DE69822206D1 - Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen - Google Patents

Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen

Info

Publication number
DE69822206D1
DE69822206D1 DE69822206T DE69822206T DE69822206D1 DE 69822206 D1 DE69822206 D1 DE 69822206D1 DE 69822206 T DE69822206 T DE 69822206T DE 69822206 T DE69822206 T DE 69822206T DE 69822206 D1 DE69822206 D1 DE 69822206D1
Authority
DE
Germany
Prior art keywords
findings
search
genome research
new ingredients
effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69822206T
Other languages
English (en)
Other versions
DE69822206T2 (de
Inventor
J Lockhart
Lisa Wodicka
Hsui Ho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymetrix Inc
Original Assignee
Affymetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Publication of DE69822206D1 publication Critical patent/DE69822206D1/de
Application granted granted Critical
Publication of DE69822206T2 publication Critical patent/DE69822206T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69822206T 1997-12-19 1998-12-18 Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen Expired - Lifetime DE69822206T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6828997P 1997-12-19 1997-12-19
US68289P 1997-12-19
PCT/US1998/026925 WO1999032660A1 (en) 1997-12-19 1998-12-18 Exploiting genomics in the search for new drugs

Publications (2)

Publication Number Publication Date
DE69822206D1 true DE69822206D1 (de) 2004-04-08
DE69822206T2 DE69822206T2 (de) 2005-02-17

Family

ID=22081628

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69822206T Expired - Lifetime DE69822206T2 (de) 1997-12-19 1998-12-18 Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen

Country Status (6)

