DE60222596T2 - Fettsäureverbindungen und deren herstellung und verwendungen - Google Patents
Fettsäureverbindungen und deren herstellung und verwendungen Download PDFInfo
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- DE60222596T2 DE60222596T2 DE60222596T DE60222596T DE60222596T2 DE 60222596 T2 DE60222596 T2 DE 60222596T2 DE 60222596 T DE60222596 T DE 60222596T DE 60222596 T DE60222596 T DE 60222596T DE 60222596 T2 DE60222596 T2 DE 60222596T2
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0110645A FR2828487B1 (fr) | 2001-08-09 | 2001-08-09 | Nouveaux composes derives d'acides gras, preparation et utilisations |
| FR0110645 | 2001-08-09 | ||
| PCT/FR2002/002831 WO2003014073A1 (fr) | 2001-08-09 | 2002-08-08 | Composes derives d'acides gras preparation et utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60222596D1 DE60222596D1 (de) | 2007-10-31 |
| DE60222596T2 true DE60222596T2 (de) | 2008-07-24 |
Family
ID=8866413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60222596T Expired - Fee Related DE60222596T2 (de) | 2001-08-09 | 2002-08-08 | Fettsäureverbindungen und deren herstellung und verwendungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7375135B2 (enExample) |
| EP (1) | EP1673338B1 (enExample) |
| JP (1) | JP2004537595A (enExample) |
| AT (1) | ATE373638T1 (enExample) |
| AU (1) | AU2002342968B2 (enExample) |
| CA (1) | CA2456288A1 (enExample) |
| CY (1) | CY1107806T1 (enExample) |
| DE (1) | DE60222596T2 (enExample) |
| DK (1) | DK1673338T3 (enExample) |
| ES (1) | ES2292824T3 (enExample) |
| FR (1) | FR2828487B1 (enExample) |
| PT (1) | PT1673338E (enExample) |
| WO (1) | WO2003014073A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO328803B1 (no) * | 2000-03-03 | 2010-05-18 | Thia Medica | Nye fettsyreanaloger |
| FR2828487B1 (fr) | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
| CN100351259C (zh) * | 2002-06-20 | 2007-11-28 | Icvec有限公司 | 含硫的磷脂衍生物 |
| FR2850650B1 (fr) * | 2003-01-31 | 2005-03-25 | Genfit S A | Utilisation therapeutique d'acylglycerols et de leurs analogues azotes et sulfures |
| FR2850869B1 (fr) * | 2003-02-12 | 2005-03-25 | Genfit S A | Utilisations d'aminopropanediols acyles et de leurs analogues azotes et sulfures |
| FR2850870B1 (fr) * | 2003-02-12 | 2006-07-28 | Genfit S A | Utilisation therapeutique de glycerols acyles et de leurs analogues azotes et sulfures |
| FR2853834B1 (fr) * | 2003-04-17 | 2008-08-15 | Vincience | Composition cosmetique ou pharmaceutique comprenant l'association d'au moins un diacyglycerol et d'au moins un alcool gras |
| FR2858216B1 (fr) * | 2003-07-31 | 2008-04-04 | Oreal | Composition contenant un 2-thioacetamide, son utilisation pour stimuler la pousse des fibres keratiniques et/ou freiner leur chute |
| RU2261705C1 (ru) * | 2004-01-29 | 2005-10-10 | Медведев Илья Николаевич | Способ лечения тромбоцитопатии при метаболическом синдроме |
| MX2007000816A (es) * | 2004-07-19 | 2007-06-05 | Thia Medica As | Composicion que comprende material de proteina y compuestos que comprenden entidades de acido graso no oxidable. |
| RU2394598C2 (ru) * | 2004-07-19 | 2010-07-20 | Тиа Медика Ас | Композиция, содержащая белковый материал и соединения, содержащие неокисляющиеся структурные элементы жирных кислот |
| DE102006019907A1 (de) * | 2006-04-28 | 2007-10-31 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von substituierten Glycerinderivaten zur Herstellung einer pharmazeutischen Zubereitung |
| DE102007051338A1 (de) * | 2007-10-26 | 2009-04-30 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von substituierten Glycerinderivaten zur Herstellung einer pharmazeutischen Zubereitung zur Behandlung und zur Vorbeugung von Dyslipidämien |
