DE60207275D1 - Identifizierung von eukaryotischen internal ribosome entry site elementen (ires) - Google Patents

Identifizierung von eukaryotischen internal ribosome entry site elementen (ires)

Info

Publication number
DE60207275D1
DE60207275D1 DE60207275T DE60207275T DE60207275D1 DE 60207275 D1 DE60207275 D1 DE 60207275D1 DE 60207275 T DE60207275 T DE 60207275T DE 60207275 T DE60207275 T DE 60207275T DE 60207275 D1 DE60207275 D1 DE 60207275D1
Authority
DE
Germany
Prior art keywords
ires
gene
ires element
potential
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60207275T
Other languages
English (en)
Other versions
DE60207275T2 (de
Inventor
Joseph Atabekov
Yurii Dorokhov
Maxim Skulachev
Peter Ivanov
Yuri Gleba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icon Genetics Inc
Original Assignee
Icon Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icon Genetics Inc filed Critical Icon Genetics Inc
Priority to DE60207275T priority Critical patent/DE60207275T2/de
Application granted granted Critical
Publication of DE60207275D1 publication Critical patent/DE60207275D1/de
Publication of DE60207275T2 publication Critical patent/DE60207275T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
DE60207275T 2001-09-04 2002-09-03 Identifizierung von eukaryotischen internen ribosomeneingangsstellen-elementen(ires-elements) Expired - Lifetime DE60207275T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE60207275T DE60207275T2 (de) 2001-09-04 2002-09-03 Identifizierung von eukaryotischen internen ribosomeneingangsstellen-elementen(ires-elements)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10143238A DE10143238A1 (de) 2001-09-04 2001-09-04 Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente
DE10143238 2001-09-04
DE60207275T DE60207275T2 (de) 2001-09-04 2002-09-03 Identifizierung von eukaryotischen internen ribosomeneingangsstellen-elementen(ires-elements)
PCT/EP2002/009844 WO2003020928A2 (en) 2001-09-04 2002-09-03 Identification of eukaryotic internal ribosome entry site (ires) elements

Publications (2)

Publication Number Publication Date
DE60207275D1 true DE60207275D1 (de) 2005-12-15
DE60207275T2 DE60207275T2 (de) 2006-07-13

Family

ID=7697618

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10143238A Withdrawn DE10143238A1 (de) 2001-09-04 2001-09-04 Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente
DE60207275T Expired - Lifetime DE60207275T2 (de) 2001-09-04 2002-09-03 Identifizierung von eukaryotischen internen ribosomeneingangsstellen-elementen(ires-elements)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10143238A Withdrawn DE10143238A1 (de) 2001-09-04 2001-09-04 Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente

Country Status (9)