Country Link
US (3) US6333155B1 (de)
EP (1) EP1040204B1 (de)
AT (1) ATE260989T1 (de)
AU (1) AU1926899A (de)
DE (1) DE69822206T2 (de)
WO (1) WO1999032660A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US6165709A (en) 1997-02-28 2000-12-26 Fred Hutchinson Cancer Research Center Methods for drug target screening
US20030124555A1 (en) * 2001-05-21 2003-07-03 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
JP4303418B2 (ja) * 1997-10-24 2009-07-29 ライフ テクノロジーズ コーポレーション 組換え部位を有する核酸を使用する組換えクローニング
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US6593084B2 (en) * 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
DE60042969D1 (de) 1999-03-02 2009-10-29 Life Technologies Corp Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001033228A2 (en) * 1999-11-03 2001-05-10 Oncotech, Inc. Cancer diagnosis employing cell-sorting and gene-profiles
ATE391789T1 (de) * 1999-12-10 2008-04-15 Invitrogen Corp Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen
US8288128B2 (en) 2004-11-18 2012-10-16 Eppendorf Array Technologies S.A. Real-time quantification of multiple targets on a micro-array
US7829313B2 (en) 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
AU2001256244A1 (en) * 2000-03-31 2001-10-08 Memorec Stoffel Gmbh - Medizinisch-Molekulare Entwicklung, Koln Use of particles which have signal-emitting characteristics and at least one group with an affinity for marked nucleic acids
US7157227B2 (en) * 2000-03-31 2007-01-02 University Of Louisville Research Foundation Microarrays to screen regulatory genes
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6743583B2 (en) * 2000-07-14 2004-06-01 The Board Of Trustees Of The Leland Stanford Junior University Identification of drugs and drug targets by detection of the stress response
EP1301632A2 (de) * 2000-07-19 2003-04-16 Pointilliste, Inc. Eingebettetes sortieren und hochdurchsatzscreening
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6998234B2 (en) * 2000-11-03 2006-02-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
US7415358B2 (en) 2001-05-22 2008-08-19 Ocimum Biosolutions, Inc. Molecular toxicology modeling
US20050009022A1 (en) * 2001-07-06 2005-01-13 Weiner Michael P. Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
CA2472030A1 (en) * 2002-01-24 2003-07-31 Pointilliste, Inc. Use of collections of binding sites for sample profiling and other applications
US20030195431A1 (en) * 2002-04-10 2003-10-16 Sukhatme Vikas P. Observation of effects of body fluids on indicator cells for disease diagnosis
JP2006507482A (ja) * 2002-09-17 2006-03-02 フアルマシア・コーポレーシヨン 遺伝子発現分析に使用するための複雑な生物構造物からの遺伝子分子の単離
US7364846B2 (en) * 2002-10-11 2008-04-29 Molecular Devices Corporation Gene expression profiling from FFPE samples
WO2004063339A2 (en) 2003-01-08 2004-07-29 Lesley Davenport G-quadruplex binding assays and compounds therefor
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
EP2159285B1 (de) 2003-01-29 2012-09-26 454 Life Sciences Corporation Verfahren zur Verstärkung und Sequenzierung von Nukleinsäuren
WO2004079000A1 (en) * 2003-03-07 2004-09-16 National Research Council Of Canada The determination of function of mammalian proteins by analysis of global gene expression profiles
WO2004090161A1 (en) 2003-04-14 2004-10-21 Novartis Ag Gene expression associated with osteoblast differentiation
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
JP4909072B2 (ja) 2003-06-06 2012-04-04 アーバージェン インコーポレイテッド 転写因子
MXPA05013188A (es) 2003-06-06 2007-01-30 Arborgen Llc Composiciones y metodos para regular polisacaridos de una celula vegetal.
US20050064462A1 (en) * 2003-06-17 2005-03-24 Bernd Stein Methods, compositions, and kits for predicting the effect of compounds on hot flash symptoms
US20050064472A1 (en) * 2003-07-23 2005-03-24 Affymetrix, Inc. Methods of monitoring gene expression
ES2627048T3 (es) 2003-10-24 2017-07-26 Aushon Biosystems, Inc. Aparato y procedimiento para la dispensación de muestras fluidas, semisólidas y sólidas
EP1697534B1 (de) 2003-12-01 2010-06-02 Life Technologies Corporation Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
AR047574A1 (es) 2003-12-30 2006-01-25 Arborgen Llc 2 Genesis Res 1 Genes del ciclo celular y metodos de uso relacionados
US7598080B2 (en) 2004-08-20 2009-10-06 Carl Deirmengian Diagnostic assay for source of inflammation
FI20041204A0 (fi) 2004-09-16 2004-09-16 Riikka Lund Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
US7799906B1 (en) 2004-09-22 2010-09-21 Arborgen, Llc Compositions and methods for modulating lignin of a plant
DE602005023705D1 (de) 2004-11-18 2010-11-04 Eppendorf Array Technologies Echtzeit-pcr von zielen auf einem mikroarray
US20090215028A1 (en) 2005-02-18 2009-08-27 Ellen Paxinos Methods and Compositions for Determining Anti-HIV Drug Susceptibility and Replication Capacity of HIV
WO2006089045A2 (en) 2005-02-18 2006-08-24 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors
US20070072175A1 (en) * 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
US20090087841A1 (en) * 2005-05-27 2009-04-02 Monogram Biosciences, Inc. Methods and compositions for determining resistance of hiv-1 to protease inhibitors
US8071284B2 (en) 2005-06-06 2011-12-06 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs
US9506121B2 (en) 2005-06-06 2016-11-29 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to HIV entry inhibitors
EP1736780A1 (de) 2005-06-24 2006-12-27 Eppendorf Array Technologies S.A. Verfahren und Vorrichtungen zum Nachweis und/oder zur Quantifizierung hierarchischer, molekularer Veränderungen einer Zellantwort auf einen externen Stimulus
US20070092892A1 (en) * 2005-09-02 2007-04-26 Willey James C Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states
EP1762628B1 (de) 2005-09-13 2008-03-12 Eppendorf Array Technologies SA Verfahren zum Nachweis von homologen Sequenzen, welche sich durch eine Base unterscheiden, auf einem Mikroarray
US20070092903A1 (en) * 2005-10-24 2007-04-26 Fulmer-Smentek Stephanie B One-color microarray analysis methods, reagents and kits
AU2005239672B2 (en) * 2005-11-30 2009-06-11 Canon Kabushiki Kaisha Sortable collection browser
WO2007098065A2 (en) * 2006-02-17 2007-08-30 The United States Of America As Represented By The Department Of Veterans Affairs Human sodium channel isoforms
EP1999668B1 (de) * 2006-03-15 2014-07-30 Bryan R. Soper Verfahren für die suche nach und abbildung von phänotypischen und genotypischen variationen in zellen
US7901882B2 (en) * 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8257929B2 (en) 2006-10-20 2012-09-04 University Of Miami Gene expression profiling of Parkinson's Disease
EP1935496A1 (de) 2006-12-22 2008-06-25 Eppendorf Array Technologies SA Vorrichtung und/oder Verfahren zur Detektion erweiterter Nukleotidsequenzen auf Mikro-Arrays
EP1961825A1 (de) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Verfahren zur Vorhersage des Auftretens von Metastasen bei Brustkrebspatienten
WO2008106115A2 (en) 2007-02-26 2008-09-04 Monogram Biosciences, Inc. Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
EP2107125A1 (de) 2008-03-31 2009-10-07 Eppendorf Array Technologies SA (EAT) Echtzeit-PCR von Targets auf einem Mikroarray
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US20110190662A1 (en) * 2008-10-01 2011-08-04 Beacon Endoscopic Corporation Rapid exchange fna biopsy device with diagnostic and therapeutic capabilities
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
BR112012015959A2 (pt) 2009-12-29 2019-09-24 Hills Pet Nutrition Inc composições incluindo gengibre para a melhora ou prevenção de condições inflamatórias
FI20105166A0 (fi) 2010-02-19 2010-02-19 Suomen Punainen Risti Veripalv Menetelmä kantasolupopulaation erilaistumistilan osoittamiseksi
EP2369325A1 (de) 2010-03-12 2011-09-28 Eppendorf Ag Arrayanalyse für Online-Detektion
US9453261B2 (en) 2011-09-20 2016-09-27 The George Washington University Alternative splicing variants of genes associated with prostate cancer risk and survival
US9988687B2 (en) 2011-09-20 2018-06-05 The George Washington Univeristy Companion diagnostics for cancer and screening methods to identify companion diagnostics for cancer based on splicing variants
EP2807271B1 (de) 2012-01-24 2018-08-22 CD Diagnostics, Inc. System zum nachweis einer infektion in der synovialflüssigkeit
EP2664619B1 (de) * 2012-05-16 2017-07-12 Manros Therapeutics Purinderivate als Werkzeuge zum Abtasten von Verbindungen gegen Alzheimer
WO2014047285A1 (en) 2012-09-19 2014-03-27 Paraskevi Giannakakou Identifying taxane sensitivity in prostate cancer patients
EP3736570A1 (de) 2019-05-09 2020-11-11 Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León Verfahren zur diagnose, subklassifizierung und prognose von akuter nierenverletzung durch detektion von cct7

