DE602006018317D1 - Massenmarkierungen - Google Patents
MassenmarkierungenInfo
- Publication number
- DE602006018317D1 DE602006018317D1 DE200660018317 DE602006018317T DE602006018317D1 DE 602006018317 D1 DE602006018317 D1 DE 602006018317D1 DE 200660018317 DE200660018317 DE 200660018317 DE 602006018317 T DE602006018317 T DE 602006018317T DE 602006018317 D1 DE602006018317 D1 DE 602006018317D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- mass
- group
- unsubstituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Inorganic Insulating Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Liquid Crystal Substances (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0515323A GB0515323D0 (en) | 2005-07-26 | 2005-07-26 | Mass labels |
| PCT/GB2006/002787 WO2007012849A2 (en) | 2005-07-26 | 2006-07-26 | MASS LABELS FOR BIOMOLECULES CONTAINING A 2,6-DIMETHYL-PIPERIDIN-l-YL METHYLENE OR A PYRIMIDIN-2-YL THIOMETHYLENE MASS MARKER MOIETY AND A SUCCINIMID-OXY-CARBONYL REACTIVE FUNCTIONAL GROUP |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006018317D1 true DE602006018317D1 (de) | 2010-12-30 |
Family
ID=34976608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE200660018317 Active DE602006018317D1 (de) | 2005-07-26 | 2006-07-26 | Massenmarkierungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9023656B2 (de) |
| EP (1) | EP1907860B1 (de) |
| JP (1) | JP5054690B2 (de) |
| CN (2) | CN104987326B (de) |
| AT (1) | ATE488771T1 (de) |
| AU (1) | AU2006273834B2 (de) |
| CA (1) | CA2616985C (de) |
| DE (1) | DE602006018317D1 (de) |
| GB (1) | GB0515323D0 (de) |
| NZ (1) | NZ565513A (de) |
| WO (1) | WO2007012849A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| GB0809488D0 (en) * | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| WO2010104981A2 (en) | 2009-03-10 | 2010-09-16 | University Of Maryland Biotechnology Institute | Deuterium isobaric tag reagents for quantitative analysis |
| US20110046489A1 (en) * | 2009-08-18 | 2011-02-24 | University Of Calcutta | Systems and methods employing giant stokes shift |
| GB0916881D0 (en) * | 2009-09-25 | 2009-11-11 | Electrophoretics Ltd | Mass labels |
| WO2011047192A2 (en) | 2009-10-14 | 2011-04-21 | Dana-Farber Cancer Institute, Inc. | Protected amine labels and use in detecting analytes |
| US9354170B2 (en) | 2011-02-15 | 2016-05-31 | University Of Calcutta | NIR fluorescence of heavy water |
| CN104508487B (zh) | 2012-05-10 | 2017-04-19 | 萨默费尼根有限公司 | 用于通过质谱法高度多路复用地定量肽类的方法以及用于其的标记试剂 |
| JP5895694B2 (ja) * | 2012-05-11 | 2016-03-30 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| US9835629B2 (en) * | 2012-05-18 | 2017-12-05 | Pierce Biotechnology, Inc. | Methods and reagents for biomolecule labeling, enrichment and gentle elution |
| US9366678B2 (en) | 2012-10-25 | 2016-06-14 | Wisconsin Alumni Research Foundation | Neutron encoded mass tags for analyte quantification |
| JP2014215187A (ja) * | 2013-04-25 | 2014-11-17 | 株式会社島津製作所 | ペプチドの解析法 |
| GB201308765D0 (en) * | 2013-05-15 | 2013-06-26 | Electrophoretics Ltd | Mass Tag Reagents |
| GB201322567D0 (en) * | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| US9146219B2 (en) * | 2014-01-27 | 2015-09-29 | National Medical Services, Inc. | Sensitive method for measuring cis-diol containing compounds in plasma using 2D-LC-MS/MS |
| GB201410523D0 (en) * | 2014-06-12 | 2014-07-30 | Electrophoretics Ltd | Mass labels |
| EP3304058B1 (de) | 2015-06-03 | 2023-08-02 | President and Fellows of Harvard College | Reagenzien für quantitative massenspektrometrie |
| AU2016338691A1 (en) * | 2015-10-14 | 2018-04-12 | Wisconsin Alumni Research Foundation | Mass defect-based multiplex dimethyl pyrimidinyl ornithine (DiPyrO) tags for high-throughput quantitative proteomics and peptidomics |
| GB201519186D0 (en) * | 2015-10-30 | 2015-12-16 | Electrophoretics Ltd | Isotopic methods for measurement of tryptophan and metabolites thereof |
| GB201521903D0 (en) | 2015-12-11 | 2016-01-27 | Electrophoretics Ltd | Isorbaric mass labels |
| GB201521919D0 (en) | 2015-12-11 | 2016-01-27 | Electrophoretics Ltd | Isobaric mass labels |
| CN108658762B (zh) * | 2018-06-12 | 2021-03-02 | 浙江凯普化工有限公司 | 一种脂环邻二酯的合成方法 |
| US11022593B2 (en) | 2018-10-25 | 2021-06-01 | Savannah River Nuclear Solutions, Llc | Solid phase sampling device and methods for point-source sampling of polar organic analytes |
| JP2022533145A (ja) * | 2019-05-13 | 2022-07-21 | シャンハイ ポラリス バイオロジー カンパニー， リミテッド | 生体分子を標識するためのタグ |
| US20240230687A1 (en) * | 2021-04-07 | 2024-07-11 | The Texas A&M University System | Mass tags for lipid analyses |
| CN113788788B (zh) * | 2021-07-23 | 2023-12-05 | 浙江工业大学 | 一种荧光离子液体及其合成方法与应用 |
