DE602006016233D1 - Substituierte pyrazolopyridine, diese enthaltende sowie deren verwendung - Google Patents

Substituierte pyrazolopyridine, diese enthaltende sowie deren verwendung

Info

Publication number
DE602006016233D1
DE602006016233D1 DE602006016233T DE602006016233T DE602006016233D1 DE 602006016233 D1 DE602006016233 D1 DE 602006016233D1 DE 602006016233 T DE602006016233 T DE 602006016233T DE 602006016233 T DE602006016233 T DE 602006016233T DE 602006016233 D1 DE602006016233 D1 DE 602006016233D1
Authority
DE
Germany
Prior art keywords
containers
substituted pyrazolopyridines
pyrazolopyridines
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006016233T
Other languages
English (en)
Inventor
Baptiste Ronan
Michel Tabart
Frank Halley
Eric Bacque
Catherine Souaille
Antonio Ugolini
Fabrice Viviani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36593766&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006016233(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0500555A external-priority patent/FR2880891B1/fr
Priority claimed from FR0507505A external-priority patent/FR2888579A1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE602006016233D1 publication Critical patent/DE602006016233D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602006016233T 2005-01-19 2006-01-18 Substituierte pyrazolopyridine, diese enthaltende sowie deren verwendung Active DE602006016233D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0500555A FR2880891B1 (fr) 2005-01-19 2005-01-19 Pyrazolo pyridines substituees, compositions les contenant, procede de fabrication et utilisation
FR0507505A FR2888579A1 (fr) 2005-07-13 2005-07-13 Pyrazolo pyridines substituees, compositions les contenant, procede de fabrication et utilisation
PCT/FR2006/000114 WO2006077319A1 (fr) 2005-01-19 2006-01-18 Pyrazolo pyridines substituees, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
DE602006016233D1 true DE602006016233D1 (de) 2010-09-30

Family

ID=36593766

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006016233T Active DE602006016233D1 (de) 2005-01-19 2006-01-18 Substituierte pyrazolopyridine, diese enthaltende sowie deren verwendung

Country Status (24)

Country Link
US (2) US8008322B2 (de)
EP (1) EP1845978B1 (de)
JP (1) JP2008527025A (de)
KR (1) KR20070098923A (de)
AR (1) AR052357A1 (de)
AT (1) ATE477799T1 (de)
AU (1) AU2006207442A1 (de)
BR (1) BRPI0606504A2 (de)
CA (1) CA2595041A1 (de)
CY (1) CY1110926T1 (de)
DE (1) DE602006016233D1 (de)
DK (1) DK1845978T3 (de)
HR (1) HRP20100624T8 (de)
IL (1) IL184524A0 (de)
MX (1) MX2007008790A (de)
PA (1) PA8660301A1 (de)
PE (1) PE20061119A1 (de)
PL (1) PL1845978T3 (de)
PT (1) PT1845978E (de)
RU (1) RU2375360C2 (de)
SI (1) SI1845978T1 (de)
TW (1) TW200639173A (de)
UY (1) UY29341A1 (de)
WO (1) WO2006077319A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2871158A1 (fr) 2004-06-04 2005-12-09 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
TW200815438A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP1870410A1 (de) 2006-06-13 2007-12-26 Bayer Schering Pharma Aktiengesellschaft Substituierte Arylpyrazolopyridine und ihre Salze, diese enthaltende pharmazeutische Zubereitungen, verfahren zu ihrer Herstellung und ihre Verwendung
EP1932845A1 (de) * 2006-12-15 2008-06-18 Bayer Schering Pharma Aktiengesellschaft 3-H-Pyrazolopyridine und Salze davon, diese enthaltende pharmazeutische Zusammensetzungen , Verfahren zur ihrer Herstellung und ihre Verwendung
EP2042500A1 (de) * 2007-09-21 2009-04-01 Bayer Schering Pharma Aktiengesellschaft N-[4-(1-H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-[(hetero)aryl]-Harnstoff-Verbindungen deren pharmazeutische Zusammensetzungen, Verfahren zu deren Herstellung und Verwendungen als Tie2-Kinase Hemmer
KR20090088962A (ko) * 2006-12-15 2009-08-20 바이엘 쉐링 파마 악티엔게젤샤프트 ３-ｈ-피라졸로피리딘 및 그의 염, 이를 포함하는 제약 조성물, 이의 제조 방법 및 이의 용도
US20110160232A1 (en) * 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
WO2009073300A1 (en) * 2007-11-02 2009-06-11 Vertex Pharmaceuticals Incorporated [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta
EP2070929A1 (de) 2007-12-11 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Alkynylarylverbindungen und Salze davon, pharmazeutische Zusammensetzungen damit sowie Verfahren zu ihrer Herstellung und Verwendung
CN101959887B (zh) 2008-01-08 2013-07-31 阵列生物制药公司 作为激酶抑制剂的吡咯并吡啶
ES2392014T3 (es) 2008-01-09 2012-12-03 Array Biopharma, Inc. Pirazolopiridinas como inhibidores de la cinasa
US8993580B2 (en) * 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) * 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
MX2011000216A (es) 2008-07-08 2011-03-29 Intellikine Inc Inhibidores de cinasa y metodos para su uso.
US8476282B2 (en) * 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
EP2408772B1 (de) * 2009-03-19 2015-07-01 Medical Research Council Technology Verbindungen
EP2464647B1 (de) 2009-08-11 2016-09-21 Bristol-Myers Squibb Company Azaindole als btk kinase modulatoren und deren verwendung
US8222416B2 (en) * 2009-12-14 2012-07-17 Hoffmann-La Roche Inc. Azaindole glucokinase activators
GB201008134D0 (en) * 2010-05-14 2010-06-30 Medical Res Council Technology Compounds
EP2598481B1 (de) 2010-07-26 2016-08-31 Bristol-Myers Squibb Company Sulfonamidverbindungen als cyp17-hemmer
GB201015949D0 (en) * 2010-09-22 2010-11-03 Medical Res Council Technology Compounds
US9266880B2 (en) 2010-11-12 2016-02-23 Bristol-Myers Squibb Company Substituted azaindazole compounds
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
WO2012162627A1 (en) * 2011-05-26 2012-11-29 The General Hospital Corporation Treatment of angiogenic- or vascular-associated diseases
KR20140071361A (ko) * 2011-08-12 2014-06-11 에프. 호프만-라 로슈 아게 피라졸로[3,4-c]피리딘 화합물 및 사용 방법
JPWO2013125543A1 (ja) * 2012-02-20 2015-07-30 武田薬品工業株式会社 複素環化合物
AU2013323508B2 (en) * 2012-09-28 2017-11-02 Merck Sharp & Dohme Corp. Novel compounds that are ERK inhibitors
ES2696700T3 (es) * 2012-12-28 2019-01-17 Crystalgenomics Inc Derivado de 2,3-dihidro-isoindol-1-on como supresor de quinasa BTK y composición farmacéutica que incluye el mismo
TWI629275B (zh) * 2013-03-13 2018-07-11 賽諾菲公司 Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途
CN103524421B (zh) * 2013-09-29 2015-04-01 镇江蓝德特药业科技有限公司 新型萘脲类衍生物及其医疗应用
KR20200140302A (ko) 2018-04-05 2020-12-15 메르크 파텐트 게엠베하 타입 ii irak 억제제로서 헤테로아릴 화합물 및 이의 용도
UY38349A (es) 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
WO2023115142A1 (en) * 2021-12-22 2023-06-29 Anaxis Pharma Pty Ltd Arylsulphonamide compounds