| EP2217224B1 (en) | 2007-11-09 | 2019-05-08 | Basf As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
| EP2147910A1 (en) | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| EA021177B1 (ru) | 2009-05-08 | 2015-04-30 | Пронова Биофарма Норге Ас | Полиненасыщенные жирные кислоты для лечения заболеваний, связанных с сердечно-сосудистыми, метаболическими и воспалительными заболеваниями |
| EP2445494A4 (en) * | 2009-06-24 | 2012-12-12 | Univ Koebenhavn | TREATMENT OF INSULIN RESISTANCE AND OBESITY BY STIMULATING GLP-1 RELEASE |
| ES2618604T3 (es) | 2010-11-05 | 2017-06-21 | Pronova Biopharma Norge As | Métodos de tratamiento usando compuestos lipídicos |
| KR102213143B1 (ko) | 2013-02-28 | 2021-02-08 | 바스프 에이에스 | 지방질 화합물, 트리글리세리드 및 계면활성제를 포함하는 조성물 및 이를 이용하는 방법 |
| CA2904898C (en) | 2013-03-11 | 2019-10-15 | Jan Remmereit | Lipid compositions containing bioactive fatty acids |
| HK1220606A1 (zh) | 2013-03-11 | 2017-05-12 | Nobesita As | 包含非可氧化脂肪酸的天然脂类 |
| US9744542B2 (en) | 2013-07-29 | 2017-08-29 | Apeel Technology, Inc. | Agricultural skin grafting |
| KR102644400B1 (ko) | 2015-04-28 | 2024-03-06 | 바스프 에이에스 | 비알코올성 지방간염의 예방 및/또는 치료를 위한 구조적으로 강화된 함황 지방산의 용도 |
| CN107709349B (zh) | 2015-05-20 | 2022-01-28 | 阿比尔技术公司 | 植物提取物组合物和制备其的方法 |
| US10266708B2 (en) | 2015-09-16 | 2019-04-23 | Apeel Technology, Inc. | Precursor compounds for molecular coatings |
| FR3044556B1 (fr) | 2015-12-08 | 2019-10-18 | Pierre Fabre Dermo-Cosmetique | Utilisation de diglyceride 1,3 dans une composition topique pour lutter contre la fragilisation de la barriere cutanee |
| CN112841185A (zh) | 2015-12-10 | 2021-05-28 | 阿比尔技术公司 | 用于形成保护性涂层的植物提取物组合物 |
| CN109068627B (zh) | 2016-01-26 | 2022-03-18 | 阿比尔技术公司 | 用于制备和保存消毒产品的方法 |
| EP3541192B1 (en) | 2016-11-17 | 2025-06-25 | Apeel Technology, Inc. | Methods of preparing fatty acid esters from crosslinked polyesters |
| EP3661600A4 (en) | 2017-10-23 | 2021-08-11 | Epitracker, Inc. | FATTY ACID ANALOGS AND ITS USE IN THE TREATMENT OF DISEASES RELATED TO METABOLISM SYNDROME |
| US11925614B2 (en) | 2017-12-06 | 2024-03-12 | Basf As | Fatty acid derivatives for treating non-alcoholic steatohepatitis |
| CA3099561A1 (en) * | 2018-05-16 | 2019-11-21 | Epitracker, Inc. | Compositions and methods for diagnosis and treatment of conditions related to aging |
| JP2021525249A (ja) | 2018-05-23 | 2021-09-24 | エピトラッカー インコーポレイテッドＥｐｉｔｒａｃｋｅｒ， Ｉｎｃ． | 加齢及び長期性の質に関連する状態の診断及び治療のための組成物及び方法 |
| US12245605B2 (en) | 2018-09-05 | 2025-03-11 | Apeel Technology, Inc. | Compounds and formulations for protective coatings |
| WO2020146263A1 (en) | 2019-01-09 | 2020-07-16 | Epitracker, Inc. | Compositions and methods for diagnosis and treatment of neurodegenerative diseases |
| JP7404382B2 (ja) | 2019-03-04 | 2023-12-25 | エピトラッカー インコーポレイテッド | 脂肪酸アナログ、ならびに認知機能障害、行動症状および慢性疼痛の処置におけるそれらの使用 |
| WO2021178553A1 (en) | 2020-03-04 | 2021-09-10 | Apeel Technology, Inc. | Coated agricultural products and corresponding methods |
| WO2022094339A1 (en) | 2020-10-30 | 2022-05-05 | Apeel Technology, Inc. | Compositions and methods of preparation thereof |
| WO2023039077A1 (en) | 2021-09-08 | 2023-03-16 | Apeel Technology, Inc. | Compounds and formulations for protective coatings |
| WO2023080939A1 (en) | 2021-11-03 | 2023-05-11 | Epitracker, Inc. | Pentadecanoylcarnitine for treatment of conditions related to the quality of aging and longevity |
| US12133863B1 (en) * | 2023-06-07 | 2024-11-05 | King Saud University | Green synthesis of silver nanoparticles encapsulated in a nanostructured lipid carrier |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2010154A (en) * | 1933-06-27 | 1935-08-06 | Herbert S Kreighbaum | Ether acid ester of polyhydric alcohols |