| CN115260288B (zh) * | 2022-06-14 | 2024-08-27 | 东莞理工学院 | 一种干腌火腿来源抗氧化肽复合物及应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2856405A (en) * | 1956-06-04 | 1958-10-14 | Lakeside Lab Inc | Mecuration products of 1-(2-pyrimidyl)-3-allylurea |
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| FR2036922A1 (en) | 1969-04-18 | 1970-12-31 | Leurquin Lab | 2-amino pyrimidine derivs prepn |
| JP2753622B2 (ja) | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| JP2000503845A (ja) | 1996-01-23 | 2000-04-04 | ラピジーン，インコーポレイテッド | サイジング技術を用いる核酸分子の分析のための方法および組成物 |
| DE69701671T3 (de) | 1996-01-23 | 2006-08-17 | Qiagen Genomics, Inc., Bothell | Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekülen |
| CA2274587A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| AU725966B2 (en) | 1997-01-15 | 2000-10-26 | Xzillion Gmbh & Co. Kg | Mass label linked hybridisation probes |
| JP3795534B2 (ja) | 1997-01-23 | 2006-07-12 | イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | ポリペプチドの特性検査 |
| WO1999009217A1 (en) * | 1997-08-15 | 1999-02-25 | Hyseq, Inc. | Methods and compositions for detection or quantification of nucleic acid species |
| GB9815166D0 (en) | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
| GB9815163D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds |
| KR20010042296A (ko) * | 1998-03-31 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 세린 프로테아제 억제제로서의 벤즈옥사지논/벤조티아지논 |
| JP2002509928A (ja) * | 1998-03-31 | 2002-04-02 | ワーナー−ランバート・カンパニー | セリンプロテアーゼ阻害剤としてのキノロン |
| GB9821393D0 (en) | 1998-10-01 | 1998-11-25 | Brax Genomics Ltd | Protein profiling 2 |
| GB0006141D0 (en) * | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| ATE360620T1 (de) | 2000-08-01 | 2007-05-15 | Sod Conseils Rech Applic | Imidazolderivate |
| WO2002055496A1 (en) | 2001-01-15 | 2002-07-18 | Glaxo Group Limited | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| US7183116B2 (en) * | 2001-05-14 | 2007-02-27 | The Institute For Systems Biology | Methods for isolation and labeling of sample molecules |
| EP1267170A1 (de) | 2001-06-07 | 2002-12-18 | Xzillion GmbH & CO.KG | Verfahren zur Charakterisierung von Polypeptiden |
| ES2296996T3 (es) * | 2001-09-14 | 2008-05-01 | Electrophoretics Limited | Marcaje de moleculas. |
| WO2003040093A2 (de) | 2001-11-09 | 2003-05-15 | Bayer Healthcare Ag | Isotopencodierte affinitätsmarker 2 |
| GB0131014D0 (en) * | 2001-12-28 | 2002-02-13 | James Peter | Method for molecule-mlecule analysis |
| GB0215392D0 (en) | 2002-07-03 | 2002-08-14 | Glaxo Group Ltd | Chemical compounds |
| US20060051879A9 (en) * | 2003-01-16 | 2006-03-09 | Hubert Koster | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| GB0306756D0 (en) * | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
| TW200519105A (en) | 2003-10-20 | 2005-06-16 | Lg Life Science Ltd | Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
| TW200533919A (en) | 2003-12-08 | 2005-10-16 | Oxford Gene Tech Ip Ltd | Derivatived molecules for mass spectrometry |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
-
2005
- 2005-07-26 GB GB0515323A patent/GB0515323D0/en not_active Ceased
-
2006
- 2006-07-26 CN CN201510144106.3A patent/CN104987326B/zh active Active
- 2006-07-26 AU AU2006273834A patent/AU2006273834B2/en active Active
- 2006-07-26 WO PCT/GB2006/002787 patent/WO2007012849A2/en active Application Filing
- 2006-07-26 CA CA 2616985 patent/CA2616985C/en active Active
- 2006-07-26 US US11/996,910 patent/US9023656B2/en active Active
- 2006-07-26 CN CN200680035117.7A patent/CN101313223B/zh active Active
- 2006-07-26 NZ NZ565513A patent/NZ565513A/en unknown
- 2006-07-26 JP JP2008523449A patent/JP5054690B2/ja active Active
- 2006-07-26 DE DE200660018317 patent/DE602006018317D1/de active Active
- 2006-07-26 AT AT06765110T patent/ATE488771T1/de not_active IP Right Cessation
- 2006-07-26 EP EP20060765110 patent/EP1907860B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100178710A1 (en) | 2010-07-15 |
| CN104987326A (zh) | 2015-10-21 |
| US9023656B2 (en) | 2015-05-05 |
| CN101313223A (zh) | 2008-11-26 |
| EP1907860A2 (de) | 2008-04-09 |
| CN104987326B (zh) | 2019-08-30 |
| CA2616985A1 (en) | 2007-02-01 |
| WO2007012849A3 (en) | 2007-03-29 |
| EP1907860B1 (de) | 2010-11-17 |
| AU2006273834B2 (en) | 2011-09-01 |
| AU2006273834A1 (en) | 2007-02-01 |
| GB0515323D0 (en) | 2005-08-31 |
| AU2006273834A8 (en) | 2009-08-06 |
| WO2007012849A2 (en) | 2007-02-01 |
| JP5054690B2 (ja) | 2012-10-24 |
| NZ565513A (en) | 2011-03-31 |
| JP2009503485A (ja) | 2009-01-29 |
| ATE488771T1 (de) | 2010-12-15 |
| CN101313223B (zh) | 2017-04-12 |
| CA2616985C (en) | 2014-10-28 |
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