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1182896B (de) * 1963-04-02 1964-12-03 Merck Ag E Fungizide Mittel
PL354241A1 (en) 1999-09-17 2003-12-29 Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg Kinase inhibitors as therapeutic agents
WO2002006237A1 (fr) * 2000-07-18 2002-01-24 Yamanouchi Pharmaceutical Co., Ltd. Medicament comprenant un derive de dicyanopyridine
PL213199B1 (pl) * 2000-08-10 2013-01-31 Pharmacia Italia Spa Zwiazek bicyklo-pirazolowy, sposób wytwarzania go, jego kompozycja farmaceutyczna, oraz kombinatoryczna biblioteka chemiczna
JP4272338B2 (ja) * 2000-09-22 2009-06-03 バイエル アクチェンゲゼルシャフト ピリジン誘導体
FR2827603B1 (fr) * 2001-07-18 2003-10-17 Oreal Composes derives de diaminopyrazole substitues par un radical heteroaromatique et leur utilisation en teinture d'oxydation des fibres keratiniques
GB0128287D0 (en) * 2001-11-26 2002-01-16 Smithkline Beecham Plc Novel method and compounds
WO2004009596A2 (en) * 2002-07-23 2004-01-29 Smithkline Beecham Corporation Pyrazolopyrimidines as kinase inhibitors
US7186716B2 (en) * 2002-08-12 2007-03-06 Sugen, Inc. 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
UA81453C2 (en) * 2003-02-27 2008-01-10 Pyrazolopyridine derivates
WO2004096130A2 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
DE602004027490D1 (de) * 2003-05-22 2010-07-15 Abbott Lab Indazol-, benzisoxazol- und benzisothiazol-kinaseinhibitoren
AU2004259012C1 (en) 2003-07-23 2012-08-02 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
JP2005325099A (ja) * 2004-04-12 2005-11-24 Sankyo Co Ltd チエノピリジン誘導体
US20060074102A1 (en) * 2004-05-14 2006-04-06 Kevin Cusack Kinase inhibitors as therapeutic agents
FR2871158A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
WO2006050109A2 (en) * 2004-10-29 2006-05-11 Abbott Laboratories Novel kinase inhibitors
WO2006076442A2 (en) 2005-01-14 2006-07-20 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives
EP1683796A1 (de) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridine, ihre Herstellung und ihre medizinische Verwendung
MX2007011041A (es) 2005-03-10 2008-02-22 Cgi Pharmaceuticals Inc Ciertas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas.
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
WO2007056582A1 (en) 2005-11-09 2007-05-18 Memory Pharmaceuticals Corporation 1 h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
EP1870410A1 (de) * 2006-06-13 2007-12-26 Bayer Schering Pharma Aktiengesellschaft Substituierte Arylpyrazolopyridine und ihre Salze, diese enthaltende pharmazeutische Zubereitungen, verfahren zu ihrer Herstellung und ihre Verwendung
TW200815438A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
TW200815437A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same

