DE602005014110D1 - Zusammensetzungen und verfahren zur extraktion und detektion von mikrobiellem atp - Google Patents

Zusammensetzungen und verfahren zur extraktion und detektion von mikrobiellem atp

Info

Publication number
DE602005014110D1
DE602005014110D1 DE602005014110T DE602005014110T DE602005014110D1 DE 602005014110 D1 DE602005014110 D1 DE 602005014110D1 DE 602005014110 T DE602005014110 T DE 602005014110T DE 602005014110 T DE602005014110 T DE 602005014110T DE 602005014110 D1 DE602005014110 D1 DE 602005014110D1
Authority
DE
Germany
Prior art keywords
detection
compositions
methods
extraction
atp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005014110T
Other languages
English (en)
Inventor
Frank Fan
Braeden Butler
Keith V Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Publication of DE602005014110D1 publication Critical patent/DE602005014110D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE602005014110T 2004-07-02 2005-07-01 Zusammensetzungen und verfahren zur extraktion und detektion von mikrobiellem atp Active DE602005014110D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58497104P 2004-07-02 2004-07-02
PCT/US2005/023545 WO2006085972A2 (en) 2004-07-02 2005-07-01 Compositions and processes for the extraction and detection of microbial atp

Publications (1)

Publication Number Publication Date
DE602005014110D1 true DE602005014110D1 (de) 2009-06-04

Family

ID=36793507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005014110T Active DE602005014110D1 (de) 2004-07-02 2005-07-01 Zusammensetzungen und verfahren zur extraktion und detektion von mikrobiellem atp

Country Status (10)

