ATE448229T1 - Bicyclische pyrimidine als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes - Google Patents
Bicyclische pyrimidine als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetesInfo
- Publication number
- ATE448229T1 ATE448229T1 AT06718696T AT06718696T ATE448229T1 AT E448229 T1 ATE448229 T1 AT E448229T1 AT 06718696 T AT06718696 T AT 06718696T AT 06718696 T AT06718696 T AT 06718696T AT E448229 T1 ATE448229 T1 AT E448229T1
- Authority
- AT
- Austria
- Prior art keywords
- diabetes
- inhibitors
- prevention
- treatment
- dipeptidylpeptidase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64522005P | 2005-01-19 | 2005-01-19 | |
PCT/US2006/001660 WO2006078676A2 (en) | 2005-01-19 | 2006-01-18 | Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE448229T1 true ATE448229T1 (de) | 2009-11-15 |
Family
ID=36692794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06718696T ATE448229T1 (de) | 2005-01-19 | 2006-01-18 | Bicyclische pyrimidine als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes |
Country Status (9)
Country | Link |
---|---|
US (1) | US7956061B2 (de) |
EP (1) | EP1841770B1 (de) |
JP (1) | JP5094412B2 (de) |
CN (1) | CN101107251A (de) |
AT (1) | ATE448229T1 (de) |
AU (1) | AU2006206573B9 (de) |
CA (1) | CA2593264C (de) |
DE (1) | DE602006010320D1 (de) |
WO (1) | WO2006078676A2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007011759A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
AR056206A1 (es) * | 2005-10-06 | 2007-09-26 | Schering Corp | Pirazolpirimidinas como inhibidores de protein quinasas |
CN101394853A (zh) * | 2006-03-08 | 2009-03-25 | 诺瓦提斯公司 | 吡唑并[1,5-a]嘧啶-7-基胺衍生物在神经性障碍的治疗中的用途 |
MX2009001043A (es) | 2006-08-08 | 2009-02-06 | Sanofi Aventis | Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso. |
KR20100019470A (ko) * | 2007-04-30 | 2010-02-18 | 아보트 러보러터리즈 | 디아실글리세롤 o-아실트랜스퍼라제 타입 1 효소의 억제제 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
US20100173829A1 (en) * | 2008-11-07 | 2010-07-08 | Aston University | Glycoproteins Having Lipid Mobilizing Properties and Therapeutic Uses Thereof |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
ES2443016T3 (es) | 2009-08-26 | 2014-02-17 | Sanofi | Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo |
US8853212B2 (en) | 2010-02-22 | 2014-10-07 | Merck Sharp & Dohme Corp | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8980929B2 (en) | 2010-05-21 | 2015-03-17 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
EP2648517B1 (de) | 2010-12-06 | 2015-08-05 | Merck Sharp & Dohme Corp. | Trizyklische heterozyklen als dipeptidylpeptidase-iv-hemmer |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
RU2598072C2 (ru) | 2011-06-29 | 2016-09-20 | Мерк Шарп И Доум Корп. | Новые кристаллические формы ингибиторов дипептидилпептидазы-iv |
EP2729468A4 (de) | 2011-07-05 | 2015-03-18 | Merck Sharp & Dohme | Tricyclische heterozyklen als dipeptidylpeptidase-iv-hemmer |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (de) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren |
EP2814485A4 (de) | 2012-02-17 | 2015-08-26 | Merck Sharp & Dohme | Dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes |
MX2014008420A (es) | 2012-03-09 | 2015-03-03 | Morinaga Milk Industry Co Ltd | Inhibidor de dipeptidil peptidasa-iv. |
ITBO20120226A1 (it) | 2012-04-24 | 2013-10-25 | Alfa Wassermann Spa | Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso. |
EP2874622A4 (de) * | 2012-07-23 | 2015-12-30 | Merck Sharp & Dohme | Behandlung von diabetes mit dipeptidylpeptidase-iv-hemmern |
US9156848B2 (en) | 2012-07-23 | 2015-10-13 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-IV inhibitors |
WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
JP6574474B2 (ja) | 2014-07-21 | 2019-09-11 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | キラルジペプチジルペプチダーゼ−iv阻害剤の製造方法 |
IL252053B2 (en) | 2014-11-06 | 2024-04-01 | Lysosomal Therapeutics Inc | Converted pyrazolo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
AU2017246455B2 (en) | 2016-04-06 | 2021-09-30 | Bial - R&D Investments, S.A. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
CA3020310A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
US10787454B2 (en) | 2016-04-06 | 2020-09-29 | BIAL—BioTech Investments, Inc. | Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
JP7164774B2 (ja) | 2016-05-05 | 2022-11-02 | ビアル-アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ | 置換イミダゾ[1,2-b]ピリダジン、置換イミダゾ[1,5-b]ピリダジン、関連化合物、および医学的障害の治療におけるその使用 |
WO2018102552A1 (en) | 2016-11-30 | 2018-06-07 | Case Western Reserve University | Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof |
WO2018145080A1 (en) * | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
US11426420B2 (en) | 2017-04-07 | 2022-08-30 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60315687T2 (de) * | 2002-10-07 | 2008-06-05 | Merck & Co., Inc. | Antidiabetische heterocyclische beta-aminoverbindungen als inhibitoren von dipeptidylpeptidase |
US7635699B2 (en) * | 2004-12-29 | 2009-12-22 | Bristol-Myers Squibb Company | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods |
-
2006
- 2006-01-18 EP EP06718696A patent/EP1841770B1/de not_active Not-in-force
- 2006-01-18 DE DE602006010320T patent/DE602006010320D1/de active Active
- 2006-01-18 CN CNA200680002545XA patent/CN101107251A/zh active Pending
- 2006-01-18 AU AU2006206573A patent/AU2006206573B9/en not_active Ceased
- 2006-01-18 WO PCT/US2006/001660 patent/WO2006078676A2/en active Application Filing
- 2006-01-18 US US11/793,093 patent/US7956061B2/en active Active
- 2006-01-18 CA CA2593264A patent/CA2593264C/en not_active Expired - Fee Related
- 2006-01-18 AT AT06718696T patent/ATE448229T1/de not_active IP Right Cessation
- 2006-01-18 JP JP2007551474A patent/JP5094412B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1841770A2 (de) | 2007-10-10 |
AU2006206573A1 (en) | 2006-07-27 |
EP1841770A4 (de) | 2009-03-04 |
CA2593264A1 (en) | 2006-07-27 |
DE602006010320D1 (de) | 2009-12-24 |
AU2006206573B2 (en) | 2011-05-12 |
JP2008527011A (ja) | 2008-07-24 |
AU2006206573B9 (en) | 2011-09-29 |
CA2593264C (en) | 2012-09-25 |
WO2006078676A3 (en) | 2007-03-29 |
US7956061B2 (en) | 2011-06-07 |
JP5094412B2 (ja) | 2012-12-12 |
EP1841770B1 (de) | 2009-11-11 |
CN101107251A (zh) | 2008-01-16 |
WO2006078676A2 (en) | 2006-07-27 |
US20090105210A1 (en) | 2009-04-23 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |