DE60202278T2 - Aktivierung natürlicher killerzellen durch adenosin-a3-rezeptoragonisten - Google Patents
Aktivierung natürlicher killerzellen durch adenosin-a3-rezeptoragonisten Download PDFInfo
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- DE60202278T2 DE60202278T2 DE60202278T DE60202278T DE60202278T2 DE 60202278 T2 DE60202278 T2 DE 60202278T2 DE 60202278 T DE60202278 T DE 60202278T DE 60202278 T DE60202278 T DE 60202278T DE 60202278 T2 DE60202278 T2 DE 60202278T2
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
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- Hematology (AREA)
- Virology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/832,818 US20040204481A1 (en) | 2001-04-12 | 2001-04-12 | Activation of natural killer cells by adenosine A3 receptor agonists |
| US832818 | 2001-04-12 | ||
| PCT/IL2002/000298 WO2002083152A1 (en) | 2001-04-12 | 2002-04-11 | Activation of natural killer cells by adenosine a3 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60202278D1 DE60202278D1 (de) | 2005-01-20 |
| DE60202278T2 true DE60202278T2 (de) | 2005-12-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE60202278T Expired - Fee Related DE60202278T2 (de) | 2001-04-12 | 2002-04-11 | Aktivierung natürlicher killerzellen durch adenosin-a3-rezeptoragonisten |
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| Country | Link |
|---|---|
| US (1) | US20040204481A1 (enExample) |
| EP (1) | EP1383515B1 (enExample) |
| JP (1) | JP2004531523A (enExample) |
| AT (1) | ATE284698T1 (enExample) |
| DE (1) | DE60202278T2 (enExample) |
| IL (1) | IL157841A0 (enExample) |
| WO (1) | WO2002083152A1 (enExample) |
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| US7414036B2 (en) | 2002-01-25 | 2008-08-19 | Muscagen Limited | Compounds useful as A3 adenosine receptor agonists |
| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| ME01072B (me) | 2004-05-26 | 2012-10-20 | Inotek Pharmaceuticals Corp | Derivati purina kao agonisti receptora adenozina a1 i postupci za njihovu upotrebu |
| US7825102B2 (en) | 2004-07-28 | 2010-11-02 | Can-Fite Biopharma Ltd. | Treatment of dry eye conditions |
| ES2432113T3 (es) * | 2004-07-28 | 2013-11-29 | Can-Fite Biopharma Ltd. | Agonistas del receptor de adenosina A3 para el tratamiento de trastornos del ojo seco, incluido el síndrome de Sjogren |
| CA2581132A1 (en) | 2004-09-20 | 2006-03-30 | Inotek Pharmaceuticals Corporation | Purine 5'-carboxamide derivatives and their use as adenosine receptor agonists |
| CN101083998A (zh) * | 2004-11-22 | 2007-12-05 | 王者制药研究发展有限公司 | 用腺苷a3受体激动剂强化治疗hif－1介导的病症 |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| BRPI0619261A2 (pt) | 2005-11-30 | 2011-09-27 | Inotek Pharmaceuticals Corp | derivados de purina e métodos de uso desses |
| GB0625100D0 (en) * | 2006-12-15 | 2007-01-24 | Univ Murcia | Epigallocatechin-3-gallate compositions for cancer therapy and chemoprotection |
| US20090088403A1 (en) * | 2007-05-07 | 2009-04-02 | Randy Blakely | A3 adenosine receptors as targets for the modulation of central serotonergic signaling |
| WO2010065959A1 (en) * | 2008-12-05 | 2010-06-10 | Northeastern University | Method of preparing adenosine-resistant anti-tumor t lymphocytes for adoptive immunotherapy |
| JP2013516495A (ja) | 2010-01-11 | 2013-05-13 | イノテック ファーマシューティカルズ コーポレイション | 眼圧を低下させる組合せ、キット、および方法 |
| JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
| KR102072041B1 (ko) | 2011-12-22 | 2020-01-31 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
| SMT201700377T1 (it) | 2012-01-26 | 2017-09-07 | Inotek Pharmaceuticals Corp | Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| NZ630759A (en) | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
| CA3109139A1 (en) * | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| CN112996805A (zh) | 2018-08-30 | 2021-06-18 | Hcw生物科技公司 | 多链嵌合多肽和其用途 |
| WO2020047333A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| AU2020294797B2 (en) | 2019-06-21 | 2025-12-18 | Immunitybio, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3169243A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| WO2021163299A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Chromatography resin and uses thereof |
| CN116670163A (zh) | 2020-02-11 | 2023-08-29 | Hcw生物科技公司 | 治疗年龄相关疾病和炎性疾病的方法 |
| AU2021262794B2 (en) | 2020-04-29 | 2026-06-18 | Immunitybio, Inc. | Anti-CD26 proteins and uses thereof |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US12594323B2 (en) | 2022-04-13 | 2026-04-07 | Immunitybio, Inc. | Methods of reducing neuroinflammation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121272A (en) * | 1997-07-10 | 2000-06-01 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia |
| IL133680A0 (en) * | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
-
2001
- 2001-04-12 US US09/832,818 patent/US20040204481A1/en not_active Abandoned
-
2002
- 2002-04-11 IL IL15784102A patent/IL157841A0/xx unknown
- 2002-04-11 WO PCT/IL2002/000298 patent/WO2002083152A1/en not_active Ceased
- 2002-04-11 JP JP2002580954A patent/JP2004531523A/ja not_active Withdrawn
- 2002-04-11 EP EP02726402A patent/EP1383515B1/en not_active Expired - Lifetime
- 2002-04-11 DE DE60202278T patent/DE60202278T2/de not_active Expired - Fee Related
- 2002-04-11 AT AT02726402T patent/ATE284698T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002083152A1 (en) | 2002-10-24 |
| ATE284698T1 (de) | 2005-01-15 |
| JP2004531523A (ja) | 2004-10-14 |
| DE60202278D1 (de) | 2005-01-20 |
| EP1383515B1 (en) | 2004-12-15 |
| IL157841A0 (en) | 2004-03-28 |
| EP1383515A1 (en) | 2004-01-28 |
| US20040204481A1 (en) | 2004-10-14 |
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