DE60210794D1 - Rotor-stator apparat und verfahren zur bildung von partikeln - Google Patents
Rotor-stator apparat und verfahren zur bildung von partikelnInfo
- Publication number
- DE60210794D1 DE60210794D1 DE60210794T DE60210794T DE60210794D1 DE 60210794 D1 DE60210794 D1 DE 60210794D1 DE 60210794 T DE60210794 T DE 60210794T DE 60210794 T DE60210794 T DE 60210794T DE 60210794 D1 DE60210794 D1 DE 60210794D1
- Authority
- DE
- Germany
- Prior art keywords
- rotor
- forming particles
- stator apparatus
- stator
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/02—Crystallisation from solutions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B01F25/52—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle with a rotary stirrer in the recirculation tube
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/81—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis the stirrers having central axial inflow and substantially radial outflow
- B01F27/812—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis the stirrers having central axial inflow and substantially radial outflow the stirrers co-operating with surrounding stators, or with intermeshing stators, e.g. comprising slits, orifices or screens
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/711—Feed mechanisms for feeding a mixture of components, i.e. solids in liquid, solids in a gas stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71825—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding one phase surrounded by another phase without mixing during the feeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/006—Baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1806—Stationary reactors having moving elements inside resulting in a turbulent flow of the reactants, such as in centrifugal-type reactors, or having a high Reynolds-number
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/002—Nozzle-type elements
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/21—Mixing of ingredients for cosmetic or perfume compositions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0427—Numerical distance values, e.g. separation, position
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0481—Numerical speed values
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00033—Continuous processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00761—Details of the reactor
- B01J2219/00763—Baffles
- B01J2219/00765—Baffles attached to the reactor wall
- B01J2219/00768—Baffles attached to the reactor wall vertical
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/19—Details relating to the geometry of the reactor
- B01J2219/194—Details relating to the geometry of the reactor round
- B01J2219/1941—Details relating to the geometry of the reactor round circular or disk-shaped
- B01J2219/1946—Details relating to the geometry of the reactor round circular or disk-shaped conical
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B9/00—General processes of refining or remelting of metals; Apparatus for electroslag or arc remelting of metals
- C22B9/05—Refining by treating with gases, e.g. gas flushing also refining by means of a material generating gas in situ
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Manufacture Of Metal Powder And Suspensions Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32964101P | 2001-10-17 | 2001-10-17 | |
US329641P | 2001-10-17 | ||
PCT/US2002/033307 WO2003033097A2 (en) | 2001-10-17 | 2002-10-17 | Rotor-stator apparatus and process for the formation of particles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60210794D1 true DE60210794D1 (de) | 2006-05-24 |
DE60210794T2 DE60210794T2 (de) | 2007-05-10 |
Family