Country Link
US (1) US8257945B2 (de)
EP (1) EP1423516B1 (de)
JP (1) JP2005502348A (de)
AT (1) ATE309341T1 (de)
AU (1) AU2002339478B2 (de)
CA (1) CA2457038A1 (de)
DE (2) DE10143238A1 (de)
MX (1) MXPA04002097A (de)
WO (1) WO2003020928A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049587A1 (de) 2000-10-06 2002-05-02 Icon Genetics Ag Vektorsystem für Pflanzen
DE10061150A1 (de) 2000-12-08 2002-06-13 Icon Genetics Ag Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen
DE10102389A1 (de) 2001-01-19 2002-08-01 Icon Genetics Ag Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen
DE10114209A1 (de) * 2001-03-23 2002-12-05 Icon Genetics Ag Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren
DE10115507A1 (de) 2001-03-29 2002-10-10 Icon Genetics Ag Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus
DE10121283B4 (de) 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
DE10132780A1 (de) 2001-07-06 2003-01-16 Icon Genetics Ag Plastidäre Genexpression über autonom replizierende Vektoren
DE10143237A1 (de) * 2001-09-04 2003-03-20 Icon Genetics Ag Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente)
DE10143238A1 (de) 2001-09-04 2003-03-20 Icon Genetics Ag Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente
KR101454842B1 (ko) * 2003-03-20 2014-11-04 알파벡스, 인크. 개선된 알파바이러스 레플리콘 및 헬퍼 구축물
EP1807520B1 (de) 2004-10-25 2012-07-25 Devgen NV Rna-konstrukte
US20090239235A1 (en) * 2006-09-20 2009-09-24 Demaria Christine Facs- and Reporter Protein-Based System for High Throughput Development of Therapeutic Proteins
WO2008156829A2 (en) * 2007-06-21 2008-12-24 Alphavax, Inc. Promoterless cassettes for expression of alphavirus structural proteins
US20110040545A1 (en) * 2008-01-17 2011-02-17 Polyclone Bioservices Pvt. Ltd. Method to characterize a protein as rna binding protein
WO2014186334A1 (en) 2013-05-15 2014-11-20 Robert Kruse Intracellular translation of circular rna
IL258537B1 (en) 2015-10-09 2024-01-01 Genzyme Corp Improved combustion technology (flow cytometry that reduces the expression of the reporter) for rapid sorting of substances in high masses
US20180119192A1 (en) 2016-10-07 2018-05-03 Genzyme Corporation Early post-transfection isolation of cells (epic) for biologics production
CN110819707B (zh) * 2019-11-24 2023-07-18 中南大学湘雅医院 一种针对多种来源细胞样本中内部核糖体结合位点元件的高通量鉴定方法
CN115394376B (zh) * 2022-09-28 2023-04-18 奥明(杭州)生物医药有限公司 一种预测环状rna ires的方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229174A1 (de) 1985-07-16 1987-07-22 The Salk Institute For Biological Studies Genetische modifikation von pflanzen mittels retroviren
US6147278A (en) * 1985-10-25 2000-11-14 Monsanto Company Plant vectors
GB8626878D0 (en) 1986-11-11 1986-12-10 Ici Plc Dna
US5922602A (en) 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
US6174700B1 (en) * 1988-07-08 2001-01-16 University Of British Columbia Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation
FR2649518B1 (fr) * 1989-07-07 1991-10-18 Bioprobe Systems Sa Procede et dispositif de marquage crypte de haute securite pour la protection d'objets de valeur
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5877402A (en) * 1990-05-01 1999-03-02 Rutgers, The State University Of New Jersey DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein
US5474925A (en) * 1991-12-19 1995-12-12 Agracetus, Inc. Immobilized proteins in cotton fiber
JPH08505289A (ja) 1992-12-30 1996-06-11 バイオソース ジェネティクス コーポレイション 遺伝子導入植における組換メッセンジャーｒｎａのウィルス増幅関連出願のクロスリファレンス
US5496934A (en) * 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5576198A (en) * 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
US5723765A (en) * 1994-08-01 1998-03-03 Delta And Pine Land Co. Control of plant gene expression
NZ296197A (en) 1994-12-08 1999-11-29 Pabio Chemical labelling of objects or material; at least two chemical tags added, first not divulged to public, second indicates presence of first
US5910628A (en) * 1996-05-20 1999-06-08 Iowa State University Research Foundation, Inc. Cap-independent translation sequences derived from barley yellow dwarf virus
US6037525A (en) * 1996-08-01 2000-03-14 North Carolina State University Method for reducing expression variability of transgenes in plant cells
JP2001500009A (ja) 1996-09-09 2001-01-09 ロヨラ ユニバーシティ オブ シカゴ 植物レトロウイルスポリヌクレオチドおよびその使用のための方法