Also Published As

Publication number Publication date
CA2595041A1 (fr) 2006-07-27
CY1110926T1 (el) 2015-06-10
US20080039491A1 (en) 2008-02-14
RU2007131274A (ru) 2009-02-27
SI1845978T1 (sl) 2010-12-31
RU2375360C2 (ru) 2009-12-10
US8008322B2 (en) 2011-08-30
PE20061119A1 (es) 2006-11-27
MX2007008790A (es) 2007-09-11
HRP20100624T1 (hr) 2010-12-31
EP1845978B1 (de) 2010-08-18
UY29341A1 (es) 2006-08-31
PT1845978E (pt) 2010-11-29
PA8660301A1 (es) 2006-09-08
AU2006207442A1 (en) 2006-07-27
DK1845978T3 (da) 2010-12-13
ATE477799T1 (de) 2010-09-15
US20110190337A1 (en) 2011-08-04
AR052357A1 (es) 2007-03-14
IL184524A0 (en) 2007-10-31
PL1845978T3 (pl) 2011-02-28
BRPI0606504A2 (pt) 2009-06-30
HRP20100624T8 (en) 2011-01-31
JP2008527025A (ja) 2008-07-24
WO2006077319A1 (fr) 2006-07-27
EP1845978A1 (de) 2007-10-24
KR20070098923A (ko) 2007-10-05
TW200639173A (en) 2006-11-16

Similar Documents

Publication Publication Date Title
DE602006016233D1 (de) Substituierte pyrazolopyridine, diese enthaltende sowie deren verwendung
CY2022022I2 (el) Υποκατεστημενα 4-αρυλο-1,4-διυδρο-1,6-ναφθυριδιν αμιδια και η χρηση τους
LTC2100614I2 (lt) Antikūnas prieš PDGFR-alfa, skirtas naudoti auglių gydymui
ATE489389T1 (de) 2 -heteroaryl- pyrrolo ä3, 4-cüpyrrol- derivate und deren verwendung als scd inhibitoren
ATE487707T1 (de) (6-flu0r-benz0äl, 3üdioxolyl)-morpholin-4-yl- methanone und deren verwendung als cbl-liganden
IL184901A0 (en) 2,4-diamino-pyridopyrimidine derivatives and their use as mtor inhibitors
ATE415400T1 (de) Pyrazolopyridinderivate
ATE395342T1 (de) 2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung
ATE518859T1 (de) Neue fluorenderivate, zusammensetzung mit diesen derivaten und verwendung
DE602007012308D1 (de) Bicyclische pyrimidinone und deren verwendung
DE602005002470D1 (de) 1-aminophthalazinderivate, deren herstellung und deren therapeutische verwendung
HK1075576A2 (en) Ultra violet light sterilizer.
ATE433976T1 (de) Substituierte pyrrolopyridine, zusammensetzungen damit und verfahren zu ihrer herstellung und verwendung
ATE511507T1 (de) Piperidinylcarbonylpyrrolidine und deren verwendung als melanocortinagonisten
HK1131140A1 (en) Substituted prolinamides, and the use thereof
BRPI0922233A2 (pt) compostos, composições farmacêiticas e métodos para uso no tratamento de síndromes metabólicas.
ATE517098T1 (de) Acylaminothiazolderivate und deren verwendung als beta-amyloid-inhibitoren
ZA201002016B (en) 3-substituted 1,2,4-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses
BRPI0815768A2 (pt) Uso de absorventes de uv, e, composição cosmética.
ATE542806T1 (de) Diarylmethylpiperazinderivate, deren herstellung und deren verwendung
ZA200706672B (en) 2,4-Diamino-pyridopyrimidine derivatives and their use as mTOR inhibitors
ATE417846T1 (de) Aminotropanderivate, deren herstellung und deren therapeutische verwendung
DE602005002424D1 (de) Polyhydrosiloxanverbindungen, Erzeugnisse und deren Verwendung
ATE555097T1 (de) 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
DE602007006540D1 (de) Cyclopropancarboxylate und deren verwendung als pestizide