ID=23286346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60210794T Expired - Fee Related DE60210794T2 (de) | 2001-10-17 | 2002-10-17 | Rotor-stator apparat und verfahren zur bildung von partikeln |
Country Status (8)
Country | Link |
---|---|
US (3) | US20040187770A1 (de) |
EP (1) | EP1436057B1 (de) |
JP (1) | JP2005506174A (de) |
KR (1) | KR20050037477A (de) |
CN (1) | CN1571691A (de) |
AU (1) | AU2002335080A1 (de) |
DE (1) | DE60210794T2 (de) |
WO (1) | WO2003033097A2 (de) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60210794T2 (de) * | 2001-10-17 | 2007-05-10 | E.I. Dupont De Nemours And Co., Wilmington | Rotor-stator apparat und verfahren zur bildung von partikeln |
US20040028746A1 (en) * | 2002-08-06 | 2004-02-12 | Sonke Svenson | Crystalline drug particles prepared using a controlled precipitation (recrystallization) process |
US20040098839A1 (en) * | 2002-11-27 | 2004-05-27 | Pfizer Inc. | Crystallization method and apparatus using an impinging plate assembly |
CN100534597C (zh) * | 2003-10-01 | 2009-09-02 | 德比欧药物研究有限公司 | 制备颗粒的装置及方法 |
CA2559403C (en) | 2004-01-22 | 2013-01-15 | Amir Belson | Respiratory system for inducing therapeutic hypothermia |
US7121490B2 (en) * | 2004-04-08 | 2006-10-17 | Deseret Laboratories, Inc. | Chopper blade apparatus and method for refining particles |
US20060251808A1 (en) * | 2005-05-03 | 2006-11-09 | Lloyd Kamo | Protective coatings for pumps |
DE102005053862A1 (de) * | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
EP1957964A2 (de) * | 2005-12-07 | 2008-08-20 | Wyeth Pharmaceuticals | Verfahren zur herstellung von kristallinem rapamycin und zur messung der kristallinität von rapamycin-verbindungen über differenzscanning-kalorimetrie |
EP1986501B1 (de) * | 2006-02-22 | 2017-07-05 | Compagnie Gervais Danone | Verfahren zur herstellung einer fermentierten milch |
JP2008036545A (ja) * | 2006-08-07 | 2008-02-21 | Sumitomo Chemical Co Ltd | 晶析方法 |
US20090306339A1 (en) * | 2006-09-19 | 2009-12-10 | Van Boxtel Huibert Albertus | Preparation of Fine Particles |
WO2008035962A1 (en) * | 2006-09-19 | 2008-03-27 | Fujifilm Manufacturing Europe B.V. | Process and device for the precipitation of an organic compound |
JP5076424B2 (ja) | 2006-09-28 | 2012-11-21 | 日油株式会社 | 撹拌処理方法及び撹拌装置 |
KR20080051399A (ko) * | 2006-12-05 | 2008-06-11 | 주식회사 엘지화학 | 중합체 회수 장치 및 중합체 회수 방법 |
JP5307730B2 (ja) | 2007-01-22 | 2013-10-02 | カーギル・インコーポレイテッド | 溶媒/貧溶媒晶析を用いる精製レバウディオサイドa組成物の製法 |
CN101662955B (zh) * | 2007-01-22 | 2014-08-06 | 嘉吉公司 | 使用溶剂/抗溶剂结晶法制备提纯的莱苞迪甙a组合物的方法 |
US10287435B2 (en) * | 2007-02-19 | 2019-05-14 | Basf Se | Preparation of Pigment Red 149 |
US8282266B2 (en) * | 2007-06-27 | 2012-10-09 | H R D Corporation | System and process for inhibitor injection |
US20090005606A1 (en) * | 2007-06-27 | 2009-01-01 | H R D Corporation | High shear process for the production of cumene hydroperoxide |
US8461377B2 (en) * | 2007-06-27 | 2013-06-11 | H R D Corporation | High shear process for aspirin production |
CN102847538B (zh) | 2007-07-06 | 2016-07-06 | M技术株式会社 | 由球碳形成的结晶的制造方法及制造装置 |
US8183299B2 (en) * | 2007-07-06 | 2012-05-22 | M. Technique Co., Ltd. | Method for producing ceramic nanoparticles |
JP2009082902A (ja) * | 2007-07-06 | 2009-04-23 | M Technique Co Ltd | 強制超薄膜回転式処理法を用いたナノ粒子の製造方法 |
US8911545B2 (en) | 2007-07-06 | 2014-12-16 | M. Technique Co., Ltd. | Method for producing pigment nanoparticles by forced ultrathin film rotary reaction method, pigment nanoparticles, and inkjet ink using the same |
EP2177210B1 (de) * | 2007-07-06 | 2018-08-22 | M Technique Co., Ltd. | Verfahren zur herstellung von mikropartikeln zur aufnahme in den körper, mikropartikel zur aufnahme in den körper, dispersion und medizinische zusammensetzung damit |
JP4335968B2 (ja) * | 2007-07-06 | 2009-09-30 | エム・テクニック株式会社 | 金属微粒子の製造方法及びその金属微粒子を含む金属コロイド溶液 |