Country Link
US (2) US7422868B2 (de)
EP (1) EP1763584B1 (de)
JP (1) JP5255273B2 (de)
CN (1) CN101040054A (de)
AT (1) ATE429507T1 (de)
CA (1) CA2572608A1 (de)
DE (1) DE602005014110D1 (de)
DK (1) DK1763584T3 (de)
ES (1) ES2324952T3 (de)
WO (1) WO2006085972A2 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083911B2 (en) * 2001-02-16 2006-08-01 Promega Corporation Method for detection of ATP
CA2504129A1 (en) * 2002-11-01 2004-05-21 Promega Corporation Cell lysis compositions, methods of use, apparatus, and kit
CN101040054A (zh) * 2004-07-02 2007-09-19 普罗美加公司 微生物atp提取及检测系统
GB0513535D0 (en) * 2005-07-01 2005-08-10 Iseao Technologies Ltd Improved methods of detecting microbes
NL1030525C2 (nl) 2005-11-25 2007-05-29 Amiris B V Werkwijze voor het met luminescentie detecteren van ATP in een monster en een computerprogramma daarvoor.
ES2389111T3 (es) 2005-12-02 2012-10-23 Sirtris Pharmaceuticals, Inc. Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa
FR2897873B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Procede d'analyse microbiologique rapide.
FR2897941B1 (fr) * 2006-02-24 2009-01-16 Millipore Corp Dispositif et procede pour l'analyse microbiologique rapide.
FR2897872B1 (fr) * 2006-02-24 2008-08-15 Millipore Corp Procede d'analyse microbiologique rapide.
FR2897783B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre
WO2008045121A1 (en) * 2006-10-13 2008-04-17 Charm Sciences, Inc. Method and apparatus for reducing luminescent test result interferences
CN101636503B (zh) 2006-10-24 2012-10-03 基因流股份有限公司 萤光素酶信号增强组合物
EP2104741B1 (de) 2006-12-21 2014-12-03 Gene Stream Pty Ltd. Biolumineszenz-testverfahren mit nutzung sezernierter luciferasen
GB2448499B (en) 2007-04-17 2011-03-23 Krysium Advisors Ltd Method of testing an organic sample
FR2915487B1 (fr) 2007-04-26 2009-06-05 Millipore Corp Ensemble et procede pour analyse microbiologique
EP2203550B1 (de) * 2007-10-03 2015-12-02 3M Innovative Properties Company Verfahren zur Konzentration von Mikroorganismen
EP2500411B1 (de) 2007-10-03 2016-11-23 3M Innovative Properties Company Verfahren zur herstellung von mitteln zur konzentration von microorganismen
CN101878294B (zh) * 2007-10-03 2014-12-10 3M创新有限公司 微生物浓集方法
EP2379697A2 (de) 2008-12-31 2011-10-26 3M Innovative Properties Company Probenahmevorrichtungen und verfahren zur aufkonzentration von mikroorganismen
JP5833450B2 (ja) 2008-12-31 2015-12-16 スリーエム イノベイティブ プロパティズ カンパニー 微小粒子を用いた生きた生物負荷の検出法
BRPI0918694A2 (pt) 2008-12-31 2015-12-01 3M Innovative Properties Co processo de detecção de coliforme e kit para uso do mesmo
US9964474B2 (en) 2009-04-03 2018-05-08 3M Innovative Properties Company Microorganism concentration process and device
CN102449136B (zh) 2009-04-03 2014-06-11 3M创新有限公司 微生物浓集方法和装置
US8518658B1 (en) * 2009-04-27 2013-08-27 University Of South Florida ATP-bioluminescence immunoassay
EP2430444B1 (de) * 2009-05-12 2014-01-08 Janssen R&D Ireland Verfahren zur identifizierung von hemmern gegen das dengue-virus
JP5972174B2 (ja) 2009-12-30 2016-08-17 スリーエム イノベイティブ プロパティズ カンパニー 微小粒子を用いた生きた生物負荷の検出法
WO2011082258A2 (en) 2009-12-30 2011-07-07 Regents Of The University Of Minnesota Bone cement and method
CN107267369B (zh) 2010-12-06 2021-04-09 3M创新有限公司 微生物浓集方法和装置
WO2012078426A2 (en) 2010-12-06 2012-06-14 3M Innovative Properties Company Microorganism concentration process and device
KR101667060B1 (ko) * 2011-01-26 2016-10-18 연세대학교 산학협력단 미생물 용해 시스템과 ａｔｐ발광을 이용한 기상 중 부유 미생물 실시간 측정장치 및 측정방법
JP5591747B2 (ja) * 2011-03-30 2014-09-17 株式会社日立製作所 発光計測装置及び微生物計数装置
CN102584923B (zh) * 2012-01-30 2014-01-15 烟台大学 一种从红藻角叉菜中提取化合物的提取方法
WO2013184186A1 (en) 2012-06-05 2013-12-12 3M Innovative Properties Company Bismuth-containing concentration agents for microorganisms
JP6087426B2 (ja) 2012-06-05 2017-03-01 スリーエム イノベイティブ プロパティズ カンパニー 微生物のランタン含有濃縮剤
JP5469727B1 (ja) * 2012-10-19 2014-04-16 株式会社日立製作所 生体物質定量方法及び生体物質定量装置
US9562253B1 (en) 2012-11-09 2017-02-07 Point Of Care Diagnostics, Llc Distinguishing between a bacterial and non-bacterial infection at the point of care
CN105338815B (zh) 2013-06-28 2020-07-14 3M创新有限公司 具有含胍基的聚合物的擦拭物
US20150050358A1 (en) * 2013-08-15 2015-02-19 Regents Of The University Of Minnesota Implant support composition and methods of use
JP2017503881A (ja) 2013-12-18 2017-02-02 スリーエム イノベイティブ プロパティズ カンパニー 分離用の多孔質物品
CN105087765A (zh) * 2014-05-16 2015-11-25 深圳先进技术研究院 聚胸腺嘧啶模板、基于聚胸腺嘧啶模板的荧光铜纳米簇及其制备方法、atp的检测方法
KR102221557B1 (ko) * 2014-07-28 2021-03-02 엘지전자 주식회사 부유미생물 측정장치 및 그 측정방법
KR102288766B1 (ko) * 2014-08-18 2021-08-12 엘지전자 주식회사 포집판 제조 방법 및 부유 미생물 측정장치
JP6821586B2 (ja) 2015-03-19 2021-01-27 スリーエム イノベイティブ プロパティズ カンパニー 流体試料中の微生物株又は標的細胞検体を検出するためのデバイス、方法、キット、及びシステム
US20180051313A1 (en) 2015-03-19 2018-02-22 3M Innovative Properties Company Methods, devices, and kits for detecting microorganisms in a fluid sample
JP6838815B2 (ja) 2015-03-19 2021-03-03 スリーエム イノベイティブ プロパティズ カンパニー 流体試料中の微生物を検出するための不織布物品及び当該不織布物品の使用方法
EP3271067B1 (de) 2015-03-19 2020-10-21 3M Innovative Properties Company Guanidinfunctionalisierte perlitteilchen, artikel mit den partikeln und verfahren zur verwendung der partikel und artikel
EP3640321B1 (de) 2015-10-09 2022-04-06 DEKA Products Limited Partnership Verfahren zur erzeugung eines gewebe für die transplantation
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
JP7018729B2 (ja) * 2017-09-19 2022-02-14 東京エレクトロン株式会社 成膜方法
CN107505311A (zh) * 2017-09-25 2017-12-22 江苏中新医药有限公司 快速确定灭菌效果的方法和生物指示剂
CN107421939A (zh) * 2017-09-25 2017-12-01 江苏中新医药有限公司 一种快速定量检测抗菌药物敏感性的试剂及其应用方法
CN107841528A (zh) * 2017-11-13 2018-03-27 常州明华运输有限公司 一种矿泉水中微量大肠杆菌的检测方法
US11680877B2 (en) 2018-09-05 2023-06-20 Hero Scientific Ltd. Testing for particulates
EP4165385B1 (de) 2021-01-06 2024-04-17 Hero Scientific Ltd Vorrichtungen zur probenentnahme durch filtration
CN113444766B (zh) * 2021-06-04 2024-05-24 海天醋业集团有限公司 用于发酵酒陈酿过程中变质菌的富集培养基及的检测方法
CN115404158A (zh) * 2022-08-15 2022-11-29 国家食品安全风险评估中心 一种微生物污染程度的检测方法及设备