US5939541A (en) 1997-03-28 1999-08-17 University Of South Carolina Method for enhancing expression of a foreign or endogenous gene product in plants
US6146845A (en) * 1997-04-02 2000-11-14 Smithkline Beecham Corporation Polynucleotides encoding a sialoadhesin family member-2 (SAF-2)
FI972293A (fi) * 1997-05-30 1998-12-01 Joseph Atabekov Useamman kuin yhden geenin yhteisekspressiomenetelmät
WO1999025855A1 (en) * 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Mobilization of viral genomes from t-dna using site-specific recombination systems
EP1034262B1 (de) 1997-11-18 2005-08-17 Pioneer Hi-Bred International, Inc. Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen
CA2318662A1 (en) 1998-01-16 1999-07-22 Biosource Technologies, Inc. Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
HUP0104697A3 (en) 1998-09-23 2003-12-29 Du Pont Binary viral expression system in plants
GB9821303D0 (en) 1998-10-01 1998-11-25 Novartis Ag Organic compounds
WO2000068391A1 (en) 1998-10-23 2000-11-16 University Of British Columbia Expression of a mannan binding domain to alter plant morphology
WO2000032799A1 (en) 1998-11-25 2000-06-08 Calgene Llc Methods for transforming plastids
EP1045037A1 (de) 1999-04-12 2000-10-18 Discovery Biotech., Inc. System zu Identifizierung von Planzenzellen
ATE347617T1 (de) 1999-05-06 2006-12-15 Sinai School Medicine Steganographie auf dna basis
MXPA01011541A (es) 1999-05-17 2002-06-04 Icon Genetics Inc Proceso para una rapida transformacion de plantas independientemente de la variedad.
US6331416B1 (en) 1999-06-10 2001-12-18 Cbd Technologies Ltd. Process of expressing and isolating recombinant proteins and recombinant protein products from plants, plant derived tissues or cultured plant cells
JP2003503033A (ja) 1999-06-24 2003-01-28 メタボリックス，インコーポレイテッド 植物多重遺伝子発現構築物
EP1200557B1 (de) 1999-08-05 2006-04-26 Icon Genetics, Inc. Verfahren zur herstellung künstlicher pflanzenchromosomen
AU2001231171B2 (en) 2000-01-28 2007-01-04 The Scripps Research Institute Synthetic internal ribosome entry sites and methods of identifying same
EP1261728A2 (de) 2000-02-10 2002-12-04 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Internes, ribosomales eintrittssegment (ires) aus der pflanze
AU2001248604A1 (en) 2000-04-20 2001-11-07 Btg International Limited Transgenic plants
US6781033B2 (en) * 2000-04-26 2004-08-24 Monsanto Technology Llc Method for the transformation of plant cell plastids
GB0019745D0 (en) 2000-08-10 2000-09-27 Univ Surrey Gene expression element
DE10049587A1 (de) * 2000-10-06 2002-05-02 Icon Genetics Ag Vektorsystem für Pflanzen
DE10061150A1 (de) * 2000-12-08 2002-06-13 Icon Genetics Ag Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen
US20030049228A1 (en) * 2001-01-09 2003-03-13 Simon Santa-Cruz Expression of foreign genes from plant virus vectors
DE10101276A1 (de) * 2001-01-12 2002-07-18 Icon Genetics Ag Verfahren und Vektoren zur Transformation von Plastiden
DE10102389A1 (de) * 2001-01-19 2002-08-01 Icon Genetics Ag Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
WO2002070710A1 (en) * 2001-03-01 2002-09-12 University Of California Method to identify ires elements
DE10114209A1 (de) * 2001-03-23 2002-12-05 Icon Genetics Ag Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren
DE10115507A1 (de) * 2001-03-29 2002-10-10 Icon Genetics Ag Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus
DE10121283B4 (de) 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
DE10129010A1 (de) * 2001-06-13 2002-12-19 Icon Genetics Ag Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen
EP1270741A1 (de) * 2001-06-22 2003-01-02 Keygene N.V. An Krankheitsresistenzen beteiligte Nukleotidsequenzen in Pflanzen
DE10131680A1 (de) * 2001-06-29 2003-01-23 Voith Paper Patent Gmbh Auftragsvorrichtung
DE10131690A1 (de) 2001-06-29 2003-01-16 Icon Genetics Ag Verfahren zum kontrollierten Umordnen von Chromosomenfragmenten für die Pflanzenzucht
DE10132780A1 (de) * 2001-07-06 2003-01-16 Icon Genetics Ag Plastidäre Genexpression über autonom replizierende Vektoren
DE10143205A1 (de) * 2001-09-04 2003-03-20 Icon Genetics Ag Verfahren zur Proteinproduktion in Pflanzen
DE10143237A1 (de) * 2001-09-04 2003-03-20 Icon Genetics Ag Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente)
DE10143238A1 (de) 2001-09-04 2003-03-20 Icon Genetics Ag Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente

Also Published As

Publication number Publication date
DE60207275T2 (de) 2006-07-13
MXPA04002097A (es) 2005-02-17
US20050014150A1 (en) 2005-01-20
DE10143238A1 (de) 2003-03-20
WO2003020928A3 (en) 2003-10-09
EP1423516B1 (de) 2005-11-09
WO2003020928A2 (en) 2003-03-13
EP1423516A2 (de) 2004-06-02
CA2457038A1 (en) 2003-03-13
JP2005502348A (ja) 2005-01-27
AU2002339478B2 (en) 2007-08-23
ATE309341T1 (de) 2005-11-15
US8257945B2 (en) 2012-09-04

Similar Documents

Publication Publication Date Title
DE60207275D1 (de) Identifizierung von eukaryotischen internal ribosome entry site elementen (ires)
Zhao et al. Pseudouridines in and near the branch site recognition region of U2 snRNA are required for snRNP biogenesis and pre-mRNA splicing in Xenopus oocytes
de Moor et al. Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA
Lemm et al. Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant
Voeltz et al. AUUUA sequences direct mRNA deadenylation uncoupled from decay during Xenopus early development
Igo Jr et al. Uridylate addition and RNA ligation contribute to the specificity of kinetoplastid insertion RNA editing
DE69822206D1 (de) Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen
Hronová et al. Does eIF3 promote reinitiation after translation of short upstream ORFs also in mammalian cells?
Majumdar et al. Cell cycle modulation of gene targeting by a triple helix-forming oligonucleotide
van Leeuwen et al. Biosynthesis and function of the modified DNA base β-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei
DK1068311T3 (da) Fremgangsmåder og midler til opnåelse af modificerede fænotyper
ATE507300T1 (de) Rekombinante konstrukte und ihre verwendung bei der reduzierung der genexpression
Napierala et al. Structure-dependent recombination hot spot activity of GAA· TTC sequences from intron 1 of the Friedreich's ataxia gene
DK1017803T3 (da) Ekspression af endogene gener ved ikke-homolog rekombination af et vektorkonstrukt med cellulært DNA
Shakin et al. Destabilization of messenger RNA/complementary DNA duplexes by the elongating 80 S ribosome.
Young et al. Upstream sequences confer distinctive transcriptional properties on genes encoding silkgland-specific tRNAAla.
Schmidt et al. Mutations of the two-nucleotide bulge of D5 of a group II intron block splicing in vitro and in vivo: phenotypes and suppressor mutations.
Aboussekhra et al. TATA‐binding protein promotes the selective formation of UV‐induced (6‐4)‐photoproducts and modulates DNA repair in the TATA box
Meric et al. Masking and unmasking maternal mRNA: The role of polyadenylation, transcription, splicing, and nuclear history
Ruschak et al. Secondary structure models of the 3′ untranslated regions of diverse R2 RNAs
Zhao et al. Targeted pre-mRNA modification for gene silencing and regulation
Singh et al. High-resolution functional mapping of a cloned gene by genetic footprinting
Joshi et al. In vivo aminoacylation and ‘processing’of turnip yellow mosaic virus RNA in Xenopus laevis oocytes
Yang Promoter antisense RNAs: beyond transcription by-products of active promoters
Gera et al. Deadenylation-dependent and-independent decay pathways for α1-tubulin mRNA in Chlamydomonas reinhardtii

Legal Events

Date Code Title Description
8364 No opposition during term of opposition