ATE540950T1 - Aminocyclohexane als dipeptidylpeptidase-iv- hemmer zur behandlung bzw. prävention von diabetes - Google Patents
Aminocyclohexane als dipeptidylpeptidase-iv- hemmer zur behandlung bzw. prävention von diabetesInfo
- Publication number
- ATE540950T1 ATE540950T1 AT06770752T AT06770752T ATE540950T1 AT E540950 T1 ATE540950 T1 AT E540950T1 AT 06770752 T AT06770752 T AT 06770752T AT 06770752 T AT06770752 T AT 06770752T AT E540950 T1 ATE540950 T1 AT E540950T1
- Authority
- AT
- Austria
- Prior art keywords
- diabetes
- inhibitors
- prevention
- treatment
- aminocyclohexanes
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title 1
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 1
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical class NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68456705P | 2005-05-25 | 2005-05-25 | |
PCT/US2006/019598 WO2006127530A2 (en) | 2005-05-25 | 2006-05-19 | Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540950T1 true ATE540950T1 (de) | 2012-01-15 |
Family
ID=37452661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06770752T ATE540950T1 (de) | 2005-05-25 | 2006-05-19 | Aminocyclohexane als dipeptidylpeptidase-iv- hemmer zur behandlung bzw. prävention von diabetes |
Country Status (8)
Country | Link |
---|---|
US (1) | US7906649B2 (de) |
EP (1) | EP1888066B1 (de) |
JP (1) | JP5069678B2 (de) |
CN (2) | CN103275083A (de) |
AT (1) | ATE540950T1 (de) |
AU (1) | AU2006251660B2 (de) |
CA (1) | CA2607441C (de) |
WO (1) | WO2006127530A2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718667B2 (en) | 2004-09-28 | 2010-05-18 | Merck Sharp & Dohme Corp. | Fused aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
WO2006127530A2 (en) | 2005-05-25 | 2006-11-30 | Merck & Co., Inc. | Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
JP5075125B2 (ja) | 2005-08-26 | 2012-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療又は予防用ジペプチジルペプチダーゼiv阻害剤としての縮合アミノピペリジン |
WO2007027651A2 (en) * | 2005-08-30 | 2007-03-08 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
WO2007070434A2 (en) | 2005-12-14 | 2007-06-21 | Merck & Co., Inc. | Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes |
AU2007208405B2 (en) * | 2006-01-25 | 2011-05-26 | Merck Sharp & Dohme Corp. | Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
US7910596B2 (en) | 2006-02-15 | 2011-03-22 | Merck Sharp & Dohme Corp. | Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
TW200806669A (en) | 2006-03-28 | 2008-02-01 | Merck & Co Inc | Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
US7812027B2 (en) | 2006-05-16 | 2010-10-12 | Merck Sharp & Dohme Corp. | Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
MX2009001043A (es) | 2006-08-08 | 2009-02-06 | Sanofi Aventis | Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso. |
CA2668662A1 (en) * | 2006-11-14 | 2008-05-22 | Merck & Co., Inc. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2190428A4 (de) * | 2007-08-21 | 2012-02-29 | Merck Sharp & Dohme | Heterocyclische verbindungen als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes |
AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
ES2443016T3 (es) | 2009-08-26 | 2014-02-17 | Sanofi | Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo |
JP5734981B2 (ja) | 2009-09-02 | 2015-06-17 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼiv阻害剤としてのアミノテトラヒドロピラン |
WO2011037793A1 (en) | 2009-09-25 | 2011-03-31 | Merck Sharp & Dohme Corp. | Substituted aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
EP2538783B1 (de) | 2010-02-22 | 2016-06-01 | Merck Sharp & Dohme Corp. | Substituierte aminotetrahydrothiopyrane als dipeptidylpeptidase-iv-hemmer zur behandlung von diabetes |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011146358A1 (en) | 2010-05-21 | 2011-11-24 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