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080265A (en) * 1974-08-02 1978-03-21 Antonik Alan S Method for the determination of creative phosphokinase enzyme
GB1604249A (en) * 1977-05-31 1981-12-02 Kolehmainen S Selective measurement of somatic and microbial cells
SE428379B (sv) * 1978-05-31 1983-06-27 Lkb Produkter Ab Bioluminiscens bestemning av atp och reagens herfor
US4349510A (en) * 1979-07-24 1982-09-14 Seppo Kolehmainen Method and apparatus for measurement of samples by luminescence
US4906565A (en) * 1986-03-21 1990-03-06 Minnesota Mining And Manufacturing Company Method for the selective detection of microbial nucleotides
DK258787D0 (da) * 1987-05-21 1987-05-21 Foss Electric As N Fremgangsmaade til bestemmelse af bakteriekoncentration i en proeve
GB8722252D0 (en) * 1987-09-22 1987-10-28 Brewing Res Found Atp extraction
US5283179A (en) * 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
GB9100551D0 (en) * 1991-01-10 1991-02-20 Amersham Int Plc Method and reagent for eliminating analytical interference in enzymatic analysis from substances used for extraction of intracellular metabolites
US5648232A (en) * 1993-01-21 1997-07-15 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Microbiological best method and reagents
AT401526B (de) * 1993-02-10 1996-09-25 Scheirer Winfried Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung
JPH07203995A (ja) * 1994-01-26 1995-08-08 Toa Denpa Kogyo Kk 細胞内ａｔｐの測定方法
GB9405392D0 (en) * 1994-03-18 1994-05-04 Secr Defence Microorganism detection apparatus and method
GB9414096D0 (en) * 1994-07-13 1994-08-31 Secr Defence Labelled capture assay
JP3409962B2 (ja) * 1996-03-04 2003-05-26 キッコーマン株式会社 生物発光試薬及びその試薬を用いたアデノシンリン酸エステルの定量法並びにその試薬を用いたａｔｐ変換反応系に関与する物質の定量法
JPH1028599A (ja) * 1996-04-26 1998-02-03 Toyo Ink Mfg Co Ltd 試料中に存在する微生物細胞に由来するａｔｐを検出及び／または測定する方法、及びその試薬キット
US5908751A (en) * 1996-04-26 1999-06-01 Toyo Ink Mfg. Co., Ltd. Method for detecting and/or determining ATP from microorganism cells in a sample
JPH10165200A (ja) * 1996-12-05 1998-06-23 Toa Denpa Kogyo Kk 微生物ａｔｐの測定方法
EP1015461B1 (de) * 1997-09-12 2004-05-12 Lumigen, Inc. Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase
EP1015601B1 (de) * 1997-09-19 2015-01-07 Promega Corporation Thermostabile luciferasen und verfahren zu deren herstellung
US6602677B1 (en) * 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
JP3749628B2 (ja) * 1997-12-26 2006-03-01 キッコーマン株式会社 ルシフェラーゼおよびそれを用いる細胞内ａｔｐの測定法
US6703211B1 (en) * 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6159693A (en) * 1998-03-13 2000-12-12 Promega Corporation Nucleic acid detection
NL1010224C2 (nl) * 1998-09-30 2000-03-31 Packard Biosciene B V Werkwijze voor het detecteren van ATP.
US6174704B1 (en) * 1998-12-23 2001-01-16 Pierce Chemical Company Method for recovery of proteins prepared by recombinant DNA procedures
US6548018B2 (en) * 2000-03-31 2003-04-15 Neogen Corporation Apparatus for chemiluminescent assays
US6660489B2 (en) 2000-12-01 2003-12-09 Becton, Dickinson And Company ATP extraction method
GB0030727D0 (en) * 2000-12-15 2001-01-31 Lumitech Uk Ltd Methods and kits for detecting kinase activity
US7083911B2 (en) * 2001-02-16 2006-08-01 Promega Corporation Method for detection of ATP
US7416854B2 (en) * 2004-01-22 2008-08-26 Promega Corporation Luminogenic and nonluminogenic multiplex assay
CN101040054A (zh) * 2004-07-02 2007-09-19 普罗美加公司 微生物atp提取及检测系统

