CN1612890A (zh) 2005-05-04
AU2010200912A1 (en) 2010-04-01
TW200301777A (en) 2003-07-16
AU2002362205A1 (en) 2003-06-23
JP2005511086A (ja) 2005-04-28
US20120116052A1 (en) 2012-05-10
DK1465912T3 (da) 2009-03-16
CN1316022C (zh) 2007-05-16
WO2003050254A3 (en) 2004-03-04

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