EP2648517B1 (de) | 2010-12-06 | 2015-08-05 | Merck Sharp & Dohme Corp. | Trizyklische heterozyklen als dipeptidylpeptidase-iv-hemmer |
EP2899194A1 (de) * | 2011-03-03 | 2015-07-29 | Cadila Healthcare Limited | Amorphes besylat-salz eines dpp-iv-hemmers |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
MX341299B (es) | 2011-06-29 | 2016-08-11 | Merck Sharp & Dohme | Nuevas formas cristalinas de un inhibidor de la dipeptidil peptidasa-iv. |
EP2729468A4 (de) | 2011-07-05 | 2015-03-18 | Merck Sharp & Dohme | Tricyclische heterozyklen als dipeptidylpeptidase-iv-hemmer |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9073930B2 (en) | 2012-02-17 | 2015-07-07 | Merck Sharp & Dohme | Dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
WO2014018350A1 (en) | 2012-07-23 | 2014-01-30 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-iv inhibitors |
WO2014018355A1 (en) * | 2012-07-23 | 2014-01-30 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-iv inhibitors |
TWI500613B (zh) | 2012-10-17 | 2015-09-21 | Cadila Healthcare Ltd | 新穎之雜環化合物 |
EP2911655A1 (de) | 2012-10-24 | 2015-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tpl2-kinasehemmer zur vorbeugung oder behandlung von diabetes und zur förderung des überlebens von betazellen |
JP6574474B2 (ja) | 2014-07-21 | 2019-09-11 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | キラルジペプチジルペプチダーゼ−iv阻害剤の製造方法 |
WO2016151018A1 (en) | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
WO2016183741A1 (en) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Pyrimidinone amide compounds as pde2 inhibitors |
CN107200744A (zh) * | 2017-05-31 | 2017-09-26 | 湖南华腾制药有限公司 | 一种制备吡咯并嘧啶盐酸盐的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
NO301165B1 (no) * | 1992-12-25 | 1997-09-22 | Daiichi Seiyaku Co | Bicykliske aminderivater og antibakterielle midler inneholdende disse |
UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
CA2570807C (en) * | 2004-06-21 | 2011-12-06 | Merck & Co., Inc. | Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
CA2582447C (en) | 2004-10-01 | 2012-04-17 | Merck & Co., Inc. | Aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
CA2587800C (en) | 2004-11-29 | 2012-06-12 | Merck & Co., Inc. | Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
WO2006127530A2 (en) | 2005-05-25 | 2006-11-30 | Merck & Co., Inc. | Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
JP5075125B2 (ja) | 2005-08-26 | 2012-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療又は予防用ジペプチジルペプチダーゼiv阻害剤としての縮合アミノピペリジン |
AU2007208405B2 (en) | 2006-01-25 | 2011-05-26 | Merck Sharp & Dohme Corp. | Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
-
2006
- 2006-05-19 WO PCT/US2006/019598 patent/WO2006127530A2/en active Application Filing
- 2006-05-19 EP EP06770752A patent/EP1888066B1/de not_active Not-in-force
- 2006-05-19 JP JP2008513568A patent/JP5069678B2/ja not_active Expired - Fee Related
- 2006-05-19 AT AT06770752T patent/ATE540950T1/de active
- 2006-05-19 CN CN2013101432027A patent/CN103275083A/zh active Pending
- 2006-05-19 CN CNA2006800176568A patent/CN101500573A/zh active Pending
- 2006-05-19 US US11/920,038 patent/US7906649B2/en active Active
- 2006-05-19 AU AU2006251660A patent/AU2006251660B2/en not_active Ceased
- 2006-05-19 CA CA2607441A patent/CA2607441C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2006127530A2 (en) | 2006-11-30 |
US20090105284A1 (en) | 2009-04-23 |
JP2008545691A (ja) | 2008-12-18 |
AU2006251660B2 (en) | 2011-05-26 |
CA2607441C (en) | 2013-02-12 |
US7906649B2 (en) | 2011-03-15 |
AU2006251660A1 (en) | 2006-11-30 |
EP1888066A4 (de) | 2010-06-09 |
EP1888066B1 (de) | 2012-01-11 |
JP5069678B2 (ja) | 2012-11-07 |
CN101500573A (zh) | 2009-08-05 |
CN103275083A (zh) | 2013-09-04 |
CA2607441A1 (en) | 2006-11-30 |
EP1888066A2 (de) | 2008-02-20 |
WO2006127530A3 (en) | 2009-04-23 |
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