GB0714223D0 (en) * | 2007-07-20 | 2007-08-29 | Fujifilm Mfg Europe Bv | Preparation of fine particles |
US7441717B1 (en) * | 2007-10-31 | 2008-10-28 | Eastman Kodak Company | Micromedia milling process |
DE602007008127D1 (de) * | 2007-12-27 | 2010-09-09 | Linde Ag | Verfahren zur Oligomerisierung von Ethylen und Reaktorsystem dafür |
ES2468568T3 (es) * | 2008-01-07 | 2014-06-16 | Council Of Scientific & Industrial Research | Proceso para preparar cristales esféricos de sal común |
DE102008011253A1 (de) * | 2008-02-27 | 2009-09-10 | SÜDDEKOR GmbH | System und Verfahren |
JP4431181B2 (ja) * | 2008-03-04 | 2010-03-10 | 森永乳業株式会社 | ホエイ蛋白質の改質方法 |
US8128897B2 (en) * | 2008-05-06 | 2012-03-06 | Morton Salt, Inc. | Continuous process for purification of brine |
WO2010002712A2 (en) * | 2008-06-30 | 2010-01-07 | 3M Innovative Properties Company | Method of crystallization |
GB0909154D0 (en) * | 2008-09-25 | 2009-07-08 | Nanomaterials Tech Pte Ltd | A process for making particles for delivery of drug nanoparticles |
JP5713406B2 (ja) * | 2008-12-02 | 2015-05-07 | クール セラピューティクス, インコーポレイテッド | 微細氷粒子を有する呼吸ガスの送達のためのシステム |
JP5155840B2 (ja) * | 2008-12-12 | 2013-03-06 | 三井金属鉱業株式会社 | 金属水酸化物の粒子の製造方法 |
TWI350202B (en) * | 2009-02-06 | 2011-10-11 | Shennongshin Nanotechnology Co Ltd | Device for processing molecular clusters of liquid to nano-scale |
DE102009002592A1 (de) * | 2009-04-23 | 2010-10-28 | Evonik Röhm Gmbh | Dosierring |
SG175833A1 (en) * | 2009-05-11 | 2011-12-29 | Millipore Corp | Method for scaling mixing operations |
US9131718B2 (en) | 2009-06-16 | 2015-09-15 | Epc (Beijing) Natural Products Co., Ltd. | Process for rebaudioside D |
ITMI20091797A1 (it) * | 2009-10-19 | 2011-04-20 | Giordano Colombo | Apparecchiatura di reazione ed emulsificazione, particolarmente per emulsionare acqua e combustibile diesel e metodo di emulsificazione utilizzante tale apparecchiatura |
BR112012011591B1 (pt) * | 2009-11-02 | 2020-02-27 | Mannkind Corporation | Reator, sistema e método voltado para a produção de partículas em um processo de precipitação |
AU2015203301B2 (en) * | 2009-11-02 | 2017-05-25 | Mannkind Corporation | Reactor for producing pharmaceutical particles in a precipitation process |
SE534399C2 (sv) * | 2009-12-22 | 2011-08-09 | Anders Olsson | Reaktor innefattande en rotor |
WO2011106565A1 (en) * | 2010-02-24 | 2011-09-01 | Travers William A | Methods and devices for controlling particle size and particle size distribution |
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2002
- 2002-10-17 DE DE60210794T patent/DE60210794T2/de not_active Expired - Fee Related
- 2002-10-17 JP JP2003535891A patent/JP2005506174A/ja not_active Withdrawn
- 2002-10-17 AU AU2002335080A patent/AU2002335080A1/en not_active Abandoned
- 2002-10-17 CN CNA028205995A patent/CN1571691A/zh active Pending
- 2002-10-17 US US10/489,459 patent/US20040187770A1/en not_active Abandoned
- 2002-10-17 EP EP02801781A patent/EP1436057B1/de not_active Expired - Lifetime
- 2002-10-17 US US10/272,764 patent/US20030152500A1/en not_active Abandoned
- 2002-10-17 WO PCT/US2002/033307 patent/WO2003033097A2/en active IP Right Grant
- 2002-10-17 KR KR1020047005571A patent/KR20050037477A/ko not_active Application Discontinuation
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2005
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JP2005506174A (ja) | 2005-03-03 |
DE60210794T2 (de) | 2007-05-10 |
US20030152500A1 (en) | 2003-08-14 |
KR20050037477A (ko) | 2005-04-22 |
EP1436057B1 (de) | 2006-04-19 |
EP1436057A2 (de) | 2004-07-14 |
WO2003033097A3 (en) | 2003-07-17 |
WO2003033097A2 (en) | 2003-04-24 |
US20050202095A1 (en) | 2005-09-15 |
AU2002335080A1 (en) | 2003-04-28 |
US20040187770A1 (en) | 2004-09-30 |
CN1571691A (zh) | 2005-01-26 |
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