| GB1271179A (en) * | 1969-06-11 | 1972-04-19 | Mitsubishi Petrochemical Co | Polyolefin resin composition |
| JPS5738616B2 (enExample) * | 1974-06-19 | 1982-08-17 | ||
| US4134770A (en) * | 1976-09-22 | 1979-01-16 | Mitsubishi Paper Mills, Ltd. | Gelatin-containing photographic layer incorporated with hardener |
| IL59407A (en) * | 1979-03-06 | 1983-12-30 | Sanofi Sa | Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them |
| JPS5782573A (en) * | 1980-11-05 | 1982-05-24 | Matsumoto Yushi Seiyaku Kk | Smoothening treatment agent for thermoplastic synthetic fiber |
| GB8813012D0 (en) * | 1988-06-02 | 1988-07-06 | Norsk Hydro As | Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals |
| EP0447553B1 (en) * | 1989-09-11 | 1996-06-12 | Kao Corporation | Bleaching composition |
| NO952796D0 (no) | 1995-07-14 | 1995-07-14 | Rolf Berge | Fettsyre analoger med ikkeoksyderbart B-sete, fremstilling og anvendelse i krapeutiske preparater |
| US5885595A (en) * | 1996-05-13 | 1999-03-23 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic composition with a retinol fatty acid ester |
| CA2301943C (en) | 1997-08-29 | 2008-11-04 | The Johns Hopkins University | Antimicrobial compounds |
| JP2000169443A (ja) | 1998-10-02 | 2000-06-20 | Sankyo Co Ltd | ジチオ―ル誘導体 |
| US6117904A (en) * | 1999-09-03 | 2000-09-12 | Murphy; Donald M. | Treatment of pruritus |
| FR2828487B1 (fr) | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
| CN100351259C (zh) * | 2002-06-20 | 2007-11-28 | Icvec有限公司 | 含硫的磷脂衍生物 |
| FR2850650B1 (fr) | 2003-01-31 | 2005-03-25 | Genfit S A | Utilisation therapeutique d'acylglycerols et de leurs analogues azotes et sulfures |
| FR2850870B1 (fr) * | 2003-02-12 | 2006-07-28 | Genfit S A | Utilisation therapeutique de glycerols acyles et de leurs analogues azotes et sulfures |
| FR2850969B1 (fr) * | 2003-02-12 | 2005-03-25 | Genfit S A | Aminopropanediols acyles et analogues et leurs utilisations therapeutiques |
| FR2850869B1 (fr) * | 2003-02-12 | 2005-03-25 | Genfit S A | Utilisations d'aminopropanediols acyles et de leurs analogues azotes et sulfures |
-
2001
- 2001-08-09 FR FR0110645A patent/FR2828487B1/fr not_active Expired - Fee Related
-
2002
- 2002-08-08 JP JP2003519023A patent/JP2004537595A/ja active Pending
- 2002-08-08 AU AU2002342968A patent/AU2002342968B2/en not_active Ceased
- 2002-08-08 CA CA002456288A patent/CA2456288A1/fr not_active Abandoned
- 2002-08-08 EP EP02779622A patent/EP1673338B1/fr not_active Expired - Lifetime
- 2002-08-08 ES ES02779622T patent/ES2292824T3/es not_active Expired - Lifetime
- 2002-08-08 DK DK02779622T patent/DK1673338T3/da active
- 2002-08-08 AT AT02779622T patent/ATE373638T1/de not_active IP Right Cessation
- 2002-08-08 PT PT02779622T patent/PT1673338E/pt unknown
- 2002-08-08 US US10/484,350 patent/US7375135B2/en not_active Expired - Fee Related
- 2002-08-08 DE DE60222596T patent/DE60222596T2/de not_active Expired - Fee Related
- 2002-08-08 WO PCT/FR2002/002831 patent/WO2003014073A1/fr not_active Ceased
-
2007
- 2007-11-16 CY CY20071101482T patent/CY1107806T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222596D1 (de) | 2007-10-31 |
| FR2828487B1 (fr) | 2005-05-27 |
| EP1673338B1 (fr) | 2007-09-19 |
| DK1673338T3 (da) | 2008-01-14 |
| US7375135B2 (en) | 2008-05-20 |
| PT1673338E (pt) | 2007-12-12 |
| FR2828487A1 (fr) | 2003-02-14 |
| EP1673338A1 (fr) | 2006-06-28 |
| CA2456288A1 (fr) | 2003-02-20 |
| ATE373638T1 (de) | 2007-10-15 |
| WO2003014073A1 (fr) | 2003-02-20 |
| CY1107806T1 (el) | 2013-06-19 |
| JP2004537595A (ja) | 2004-12-16 |
| AU2002342968B2 (en) | 2008-05-15 |
| ES2292824T3 (es) | 2008-03-16 |
| US20040192908A1 (en) | 2004-09-30 |
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