EA200500125A1 - СПОСОБ ОБОГАЩЕНИЯ И ОБНАРУЖЕНИЯ ПАТОЛОГИЧЕСКИ ИЗМЕНЕННЫХ ПРИОНПРОТЕИНОВ (PrP) - Google Patents

СПОСОБ ОБОГАЩЕНИЯ И ОБНАРУЖЕНИЯ ПАТОЛОГИЧЕСКИ ИЗМЕНЕННЫХ ПРИОНПРОТЕИНОВ (PrP)

Info

Publication number
EA200500125A1
EA200500125A1 EA200500125A EA200500125A EA200500125A1 EA 200500125 A1 EA200500125 A1 EA 200500125A1 EA 200500125 A EA200500125 A EA 200500125A EA 200500125 A EA200500125 A EA 200500125A EA 200500125 A1 EA200500125 A1 EA 200500125A1
Authority
EA
Eurasian Patent Office
Prior art keywords
prp
pronproteinov
enrichment
detection
pathologically modified
Prior art date
Application number
EA200500125A
Other languages
English (en)
Inventor
Клаудиа Енгеманн
Катя Хоешлер
Йорг Лехманн
Йорг Габерт
Улрике Круммреи
Original Assignee
Прионтайп Гмбх & Ко. Кг
Шлеусснер, Катрин
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Прионтайп Гмбх & Ко. Кг, Шлеусснер, Катрин filed Critical Прионтайп Гмбх & Ко. Кг
Publication of EA200500125A1 publication Critical patent/EA200500125A1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Данное изобретение относится к способу обогащения и обнаружения патологически измененных прионпротеинов (PrP) живых организмов.Отчет о международном поиске был опубликован 2004.04.29.
EA200500125A 2002-07-04 2003-07-04 СПОСОБ ОБОГАЩЕНИЯ И ОБНАРУЖЕНИЯ ПАТОЛОГИЧЕСКИ ИЗМЕНЕННЫХ ПРИОНПРОТЕИНОВ (PrP) EA200500125A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10230141A DE10230141B4 (de) 2002-07-04 2002-07-04 Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
PCT/DE2003/002249 WO2004005920A2 (de) 2002-07-04 2003-07-04 Verfahren zur anreicherung und zum nachweis von pathologisch veränderten prion-proteinen (prpsc)

Publications (1)

Publication Number Publication Date
EA200500125A1 true EA200500125A1 (ru) 2005-08-25

Family

ID=30009806

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500125A EA200500125A1 (ru) 2002-07-04 2003-07-04 СПОСОБ ОБОГАЩЕНИЯ И ОБНАРУЖЕНИЯ ПАТОЛОГИЧЕСКИ ИЗМЕНЕННЫХ ПРИОНПРОТЕИНОВ (PrP)

Country Status (12)

Country Link
US (1) US20060094071A1 (ru)
EP (1) EP1520178A2 (ru)
JP (1) JP2005531775A (ru)
CN (1) CN1666106A (ru)
AU (1) AU2003250773A1 (ru)
BR (1) BR0312282A (ru)
CA (1) CA2489151A1 (ru)
DE (2) DE10230141B4 (ru)
EA (1) EA200500125A1 (ru)
NO (1) NO20050599L (ru)
PL (1) PL375358A1 (ru)
WO (1) WO2004005920A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
AU2004264953B2 (en) 2003-08-13 2009-07-23 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20090099343A1 (en) * 2005-01-13 2009-04-16 David Peretz Isolation of pathogenic prions
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
JP5209477B2 (ja) * 2005-09-09 2013-06-12 ノバルティス アーゲー プリオンに特異的なペプトイド試薬
WO2007123345A1 (en) * 2006-04-21 2007-11-01 Peoplebio, Inc. Method for differentially detecting multimeric form from monomeric form of multimer-forming polypeptides through three-dimensional interactions
US20100234417A1 (en) * 2006-11-10 2010-09-16 Dimerix Bioscience Pty Ltd. Thyrotropin releasing hormone receptor-orexin receptor hetero-dimers/-oligomers
EP2282753A1 (en) * 2008-04-30 2011-02-16 Novartis AG Assay for pathogenic conformers
CN103336124B (zh) * 2012-12-11 2015-07-15 武汉工业学院 一种检测朊病毒蛋白(PrPSC)的方法和试剂盒

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4233604B2 (ja) * 1991-12-03 2009-03-04 プロセリックス メディスンズ ディベロップメント リミテッド プリオンタンパク質のフラグメント
US5948763A (en) * 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
AU1072897A (en) * 1995-12-12 1997-07-03 Karolinska Innovations Ab Peptide binding the klvff-sequence of amyloid beta
FI982481A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nautaeläinten tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
US6150172A (en) * 1999-01-08 2000-11-21 The United States Of America As Represented By The Secretary Of Agriculture Method and kit for extracting prion protein
GB9917724D0 (en) * 1999-07-28 1999-09-29 Medical Res Council Peptides
GB9917725D0 (en) * 1999-07-28 1999-09-29 Medical Res Council Peptides
EP1216258A1 (en) * 1999-09-28 2002-06-26 Universität Zürich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis
CN1437442A (zh) * 1999-11-05 2003-08-20 阿克松尼克斯公司 适于体内应用治疗与折叠成淀粉样蛋白、淀粉样蛋白样沉积物的异常蛋白或其富含β－折叠的致病性前体有关的疾病的肽类似物和模拟物
CA2413742A1 (en) * 2000-06-26 2002-01-03 Universitat Zurich Prion-binding activity in serum and proteins
US20020115717A1 (en) * 2000-07-25 2002-08-22 Francine Gervais Amyloid targeting imaging agents and uses thereof
DE10120562C2 (de) * 2001-04-26 2003-04-10 Horst Messer Verfahren zur Diagnose von übertragbaren spongiformen Enzephalopathien

Also Published As

Publication number Publication date
AU2003250773A1 (en) 2004-01-23
EP1520178A2 (de) 2005-04-06
BR0312282A (pt) 2005-04-12
WO2004005920A2 (de) 2004-01-15
PL375358A1 (en) 2005-11-28
US20060094071A1 (en) 2006-05-04
DE10393421D2 (de) 2005-06-09
DE10230141A1 (de) 2004-02-05
CN1666106A (zh) 2005-09-07
NO20050599L (no) 2005-04-01
WO2004005920A3 (de) 2004-04-29
CA2489151A1 (en) 2004-01-15
DE10230141B4 (de) 2004-07-15
JP2005531775A (ja) 2005-10-20

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