Also Published As

Publication number Publication date
US20090029398A1 (en) 2009-01-29
WO2006085972A9 (en) 2007-02-15
CN101040054A (zh) 2007-09-19
US20060008860A1 (en) 2006-01-12
JP5255273B2 (ja) 2013-08-07
ES2324952T3 (es) 2009-08-20
WO2006085972A2 (en) 2006-08-17
EP1763584A2 (de) 2007-03-21
CA2572608A1 (en) 2006-08-17
EP1763584B1 (de) 2009-04-22
JP2008504841A (ja) 2008-02-21
ATE429507T1 (de) 2009-05-15
WO2006085972A3 (en) 2007-01-04
DK1763584T3 (da) 2009-08-03
US7422868B2 (en) 2008-09-09

Similar Documents

Publication Publication Date Title
ATE429507T1 (de) Zusammensetzungen und verfahren zur extraktion und detektion von mikrobiellem atp
ATE540950T1 (de) Aminocyclohexane als dipeptidylpeptidase-iv- hemmer zur behandlung bzw. prävention von diabetes
ATE549926T1 (de) Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
ATE481969T1 (de) Aminopiperidine als dipeptidylpeptidase-iv- inhibitoren zur behandlung oder prävention von diabetes
IL185021A0 (en) Diagnosis method of hepatic steatosis using biochemical markers
ATE527259T1 (de) Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
ATE323182T1 (de) Universelle methode und zusammensetzung zur schnellen lysierung von zellen zur freisetzung von nukleinsäuren und ihre detektion
WO2010129019A3 (en) Real-time sequencing methods and systems
BRPI0407397A (pt) Evento de algodão mon 88913 e composições e métodos para sua detecção
ATE488604T1 (de) System zum nachweis von polynukleotiden
ATE513838T1 (de) Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität
AR046599A1 (es) Lineas transgenicas de algodon cry1f y cry1ac e identificacion evento-especifica de las mismas
EA200970519A1 (ru) Полиморфы сукцината 2-[6-(3-аминопиперидин-1-ил)-3-метил-2,4-диоксо-3,4-дигидро-2h-пиримидин-1-илметил]-4-фторбензонитрил и способы их применения
MX2009003452A (es) Inhibidores nucleosidicos del vhc.
ATE504836T1 (de) Verfahren zur identifizierung von trpv2- modulatoren
DE602007002090D1 (de) Verfahren zur Erkennung von anaplastischem Schilddrüsenkrebs, und Verfahren zur seiner Unterdrückung
GT200500374A (es) 3,5-disubstituido y 3,5,7-trisubstituido-3h-oxazolo y 3h-tiazolo[4,5-d]pirimidina-2,1, compuestos y prodrogas que las contienen
Li et al. Effects of substratum type on bacterial community structure in biofilms in relation to settlement of plantigrades of the mussel Mytilus coruscus
ATE538651T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
WO2012061157A8 (en) Method for high-throughput identification of microbial antagonists against pathogens
DE502006002073D1 (de) Verfahren zur verhinderung der zeitabhängigen rna-expression in biologischen zellen
DE602005000249D1 (de) Verfahren zur Isolierung von Bakterien aus biologischen Proben
WO2005042060A3 (en) Method and composition comprising pyruvate, inosine, adenine, phosphate and an aziridino compound for treating a biological sample
ATE538796T1 (de) Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit
EA200500125A1 (ru) СПОСОБ ОБОГАЩЕНИЯ И ОБНАРУЖЕНИЯ ПАТОЛОГИЧЕСКИ ИЗМЕНЕННЫХ ПРИОНПРОТЕИНОВ (PrP)

Legal Events

Date Code Title Description
8364 No opposition during term of opposition