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
ES2325393T3 (es) * 1993-10-28 2009-09-03 Houston Advanced Research Center Aparato poroso de flujo a traves microfabricado para la deteccion diferenciada de reacciones de union.
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
JP2000504672A (ja) 1996-02-09 2000-04-18 フィテラ シンビオン エイピーエス バラノール類似体
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US5965352A (en) 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action

Also Published As

Publication number Publication date
US20010055771A1 (en) 2001-12-27
EP1040204A1 (de) 2000-10-04
DE69822206T2 (de) 2005-02-17
EP1040204B1 (de) 2004-03-03
US20030180774A1 (en) 2003-09-25
AU1926899A (en) 1999-07-12
WO1999032660A9 (en) 1999-09-23
WO1999032660A1 (en) 1999-07-01
US6333155B1 (en) 2001-12-25
ATE260989T1 (de) 2004-03-15
US6524800B2 (en) 2003-02-25

Similar Documents

Publication Publication Date Title
DE69822206D1 (de) Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen
Lohse et al. Double duplex invasion by peptide nucleic acid: a general principle for sequence-specific targeting of double-stranded DNA
Tang et al. Structural diversity of self-cleaving ribozymes
ATE346156T1 (de) Umkehrtransfektionsverfahren
EP1546174A4 (de) Verfahren und zusammensetzungen für rna-interferenz
DE69433626D1 (de) N-2 substituierte purine
DE69906977D1 (de) In liposomen verkapselte nukleinsäurekomplexe
DK1681355T3 (da) Sekvensspecifik DNA-rekombination i eukaryote celler
IL180924A (en) Method for regulating cell proliferation and cell death
NZ538852A (en) Selection and isolation of living cells using mRNA-binding probes
DE69939056D1 (de) Vektoren für genmutagenese und genentdeckung
HUP0001937A2 (hu) Új vegyületek, eljárás előállításukra és alkalmazásuk nukleinsavak sejtekbe való bevitelére
DE69937689D1 (de) Stabiele transfizierte zellen zum auffinden von wirkstoffen, die die mrna stabilität beeinflussen
DE60207275D1 (de) Identifizierung von eukaryotischen internal ribosome entry site elementen (ires)
DE69941451D1 (de) Verfahren zur unterdrückung der genexpression in pflanzen
DE69805627T2 (de) Verbesserte stämme für die protein-expression
TR200000140T2 (tr) Endojenik gen etkinliği ile insan proteini üretimi için insan hücre sıralarının belirlenmesi
NO974367L (no) Vektorer samt fremgangsmåter for gen-ekspresjon i pattedyrceller
ES8602123A1 (es) Un metodo para clonar un gen que codifica la cobre-meta-lotioneina de levadura
AU2294102A (en) Mutant muscle-specific enhancers
NZ508103A (en) Photoinhibitory promoter
Lambson et al. Chromosomal evolution in secretory and nonsecretory subline of MOPC 21
ATE275267T1 (de) Verfahren zur parallelen bestimmung der zellvitalität und gentransfer-effizienz
Shugart et al. Poly (ADP-ribosylation) in N, N-diethylnitrosamine-treated mice.
ATE288476T1 (de) Herstellung von proteinen

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition